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Bislang findet die FCM Anwendung in der Derma\u2011\/Uro- und Gyn\u00e4kopathologie. Die FCM er\u00f6ffnet die Perspektive eines digitalen Gefrierschnitts, der den herk\u00f6mmlichen Gefrierschnitt in Zukunft ersetzen k\u00f6nnte.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit (Fragestellung)<\/jats:title>\n                <jats:p>Ziel unserer aktuellen Arbeit ist die Implementierung der FCM als Bestandteil vollst\u00e4ndig digitalisierter Abl\u00e4ufe im pathologischen Workflow. Hierf\u00fcr wird der aktuelle Einsatz der FCM in der Transplantationspathologie auf weitere Fachdisziplinen wie Urologie und HNO ausgeweitet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Der Einsatz der FCM-Technik erfolgt aktuell weiterhin prospektiv bei nativen Gewebeproben potenzieller Spenderlebern. Die herk\u00f6mmliche Schnellschnittdiagnostik in Gefriertechnik wird vergleichend zu virtuellen FCM-Scans angewandt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Die Daten zeigen eine nahezu perfekte \u00dcbereinstimmung f\u00fcr den Nachweis von Cholangitis, Fibrose und Malignit\u00e4t sowie ein hohes Ma\u00df an \u00dcbereinstimmung f\u00fcr z.\u202fB. makrovesikul\u00e4re Steatose, Entz\u00fcndung, Steatohepatitis und Nekrose zwischen virtuellem FCM-Scan und herk\u00f6mmlichen Schnellschnitt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Da die Verf\u00fcgbarkeit der zeit-, und kostenintensiven Schnellschnittdiagnostik im Rahmen der Transplantationspathologie im Dauerbetrieb (24\/7) aufgrund eines zunehmenden Fachkr\u00e4ftemangels mittlerweile nur noch an sehr wenigen universit\u00e4ren Zentren in Deutschland etabliert ist, k\u00f6nnte der Einsatz der FCM-Technik ein wichtiger Baustein im aktuellen Prozess hin zu einer vollst\u00e4ndig digitalisierten Pathologie sein und sollte somit auf verschiedene Fachdisziplinen ausgeweitet werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00292-024-01311-y","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T10:02:26Z","timestamp":1709719346000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fluoreszenzbasierte Konfokalmikroskopie\u00a0\u2013 vollst\u00e4ndige Digitalisierung der Pathologie","Fluorescence confocal microscopy\u2014complete digitization of pathology"],"prefix":"10.1007","volume":"45","author":[{"given":"Andreas G.","family":"Loth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Fassl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K. 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