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VMScope, Berlin). PitNET\/Hypophysenadenomen weisen h\u00e4ufig einen geringen Proliferationsindex aus. Eine hohe Observervariabilit\u00e4t besteht v.\u202fa. bei der Sch\u00e4tzung in diesem niedrigen Prozentbereich. Eine zuverl\u00e4ssigere Festlegung w\u00e4re durch das 4\u2011Augen-Prinzip m\u00f6glich, das jedoch nicht kontinuierlich zu realisieren ist. Abhilfe verspricht hier die digitale Bildanalyse. In der Untersuchung konnte eine deutliche \u00dcbereinstimmung der Ki-67-Sch\u00e4tzung durch zwei erfahrene Pathologen und der Bestimmung mit Hilfe der digitalen Bildanalyse gezeigt werden. Das digitale Bildanalysesystem ist hervorragend zur Bestimmung der Proliferationsrate von PitNET\/Hypophysenadenomen geeignet und kann daher das \u201edritte\u201c und \u201evierte Auge\u201c darstellen.<\/jats:p>","DOI":"10.1007\/s00292-024-01319-4","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T17:01:29Z","timestamp":1720717289000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantifizierung von Ki-67 in PitNET\u00a0(\u201epituitary\u00a0neuroendocrine tumors\u201c)\/Adenomen","Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)\/adenomas"],"prefix":"10.1007","volume":"45","author":[{"given":"Judith","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Saeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-8523","authenticated-orcid":false,"given":"Wolfgang","family":"Saeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"1319_CR1","volume-title":"WHO Classification of Tumours Editorial Board. 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