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Die Kenntnis von Indikationen und Techniken der Transplantation selbst als auch der histopathologischen Absto\u00dfungsdiagnostik mittels Pankreas- oder selten Duodenalbiopsie ist nicht sehr weit verbreitet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Darstellung der Entwicklung und des aktuellen Stands der Pankreas-Nieren-Transplantation in Deutschland anhand der Erfahrungen des gr\u00f6\u00dften deutschen Zentrums und Analyse der Ergebnisse der zwischen 06\/2017 und 12\/2020 durchgef\u00fchrten Absto\u00dfungsbiopsien inklusive ausf\u00fchrlicher Darstellung und Bebilderung der verschiedenen Absto\u00dfungskategorien<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methode<\/jats:title>\n                <jats:p>Es wurde eine ausf\u00fchrliche Literaturrecherche zur Historie, Technik und Indikation der Pankreastransplantation durchgef\u00fchrt und die technischen Besonderheiten und Erfahrungen am Bochumer Zentrum, insbesondere auch die Komplikationen, im internationalen Vergleich dargestellt. Desweiteren wurden alle im Zeitraum zwischen 06\/2017 und 12\/2020 durchgef\u00fchrten Pankreas- oder Duodenalbiopsien, die zur Absto\u00dfungsdiagnostik nach Erlangen gegangen waren und mittels der Banff-Klassifikation standardisiert bearbeitet wurden, anhand der vorliegenden Befunde ausgewertet und zusammenfassend dargestellt. Zum besseren Verst\u00e4ndnis wurden die wichtigsten histologischen Entit\u00e4ten bildhaft dargestellt und differenzialdiagnostische Aspekte diskutiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt wurden 93 Pankreastransplantat- und 3 Duodenalbiopsien untersucht. In 32 Pankreasbiopsien, d.h. 34,4\u202f%, war kein diagnostisch verwertbares Material enthalten. Bei den verbliebenen 61 Pankreasbiopsien fanden sich bei 24,6\u202f% keine Absto\u00dfungszeichen, 62,3\u202f% eine akute T-Zell-vermittelte Absto\u00dfungsreaktion (TCMR) und 8,2\u202f% Hinweise auf eine aktive Antik\u00f6rper-vermittelte Absto\u00dfung (ABMR). Ein akuter Azinuszellschaden wurde in 59\u202f% der Biopsien gesehen, eine Pankreatitis in 8,2\u202f% und eine Allograft-Fibrose in immerhin 54,1\u202f%. Die Calcineurin-Inhibitor (CNI) Toxizit\u00e4t war mit 4,9% eher selten.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die Pankreas-Nieren-Transplantation inklusive der Biopsie des transplantierten Pankreas oder in seltenen F\u00e4llen auch des Spenderduodenums mit anschlie\u00dfender standardisierter Beurteilung entsprechend der aktuellen international g\u00fcltigen Banff-Klassifikation der Pankreasabsto\u00dfung und der Empfehlungen zur Beurteilung von Duodenalbiopsien hat ihren festen Stellenwert in der Behandlung von Diabetikern.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00292-021-00982-1","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T09:03:11Z","timestamp":1629450191000},"page":"509-523","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pankreastransplantation\u00a0\u2013 Klinik, Technik und histologische Beurteilung","Pancreas transplantation\u2014clinic, technique, and histological assessment"],"prefix":"10.1007","volume":"42","author":[{"given":"Maike","family":"B\u00fcttner-Herold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tannapfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Maslova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wunsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Pillokeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Viebahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"issue":"6","key":"982_CR1","first-page":"827","volume":"61","author":"WD Kelly","year":"1967","unstructured":"Kelly\u00a0WD, Lillehei\u00a0RC, Merkel\u00a0FK et\u00a0al (1967) Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. 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