{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:07:13Z","timestamp":1767636433439,"version":"3.48.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Genet"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s00294-007-0125-2","type":"journal-article","created":{"date-parts":[[2007,3,21]],"date-time":"2007-03-21T12:11:57Z","timestamp":1174479117000},"page":"297-307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Performance of a tetracycline-responsive transactivator system for regulating transgenes in the oomycete Phytophthora infestans"],"prefix":"10.1007","volume":"51","author":[{"given":"Howard S.","family":"Judelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey M. V.","family":"Ah Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,3,22]]},"reference":[{"key":"125_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1046\/j.1365-2958.2003.03735.x","volume":"50","author":"A Ah Fong","year":"2003","unstructured":"Ah Fong A, Judelson HS (2003) Cell cycle regulator Cdc14 is expressed during sporulation but not hyphal growth in the fungus-like oomycete Phytophthora\n                           infestans. Mol Microbiol 50:487\u2013494","journal-title":"Mol Microbiol"},{"key":"125_CR2","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1126\/science.1085544","volume":"300","author":"SL Baldauf","year":"2003","unstructured":"Baldauf SL (2003) The deep roots of eukaryotes. Science 300:1703\u20131706","journal-title":"Science"},{"key":"125_CR3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0958-1669(99)00003-8","volume":"10","author":"F Baneyx","year":"1999","unstructured":"Baneyx F (1999) Recombinant protein expression in Escherichia coli. Curr Opin Biotechnol 10:411\u2013421","journal-title":"Curr Opin Biotechnol"},{"key":"125_CR4","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1093\/nar\/gni137","volume":"33","author":"GW Bornkamm","year":"2005","unstructured":"Bornkamm GW et al (2005) Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res 33:e137","journal-title":"Nucleic Acids Res"},{"key":"125_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1574-6968.1999.tb13641.x","volume":"176","author":"A Bottin","year":"1999","unstructured":"Bottin A, Larche L, Villalba F, Gaulin E, Esquerre-Tugaye M-T, Rickauer M (1999) Green fluorescent protein (GFP) as gene expression reporter and vital marker for studying development and microbe-plant interaction in the tobacco pathogen Phytophthora parasitica var. nicotianae. FEMS Microbiol Lett 176:51\u201356","journal-title":"FEMS Microbiol Lett"},{"key":"125_CR6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1051\/rnd:2004001","volume":"43","author":"V Bryja","year":"2003","unstructured":"Bryja V, Pachernik J, Kubala L, Hampl A, Dvorak P (2003) The reverse tetracycline-controlled transactivator rtTA2s-S2 is toxic in mouse embryonic stem cells. Reprod Nutr Dev 43:477\u2013486","journal-title":"Reprod Nutr Dev"},{"key":"125_CR7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00294-002-0354-3","volume":"42","author":"C Cvitanich","year":"2003a","unstructured":"Cvitanich C, Judelson HS (2003a) Stable transformation of the oomycete, Phytophthora infestans, using microprojectile bombardment. Curr Genet 42:228\u2013235","journal-title":"Curr Genet"},{"key":"125_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1128\/EC.2.3.465-473.2003","volume":"2","author":"C Cvitanich","year":"2003b","unstructured":"Cvitanich C, Judelson HS (2003b) A gene expressed during sexual and asexual sporulation in Phytophthora infestans is a member of the Puf family of translational regulators. Eukaryot Cell 2:465\u2013473","journal-title":"Eukaryot Cell"},{"key":"125_CR9","volume-title":"Phytophthora diseases worldwide","author":"DC Erwin","year":"1996","unstructured":"Erwin DC, Ribeiro OK (1996) Phytophthora diseases worldwide. APS Press, St. Paul"},{"key":"125_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/(SICI)1521-2254(199901\/02)1:1<4::AID-JGM4>3.0.CO;2-Y","volume":"1","author":"S Freundlieb","year":"1999","unstructured":"Freundlieb S, Schirra-Muller C, Bujard H (1999) A tetracycline controlled activation\/repression system with increased potential for gene transfer into mammalian cells. J Gene Med 1:4\u201312","journal-title":"J Gene Med"},{"key":"125_CR11","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/334721a0","volume":"334","author":"G Gill","year":"1988","unstructured":"Gill G, Ptashne M (1988) Negative effect of the transcriptional activator GAL4. Nature 334:721\u2013724","journal-title":"Nature"},{"key":"125_CR12","doi-asserted-by":"publisher","first-page":"8036","DOI":"10.1073\/pnas.94.15.8036","volume":"94","author":"E Gonzalez-Couto","year":"1997","unstructured":"Gonzalez-Couto E, Klages N, Strubin M (1997) Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB. Proc Natl Acad Sci USA 94:8036\u20138041","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR13","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.1073\/pnas.89.12.5547","volume":"89","author":"M Gossen","year":"1992","unstructured":"Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547\u20135551","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.genet.36.041002.120114","volume":"36","author":"M Gossen","year":"2002","unstructured":"Gossen M, Bujard H (2002) Studying gene function in eukaryotes by conditional gene inactivation. Ann Rev Genet 36:153\u2013173","journal-title":"Ann Rev Genet"},{"key":"125_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/nar\/24.3.501","volume":"24","author":"CH Herrmann","year":"1996","unstructured":"Herrmann CH, Gold MO, Rice AP (1996) Viral transactivators specifically target distinct cellular protein kinases that phosphorylate the RNA polymerase II C-terminal domain. Nucleic Acids Res 24:501\u2013508","journal-title":"Nucleic Acids Res"},{"key":"125_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1356-9597.2001.00492.x","volume":"7","author":"K Ikeda","year":"2002","unstructured":"Ikeda K, Stuehler T, Meisterernst M (2002) The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms. Genes Cells 7:49\u201358","journal-title":"Genes Cells"},{"key":"125_CR17","doi-asserted-by":"publisher","first-page":"5208","DOI":"10.1073\/pnas.93.11.5208","volume":"93","author":"V Iyer","year":"1996","unstructured":"Iyer V, Struhl K (1996) Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93:5208\u20135212","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR18","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1002\/j.1460-2075.1987.tb02730.x","volume":"6","author":"RA Jefferson","year":"1987","unstructured":"Jefferson RA, Kavanagh TA, Bevan MW (1987) Gus fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J 6:3901\u20133908","journal-title":"EMBO J"},{"key":"125_CR19","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/(SICI)1096-9063(199812)54:4<360::AID-PS847>3.0.CO;2-8","volume":"54","author":"I Jepson","year":"1998","unstructured":"Jepson I, Martinez A, Sweetman JP (1998) Chemical-inducible gene expression system for plants: a review. Pest Sci 54:360\u2013367","journal-title":"Pest Sci"},{"key":"125_CR20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF00281624","volume":"239","author":"HS Judelson","year":"1993","unstructured":"Judelson HS (1993) Intermolecular ligation mediates efficient cotransformation in Phytophthora infestans. Mol Gen Genet 239:241\u2013250","journal-title":"Mol Gen Genet"},{"key":"125_CR21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/genetics\/144.3.1005","volume":"144","author":"HS Judelson","year":"1996","unstructured":"Judelson HS (1996) Genetic and physical variability at the mating type locus of the oomycete, Phytophthora infestans. Genetics 144:1005\u20131013","journal-title":"Genetics"},{"key":"125_CR22","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/BF00312736","volume":"19","author":"HS Judelson","year":"1991","unstructured":"Judelson HS, Michelmore RW (1991) Transient expression of genes in the oomycete Phytophthora infestans using Bremia lactucae regulatory sequences. Curr Genet 19:453\u2013460","journal-title":"Curr Genet"},{"key":"125_CR23","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1139\/gen-41-4-605","volume":"41","author":"HS Judelson","year":"1998","unstructured":"Judelson HS, Randall TA (1998) Families of repeated DNA in the oomycete Phytophthora infestans and their distribution within the genus. Genome 41:605\u2013615","journal-title":"Genome"},{"key":"125_CR24","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1128\/EC.1.5.687-695.2002","volume":"1","author":"HS Judelson","year":"2002","unstructured":"Judelson HS, Roberts S (2002) Novel protein kinase induced during sporangial cleavage in the oomycete Phytophthora infestans. Eukaryot Cell 1:687\u2013695","journal-title":"Eukaryot Cell"},{"key":"125_CR25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1364-3703.2005.00313.x","volume":"7","author":"HS Judelson","year":"2006","unstructured":"Judelson HS, Senthil GS (2006) Investigating the role of ABC transporters in multifungicide insensitivity in Phytophthora infestans. Mol Plant Pathol 7:17\u201329","journal-title":"Mol Plant Pathol"},{"key":"125_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/BF00518171","volume":"28","author":"HS Judelson","year":"1995","unstructured":"Judelson HS, Whittaker SL (1995) Inactivation of transgenes in Phytophthora infestans is not associated with their deletion, methylation, or mutation. Curr Genet 28:571\u2013579","journal-title":"Curr Genet"},{"key":"125_CR27","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1094\/MPMI-4-602","volume":"4","author":"HS Judelson","year":"1991","unstructured":"Judelson HS, Tyler BM, Michelmore RW (1991) Transformation of the oomycete pathogen, Phytophthora infestans. Mol Plant Microbe Interact 4:602\u2013607","journal-title":"Mol Plant Microbe Interact"},{"key":"125_CR28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF00272355","volume":"234","author":"HS Judelson","year":"1992","unstructured":"Judelson HS, Tyler BM, Michelmore RW (1992) Regulatory sequences for expressing genes in oomycete fungi. Mol Gen Genet 234:138\u2013146","journal-title":"Mol Gen Genet"},{"key":"125_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF00351498","volume":"23","author":"HS Judelson","year":"1993a","unstructured":"Judelson HS, Coffey MD, Arredondo FR, Tyler BM (1993a) Transformation of the oomycete pathogen Phytophthora megasperma f. sp. glycinea occurs by DNA integration into single or multiple chromosomes. Curr Genet 23:211\u2013218","journal-title":"Curr Genet"},{"key":"125_CR30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0378-1119(93)90225-R","volume":"133","author":"HS Judelson","year":"1993b","unstructured":"Judelson HS, Dudler R, Pieterse CMJ, Unkles SE, Michelmore RW (1993b) Expression and antisense inhibition of transgenes in Phytophthora infestans is modulated by choice of promoter and position effects. Gene 133:63\u201369","journal-title":"Gene"},{"key":"125_CR31","unstructured":"Kim KS (2006) Molecular mechanisms governing the development of sporangia in the oomycete phytopathogen Phytophthora infestans. Ph D thesis, University of California"},{"key":"125_CR32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1046\/j.1365-2958.2003.03893.x","volume":"51","author":"M Latijnhouwers","year":"2004","unstructured":"Latijnhouwers M, Ligterink W, Vleeshouwers VGAA, van West P, Govers F (2004) A G-alpha subunit controls zoospore motility and virulence in the potato late blight pathogen Phytophthora infestans. Mol Microbiol 51:925\u2013936","journal-title":"Mol Microbiol"},{"key":"125_CR33","doi-asserted-by":"publisher","first-page":"6827","DOI":"10.1073\/pnas.79.22.6827","volume":"79","author":"A Laughon","year":"1982","unstructured":"Laughon A, Gesteland RF (1982) Isolation and preliminary characterization of the gal-4 gene a positive regulator of transcription in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 79:6827\u20136831","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1094\/PHYTO.1997.87.7.685","volume":"87","author":"FN Martin","year":"1997","unstructured":"Martin FN, Semer CR (1997) Selection of drug-tolerant strains of Pythium sylvaticum using sublethal enrichment. Phytopathology 87:685\u2013692","journal-title":"Phytopathology"},{"key":"125_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1128\/EC.3.1.91-99.2004","volume":"3","author":"A McLeod","year":"2004","unstructured":"McLeod A, Smart CD, Fry WE (2004) Core promoter structure in the oomycete Phytophthora infestans. Eukaryot Cell 3:91\u201399","journal-title":"Eukaryot Cell"},{"key":"125_CR36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S1097-2765(00)80216-6","volume":"4","author":"KE Neely","year":"1999","unstructured":"Neely KE et al (1999) Activation domain-mediated targeting of the SWI\/SNF complex to promoters stimulates transcription from nucleosome arrays. Mol Cell 4:649\u2013655","journal-title":"Mol Cell"},{"key":"125_CR37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1094\/MPMI-18-0229","volume":"18","author":"TA Randall","year":"2005","unstructured":"Randall TA et al (2005) Large-scale gene discovery in the oomycete Phytophthora infestans reveals likely components of phytopathogenicity shared with true fungi. Mol Plant Microbe Interact 18:229\u2013243","journal-title":"Mol Plant Microbe Interact"},{"key":"125_CR38","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1093\/nar\/15.3.1281","volume":"15","author":"PM Sharp","year":"1987","unstructured":"Sharp PM, Li WH (1987) The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res 15:1281\u20131295","journal-title":"Nucleic Acids Res"},{"key":"125_CR39","doi-asserted-by":"publisher","first-page":"6522","DOI":"10.1073\/pnas.92.14.6522","volume":"92","author":"P Shockett","year":"1995","unstructured":"Shockett P, Difilippantonio M, Hellman N, Schatz DG (1995) A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA 92:6522\u20136526","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR40","doi-asserted-by":"publisher","first-page":"10775","DOI":"10.1073\/pnas.121186498","volume":"98","author":"MJ Stebbins","year":"2001","unstructured":"Stebbins MJ, Urlinger S, Byrne G, Bello B, Hillen W, Yin JCP (2001) Tetracycline-inducible systems for Drosophila. Proc Natl Acad Sci USA 98:10775\u201310780","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0378-1119(99)00045-1","volume":"229","author":"CA Strathdee","year":"1999","unstructured":"Strathdee CA, McLeod MR, Hall JR (1999) Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector. Gene 229:21\u201329","journal-title":"Gene"},{"key":"125_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.fgb.2004.09.005","volume":"42","author":"S Tani","year":"2005","unstructured":"Tani S, Kim KS, Judelson HS (2005) A cluster of NIF transcriptional regulators with divergent patterns of spore-specific expression in Phytophthora infestans. Fungal Genet Biol 42:42\u201350","journal-title":"Fungal Genet Biol"},{"key":"125_CR43","doi-asserted-by":"publisher","first-page":"7963","DOI":"10.1073\/pnas.130192197","volume":"97","author":"S Urlinger","year":"2000","unstructured":"Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 97:7963\u20137968","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR44","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1023\/A:1016601928465","volume":"10","author":"ML Valencik","year":"2001","unstructured":"Valencik ML, McDonald JA (2001) Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart. Transgen Res 10:269\u2013275","journal-title":"Transgen Res"},{"key":"125_CR45","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S1097-2765(00)80461-X","volume":"3","author":"P Van West","year":"1999a","unstructured":"Van West P, Kamoun S, Van \u2018t Klooster JW, Govers F (1999a) Internuclear gene silencing in Phytophthora infestans. Mol Cell 3:339\u2013348","journal-title":"Mol Cell"},{"key":"125_CR46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1574-6968.1999.tb13761.x","volume":"178","author":"P van West","year":"1999b","unstructured":"van West P et al (1999b) Green fluorescent protein (GFP) as a reporter gene for the plant pathogenic oomycete Phytophthora palmivora. FEMS Microbiol Lett 178:71\u201380","journal-title":"FEMS Microbiol Lett"},{"key":"125_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2180-5-1","volume":"5","author":"K Vogt","year":"2005","unstructured":"Vogt K, Bhabhra R, Rhodes JC, Askew DS (2005) Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus. BMC Microbiol 5:1","journal-title":"BMC Microbiol"},{"key":"125_CR48","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-313X.1994.5040559.x","volume":"5","author":"P Weinmann","year":"1994","unstructured":"Weinmann P, Gossen M, Hillen W, Bujard H, Gatz C (1994) A chimeric transactivator allows tetracycline-responsive gene expression in whole plants. Plant J 5:559\u2013569","journal-title":"Plant J"},{"key":"125_CR49","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.fgb.2006.05.006","volume":"43","author":"K Zarnack","year":"2006","unstructured":"Zarnack K et al (2006) Tetracycline-regulated gene expression in the pathogen Ustilago maydis. Fungal Genet Biol 43:727\u2013738","journal-title":"Fungal Genet Biol"}],"container-title":["Current Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-007-0125-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00294-007-0125-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-007-0125-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-007-0125-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:17:04Z","timestamp":1767622624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00294-007-0125-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,22]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["125"],"URL":"https:\/\/doi.org\/10.1007\/s00294-007-0125-2","relation":{},"ISSN":["0172-8083","1432-0983"],"issn-type":[{"type":"print","value":"0172-8083"},{"type":"electronic","value":"1432-0983"}],"subject":[],"published":{"date-parts":[[2007,3,22]]},"assertion":[{"value":"20 November 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}