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Weitere Merkmale sind eine bevorzugte inguinale Lokalisation der Lymphome sowie ein lokalisiertes Stadium mit einer guten Prognose. Genetisch zeichnet sich diese Lymphomgruppe durch eine hohe Rate an <jats:italic>STAT6<\/jats:italic>- beziehungsweise <jats:italic>SOCS1<\/jats:italic>-Mutationen aus.<\/jats:p><jats:p>Die ICC-Klassifikation trug dieser Entwicklung durch die Einf\u00fchrung der provisorischen Entit\u00e4t \u201eCD23-positives, <jats:italic>BCL2<\/jats:italic>-Rearrangement-negatives Keimzentrumslymphom\u201c Rechnung. Weitere Studien m\u00fcssen nun zeigen, wie genau sich diese Entit\u00e4t definieren l\u00e4sst (Kombination aus Morphologie, immunhistochemischem Ph\u00e4notyp, Fokus auf genetische Alterationen), um so den Weg hin zu einer einheitlichen Klassifikation und auch einer besseren klinischen Charakterisierung dieser F\u00e4lle \u2013\u00a0insbesondere auch im Hinblick auf die m\u00f6glichen therapeutischen Optionen\u00a0\u2013 zu erm\u00f6glichen.<\/jats:p>","DOI":"10.1007\/s00292-023-01250-0","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T17:03:08Z","timestamp":1699290188000},"page":"160-163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CD23-positive, BCL2-Rearrangement-negative Keimzentrumslymphome","CD23 positive, BCL2 rearrangement-negative germinal centre lymphomas"],"prefix":"10.1007","volume":"44","author":[{"given":"Thomas","family":"Menter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"issue":"7","key":"1250_CR1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio\u00a0R, Amador\u00a0C, Anagnostopoulos\u00a0I, Attygalle\u00a0AD, Araujo\u00a0IBO, Berti\u00a0E et\u00a0al (2022) The 5th\u00a0edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms. 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