{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:40:01Z","timestamp":1750833601983,"version":"3.41.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Wir berichten \u00fcber einen nicht immunsupprimierten 60-j\u00e4hrigen Patienten mit \u00fcber mehrere Wochen progredienten, schmerzlosen subkutanen Noduli an der dominanten Hand bis Unterarm, die klinisch als Weichteiltumor vorrangig mesenchymaler Herkunft eingestuft wurden. Nach Exstirpation zweier Kn\u00f6tchen zur diagnostischen Abkl\u00e4rung zeigte die Histologie eine chronisch-granulomat\u00f6se Entz\u00fcndung der Dermis und Subkutis mit zentralen, eosinophilen Nekrosen unter Einschluss von Zelldebris. Mittels Lichtmikroskopie wurden keine s\u00e4urefesten St\u00e4bchen nachgewiesen. Mittels molekularer Diagnostik konnte DNA von <jats:italic>Mycobacterium haemophilum<\/jats:italic> als nichttuberkuloides Mykobakterium (NTM) nachgewiesen werden. Diese Infektion als Ursache der Noduli konnte anhand der klassischen Histomorphologie einer nekrotisierend-granulomat\u00f6sen Entz\u00fcndung in Erg\u00e4nzung mit einer PCR-basierten Erregerdiagnostik identifiziert werden. Dieses Fallbeispiel veranschaulicht die klinische Pr\u00e4senz mykobakterieller Infektionen insbesondere extrapulmonaler und extranodaler Lokalisationen. Neben kutanen Infektionsherden k\u00f6nnen Infektionen durch NTM in Abh\u00e4ngigkeit von der Immunkompetenz des Wirts Multisystemerkrankungen unter Beteiligung des Gelenksystems verursachen, welche antibiotisch therapierbar sind.<\/jats:p>","DOI":"10.1007\/s00292-025-01442-w","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:14:43Z","timestamp":1748862883000},"page":"236-239","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypische Mykobakteriose der Haut","Atypical mycobacteriosis of the skin"],"prefix":"10.1007","volume":"46","author":[{"given":"Anna","family":"Vetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilte","family":"Geerdes-Fenge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Sa\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"H\u00fchns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-2986","authenticated-orcid":false,"given":"Anne-Sophie","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"1442_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092404","author":"H-U Schildhaus","year":"2022","unstructured":"Schildhaus\u00a0H\u2011U, Steindor\u00a0M, K\u00f6lsch\u00a0B, Herold\u00a0T, Buer\u00a0J, Kehrmann\u00a0J (2022) GenoType CM Direct(\u00ae) and VisionArray Myco(\u00ae) for the Rapid Identification of Mycobacteria from Clinical Specimens. J\u00a0Clin Med. https:\/\/doi.org\/10.3390\/jcm11092404","journal-title":"J Clin Med"},{"key":"1442_CR2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00069-18","author":"C Franco-Paredes","year":"2018","unstructured":"Franco-Paredes\u00a0C, Marcos\u00a0LA, Henao-Mart\u00ednez\u00a0AF, Rodr\u00edguez-Morales\u00a0AJ, Villamil-G\u00f3mez\u00a0WE, Gotuzzo\u00a0E, Bonifaz\u00a0A (2018) Cutaneous Mycobacterial Infections. Clin Microbiol Rev. https:\/\/doi.org\/10.1128\/CMR.00069-18","journal-title":"Clin Microbiol Rev"},{"key":"1442_CR3","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3899\/jrheum.221296","volume":"50","author":"K Yamamoto","year":"2023","unstructured":"Yamamoto\u00a0K, Rokutanda\u00a0R (2023) Disseminated Mycobacterium haemophilum Infection Mimicking Rheumatoid Nodules. J\u00a0Rheumatol 50:1193. https:\/\/doi.org\/10.3899\/jrheum.221296","journal-title":"J Rheumatol"},{"key":"1442_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00393-022-01251-z","volume":"81","author":"I K\u00f6tter","year":"2022","unstructured":"K\u00f6tter\u00a0I (2022) Granulomatous diseases-Granuloma, the (un)known species? : A\u00a0brief introduction. (Granulomat\u00f6se Erkrankungen \u2013 Das Granulom, das (un)bekannte Wesen? : Eine kurze Einf\u00fchrung). Z\u00a0Rheumatol 81:531\u2013534. https:\/\/doi.org\/10.1007\/s00393-022-01251-z","journal-title":"Z Rheumatol"},{"key":"1442_CR5","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1111\/ddg.15163_g","volume":"21","author":"D Yasen","year":"2023","unstructured":"Yasen\u00a0D, Liu\u00a0C, Mei\u00a0X, Zhou\u00a0H, Tang\u00a0X, Chen\u00a0X (2023) Hautbeteiligung bei Infektionen mit Mycobacterium haemophilum: Zwei Fallberichte und eine aktualisierte Literatur\u00fcbersicht: Mycobacterium haemophilum infection with cutaneous involvement: Two case reports and an updated literature review. J\u00a0Dtsch Dermatol Ges 21:1291\u20131307. https:\/\/doi.org\/10.1111\/ddg.15163_g","journal-title":"J Dtsch Dermatol Ges"},{"key":"1442_CR6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/ijd.16874","volume":"63","author":"Y Sun","year":"2024","unstructured":"Sun\u00a0Y, Li\u00a0H (2024) Mycobacterium haemophilum infection in immunocompetent adults: a\u00a0literature review and case report. Int J Dermatol 63:169\u2013176. https:\/\/doi.org\/10.1111\/ijd.16874","journal-title":"Int J Dermatol"},{"key":"1442_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/nu15173842","author":"SJ Wimalawansa","year":"2023","unstructured":"Wimalawansa\u00a0SJ (2023) Infections and Autoimmunity-The Immune System and Vitamin\u00a0D: A\u00a0Systematic Review. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}