{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:26:39Z","timestamp":1771554399158,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pathologie"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00292-025-01464-4","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:35:33Z","timestamp":1756290933000},"page":"356-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cholangiokarzinom","Cholangiocarcinoma"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-9250","authenticated-orcid":false,"given":"Benjamin","family":"Goeppert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"1464_CR1","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1053\/j.gastro.2023.07.026","volume":"165","author":"T Albrecht","year":"2023","unstructured":"Albrecht\u00a0T, Rossberg\u00a0A, Albrecht JD et\u00a0al (2023) Deep Learning-Enabled Diagnosis of Liver Adenocarcinoma. Gastroenterology 165:1262\u20131275","journal-title":"Gastroenterology"},{"key":"1464_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1136\/jcp-2024-209429","volume":"78","author":"T Albrecht","year":"2025","unstructured":"Albrecht\u00a0T, Rossberg\u00a0A, Rose\u00a0F et\u00a0al (2025) Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a\u00a0molecular classification paradigm. J\u00a0Clin Pathol 78:307\u2013316","journal-title":"J Clin Pathol"},{"key":"1464_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.humpath.2020.12.005","volume":"109","author":"M Akita","year":"2021","unstructured":"Akita\u00a0M, Sawada\u00a0R, Komatsu\u00a0M et\u00a0al (2021) An immunostaining panel of C\u2011reactive protein, N\u2011Cadherin, and S100 calcium binding protein P is useful for Intrahepatic Cholangiocarcinoma Subtyping. Hum Pathol 109:45\u201352","journal-title":"Hum Pathol"},{"key":"1464_CR4","unstructured":"Amin MB, Edge SB, Greene FL. (2016) AJCC Cancer Staging Manual, 8th\u00a0Ed."},{"key":"1464_CR5","volume-title":"WHO Classification of Tumours, Digestive System Tumours","author":"MJ Arends","year":"2019","unstructured":"Arends\u00a0MJ, Fukayama\u00a0M, Klimstra\u00a0DS et\u00a0al (2019) WHO Classification of Tumours, Digestive System Tumours, 5.\u00a0Aufl. International Agency for Research on Cancer (IARC)","edition":"5"},{"key":"1464_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","volume":"17","author":"JM Banales","year":"2020","unstructured":"Banales\u00a0JM, Marin\u00a0JJG, Lamarca\u00a0A et\u00a0al (2020) Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol 17:557\u2013588","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1464_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1634\/theoncologist.2011-0386","volume":"17","author":"DR Borger","year":"2012","unstructured":"Borger\u00a0DR, Tanabe\u00a0KK, Fan\u00a0KC et\u00a0al (2012) Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist 17:72\u201379","journal-title":"Oncologist"},{"key":"1464_CR8","doi-asserted-by":"publisher","first-page":"8290","DOI":"10.1038\/s41467-023-43749-3","volume":"14","author":"J Calderaro","year":"2023","unstructured":"Calderaro\u00a0J, Ghaffari\u00a0LN, Zeng\u00a0Q et\u00a0al (2023) Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma. Nat Commun 14:8290","journal-title":"Nat Commun"},{"key":"1464_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ccell.2017.05.009","volume":"32","author":"J Chaisaingmongkol","year":"2017","unstructured":"Chaisaingmongkol\u00a0J, Budhu\u00a0A, Dang\u00a0H et\u00a0al (2017) Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma. Cancer Cell 32:57\u201370","journal-title":"Cancer Cell"},{"key":"1464_CR10","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/ng.2806","volume":"45","author":"W Chan-On","year":"2013","unstructured":"Chan-On\u00a0W, Nairismagi\u00a0ML, Ong\u00a0CK et\u00a0al (2013) Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat Genet 45:1474\u20131478","journal-title":"Nat Genet"},{"key":"1464_CR11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.humpath.2024.05.006","volume":"148","author":"J Chun","year":"2024","unstructured":"Chun\u00a0J, Sung\u00a0YN, An\u00a0S et\u00a0al (2024) Oncocytic type has distinct immunohistochemical and recurrence-free survival than other histologic types of the intraductal papillary neoplasm of the bile duct. Hum Pathol 148:72\u201380","journal-title":"Hum Pathol"},{"key":"1464_CR12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jhep.2019.09.007","volume":"72","author":"O Clements","year":"2020","unstructured":"Clements\u00a0O, Eliahoo\u00a0J, Kim\u00a0JU et\u00a0al (2020) Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A\u00a0systematic review and meta-analysis. J\u00a0Hepatol 72:95\u2013103","journal-title":"J Hepatol"},{"key":"1464_CR13","doi-asserted-by":"publisher","first-page":"104657","DOI":"10.1016\/j.ebiom.2023.104657","volume":"93","author":"MP Dragomir","year":"2023","unstructured":"Dragomir\u00a0MP, Calina\u00a0TG, Perez\u00a0E et\u00a0al (2023) DNA methylation-based classifier differentiates intrahepatic pancreato-biliary tumours. eBioMedicine 93:104657","journal-title":"eBioMedicine"},{"key":"1464_CR14","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1158\/2159-8290.CD-21-0209","volume":"11","author":"C Falcomata","year":"2021","unstructured":"Falcomata\u00a0C, B\u00e4rthel\u00a0S, Ulrich\u00a0A et\u00a0al (2021) Genetic Screens Identify a\u00a0Context-Specific PI3K\/p27Kip1 Node Driving Extrahepatic Biliary Cancer. Cancer Discov 11:3158\u20133177","journal-title":"Cancer Discov"},{"key":"1464_CR15","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1172\/JCI63212","volume":"122","author":"B Fan","year":"2012","unstructured":"Fan\u00a0B, Malato\u00a0Y, Calvisi\u00a0DF et\u00a0al (2012) Cholangiocarcinomas can originate from hepatocytes in mice. J\u00a0Clin Invest 122:2911\u20132915","journal-title":"J Clin Invest"},{"key":"1464_CR16","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1245\/s10434-014-4247-8","volume":"23","author":"CR Ferrone","year":"2016","unstructured":"Ferrone\u00a0CR, Ting\u00a0DT, Shahid\u00a0M et\u00a0al (2016) The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology. Ann Surg Oncol 23:290\u2013296","journal-title":"Ann Surg Oncol"},{"key":"1464_CR17","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1002\/ijc.34836","volume":"154","author":"TS Gerber","year":"2024","unstructured":"Gerber\u00a0TS, Ridder\u00a0DA, Goeppert\u00a0B et\u00a0al (2024) N\u2011cadherin: A\u00a0diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas. Int J Cancer 154:1857\u20131868","journal-title":"Int J Cancer"},{"key":"1464_CR18","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/hep.31110","volume":"72","author":"B Goeppert","year":"2020","unstructured":"Goeppert\u00a0B, Folseraas\u00a0T, Roessler\u00a0S et\u00a0al (2020) Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities. Hepatology 72:1253\u20131266","journal-title":"Hepatology"},{"key":"1464_CR19","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/modpathol.2013.206","volume":"27","author":"B Goeppert","year":"2014","unstructured":"Goeppert\u00a0B, Frauenschuh\u00a0L, Renner\u00a0M et\u00a0al (2014) BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma. Mod Pathol 27:1028\u20131034","journal-title":"Mod Pathol"},{"key":"1464_CR20","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/hep.26721","volume":"59","author":"B Goeppert","year":"2014","unstructured":"Goeppert\u00a0B, Konermann\u00a0C, Schmidt\u00a0CR et\u00a0al (2014) Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology 59:544\u2013554","journal-title":"Hepatology"},{"key":"1464_CR21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41416-018-0199-2","volume":"120","author":"B Goeppert","year":"2019","unstructured":"Goeppert\u00a0B, Roessler\u00a0S, Renner\u00a0M et\u00a0al (2019) Mismatch repair deficiency is a\u00a0rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma. Br J Cancer 120:109\u2013114","journal-title":"Br J Cancer"},{"key":"1464_CR22","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1136\/gutjnl-2020-322983","volume":"71","author":"B Goeppert","year":"2022","unstructured":"Goeppert\u00a0B, Stichel\u00a0D, Toth\u00a0R et\u00a0al (2022) Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis. Gut 71:391\u2013401","journal-title":"Gut"},{"key":"1464_CR23","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/hep.30493","volume":"69","author":"B Goeppert","year":"2019","unstructured":"Goeppert\u00a0B, Toth\u00a0R, Singer\u00a0S et\u00a0al (2019) Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma. Hepatology 69:2091\u20132106","journal-title":"Hepatology"},{"key":"1464_CR24","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ng.2813","volume":"45","author":"Y Jiao","year":"2013","unstructured":"Jiao\u00a0Y, Pawlik\u00a0TM, Anders\u00a0RA et\u00a0al (2013) Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 45:1470\u20131473","journal-title":"Nat Genet"},{"key":"1464_CR25","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1158\/2159-8290.CD-17-0368","volume":"7","author":"A Jusakul","year":"2017","unstructured":"Jusakul\u00a0A, Cutcutache\u00a0I, Yong\u00a0CH et\u00a0al (2017) Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma. Cancer Discov 7:1116\u20131135","journal-title":"Cancer Discov"},{"issue":"Suppl 1","key":"1464_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/liv.14093","volume":"39","author":"T Kendall","year":"2019","unstructured":"Kendall\u00a0T, Verheij\u00a0J, Gaudio\u00a0E et\u00a0al (2019) Anatomical, histomorphological and molecular classification of cholangiocarcinoma. Liver Int 39(Suppl 1):7\u201318","journal-title":"Liver Int"},{"key":"1464_CR27","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jhep.2022.11.030","volume":"78","author":"G Kendre","year":"2023","unstructured":"Kendre\u00a0G, Murugesan\u00a0K, Brummer\u00a0T et\u00a0al (2023) Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma. J\u00a0Hepatol 78:614\u2013626","journal-title":"J Hepatol"},{"key":"1464_CR28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/path.5514","volume":"252","author":"MA Loeffler","year":"2020","unstructured":"Loeffler\u00a0MA, Hu\u00a0J, Kirchner\u00a0M et\u00a0al (2020) miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR-451a\/ATF2 axis. J\u00a0Pathol 252:239\u2013251","journal-title":"J Pathol"},{"key":"1464_CR29","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/ng.3375","volume":"47","author":"H Nakamura","year":"2015","unstructured":"Nakamura\u00a0H, Arai\u00a0Y, Totoki\u00a0Y et\u00a0al (2015) Genomic spectra of biliary tract cancer. Nat Genet 47:1003\u20131010","journal-title":"Nat Genet"},{"key":"1464_CR30","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/PAS.0000000000002347","volume":"49","author":"Y Nakanuma","year":"2025","unstructured":"Nakanuma\u00a0Y, Kakuda\u00a0Y, Matsubayashi\u00a0H et\u00a0al (2025) Intraductal Polypoid Neoplasm in the Intrahepatic Large Bile Ducts of Small Duct-type Intrahepatic Cholangiocarcinoma May Result From Cancerization of Ducts. Am J Surg Pathol 49:284\u2013293","journal-title":"Am J Surg Pathol"},{"key":"1464_CR31","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jhep.2014.09.007","volume":"62","author":"C Raggi","year":"2015","unstructured":"Raggi\u00a0C, Invernizzi\u00a0P, Andersen\u00a0JB (2015) Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: molecular networks and biological concepts. J\u00a0Hepatol 62:198\u2013207","journal-title":"J Hepatol"},{"key":"1464_CR32","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1053\/j.gastro.2013.10.013","volume":"145","author":"S Rizvi","year":"2013","unstructured":"Rizvi\u00a0S, Gores\u00a0GJ (2013) Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 145:1215\u20131229","journal-title":"Gastroenterology"},{"key":"1464_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/modpathol.2013.112","volume":"27","author":"AM Schlitter","year":"2014","unstructured":"Schlitter\u00a0AM, Born\u00a0D, Bettstetter\u00a0M et\u00a0al (2014) Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. Mod Pathol 27:73\u201386","journal-title":"Mod Pathol"},{"key":"1464_CR34","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/modpathol.2015.61","volume":"28","author":"AM Schlitter","year":"2015","unstructured":"Schlitter\u00a0AM, Jang\u00a0KT, Kloppel\u00a0G et\u00a0al (2015) Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20\u00a0cases. Mod Pathol 28:1249\u20131264","journal-title":"Mod Pathol"},{"key":"1464_CR35","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1053\/j.gastro.2019.10.028","volume":"158","author":"AD Singhi","year":"2020","unstructured":"Singhi\u00a0AD, Wood\u00a0LD, Parks\u00a0E et\u00a0al (2020) Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct. Gastroenterology 158:573\u2013582","journal-title":"Gastroenterology"},{"key":"1464_CR36","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1097\/PAS.0000000000002259","volume":"48","author":"M Tanaka","year":"2024","unstructured":"Tanaka\u00a0M, Takeshita\u00a0K, Kunita\u00a0A et\u00a0al (2024) PRKACA\/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum. Am J Surg Pathol 48:1032\u20131040","journal-title":"Am J Surg Pathol"},{"key":"1464_CR37","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/liv.13954","volume":"39","author":"D Walter","year":"2019","unstructured":"Walter\u00a0D, Ferstl\u00a0P, Waidmann\u00a0O et\u00a0al (2019) Cholangiocarcinoma in Germany: epidemiologic trends and impact of misclassification. Liver Int 39:316\u2013323","journal-title":"Liver Int"},{"key":"1464_CR38","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2018.01.009","volume":"68","author":"CP Wardell","year":"2018","unstructured":"Wardell\u00a0CP, Fujita\u00a0M, Yamada\u00a0T et\u00a0al (2018) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. J\u00a0Hepatol 68:959\u2013969","journal-title":"J Hepatol"},{"key":"1464_CR39","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1097\/PAS.0000000000000957","volume":"41","author":"YC Yeh","year":"2017","unstructured":"Yeh\u00a0YC, Lei\u00a0HJ, Chen\u00a0MH et\u00a0al (2017) C\u2011reactive protein (CRP) is a\u00a0promising diagnostic immunohistochemical marker for Intrahepatic Cholangiocarcinoma and is associated with better prognosis. Am J Surg Pathol 41:1630\u20131641","journal-title":"Am J Surg Pathol"},{"key":"1464_CR40","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/modpathol.3800788","volume":"20","author":"Y Zen","year":"2007","unstructured":"Zen\u00a0Y, Adsay\u00a0NV, Bardadin\u00a0K et\u00a0al (2007) Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria. Mod Pathol 20:701\u2013709","journal-title":"Mod Pathol"}],"container-title":["Die Pathologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01464-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00292-025-01464-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00292-025-01464-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:13:02Z","timestamp":1761315182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00292-025-01464-4"}},"subtitle":["Histopathologische Diagnose, Klassifikation und Molekulardiagnostik\u00a0\u2013 ein Update","Histopathological diagnosis, classification and molecular diagnostics\u2014an update"],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1464"],"URL":"https:\/\/doi.org\/10.1007\/s00292-025-01464-4","relation":{},"ISSN":["2731-7188","2731-7196"],"issn-type":[{"value":"2731-7188","type":"print"},{"value":"2731-7196","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"29 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"B.\u00a0Goeppert gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}