{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:05:36Z","timestamp":1767139536542,"version":"build-2238731810"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologie"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00292-025-01461-7","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T14:44:19Z","timestamp":1754491459000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathologie der Echinokokkose","Pathology of echinococcosis"],"prefix":"10.1007","volume":"46","author":[{"given":"Thomas F. E.","family":"Barth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Reinehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Frey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"issue":"3","key":"1461_CR1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0889-8553(05)70268-5","volume":"25","author":"R Ammann","year":"1996","unstructured":"Ammann\u00a0R, Eckert\u00a0J (1996) Cestodes: Echinococcus. Gastroenterol Clin North Am 25(3):655\u2013689","journal-title":"Gastroenterol Clin North Am"},{"issue":"10","key":"1461_CR2","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.3390\/pathogens10101326","volume":"10","author":"TFE Barth","year":"2021","unstructured":"Barth\u00a0TFE, Casulli\u00a0A (2021) Morphological Characteristics of Alveolar and Cystic Echinococcosis Lesions in Human Liver and Bone. Pathogens 10(10):1326","journal-title":"Pathogens"},{"issue":"10","key":"1461_CR3","doi-asserted-by":"publisher","first-page":"e1877","DOI":"10.1371\/journal.pntd.0001877","volume":"6","author":"TFE Barth","year":"2012","unstructured":"Barth\u00a0TFE, Herrmann\u00a0TS, Tappe\u00a0D et\u00a0al (2012) Sensitive and Specific Immunohistochemical Diagnosis of Human Alveolar Echinococcosis with the Monoclonal Antibody Em2G11. PLoS Negl Trop Dis 6(10):e1877","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"1461_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","volume":"114","author":"E Brunetti","year":"2010","unstructured":"Brunetti\u00a0E, Kern\u00a0P, Vuitton\u00a0DA (2010) Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114(1):1\u201316","journal-title":"Acta Trop"},{"issue":"2","key":"1461_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3201\/eid1202.050499","volume":"12","author":"CM Budke","year":"2006","unstructured":"Budke\u00a0CM, Deplazes\u00a0P, Torgerson\u00a0PR (2006) Global Socioeconomic Impact of Cystic Echinococcosis. Emerg Infect Dis 12(2):296\u2013303","journal-title":"Emerg Infect Dis"},{"key":"1461_CR6","first-page":"428","volume-title":"Ueber die zusammengesetzte Echinokokkengeschwulst der Leber. Briefliche Mitteilungen, Verhandlungen der physikalisch-medizinischen Gesellschaft zu W\u00fcrzburg","author":"L Buhl","year":"1855","unstructured":"Buhl\u00a0L (1855) Ueber die zusammengesetzte Echinokokkengeschwulst der Leber. Briefliche Mitteilungen, Verhandlungen der physikalisch-medizinischen Gesellschaft zu W\u00fcrzburg Bd. 6, S\u00a0428\u2013429"},{"issue":"1-2","key":"1461_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0001-706X(97)00048-X","volume":"67","author":"A D\u2019Alessandro","year":"1997","unstructured":"D\u2019Alessandro\u00a0A (1997) Polycystic echinococcosis in tropical America: Echinococcus vogeli and E.\u00a0oligarthrus. Acta Trop 67(1-2):43\u201365","journal-title":"Acta Trop"},{"issue":"103","key":"1461_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1017\/S0031182000059278","volume":"1","author":"P Deplazes","year":"1991","unstructured":"Deplazes\u00a0P, Gottstein\u00a0B (1991) A monoclonal antibody against Echinococcus multilocularis Em2 antigen. Parasitology 1(103):41\u201349","journal-title":"Parasitology"},{"key":"1461_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.exppara.2015.03.019","volume":"158","author":"\u00c1 D\u00edaz","year":"2015","unstructured":"D\u00edaz \u00c1, Fern\u00e1ndez\u00a0C, Pittini \u00c1 et\u00a0al (2015) The laminated layer: Recent advances and insights into Echinococcus biology and evolution. Exp Parasitol 158:23\u201330","journal-title":"Exp Parasitol"},{"issue":"1","key":"1461_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","volume":"17","author":"J Eckert","year":"2004","unstructured":"Eckert\u00a0J, Deplazes\u00a0P (2004) Biological, epidemiological, and clincal aspects of echinococcosis, a\u00a0zoonosis of increasing concern. Clin Microbiol Rev 17(1):107\u2013135","journal-title":"Clin Microbiol Rev"},{"key":"1461_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.apar.2016.07.003","volume":"95","author":"J Eckert","year":"2017","unstructured":"Eckert\u00a0J, Thompson\u00a0RC (2017) Historical Aspects of Echinococcosis. Adv Parasitol 95:1\u201364","journal-title":"Adv Parasitol"},{"issue":"13","key":"1461_CR12","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.3748\/wjg.v22.i13.3621","volume":"22","author":"T Graeter","year":"2016","unstructured":"Graeter\u00a0T, Kratzer\u00a0W, Oeztuerk\u00a0S et\u00a0al (2016) Proposal of a\u00a0computed tomography classification for hepatic alveolar echinococcosis. World J Gastroenterol 22(13):3621\u20133631","journal-title":"World J Gastroenterol"},{"issue":"8","key":"1461_CR13","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/pathogens9080634","volume":"9","author":"J Grimm","year":"2020","unstructured":"Grimm\u00a0J, Beck\u00a0A, Nell\u00a0J et\u00a0al (2020) Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis. Pathogens 9(8):634","journal-title":"Pathogens"},{"issue":"12","key":"1461_CR14","doi-asserted-by":"publisher","first-page":"e0008921","DOI":"10.1371\/journal.pntd.0008921","volume":"14","author":"J Grimm","year":"2020","unstructured":"Grimm\u00a0J, Nell\u00a0J, Hillenbrand\u00a0A et\u00a0al (2020) Immunohistological detection of small particles of Echinococcus multilocularis and Echinococcus granulosus in lymph nodes is associated with enlarged lymph nodes in alveolar and cystic echinococcosis. PLoS Negl Trop Dis 14(12):e8921","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"1461_CR15","doi-asserted-by":"publisher","first-page":"e0009155","DOI":"10.1371\/journal.pntd.0009155","volume":"15","author":"J Grimm","year":"2021","unstructured":"Grimm\u00a0J, Krickl\u00a0J, Beck\u00a0A et\u00a0al (2021) Establishing and evaluation of a\u00a0polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue. PLoS Negl Trop Dis 15(2):e9155","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"1461_CR16","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.1074\/jbc.M107161200","volume":"277","author":"AJ H\u00fclsmeier","year":"2002","unstructured":"H\u00fclsmeier\u00a0AJ, Gehrig\u00a0PM, Geyer\u00a0R et\u00a0al (2002) A major Echinococcus multilocularis antigen is a\u00a0mucin-type glycoprotein. J\u00a0Biol Chem 277(8):5742\u20135748","journal-title":"J Biol Chem"},{"issue":"4","key":"1461_CR17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1055\/a-1670-7485","volume":"85","author":"I Kwiedor","year":"2023","unstructured":"Kwiedor\u00a0I, Kratzer\u00a0W, Schlingeloff\u00a0P et\u00a0al (2023) Spread and Development of Alveolar Echinococcosis in Germany, 1992\u20132018. Gesundheitswesen 85(4):258\u2013265","journal-title":"Gesundheitswesen"},{"key":"1461_CR18","unstructured":"Neglected Tropical Diseases https:\/\/www.who.int\/health-topics\/neglected-tropical-diseases. Zugegriffen: 7. Mai 2025"},{"key":"1461_CR19","volume-title":"Die Echinococcen-Krankheit","author":"A Neisser","year":"1877","unstructured":"Neisser\u00a0A (1877) Die Echinococcen-Krankheit. August Hirschwald, Berlin"},{"issue":"1","key":"1461_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/PAS.0000000000001374","volume":"44","author":"M Reinehr","year":"2020","unstructured":"Reinehr\u00a0M, Micheloud\u00a0C, Grimm\u00a0F et\u00a0al (2020) Pathology of Echinococcosis: A\u00a0Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis. Am J Surg Pathol 44(1):43\u201354","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1461_CR21","doi-asserted-by":"publisher","first-page":"e0005636","DOI":"10.1371\/journal.pntd.0005636","volume":"11","author":"FJ Ricken","year":"2017","unstructured":"Ricken\u00a0FJ, Nell\u00a0J, Gr\u00fcner\u00a0B et\u00a0al (2017) Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions. PLoS Negl Trop Dis 11(5):e5636","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"1461_CR22","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1111\/his.15280","volume":"85","author":"S Robers","year":"2024","unstructured":"Robers\u00a0S, Reinehr\u00a0M, Haibach\u00a0L et\u00a0al (2024) Histopathological assessment of the viability of hepatic alveolar echinococcosis. Histopathology 85(6):857\u2013867","journal-title":"Histopathology"},{"issue":"5","key":"1461_CR23","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3201\/eid1305.070216","volume":"13","author":"D Tappe","year":"2007","unstructured":"Tappe\u00a0D, Frosch\u00a0M (2007) Rudolf Virchow and the recognition of alveolar echinococcosis, 1850s. Emerg Infect Dis 13(5):732\u2013735","journal-title":"Emerg Infect Dis"},{"key":"1461_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.actatropica.2010.03.001","volume":"115","author":"D Tappe","year":"2010","unstructured":"Tappe\u00a0D, Kern\u00a0P, Frosch\u00a0M et\u00a0al (2010) A hundred years of controversy about the taxonomic status of Echinococcus species. Acta Trop 115:167\u2013174","journal-title":"Acta Trop"},{"issue":"1","key":"1461_CR25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jhep.2008.03.023","volume":"49","author":"PR Torgerson","year":"2008","unstructured":"Torgerson\u00a0PR, Schweiger\u00a0A, Deplazes\u00a0P et\u00a0al (2008) Alveolar echinococcosis: From a\u00a0deadly disease to a\u00a0well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35\u00a0years. J\u00a0Hepatol 49(1):72\u201377","journal-title":"J Hepatol"},{"key":"1461_CR26","first-page":"84","volume-title":"Die multilocul\u00e4re, ulcerirende Echinokokkengeschwulst der Leber. Verhandlungen der physikalisch-medizinischen Gesellschaft zu W\u00fcrzburg","author":"RL Virchow","year":"1856","unstructured":"Virchow\u00a0RL (1856) Die multilocul\u00e4re, ulcerirende Echinokokkengeschwulst der Leber. Verhandlungen der physikalisch-medizinischen Gesellschaft zu W\u00fcrzburg Bd. 6, S\u00a084\u201395"},{"key":"1461_CR27","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1055\/s-0028-1116546","volume":"80","author":"H Vogel","year":"1955","unstructured":"Vogel\u00a0H (1955) Ueber den Entwicklungszyklus und die Artzugeh\u00f6rigkeit des europ\u00e4ischen Alveolarechinococcus. Dtsch Med Wochenschr 80:931\u2013932","journal-title":"Dtsch Med Wochenschr"},{"issue":"3","key":"1461_CR28","first-page":"404","volume":"8","author":"H Vogel","year":"1957","unstructured":"Vogel\u00a0H (1957) Ueber den Echinococcus multilocularis Sueddeutschlands. I. Das Bandwurmstadium von St\u00e4mmen menschlicher und tierischer Herkunft. Z\u00a0Tropenmed Parasitol 8(3):404\u2013454","journal-title":"Z Tropenmed Parasitol"},{"key":"1461_CR29","doi-asserted-by":"publisher","first-page":"923193","DOI":"10.1155\/2010\/923193","volume":"2010","author":"DA Vuitton","year":"2010","unstructured":"Vuitton\u00a0DA, Gottstein\u00a0B (2010) Echinococcus multilocularis and Its Intermediate Host: A\u00a0Model of Parasite-Host-Interplay. J\u00a0Biomed Biotechnol 2010:923193","journal-title":"J Biomed Biotechnol"},{"key":"1461_CR30","volume-title":"WHO\/OIE Manual on Echinococcosis in Humans and Animals: a\u00a0Public Health Problem of Global Concern","author":"World Health Organization","year":"2001","unstructured":"World Health Organization, World Organisation for Animal Health (2001) WHO\/OIE Manual on Echinococcosis in Humans and Animals: a\u00a0Public Health Problem of Global Concern. World Organisation for Animal Health, Paris"}],"updated-by":[{"DOI":"10.1007\/s00292-025-01475-1","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000}}],"container-title":["Die Pathologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00292-025-01461-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:13:17Z","timestamp":1761315197000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00292-025-01461-7"}},"subtitle":["Eine nichtneoplastische tumorartige L\u00e4sion der Leber","A non-neoplastic tumour-like lesion of the liver"],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1461"],"URL":"https:\/\/doi.org\/10.1007\/s00292-025-01461-7","relation":{},"ISSN":["2731-7188","2731-7196"],"issn-type":[{"value":"2731-7188","type":"print"},{"value":"2731-7196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"18 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Im \u201eFazit f\u00fcr die Praxis\u201c wurde Punkt 4 korrigiert.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Zu diesem Beitrag wurde ein Erratum ver\u00f6ffentlicht:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00292-025-01475-1","URL":"https:\/\/doi.org\/10.1007\/s00292-025-01475-1","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"T.F.E.\u00a0Barth, M.\u00a0Reinehr, H.\u00a0Frey und A.\u00a0Weber geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}