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Vor allem die Entscheidung \u00fcber die Schritte nach der Diagnose einer B3-L\u00e4sion an Stanzbiopsie oder Vakuumbiopsie k\u00f6nnen eine Herausforderung darstellen. B3-L\u00e4sionen werden oft wegen bildgebenden Kalzifikationen oder Herdbefunden entdeckt und biopsiert. Histologisch k\u00f6nnen die Ver\u00e4nderungen einer Reihe von h\u00e4ufigen Diagnosen (wie die atypische duktale Hyperplasie, die klassische lobul\u00e4re Neoplasie, flache Epithelatypien, intraduktale Papillome, radi\u00e4re Narben oder fibroepitheliale Tumoren vom Typ eines Phylloidestumors) oder seltenen Diagnosen (wie Mukozelen-\u00e4hnliche L\u00e4sion, atypische apokrine L\u00e4sionen und seltene stromale Proliferate) zugeordnet werden. Immunhistochemie ist hilfreich in der Differenzierung und einer korrekten nomenklatorischen Zuordnung dieser L\u00e4sionen (vor allem \u00d6strogenrezeptoren, basale Zytokeratine, Myoepithelmarker oder stromale Markerpanel). Im klinischen Kontext bleibt die Korrelation der bildgebenden und histologischen Befunde der wichtigste Faktor in der Entscheidung der n\u00e4chsten diagnostischen\/therapeutischen Schritte.<\/jats:p>","DOI":"10.1007\/s00292-022-01180-3","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T23:02:33Z","timestamp":1673564553000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["B3-L\u00e4sionen der Mamma: Histologische, klinische und epidemiologische Aspekte","B3 lesions of the breast: histological, clinical, and epidemiological aspects"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-983X","authenticated-orcid":false,"given":"Zsuzsanna","family":"Varga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Lebeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"1180_CR1","unstructured":"Ago German Commission Breast SOaG (2022) AGO German commission breast, state of art guidelines 2022. https:\/\/www.ago-online.de\/en\/leitlinien-empfehlungen\/leitlinien-empfehlungen\/kommission-mamma. 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