{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:35:49Z","timestamp":1757543749540},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Leipzig"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologie"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Im Jahr 2015 wurde die S3-Leitlinie f\u00fcr Diagnostik und Therapie des Zervixkarzinoms erstellt, die 2021 in ihrer revidierten Fassung vorliegt. Neu f\u00fcr die Pathologie sind die Aufnahme der International Endocervical Adenocarcinoma Classification (IECC), die zwischen HPV-assoziierten und non-HPV-assoziierten Karzinomen unterschiedet, sowie des prognostisch relevanten morphologischen Wachstumsmusters bei (HPV-assoziierten) Adenokarzinomen (sog. Silva-Pattern). Die Multifokalit\u00e4t beim mikroinvasiven Zervixkarzinom ist nun definiert als der Nachweis voneinander histologisch klar separierter invasiver Foci mit einem minimalen Abstand von 0,2\u202fcm. Aufgrund einer m\u00f6glichen intratumoralen Heterogenit\u00e4t sollen Zervixkarzinome \u2264\u202f2\u202fcm vollst\u00e4ndig und Tumoren &gt;\u202f2\u202fcm mit einem Block pro Zentimeter gr\u00f6\u00dfter Ausdehnung eingebettet werden. Bei der (radikalen) Trachelektomie\/Hysterektomie sollen der vaginale Resektionsrand und das parametrane Gewebe vollst\u00e4ndig eingebettet werden. Neu ist die Empfehlung zur Aufarbeitung von Sentinellymphknoten. Diese sollen entlang ihrer L\u00e4ngsachse in 0,2\u202fcm Abstand lamelliert, vollst\u00e4ndig eingebettet und mittels Ultrastaging aufgearbeitet werden. Die FIGO-Klassifikation von 2009 bzw. TNM-Kategorisierung von 2017 wird beibehalten, die Angabe der FIGO-Klassifikation 2018\/19 ist optional. Molekulare Marker spielen derzeit noch keine relevante Rolle in der Prognose und zum Therapieentscheid.<\/jats:p>","DOI":"10.1007\/s00292-021-01051-3","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T10:02:59Z","timestamp":1645524179000},"page":"292-302","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Revidierte Fassung der S3-Leitlinie Zervixkarzinom 2021\u00a0\u2013 Anforderungen an die Pathologie","Revised German guidelines on the diagnosis and treatment of carcinoma of the uterine cervix\u2014what\u2019s new for pathologists in 2021?"],"prefix":"10.1007","volume":"43","author":[{"given":"Lars-Christian","family":"Horn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Follmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin C.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Nothacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"P\u00f6schel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"St\u00fcbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Kathrin","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Kommission zur Erstellung der S3-Leitlinie Zervixkarzinom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"issue":"6","key":"1051_CR1","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1097\/PAS.0000000000001245","volume":"43","author":"I Alvarado-Cabrero","year":"2019","unstructured":"Alvarado-Cabrero\u00a0I et al (2019) Micropapillary cervical adenocarcinoma: a clinicopathologic study of 44 cases. Am J Surg Pathol 43(6):802\u2013809","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1051_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/IGC.0000000000000034","volume":"24","author":"V Andikyan","year":"2014","unstructured":"Andikyan\u00a0V et\u00a0al (2014) Cervical conization and sentinel lymph node mapping in the treatment of stage I cervical cancer: Is less enough? Int J Gynecol Cancer 24(1):113\u2013117","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"1051_CR3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ijgo.12749","volume":"145","author":"N Bhatla","year":"2019","unstructured":"Bhatla\u00a0N, Berek\u00a0JS, Cuello Fredes\u00a0M, Denny\u00a0LA, Grenman\u00a0S, Karunaratne\u00a0K, Kehoe\u00a0ST, Konishi\u00a0I, Olawaiye\u00a0AB, Prat\u00a0J, Sankaranarayanan\u00a0R, Brierley\u00a0J, Mutch\u00a0D, Querleu\u00a0D, Cibula\u00a0D, Quinn\u00a0M, Botha\u00a0H, Sigurd\u00a0L, Rice\u00a0L, Ryu\u00a0HS, Ngan\u00a0H, M\u00e4enp\u00e4\u00e4\u00a0J, Andrijono\u00a0A, Purwoto\u00a0G, Maheshwari\u00a0A, Bafna\u00a0UD, Plante\u00a0M, Natarajan\u00a0J (2019) Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet 145(1):129\u2013135","journal-title":"Int J Gynaecol Obstet"},{"issue":"13","key":"1051_CR4","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/j.ejca.2015.05.015","volume":"51","author":"T Bosse","year":"2015","unstructured":"Bosse\u00a0T et al (2015) Substantial lymph-vascular space invasion (LVSI) is a\u00a0significant risk factor for recurrence in endometrial cancer\u2014a pooled analysis of PORTEC 1 and 2 trials. Eur J Cancer 51(13):1742\u20131750","journal-title":"Eur J Cancer"},{"issue":"2","key":"1051_CR5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1055\/a-0828-7681","volume":"79","author":"CE Brambs","year":"2019","unstructured":"Brambs\u00a0CE et\u00a0al (2019) The prognostic impact of grading in FIGO IB and IIB squamous cell cervical carcinomas. Geburtshilfe Frauenheilkd 79(2):198\u2013204","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"7645","key":"1051_CR6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature21386","volume":"543","author":"RD Burk","year":"2017","unstructured":"Burk\u00a0RD, Cancer Genome Atlas Research Network (2017) Integrated genomic and molecular characterization of cervical cancer. Nature 543(7645):378\u2013384","journal-title":"Nature"},{"key":"1051_CR7","unstructured":"College of American Pathologists (2013) Protocol for the examination of specimens from patients withcarcinoma of the uterine cervix. http:\/\/www.cap.org\/apps\/docs\/committees\/cancer\/cancer_protocols\/2013\/Cervix_13protocol_3210.pdf. Zugegriffen: 9. Juni 2021"},{"issue":"4","key":"1051_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/IGC.0000000000001216","volume":"28","author":"D Cibula","year":"2018","unstructured":"Cibula\u00a0D et\u00a0al (2018) The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology guidelines for the management of patients with cervical cancer. Int J Gynecol Cancer 28(4):641\u2013655","journal-title":"Int J Gynecol Cancer"},{"issue":"10167","key":"1051_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","volume":"393","author":"PA Cohen","year":"2019","unstructured":"Cohen\u00a0PA, Jhingran\u00a0A, Oaknin\u00a0A, Denny\u00a0L (2019) Cervical cancer. Lancet 393(10167):169\u2013182","journal-title":"Lancet"},{"issue":"5","key":"1051_CR10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/PGP.0000000000000269","volume":"35","author":"E Day","year":"2016","unstructured":"Day\u00a0E, Duffy\u00a0S, Bryson\u00a0G, Syed\u00a0S, Shanbhag\u00a0S, Burton\u00a0K, Lindsay\u00a0R, Siddiqui\u00a0N, Millan\u00a0D (2016) Multifocal FIGO stage IA1 squamous carcinoma of the cervix: criteria for identification, staging, and its good clinical outcome. Int J Gynecol Pathol 35(5):467\u2013474","journal-title":"Int J Gynecol Pathol"},{"key":"1051_CR11","unstructured":"ESGO (2018) ESGO\/ESTRO\/ESP\u2014guidelines for cervical carcinoma. https:\/\/guidelines.esgo.org\/media\/2018\/04\/Cervical-cancer-Guidelines-Complete-report.pdf. Zugegriffen: 9. Juni 2021"},{"issue":"9","key":"1051_CR12","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1097\/PAS.0b013e31816ecfe4","volume":"32","author":"ED Euscher","year":"2008","unstructured":"Euscher\u00a0ED et\u00a0al (2008) Ultrastaging improves detection of metastases in sentinel lymph nodes of uterine cervix squamous cell carcinoma. Am J Surg Pathol 32(9):1336\u20131343","journal-title":"Am J Surg Pathol"},{"key":"1051_CR13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.critrevonc.2019.01.006","volume":"135","author":"A Gadducci","year":"2019","unstructured":"Gadducci\u00a0A, Guerrieri\u00a0ME, Cosio\u00a0S (2019) Adenocarcinoma of the uterine cervix: pathologic features, treatment options, clinical outcome and prognostic variables. Crit Rev Oncol Hematol 135:103\u2013114","journal-title":"Crit Rev Oncol Hematol"},{"issue":"6","key":"1051_CR14","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1177\/1066896916643385","volume":"24","author":"R Ganesan","year":"2016","unstructured":"Ganesan\u00a0R et\u00a0al (2016) Neuroendocrine carcinoma of the cervix: review of a\u00a0series of cases and correlation with outcome. Int J Surg Pathol 24(6):490\u2013496","journal-title":"Int J Surg Pathol"},{"issue":"3","key":"1051_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/ijgc-2018-000089","volume":"29","author":"B Guani","year":"2019","unstructured":"Guani\u00a0B et\u00a0al (2019) Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL trial. Int J Gynecol Cancer 29(3):447\u2013452","journal-title":"Int J Gynecol Cancer"},{"issue":"7","key":"1051_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/modpathol.2016.64","volume":"29","author":"AM Heeren","year":"2016","unstructured":"Heeren\u00a0AM, Punt\u00a0S, Bleeker\u00a0MC, Gaarenstroom\u00a0KN, van der Velden\u00a0J, Kenter\u00a0GG, de Gruijl\u00a0TD, Jordanova\u00a0ES (2016) Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix. Mod Pathol 29(7):753\u2013763","journal-title":"Mod Pathol"},{"key":"1051_CR17","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1746-1596-2-40","volume":"2","author":"L Hirschowitz","year":"2007","unstructured":"Hirschowitz\u00a0L, Sen\u00a0C, Murdoch\u00a0J (2007) Primary endometrioid adenocarcinoma of the cervix with widespread squamous metaplasia\u2014a potential diagnostic pitfall. Diagn Pathol 2:40","journal-title":"Diagn Pathol"},{"issue":"1","key":"1051_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/PAS.0000000000001095","volume":"43","author":"A Hodgson","year":"2019","unstructured":"Hodgson\u00a0A et\u00a0al (2019) International endocervical adenocarcinoma criteria and classification: validation and interobserver reproducibility. Am J Surg Pathol 43(1):75\u201383","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1051_CR19","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s00292-015-0114-z","volume":"36","author":"LC Horn","year":"2015","unstructured":"Horn\u00a0LC, Beckmann\u00a0MW, Follmann\u00a0M, Koch\u00a0MC, Mallmann\u00a0P, Marnitz\u00a0S, Schmidt\u00a0D, German Cancer Society (2015) S3-Leitlinie Diagnostik und Therapie des Zervixkarzinoms. Pathologe 36(6):585\u2013593","journal-title":"Pathologe"},{"key":"1051_CR20","volume-title":"Processing and histopathological workup of hysterectomy specimens","author":"LC Horn","year":"2017","unstructured":"Horn\u00a0LC, H\u00f6hn\u00a0AK (2017) Processing and histopathological workup of hysterectomy specimens. Springer Nature,"},{"issue":"4","key":"1051_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s00292-005-0764-3","volume":"26","author":"LC Horn","year":"2005","unstructured":"Horn\u00a0LC et\u00a0al (2005) Recommendations for the handling and oncologic pathology report of lymph node specimens submitted for evaluation of metastatic disease in gynecologic malignancies. Pathologe 26(4):266\u2013272","journal-title":"Pathologe"},{"issue":"3","key":"1051_CR22","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.anndiagpath.2005.07.019","volume":"10","author":"LC Horn","year":"2006","unstructured":"Horn\u00a0LC et al (2006) Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index. Ann Diagn Pathol 10(3):140\u2013143","journal-title":"Ann Diagn Pathol"},{"issue":"1","key":"1051_CR23","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ygyno.2014.04.011","volume":"134","author":"LC Horn","year":"2014","unstructured":"Horn\u00a0LC et al (2014) A cut-off value of 2\u202fcm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer. Gynecol Oncol 134(1):42\u201346","journal-title":"Gynecol Oncol"},{"issue":"4","key":"1051_CR24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00292-016-0183-7","volume":"37","author":"LC Horn","year":"2016","unstructured":"Horn\u00a0LC et\u00a0al (2016) Grading of gynecological tumors: current aspects. Pathologe 37(4):337\u2013351","journal-title":"Pathologe"},{"issue":"6","key":"1051_CR25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00292-019-00675-w","volume":"40","author":"LC Horn","year":"2019","unstructured":"Horn\u00a0LC et\u00a0al (2019) The 2019 FIGO classification for cervical carcinoma\u2014what\u2019s new? Pathologe 40(6):629\u2013635","journal-title":"Pathologe"},{"issue":"10","key":"1051_CR26","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1007\/s00432-019-02991-3","volume":"145","author":"LC Horn","year":"2019","unstructured":"Horn\u00a0LC et al (2019) Invasive stratified mucin-producing carcinoma (i-SMILE) of the uterine cervix: report of a\u00a0case series and review of the literature indicating poor prognostic subtype of cervical adenocarcinoma. J\u00a0Cancer Res Clin Oncol 145(10):2573\u20132582","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"1051_CR27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00432-018-2793-3","volume":"145","author":"LC Horn","year":"2019","unstructured":"Horn\u00a0LC et al (2019) Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas. J\u00a0Cancer Res Clin Oncol 145(2):457\u2013462","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"1051_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/cjp2.95","volume":"4","author":"M Jesinghaus","year":"2018","unstructured":"Jesinghaus\u00a0M et\u00a0al (2018) Introducing a\u00a0novel highly prognostic grading scheme based on tumour budding and cell nest size for squamous cell carcinoma of the uterine cervix. J\u00a0Pathol Clin Res 4(2):93\u2013102","journal-title":"J Pathol Clin Res"},{"issue":"3","key":"1051_CR29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/PGP.0000000000000612","volume":"39","author":"M Kaliff","year":"2020","unstructured":"Kaliff\u00a0M, Karlsson\u00a0MG, Sorbe\u00a0B, Bohr Mordhorst\u00a0L, Helenius\u00a0G, Lillsunde-Larsson\u00a0G (2020) HPV-negative tumors in a\u00a0Swedish cohort of cervical cancer. Int J Gynecol Pathol 39(3):279\u2013288","journal-title":"Int J Gynecol Pathol"},{"issue":"11","key":"1051_CR30","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1097\/PAS.0000000000000532","volume":"39","author":"YS Karamurzin","year":"2015","unstructured":"Karamurzin\u00a0YS, Kiyokawa\u00a0T, Parkash\u00a0V, Jotwani\u00a0AR, Patel\u00a0P, Pike\u00a0MC, Soslow\u00a0RA, Park\u00a0KJ (2015) Gastric-type endocervical adenocarcinoma: an aggressive tumor with unusual metastatic patterns and poor prognosis. Am J Surg Pathol 39(11):1449\u20131457","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1051_CR31","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1097\/IGC.0b013e3182954da8","volume":"23","author":"CH Kim","year":"2013","unstructured":"Kim\u00a0CH et\u00a0al (2013) Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging. Int J Gynecol Cancer 23(5):964\u2013970","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"1051_CR32","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/1754-9485.12411","volume":"60","author":"C Lapuz","year":"2016","unstructured":"Lapuz\u00a0C, Kondalsamy-Chennakesavan\u00a0S, Bernshaw\u00a0D, Khaw\u00a0P, Narayan\u00a0K (2016) Stage IB cervix cancer with nodal involvement treated with primary surgery or primary radiotherapy: patterns of failure and outcomes in a\u00a0contemporary population. J\u00a0Med Imaging Radiat Oncol 60(2):274\u2013282","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"3","key":"1051_CR33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ygyno.2018.06.023","volume":"150","author":"DT Le","year":"2018","unstructured":"Le\u00a0DT, Durham\u00a0JN, Smith\u00a0KN, Wang\u00a0H, Bartlett\u00a0BR, Aulakh\u00a0LK, Lu\u00a0S, Kemberling\u00a0H, Wilt\u00a0C, Luber\u00a0BS, Wong\u00a0F, Azad\u00a0NS, Rucki\u00a0AA, Laheru\u00a0D, Donehower\u00a0R, Zaheer\u00a0A, Fisher\u00a0GA, Crocenzi\u00a0TS, Lee\u00a0JJ, Greten\u00a0TF, Duffy\u00a0AG, Ciombor\u00a0KK, Eyring\u00a0AD, Lam\u00a0BH, Joe\u00a0A, Kang\u00a0SP, Holdhoff\u00a0M, Danilova\u00a0L, Cope\u00a0L, Meyer\u00a0C, Zhou\u00a0S, Goldberg\u00a0RM, Armstrong\u00a0DK, Bever\u00a0KM, Fader\u00a0AN, Taube\u00a0J, Housseau\u00a0F, Spetzler\u00a0D, Xiao\u00a0N, Pardoll\u00a0DM, Papadopoulos\u00a0N, Kinzler\u00a0KW, Eshleman\u00a0JR, Vogelstein\u00a0B, Anders\u00a0RA, Leath\u00a0CA 3rd, Monk\u00a0BJ (2018) Twenty-first century cervical cancer management: a historical perspective of the gynecologic oncology group\/NRG oncology over the past twenty years. Gynecol Oncol 150(3):391\u2013397","journal-title":"Gynecol Oncol"},{"issue":"9","key":"1051_CR34","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1080\/14712598.2019.1646721","volume":"19","author":"G Marret","year":"2019","unstructured":"Marret\u00a0G, Borcoman\u00a0E, Le Tourneau\u00a0C (2019) Pembrolizumab for the treatment of cervical cancer. Expert Opin Biol Ther 19(9):871\u2013877","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"1051_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ygyno.2018.10.026","volume":"152","author":"K Matsuo","year":"2019","unstructured":"Matsuo\u00a0K et\u00a0al (2019) Validation of the 2018 FIGO cervical cancer staging system. Gynecol Oncol 152(1):87\u201393","journal-title":"Gynecol Oncol"},{"issue":"3","key":"1051_CR36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00292-021-00933-w","volume":"42","author":"D Mayr","year":"2021","unstructured":"Mayr\u00a0D, Schmoeckel\u00a0E, H\u00f6hn\u00a0AK, Hiller\u00a0GGR, Horn\u00a0LC (2021) Aktuelle WHO-Klassifikation des weiblichen Genitale: Viel Neues, aber auch manch Altes. Pathologe 42(3):259\u2013269","journal-title":"Pathologe"},{"issue":"3","key":"1051_CR37","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/PGP.0000000000000412","volume":"37","author":"WG McCluggage","year":"2018","unstructured":"McCluggage\u00a0WG et\u00a0al (2018) Data set for the reporting of carcinomas of the cervix: recommendations from the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol 37(3):205\u2013228","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"1051_CR38","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/PGP.0b013e31829040ce","volume":"33","author":"P McIlwaine","year":"2014","unstructured":"McIlwaine\u00a0P, Nagar\u00a0H, McCluggage\u00a0WG (2014) Multifocal FIGO stage 1A1 cervical squamous carcinomas have an extremely good prognosis equivalent to unifocal lesions. Int J Gynecol Pathol 33(3):213\u2013217","journal-title":"Int J Gynecol Pathol"},{"issue":"16","key":"1051_CR39","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.7150\/jca.22532","volume":"9","author":"Y Meng","year":"2018","unstructured":"Meng\u00a0Y, Liang\u00a0H, Hu\u00a0J, Liu\u00a0S, Hao\u00a0X, Wong\u00a0MSK, Li\u00a0X, Hu\u00a0L (2018) PD-L1 expression correlates with tumor infiltrating lymphocytes and response to neoadjuvant chemotherapy in cervical cancer. J\u00a0Cancer 9(16):2938\u20132945","journal-title":"J Cancer"},{"issue":"3","key":"1051_CR40","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.ygyno.2018.01.009","volume":"148","author":"LE Minion","year":"2018","unstructured":"Minion\u00a0LE, Tewari\u00a0KS (2018) Cervical cancer\u2014state of the science: from angiogenesis blockade to checkpoint inhibition. Gynecol Oncol 148(3):609\u2013621","journal-title":"Gynecol Oncol"},{"issue":"11","key":"1051_CR41","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/modpathol.2015.103","volume":"28","author":"J Mirkovic","year":"2015","unstructured":"Mirkovic\u00a0J et\u00a0al (2015) Targeted genomic profiling reveals recurrent KRAS mutations and gain of chromosome 1q in mesonephric carcinomas of the female genital tract. Mod Pathol 28(11):1504\u20131514","journal-title":"Mod Pathol"},{"issue":"7","key":"1051_CR42","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/his.13825","volume":"74","author":"S Morgan","year":"2019","unstructured":"Morgan\u00a0S, Slodkowska\u00a0E, Parra-Herran\u00a0C, Mirkovic\u00a0J (2019) PD-L1, RB1 and mismatch repair protein immunohistochemical expression in neuroendocrine carcinoma, small cell type, of the uterine cervix. Histopathology 74(7):997\u20131004","journal-title":"Histopathology"},{"issue":"7488","key":"1051_CR43","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature12881","volume":"506","author":"AI Ojesina","year":"2014","unstructured":"Ojesina\u00a0AI, Lichtenstein\u00a0L, Freeman\u00a0SS, Pedamallu\u00a0CS, Imaz-Rosshandler\u00a0I, Pugh\u00a0TJ, Cherniack\u00a0AD, Ambrogio\u00a0L, Cibulskis\u00a0K, Bertelsen\u00a0B, Romero-Cordoba\u00a0S, Trevi\u00f1o\u00a0V, Vazquez-Santillan\u00a0K, Guadarrama\u00a0AS, Wright\u00a0AA, Rosenberg\u00a0MW, Duke\u00a0F, Kaplan\u00a0B, Wang\u00a0R, Nickerson\u00a0E, Walline\u00a0HM, Lawrence\u00a0MS, Stewart\u00a0C, Carter\u00a0SL, McKenna\u00a0A, Rodriguez-Sanchez\u00a0IP, Espinosa-Castilla\u00a0M, Woie\u00a0K, Bjorge\u00a0L, Wik\u00a0E, Halle\u00a0MK, Hoivik\u00a0EA, Krakstad\u00a0C, Gabi\u00f1o\u00a0NB, G\u00f3mez-Mac\u00edas\u00a0GS, Valdez-Chapa\u00a0LD, Garza-Rodr\u00edguez\u00a0ML, Maytorena\u00a0G, Vazquez\u00a0J, Rodea\u00a0C, Cravioto\u00a0A, Cortes\u00a0ML, Greulich\u00a0H, Crum\u00a0CP, Neuberg\u00a0DS, Hidalgo-Miranda\u00a0A, Escareno\u00a0CR, Akslen\u00a0LA, Carey\u00a0TE, Vintermyr\u00a0OK, Gabriel\u00a0SB, Barrera-Salda\u00f1a\u00a0HA, Melendez-Zajgla\u00a0J, Getz\u00a0G, Salvesen\u00a0HB, Meyerson\u00a0M (2014) Landscape of genomic alterations in cervical carcinomas. Nature 506(7488):371\u2013375","journal-title":"Nature"},{"issue":"2","key":"1051_CR44","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/PGP.0000000000000121","volume":"34","author":"M Omori","year":"2015","unstructured":"Omori\u00a0M, Hashi\u00a0A, Kondo\u00a0T, Katoh\u00a0R, Hirata\u00a0S (2015) Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. Int J Gynecol Pathol 34(2):196\u2013203","journal-title":"Int J Gynecol Pathol"},{"issue":"4","key":"1051_CR45","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/cyt.12718","volume":"30","author":"O Ondi\u010d","year":"2019","unstructured":"Ondi\u010d\u00a0O, N\u011bmcov\u00e1\u00a0J, Alaghehbandan\u00a0R, \u010cern\u00e1\u00a0K, Gomol\u010d\u00e1kov\u00e1\u00a0B, Kinkorov\u00e1-Lu\u0148\u00e1\u010dkov\u00e1\u00a0I, Chytra\u00a0J, \u0160idlov\u00e1\u00a0H, M\u00e1jek\u00a0O, Bouda\u00a0J (2019) The detection of DNA methylation of tumour suppressor genes in cervical high-grade squamous intraepithelial lesion: a prospective cytological-histological correlation study of 70\u00a0cases. Cytopathology 30(4):426\u2013431","journal-title":"Cytopathology"},{"issue":"4","key":"1051_CR46","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3346\/jkms.2009.24.4.767","volume":"24","author":"HM Park","year":"2009","unstructured":"Park\u00a0HM et\u00a0al (2009) Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a\u00a0case report. J\u00a0Korean Med Sci 24(4):767\u2013771","journal-title":"J Korean Med Sci"},{"key":"1051_CR47","first-page":"367","volume-title":"WHO classification of tumours of the female genital tract","author":"C Parra-Herran","year":"2020","unstructured":"Parra-Herran\u00a0C, Alvarado-Cebrero\u00a0I, Hoang\u00a0LN, Kiyokawa\u00a0T, Kong\u00a0CS, Park\u00a0KJ, Stolnicu\u00a0S, Zannoni (2020) Adenocarcinoma, HPV-associated of the uterine cervix. In: WHO classification of tumours of the female genital tract. IARC, Lyon, S 367\u2013371"},{"issue":"1","key":"1051_CR48","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/his.13871","volume":"75","author":"EEM Peters","year":"2019","unstructured":"Peters\u00a0EEM et\u00a0al (2019) Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer. Histopathology 75(1):128\u2013136","journal-title":"Histopathology"},{"issue":"12","key":"1051_CR49","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/jcp.2007.054031","volume":"62","author":"G Rasty","year":"2009","unstructured":"Rasty\u00a0G, Hauspy\u00a0J, Bandarchi\u00a0B (2009) Assessment of sentinel lymph node in cervical cancer: review of literature. J\u00a0Clin Pathol 62(12):1062\u20131065","journal-title":"J Clin Pathol"},{"issue":"4","key":"1051_CR50","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/00004347-200210000-00013","volume":"21","author":"O Reich","year":"2002","unstructured":"Reich\u00a0O, Pickel\u00a0H (2002) Multifocal stromal invasion in microinvasive squamous cell carcinoma of the cervix: how to measure and stage these lesions. Int J Gynecol Pathol 21(4):416\u2013417","journal-title":"Int J Gynecol Pathol"},{"issue":"6","key":"1051_CR51","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00428-018-2312-6","volume":"472","author":"AA Roma","year":"2018","unstructured":"Roma\u00a0AA, Fadare\u00a0O (2018) The pattern is the issue: recent advances in adenocarcinoma of the uterine cervix. Virchows Arch 472(6):897\u2013905","journal-title":"Virchows Arch"},{"issue":"5","key":"1051_CR52","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1097\/PAS.0000000000000402","volume":"39","author":"AA Roma","year":"2015","unstructured":"Roma\u00a0AA et al (2015) Invasive endocervical adenocarcinoma: a\u00a0new pattern-based classification system with important clinical significance. Am J Surg Pathol 39(5):667\u2013672","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1051_CR53","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ygyno.2016.02.028","volume":"141","author":"AA Roma","year":"2016","unstructured":"Roma\u00a0AA et al (2016) New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome. Gynecol Oncol 141(1):36\u201342","journal-title":"Gynecol Oncol"},{"key":"1051_CR54","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.3389\/fimmu.2018.02102","volume":"9","author":"J Roszik","year":"2018","unstructured":"Roszik\u00a0J et\u00a0al (2018) Gene expression analysis identifies novel targets for cervical cancer therapy. Front Immunol 9:2102","journal-title":"Front Immunol"},{"issue":"2","key":"1051_CR55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ygyno.2011.04.002","volume":"122","author":"M Roy","year":"2011","unstructured":"Roy\u00a0M et\u00a0al (2011) Value of sentinel node mapping in cancer of the cervix. Gynecol Oncol 122(2):269\u2013274","journal-title":"Gynecol Oncol"},{"key":"1051_CR56","first-page":"347","volume-title":"WHO classification of tumours of the female genital tract","author":"A Saco","year":"2020","unstructured":"Saco\u00a0A, Carrilho\u00a0C, Focchi\u00a0GRA, Kong\u00a0CS, Mills\u00a0AM, Park\u00a0KJ, Regauer\u00a0S (2020) Squamous cell carcinoma, of the uterine cervix. In: WHO classification of tumours of the female genital tract. IARC, Lyon, S\u00a0347\u2013350"},{"issue":"6","key":"1051_CR57","first-page":"1717","volume":"18","author":"N Satabongkoch","year":"2017","unstructured":"Satabongkoch\u00a0N et al (2017) Prognostic value of tumor budding in early-stage cervical adenocarcinomas. Asian Pac J Cancer Prev 18(6):1717\u20131722","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"1051_CR58","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/his.13080","volume":"70","author":"N Singh","year":"2017","unstructured":"Singh\u00a0N, Gilks\u00a0CB (2017) The changing landscape of gynaecological cancer diagnosis: implications for histopathological practice in the 21st century. Histopathology 70(1):56\u201369","journal-title":"Histopathology"},{"issue":"4","key":"1051_CR59","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/PAS.0000000000001224","volume":"43","author":"S Stolnicu","year":"2019","unstructured":"Stolnicu\u00a0S et al (2019) Clinical outcomes of HPV-associated and unassociated endocervical adenocarcinomas categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). Am J Surg Pathol 43(4):466\u2013474","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"1051_CR60","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1097\/PAS.0000000000001485","volume":"44","author":"S Stolnicu","year":"2020","unstructured":"Stolnicu\u00a0S et al (2020) Invasive stratified mucinous carcinoma (iSMC) of the cervix often presents with high-risk features that are determinants of poor outcome: an international multicenter study. Am J Surg Pathol 44(10):1374\u20131380","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1051_CR61","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ygyno.2018.04.570","volume":"150","author":"S Stolnicu","year":"2018","unstructured":"Stolnicu\u00a0S et al (2018) Stromal invasion pattern identifies patients at lowest risk of lymph node metastasis in HPV-associated endocervical adenocarcinomas, but is irrelevant in adenocarcinomas unassociated with HPV. Gynecol Oncol 150(1):56\u201360","journal-title":"Gynecol Oncol"},{"issue":"5","key":"1051_CR62","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00428-019-02601-0","volume":"475","author":"S Stolnicu","year":"2019","unstructured":"Stolnicu\u00a0S, Hoang\u00a0L, Soslow\u00a0RA (2019) Recent advances in invasive adenocarcinoma of the cervix. Virchows Arch 475(5):537\u2013549","journal-title":"Virchows Arch"},{"issue":"8","key":"1051_CR63","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1056\/NEJMoa1309748","volume":"370","author":"KS Tewari","year":"2014","unstructured":"Tewari\u00a0KS et\u00a0al (2014) Improved survival with bevacizumab in advanced cervical cancer. N\u00a0Engl J Med 370(8):734\u2013743","journal-title":"N Engl J Med"},{"issue":"1","key":"1051_CR64","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00404-019-05164-2","volume":"300","author":"GF Vercellino","year":"2019","unstructured":"Vercellino\u00a0GF, Erdemoglu\u00a0E, Lichtenberg\u00a0P, Muallem\u00a0MZ, Richter\u00a0R, Abu-Rustum\u00a0NR, Plante\u00a0M, L\u00e9curu\u00a0F, Greggi\u00a0S, Monk\u00a0BJ, Sagae\u00a0S, Denkert\u00a0C, Keller\u00a0M, Alhakeem\u00a0M, Hellriegel\u00a0M, D\u00fcckelmann\u00a0AM, Chiantera\u00a0V, Sehouli\u00a0J (2019) A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer. Arch Gynecol Obstet 300(1):191\u2013199","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"1051_CR65","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ygyno.2013.03.008","volume":"129","author":"AE Wagner","year":"2013","unstructured":"Wagner\u00a0AE et\u00a0al (2013) Impact of tumor size on survival in cancer of the cervix and validation of stage IIA1 and IIA2 subdivisions. Gynecol Oncol 129(3):517\u2013521","journal-title":"Gynecol Oncol"},{"key":"1051_CR66","volume-title":"WHO classification of tumours of the femal genital tract","author":"WHO","year":"2020","unstructured":"WHO (2020) WHO classification of tumours of the femal genital tract. IARC, Lyon"},{"key":"1051_CR67","volume-title":"TNM supplement. A comentary on uniform use","author":"C Wittekind","year":"2012","unstructured":"Wittekind\u00a0C et al (2012) TNM supplement. A comentary on uniform use. Wiley-Blackwell, London"},{"key":"1051_CR68","volume-title":"TNM Klassifikation maligner Tumoren \u2013 Korrigierter Nachdruck 2020 mit allen Erg\u00e4nzungen der UICC aus den Jahren 2017 bis 2019","author":"C Wittekind","year":"2020","unstructured":"Wittekind\u00a0C (2020) TNM Klassifikation maligner Tumoren \u2013 Korrigierter Nachdruck 2020 mit allen Erg\u00e4nzungen der UICC aus den Jahren 2017 bis 2019. Wiley-VCH, Weinheim"},{"key":"1051_CR69","volume-title":"TNM Klassifikation maligner Tumoren","author":"C Wittekind","year":"2017","unstructured":"Wittekind\u00a0C (2017) TNM Klassifikation maligner Tumoren. Wiley-VCH, Weinheim"},{"issue":"21","key":"1051_CR70","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1002\/cncr.28288","volume":"119","author":"AA Wright","year":"2013","unstructured":"Wright\u00a0AA et\u00a0al (2013) Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer 119(21):3776\u20133783","journal-title":"Cancer"},{"issue":"1","key":"1051_CR71","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/AOG.0000000000003311","volume":"134","author":"JD Wright","year":"2019","unstructured":"Wright\u00a0JD et\u00a0al (2019) Prognostic performance of the 2018 International Federation of Gynecology and Obstetrics cervical cancer staging guidelines. Obstet Gynecol 134(1):49\u201357","journal-title":"Obstet Gynecol"}],"container-title":["Die Pathologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-021-01051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00292-021-01051-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-021-01051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:27:38Z","timestamp":1726705658000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00292-021-01051-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1051"],"URL":"https:\/\/doi.org\/10.1007\/s00292-021-01051-3","relation":{},"ISSN":["2731-7188","2731-7196"],"issn-type":[{"type":"print","value":"2731-7188"},{"type":"electronic","value":"2731-7196"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"25 October 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.-C.\u00a0Horn, M.\u00a0W.\u00a0Beckmann, M.\u00a0Follmann, M.\u00a0C.\u00a0Koch, M.\u00a0Nothacker, B.\u00a0P\u00f6schel, F.\u00a0St\u00fcbs, D.\u00a0Schmidt und A.\u00a0K.\u00a0H\u00f6hn geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}