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Morphologisch definierte Entit\u00e4ten konnten zu einem Gro\u00dfteil auch molekular mit einem oftmals distinkten Genotyp charakterisiert werden. Der erste Teil des Artikels gibt einen \u00dcberblick \u00fcber die Fortschritte der molekularen Charakteristiken des Mukoepidermoidkarzinoms, adenoid-zystischen Karzinoms, Azinuszellkarzinoms, des sekretorischen und intraduktalen Karzinoms sowie des hyalinisierenden klarzelligen Karzinoms. Der molekulare Genotyp kann dabei insbesondere bei der Klassifizierung ungew\u00f6hnlicher morphologischer Varianten von gro\u00dfem Nutzen sein. Rekurrente <jats:italic>NTRK<\/jats:italic>- oder <jats:italic>RET<\/jats:italic>-Genfusionen k\u00f6nnen dabei nicht nur als diagnostisches Hilfsmittel, sondern auch f\u00fcr eine potenzielle gezielte Therapie genutzt werden.<\/jats:p>","DOI":"10.1007\/s00292-022-01123-y","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T13:04:18Z","timestamp":1665666258000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Speicheldr\u00fcsenkarzinome\u00a0\u2013 ein aktueller \u00dcberblick","Salivary gland tumors\u2014an\u00a0overview"],"prefix":"10.1007","volume":"43","author":[{"given":"Niels J.","family":"Rupp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra N.","family":"Freiberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"1123_CR1","unstructured":"WHO Classification of Tumours Editorial Board. 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Freiberger-Rupp<\/b>: A.\u00a0Finanzielle Interessen: S.\u00a0N. Freiberger-Rupp gibt an, dass kein finanzieller Interessenkonflikt besteht.\u00a0\u2013 B.\u00a0Nichtfinanzielle Interessen: wissenschaftliche Mitarbeiterin, Institut f\u00fcr Pathologie und Molekularpathologie, Universit\u00e4tsspital Z\u00fcrich, Z\u00fcrich, Schweiz | Mitgliedschaft: Deutsche Gesellschaft f\u00fcr Pathologie (DGP).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Autoren"}},{"value":"Die vollst\u00e4ndige Erkl\u00e4rung zum Interessenkonflikt der wissenschaftlichen Leitung finden Sie am Kurs der zertifizierten Fortbildung auf .","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Wissenschaftliche Leitung"}},{"value":"erkl\u00e4rt, dass f\u00fcr die Publikation dieser CME-Fortbildung keine Sponsorengelder an den Verlag flie\u00dfen.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Der Verlag"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Der Verlag"}}]}}