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Bei den unterschiedlichen Muskelerkrankungen kann es ultrastrukturelle Besonderheiten geben, welche helfen, die Erkrankung weiter einzugrenzen. Spezifische Ver\u00e4nderungen der Sarkomerenstruktur helfen bei der Einordnung einer kongenitalen Myopathie. Die Detektion von zellul\u00e4ren Aggregaten unterst\u00fctzt die Klassifizierung einer Myositis. Pathologisch ver\u00e4nderte Mitochondrien k\u00f6nnen dagegen sowohl bei genetisch bedingten Mitochondriopathien, aber auch sekund\u00e4r bei erworbenen Muskelerkrankungen auftreten, wie z.\u202fB. einer Myositis. Die ultrastrukturelle Beurteilung der Herzmuskulatur kann insbesondere bei kindlichen heredit\u00e4ren Kardiomyopathien die Erkrankung weiter eingrenzen. Dieser \u00dcbersichtsartikel stellt die ultrastrukturellen Besonderheiten bei den unterschiedlichen Muskelerkrankungen heraus, wobei insbesondere auf pathognomonische Befunde bei bestimmten Krankheitsgruppen eingegangen wird.<\/jats:p>","DOI":"10.1007\/s00292-022-01163-4","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T09:05:02Z","timestamp":1669971902000},"page":"104-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuropathologie\u00a0I: Muskul\u00e4re Erkrankungen","Neuropathology I: muscular diseases"],"prefix":"10.1007","volume":"44","author":[{"given":"Anne","family":"Sch\u00e4nzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Dittmayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Porubsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Hilmar","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"1163_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/nan.12380","volume":"43","author":"Y Allenbach","year":"2017","unstructured":"Allenbach\u00a0Y, Benveniste\u00a0O, Goebel\u00a0HH, Stenzel\u00a0W (2017) Integrated classification of inflammatory myopathies. 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