{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:20:31Z","timestamp":1761315631076,"version":"build-2065373602"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologie"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00292-025-01440-y","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T05:22:30Z","timestamp":1750828950000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["N-Cadherin als neuer diagnostischer Marker","N-cadherin as a\u00a0novel diagnostic marker"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-2186","authenticated-orcid":false,"given":"Tiemo S.","family":"Gerber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk A.","family":"Ridder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate K.","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"1440_CR1","first-page":"394","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray\u00a0F, Ferlay\u00a0J, Soerjomataram\u00a0I et\u00a0al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J Clin 68:394\u2013424","journal-title":"CA: A Cancer J Clin"},{"key":"1440_CR2","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1038\/modpathol.3800682","volume":"20","author":"ZD Goodman","year":"2007","unstructured":"Goodman\u00a0ZD (2007) Neoplasms of the liver. Mod Pathol 20:S49\u2013S60","journal-title":"Mod Pathol"},{"key":"1440_CR3","volume-title":"Analysis of autopsy data","author":"JTY Pickren","year":"1982","unstructured":"Pickren\u00a0JTY, Lane\u00a0W (1982) Liver metastasis. In: Analysis of autopsy data. GK Hall Medical Publishers,"},{"key":"1440_CR4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/01.sla.0000217629.94941.cf","volume":"244","author":"S Manfredi","year":"2006","unstructured":"Manfredi\u00a0S, Lepage\u00a0C, Hatem\u00a0C et\u00a0al (2006) Epidemiology and management of liver metastases from colorectal cancer. Ann Surg 244:254\u2013259","journal-title":"Ann Surg"},{"key":"1440_CR5","doi-asserted-by":"publisher","first-page":"101760","DOI":"10.1016\/j.canep.2020.101760","volume":"67","author":"SR Horn","year":"2020","unstructured":"Horn\u00a0SR, Stoltzfus\u00a0KC, Lehrer\u00a0EJ et\u00a0al (2020) Epidemiology of liver metastases. Cancer Epidemiol 67:101760","journal-title":"Cancer Epidemiol"},{"key":"1440_CR6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00292-020-00803-x","volume":"41","author":"I Tischoff","year":"2020","unstructured":"Tischoff\u00a0I, Tannapfel\u00a0A (2020) CUP in der Leber. Pathologe 41:495\u2013504","journal-title":"Pathologe"},{"key":"1440_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/PGP.0000000000000582","volume":"39","author":"A Chiesa-Vottero","year":"2020","unstructured":"Chiesa-Vottero\u00a0A (2020) CDX2, SATB2, GATA3, TTF1, and PAX8 Immunohistochemistry in Krukenberg Tumors. Int J Gynecol Pathol 39:170\u2013177","journal-title":"Int J Gynecol Pathol"},{"key":"1440_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.humpath.2006.08.025","volume":"38","author":"JT Ney","year":"2007","unstructured":"Ney\u00a0JT, Zhou\u00a0H, Sipos\u00a0B et\u00a0al (2007) Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts. Hum Pathol 38:359\u2013364","journal-title":"Hum Pathol"},{"key":"1440_CR9","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1074\/mcp.M115.054585","volume":"15","author":"J Padden","year":"2016","unstructured":"Padden\u00a0J, Ahrens\u00a0M, K\u00e4lsch\u00a0J et\u00a0al (2016) Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells. Mol Cell Proteomics 15:1072\u20131082","journal-title":"Mol Cell Proteomics"},{"key":"1440_CR10","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.humpath.2013.10.004","volume":"45","author":"T Lok","year":"2014","unstructured":"Lok\u00a0T, Chen\u00a0L, Lin\u00a0F et\u00a0al (2014) Immunohistochemical distinction between intrahepatic cholangiocarcinoma and pancreatic ductal adenocarcinoma. Hum Pathol 45:394\u2013400","journal-title":"Hum Pathol"},{"key":"1440_CR11","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.humpath.2011.11.012","volume":"43","author":"JE Hooper","year":"2012","unstructured":"Hooper\u00a0JE, Morgan\u00a0TK, Grompe\u00a0M et\u00a0al (2012) The novel monoclonal antibody HPC2 and N\u2011cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma. Hum Pathol 43:1583\u20131589","journal-title":"Hum Pathol"},{"key":"1440_CR12","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/modpathol.2008.123","volume":"22","author":"JF Mosnier","year":"2009","unstructured":"Mosnier\u00a0JF, Kandel\u00a0C, Cazals-Hatem\u00a0D et\u00a0al (2009) N\u2011cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol 22:182\u2013190","journal-title":"Mod Pathol"},{"key":"1440_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrc3647","volume":"14","author":"F Van Roy","year":"2014","unstructured":"Van Roy\u00a0F (2014) Beyond E\u2011cadherin: roles of other cadherin superfamily members in cancer. Nat Rev Cancer 14:121\u2013134","journal-title":"Nat Rev Cancer"},{"key":"1440_CR14","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1016\/j.bpj.2021.03.025","volume":"120","author":"FN Arslan","year":"2021","unstructured":"Arslan\u00a0FN, Eckert\u00a0J, Schmidt\u00a0T et\u00a0al (2021) Holding it together: when cadherin meets cadherin. Biophys\u00a0J 120:4182\u20134192","journal-title":"Biophys J"},{"key":"1440_CR15","doi-asserted-by":"publisher","first-page":"a003061","DOI":"10.1101\/cshperspect.a003061","volume":"1","author":"WW Franke","year":"2009","unstructured":"Franke\u00a0WW (2009) Discovering the molecular components of intercellular junctions\u2014a historical view. Cold Spring Harb Perspect Biol 1:a3061","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"13","key":"1440_CR16","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.3390\/cancers14133091","volume":"14","author":"TS Gerber","year":"2022","unstructured":"Gerber TS, Goeppert B, Hausen A et\u00a0al (2022) N\u2011Cadherin Distinguishes Intrahepatic Cholangiocarcinoma from Liver Metastases of Ductal Adenocarcinoma of the Pancreas. Cancers 14(13):3091. https:\/\/doi.org\/10.3390\/cancers14133091","journal-title":"Cancers"},{"issue":"16","key":"1440_CR17","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.3390\/cells11162507","volume":"11","author":"TS Gerber","year":"2022","unstructured":"Gerber TS, Ridder DA, Schindeldecker M et\u00a0al (2022) Constitutive Occurrence of E:N-cadherin Heterodimers in Adherens Junctions of Hepatocytes and Derived Tumors.\nCells 11(16):2507. https:\/\/doi.org\/10.3390\/cells11162507","journal-title":"Cells"},{"key":"1440_CR18","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1002\/ijc.34836","volume":"154","author":"TS Gerber","year":"2024","unstructured":"Gerber\u00a0TS, Ridder\u00a0DA, Goeppert\u00a0B et\u00a0al (2024) N\u2011cadherin: A\u00a0diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas. Intl Journal of Cancer 154:1857\u20131868","journal-title":"Intl Journal of Cancer"},{"issue":"13","key":"1440_CR19","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.3390\/cancers14133156","volume":"14","author":"TS Gerber","year":"2022","unstructured":"Gerber TS, M\u00fcller L, Bartsch F et\u00a0al (2022) Integrative Analysis of Intrahepatic Cholangiocarcinoma Subtypes for Improved Patient Stratification: Clinical, Pathological, and Radiological Considerations. Cancers 14(13):3156. https:\/\/doi.org\/10.3390\/cancers14133156","journal-title":"Cancers"},{"key":"1440_CR20","doi-asserted-by":"publisher","first-page":"104762","DOI":"10.1016\/j.yexmp.2022.104762","volume":"126","author":"D Dum","year":"2022","unstructured":"Dum\u00a0D, Menz\u00a0A, V\u00f6lkel\u00a0C et\u00a0al (2022) Cytokeratin 7 and cytokeratin 20 expression in cancer: A\u00a0tissue microarray study on 15,424 cancers. Exp Mol Pathol 126:104762","journal-title":"Exp Mol Pathol"},{"key":"1440_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/cncy.21184","volume":"120","author":"R Mcknight","year":"2012","unstructured":"Mcknight\u00a0R, Nassar\u00a0A, Cohen\u00a0C et\u00a0al (2012) Arginase-1: a\u00a0novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology. Cancer Cytopathol 120:223\u2013229","journal-title":"Cancer Cytopathol"},{"key":"1440_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/1746-1596-7-149","volume":"7","author":"NA Radwan","year":"2012","unstructured":"Radwan\u00a0NA, Ahmed\u00a0NS (2012) The diagnostic value of arginase\u20111 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar\u20111. Diagn Pathol 7:149","journal-title":"Diagn Pathol"},{"key":"1440_CR23","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1053\/hupa.2002.130104","volume":"33","author":"SK Lau","year":"2002","unstructured":"Lau\u00a0SK, Prakash\u00a0S, Geller\u00a0SA et\u00a0al (2002) Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. Hum Pathol 33:1175\u20131181","journal-title":"Hum Pathol"},{"key":"1440_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1046\/j.1365-2559.1998.00522.x","volume":"33","author":"AS Leong","year":"1998","unstructured":"Leong\u00a0AS, Sormunen\u00a0RT, Tsui\u00a0WM et\u00a0al (1998) Hep Par 1 and selected antibodies in the immunohistological distinction of hepatocellular carcinoma from cholangiocarcinoma, combined tumours and metastatic carcinoma. Histopathology 33:318\u2013324","journal-title":"Histopathology"},{"key":"1440_CR25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1365-2559.2005.02230.x","volume":"47","author":"S Matsuura","year":"2005","unstructured":"Matsuura\u00a0S, Aishima\u00a0S, Taguchi\u00a0K et\u00a0al (2005) \u2018Scirrhous\u2019 type hepatocellular carcinomas: a\u00a0special reference to expression of cytokeratin 7 and hepatocyte paraffin 1. Histopathology 47:382\u2013390","journal-title":"Histopathology"},{"key":"1440_CR26","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/his.12342","volume":"64","author":"AW Chan","year":"2014","unstructured":"Chan\u00a0AW, Tong\u00a0JH, Chan\u00a0SL et\u00a0al (2014) Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma. Histopathology 64:935\u2013950","journal-title":"Histopathology"},{"key":"1440_CR27","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1136\/jcp.2011.090274","volume":"64","author":"G Spizzo","year":"2011","unstructured":"Spizzo\u00a0G, Fong\u00a0D, Wurm\u00a0M et\u00a0al (2011) EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. J\u00a0Clin Pathol 64:415\u2013420","journal-title":"J Clin Pathol"},{"key":"1440_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.humpath.2003.08.026","volume":"35","author":"PT Went","year":"2004","unstructured":"Went\u00a0PT, Lugli\u00a0A, Meier\u00a0S et\u00a0al (2004) Frequent EpCam protein expression in human carcinomas. Hum Pathol 35:122\u2013128","journal-title":"Hum Pathol"},{"key":"1440_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2559.1990.tb00679.x","volume":"17","author":"P Van Eyken","year":"1990","unstructured":"Van Eyken\u00a0P, Sciot\u00a0R, Brock\u00a0P et\u00a0al (1990) Abundant expression of cytokeratin 7 in fibrolamellar carcinoma of the liver. Histopathology 17:101\u2013107","journal-title":"Histopathology"},{"key":"1440_CR30","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/ijc.33898","volume":"150","author":"DA Ridder","year":"2022","unstructured":"Ridder\u00a0DA, Weinmann\u00a0A, Schindeldecker\u00a0M et\u00a0al (2022) Comprehensive clinicopathologic study of alpha fetoprotein-expression in a\u00a0large cohort of patients with hepatocellular carcinoma. Int J Cancer 150:1053\u20131066","journal-title":"Int J Cancer"},{"key":"1440_CR31","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1093\/ajcp\/99.6.726","volume":"99","author":"TS Loy","year":"1993","unstructured":"Loy\u00a0TS, Sharp\u00a0SC, Andershock\u00a0CJ et\u00a0al (1993) Distribution of CA 19\u20119 in adenocarcinomas and transitional cell carcinomas. An immunohistochemical study of 527 cases. Am J Clin Pathol 99:726\u2013728","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"1440_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1136\/jcp-2024-209429","volume":"78","author":"T Albrecht","year":"2025","unstructured":"Albrecht\u00a0T, Rossberg\u00a0A, Rose\u00a0F, Breuhahn\u00a0K, Baumann\u00a0EM, T\u00f3th\u00a0M, Brinkmann\u00a0F, Charbel\u00a0A, Vogel\u00a0MN, K\u00f6hler\u00a0B, Mehrabi\u00a0A, B\u00fcchler\u00a0MW, Singer\u00a0S, Solass\u00a0W, Straub\u00a0B, Schirmacher\u00a0P, Roessler\u00a0S, Goeppert\u00a0B (2025) Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm. J\u00a0Clin Pathol 78(5):307\u2013316. https:\/\/doi.org\/10.1136\/jcp-2024-209429","journal-title":"Clin Pathol"},{"key":"1440_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1309\/8L872RPHEJRKF5JJ","volume":"119","author":"S Kakar","year":"2003","unstructured":"Kakar\u00a0S, Muir\u00a0T, Murphy\u00a0LM et\u00a0al (2003) Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma. Am J Clin Pathol 119:361\u2013366","journal-title":"Am J Clin Pathol"},{"key":"1440_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s10020-021-00274-7","volume":"27","author":"A Menz","year":"2021","unstructured":"Menz\u00a0A, Weitbrecht\u00a0T, Gorbokon\u00a0N et\u00a0al (2021) Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a\u00a0tissue microarray study on 11,952 tumors. Mol Med 27:16","journal-title":"Mol Med"},{"key":"1440_CR35","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/modpathol.2009.191","volume":"23","author":"BK Straub","year":"2010","unstructured":"Straub\u00a0BK, Herpel\u00a0E, Singer\u00a0S et\u00a0al (2010) Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis. Mod Pathol 23:480\u2013492","journal-title":"Mod Pathol"},{"key":"1440_CR36","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.ajpath.2019.04.017","volume":"189","author":"BK Straub","year":"2019","unstructured":"Straub\u00a0BK, Witzel\u00a0HR, Pawella\u00a0LM et\u00a0al (2019) Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma. Am J Pathol 189:1547\u20131558","journal-title":"Am J Pathol"},{"key":"1440_CR37","unstructured":"Gerber\u00a0T (2025) https:\/\/BioRender.com\/esa63dq"}],"container-title":["Die Pathologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01440-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00292-025-01440-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01440-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:13:19Z","timestamp":1761315199000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00292-025-01440-y"}},"subtitle":["Abgrenzung prim\u00e4rer Lebertumoren von Metastasen eines extrahepatischen Primarius","Differentiation of primary liver tumours from metastases of an extrahepatic primary tumour"],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1440"],"URL":"https:\/\/doi.org\/10.1007\/s00292-025-01440-y","relation":{},"ISSN":["2731-7188","2731-7196"],"issn-type":[{"type":"print","value":"2731-7188"},{"type":"electronic","value":"2731-7196"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"17 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"B.K.\u00a0Straub ist Gutachterin beim Institut f\u00fcr Medizinische und Pharmazeutische Pr\u00fcfungsfragen (IMPP) und war in den vergangenen Jahren als Referentin f\u00fcr med update, BayerHealthcare, AstraZeneca sowie Bristol Myers Squibb t\u00e4tig. T.S.\u00a0Gerber, D.A.\u00a0Ridder und W.\u00a0Roth geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}