{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:55:07Z","timestamp":1770976507877,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T00:00:00Z","timestamp":1517011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T00:00:00Z","timestamp":1517011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100021016","name":"IRCCS Burlo Garofolo","doi-asserted-by":"crossref","award":["RC42\/11"],"award-info":[{"award-number":["RC42\/11"]}],"id":[{"id":"10.13039\/100021016","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Genet"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00294-018-0803-2","type":"journal-article","created":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T03:22:10Z","timestamp":1517023330000},"page":"871-881","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Respiratory deficiency in yeast mevalonate kinase deficient may explain MKD-associate metabolic disorder in humans"],"prefix":"10.1007","volume":"64","author":[{"given":"Manuella Maria Silva","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Elsztein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Barros","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"S\u00e9rgio de S\u00e1 Leit\u00e3o","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline Azev\u00eado","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-0300","authenticated-orcid":false,"suffix":"Jr","given":"Marcos Antonio","family":"De Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,27]]},"reference":[{"key":"803_CR1","doi-asserted-by":"publisher","first-page":"5410","DOI":"10.1091\/mbc.e05-07-0678","volume":"16","author":"K Altmann","year":"2005","unstructured":"Altmann K, Westermann B (2005) Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol Biol Cell 16:5410\u20135417. https:\/\/doi.org\/10.1091\/mbc.E05-07-0678","journal-title":"Mol Biol Cell"},{"key":"803_CR2","doi-asserted-by":"crossref","unstructured":"Bard M, Albrecht MR, Gupta N, Guynn CJ, Stlllwell W (1988) Geraniol interferes with membrane functions in strains of Candida and Saccharomyces. Lipids 23:534\u2013538","DOI":"10.1007\/BF02535593"},{"key":"803_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bbrc.2010.02.147","volume":"396","author":"M Bentinger","year":"2010","unstructured":"Bentinger M, Tekle M, Dallner G (2010) Coenzyme Q\u2014biosynthesis and functions. Biochem Biophys Res Commun 396:74\u201379. https:\/\/doi.org\/10.1016\/j.bbrc.2010.02.147","journal-title":"Biochem Biophys Res Commun"},{"key":"803_CR4","first-page":"260","volume":"63","author":"EJ Bodar","year":"2005","unstructured":"Bodar EJ, van der Hilst JC, Drenth JP, van der Meer JW, Simon A (2005) Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model. Neth J Med 63:260\u2013264","journal-title":"Neth J Med"},{"key":"803_CR5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.717","author":"PD Boyer","year":"1997","unstructured":"Boyer PD (1997) The ATP synthase\u2014a splendid molecular machine. Annu Rev Biochem 66:717\u2013749. https:\/\/doi.org\/10.1146\/annurev.biochem.66.1.717","journal-title":"Annu Rev Biochem"},{"key":"803_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1136\/adc.78.2.185","volume":"78","author":"PT Clayton","year":"1998","unstructured":"Clayton PT (1998) Disorders of cholesterol biosynthesis. Arch Dis Child 78:185\u2013189","journal-title":"Arch Dis Child"},{"key":"803_CR7","first-page":"712","volume":"51","author":"JE DeClue","year":"1991","unstructured":"DeClue JE, Vass WC, Papageorge AG, Lowy DR, Willumsen BM (1991) Inhibition of cell growth by lovastatin is independent of ras function. Cancer Res 51:712\u2013717","journal-title":"Cancer Res"},{"key":"803_CR8","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/j.1742-4658.2006.05116.x","volume":"273","author":"AP Demasi","year":"2006","unstructured":"Demasi AP, Pereira GA, Netto LES (2006) Yeast oxidative stress response Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state. FEBS J 273:805\u2013816. https:\/\/doi.org\/10.1111\/j.1742-4658.2006.05116.x","journal-title":"FEBS J"},{"key":"803_CR9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10545-014-9749-9","volume":"38","author":"MA Desbats","year":"2015","unstructured":"Desbats MA, Lunardi G, Doimo M, Trevisson E, Salviati L (2015) Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. J Inherit Metab Dis 38:145\u2013156. https:\/\/doi.org\/10.1007\/s10545-014-9749-9","journal-title":"J Inherit Metab Dis"},{"issue":"2\u20133","key":"803_CR10","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0005-2728(00)00092-X","volume":"1458","author":"RJ Devenish","year":"2000","unstructured":"Devenish RJ, Prescott M, Roucou X, Nagley P (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458(2\u20133):428\u2013442. https:\/\/doi.org\/10.1091\/mbc.E05-07-0678","journal-title":"Biochim Biophys Acta"},{"key":"803_CR11","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1159\/000362826","volume":"5","author":"M Doimo","year":"2014","unstructured":"Doimo M, Desbats MA, Cerqua C, Cassina M, Trevisson E, Salviati L (2014) Genetics of coenzyme q10 deficiency. Mol Syndr 5:156\u2013162. https:\/\/doi.org\/10.1159\/000362826","journal-title":"Mol Syndr"},{"key":"803_CR12","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1016\/S0021-9258(18)93170-4","volume":"243","author":"JK Dorsey","year":"1968","unstructured":"Dorsey JK, Porter JW (1968) The inhibition of mevalonic kinase by geranyl and farnesyl pyrophosphates. J Biol Chem 243:4667\u20134670","journal-title":"J Biol Chem"},{"key":"803_CR13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0022-3565(24)29496-9","volume":"298","author":"JP Drenth","year":"2001","unstructured":"Drenth JP, Vonk AG, Simon A, Powell R, van der Meer JW (2001) Limited efficacy of thalidomide in the treatment of febrile attacks of the hyper-IgD and periodic fever syndrome: a randomized, double-blind, placebo-controlled trial. J Pharmacol Exp Ther 298:1221\u20131226","journal-title":"J Pharmacol Exp Ther"},{"key":"803_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2199-12-38","volume":"12","author":"C Elsztein","year":"2011","unstructured":"Elsztein C, Lucena RM, Morais MA Jr (2011) The resistance of the yeast Saccharomyces cerevisiae to the biocide polyhexamethylene biguanide: involvement of cell wall integrity pathway and emerging role for YAP1. BMC Mol Biol 12:1\u201310. https:\/\/doi.org\/10.1186\/1471-2199-12-38","journal-title":"BMC Mol Biol"},{"key":"803_CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14712\/fb2016062020053","volume":"62","author":"Z Fi\u0161ar","year":"2016","unstructured":"Fi\u0161ar Z, Hroudov\u00e1 J, Singh N, Kop\u0159ivov\u00e1 A, Mace\u010dkov\u00e1 D (2016) Effect of simvastatin, coenzyme Q10, resveratrol, acetylcysteine and acetylcarnitine on mitochondrial respiration. Folia Biol 62:53\u201366","journal-title":"Folia Biol"},{"key":"803_CR16","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1002\/art.10550","volume":"46","author":"J Frenkel","year":"2002","unstructured":"Frenkel J, Rijkers GT, Mandey SH, Buurman SW, Houten SM, Wanders RJ, Waterham HR, Kuis W (2002) Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. Arthritis Rheum 46:2794\u20132803. https:\/\/doi.org\/10.1002\/art.10550","journal-title":"Arthritis Rheum"},{"key":"803_CR17","doi-asserted-by":"publisher","first-page":"18134","DOI":"10.1074\/jbc.M200912200","volume":"277","author":"Z Fu","year":"2002","unstructured":"Fu Z, Wang M, Potter D, Miziorko HM, Kim JJ (2002) The structure of a binary complex betweena mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem 277:18134\u201318142. https:\/\/doi.org\/10.1074\/jbc.M200912200","journal-title":"J Biol Chem"},{"key":"803_CR18","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1172\/JCI45693","volume":"121","author":"SF Heeringa","year":"2011","unstructured":"Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z et al (2011) COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121:2013\u20132024. https:\/\/doi.org\/10.1172\/JCI45693","journal-title":"J Clin Invest"},{"key":"803_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbalip.2011.01.002","volume":"181","author":"L Henneman","year":"2011","unstructured":"Henneman L, van Cruchten AG, Kulik W, Waterham HR (2011) Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS\/MS. Biochim Biophys Acta 181:227\u2013233. https:\/\/doi.org\/10.1016\/j.bbalip.2011.01.002","journal-title":"Biochim Biophys Acta"},{"key":"803_CR20","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.bbagen.2007.12.004","volume":"1780","author":"E Herrero","year":"2008","unstructured":"Herrero E, Ros J, Belli G, Cabiscol E (2008) Redox control and oxidative stress in yeast cells. Biochim Biophys Acta 1780:1217\u20131235. https:\/\/doi.org\/10.1016\/j.bbagen.2007.12.004","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"803_CR21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1203\/00006450-199308000-00004","volume":"34","author":"C Hubner","year":"1993","unstructured":"Hubner C, Hoffmann GF, Charpentier C, Gibson Km B, Finckh B, Herbert Puhl H, Kohlschtt A (1993) Hans-Anton Lehr Ha. Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency. Pediatric Res 34(2):129\u2013133. https:\/\/doi.org\/10.1203\/00006450-199308000-00004","journal-title":"Pediatric Res"},{"issue":"22","key":"803_CR22","doi-asserted-by":"publisher","first-page":"21295","DOI":"10.1074\/jbc.M501527200","volume":"280","author":"AM James","year":"2005","unstructured":"James AM, Cocheme HM, Smith RAJ, Murphy MP (2005) Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. J Biol Chem 280(22):21295\u201321312. https:\/\/doi.org\/10.1074\/jbc.M501527200","journal-title":"J Biol Chem"},{"key":"803_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/09168451.2015.1065172","volume":"80","author":"M Kawamukai","year":"2015","unstructured":"Kawamukai M (2015) Biosynthesis of coenzyme Q in eukaryotes. Biosci Biotechnol Biochem 80:23\u201333. https:\/\/doi.org\/10.1080\/09168451.2015.1065172","journal-title":"Biosci Biotechnol Biochem"},{"key":"803_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10565-011-9200-z","volume":"28","author":"M Kwolek-Mirek","year":"2012","unstructured":"Kwolek-Mirek M, Zadrag-Tecza R, Bartosz G (2012) Ascorbate and thiol antioxidants abolish sensitivity of yeast Saccharomyces cerevisiae to disulfiram. Cell Biol Toxicol 28:1\u20139. https:\/\/doi.org\/10.1007\/s10565-011-9200-z","journal-title":"Cell Biol Toxicol"},{"key":"803_CR25","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1126\/science.1230381","volume":"340","author":"E Lapuente-Brun","year":"2013","unstructured":"Lapuente-Brun E, Moreno-Loshuertos R, Acin-Perez R, Latorre-Pellicer A, Colas C, Balsa E et al (2013) Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science 340:1567\u20131570. https:\/\/doi.org\/10.1126\/science.1230381","journal-title":"Science"},{"issue":"2","key":"803_CR26","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4161\/auto.27485","volume":"10","author":"S Laxman","year":"2013","unstructured":"Laxman S, Sutter BM, Tu BP (2013) Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A. Autophagy 10(2):386\u2013387. https:\/\/doi.org\/10.4161\/auto.27485","journal-title":"Autophagy"},{"key":"803_CR27","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.ceb.2009.09.002","volume":"21","author":"H Lempiainen","year":"2009","unstructured":"Lempiainen H, Shore D (2009) Growth control and ribosome biogenesis. Curr Opin Cell Biol 21:855\u2013863. https:\/\/doi.org\/10.1016\/j.ceb.2009.09.002","journal-title":"Curr Opin Cell Biol"},{"key":"803_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00294-015-0518-6","volume":"62","author":"D Li","year":"2016","unstructured":"Li D, She X, Calderone R (2016) Functional diversity of complex I subunits in Candida albicans mitochondria. Curr Genet 62:87\u201395. https:\/\/doi.org\/10.1007\/s00294-015-0518-6","journal-title":"Curr Genet"},{"key":"803_CR29","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/cdd.2009.39","volume":"16","author":"A Longatti","year":"2009","unstructured":"Longatti A, Tooze SA (2009) Vesicular trafficking and autophagosome formation. Cell Death Differ 16:956\u2013965. https:\/\/doi.org\/10.1038\/cdd.2009.39","journal-title":"Cell Death Differ"},{"issue":"4","key":"803_CR30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00294-005-0023-4","volume":"48","author":"L Lu","year":"2005","unstructured":"Lu L, Roberts GG, Oszust C, Hudson AP (2005) The YJR127C\/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae. Curr Genet 48(4):235 \u2013 46. https:\/\/doi.org\/10.1007\/s00294-005-0023-4","journal-title":"Curr Genet"},{"key":"803_CR31","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s10482-015-0568-2","volume":"108","author":"RM Lucena","year":"2015","unstructured":"Lucena RM, Elsztein C, De Barros Pita W, De Souza RB, Paiva SSP Jr, De Morais Jr MA (2015) Transcriptomic response of Saccharomyces cerevisiae for its adaptation to sulphuric acid-induced stress. Antonie Van Leeuwenhoek 108:1147\u20131160. https:\/\/doi.org\/10.1007\/s10482-015-0568-2","journal-title":"Antonie Van Leeuwenhoek"},{"key":"803_CR32","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1128\/JB.180.17.4460-4465.1998","volume":"180","author":"K Machida","year":"1998","unstructured":"Machida K, Tanaka T, Fujita KI, Taniguchi M (1998) Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae.. J Bacteriol 180:4460\u20134465","journal-title":"J Bacteriol"},{"key":"803_CR33","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1002\/art.22194","volume":"54","author":"SH Mandey","year":"2006","unstructured":"Mandey SH, Kuijk LM, Frenkel J, Waterham HR (2006) A role for geranylgeranylation in interleukin-1\u03b2 secretion. Arthritis Rheum 54:3690\u20133695. https:\/\/doi.org\/10.1002\/art.22194","journal-title":"Arthritis Rheum"},{"key":"803_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1203\/PDR.0b013e3181761870","volume":"64","author":"A Marcuzzi","year":"2008","unstructured":"Marcuzzi A, Pontillo A, De Leo L, Tommasini A, Decorti G, Not T, Ventura A (2008) Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. Pediatr Res 64:177\u2013182. https:\/\/doi.org\/10.1203\/PDR.0b013e3181761870","journal-title":"Pediatr Res"},{"key":"803_CR35","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.intimp.2010.03.008","volume":"10","author":"A Marcuzzi","year":"2010","unstructured":"Marcuzzi A, Tommasini A, Crovella S, Pontillo A (2010) Natural isoprenoids inhibit LPS induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes. Int Immunopharmacol 10:639\u2013642. https:\/\/doi.org\/10.1016\/j.intimp.2010.03.008","journal-title":"Int Immunopharmacol"},{"key":"803_CR36","first-page":"87","volume":"25","author":"A Marcuzzi","year":"2011","unstructured":"Marcuzzi A, Crovella S, Pontillo A (2011) Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency. In Vivo 25:87\u201392","journal-title":"In Vivo"},{"key":"803_CR37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ijdevneu.2012.06.002","volume":"30","author":"A Marcuzzi","year":"2012","unstructured":"Marcuzzi A, Zanin V, Piscianz E, Tricarico PM, Vuch J, Girardelli M, Monasta L, Bianco AM, Crovella S (2012) Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line. Int J Devl Neuroscience 30:451\u2013456. https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.06.002","journal-title":"Int J Devl Neuroscience"},{"key":"803_CR38","doi-asserted-by":"publisher","first-page":"e1143546","DOI":"10.1080\/23723556.2016.1143546","volume":"3","author":"TP Miettinen","year":"2016","unstructured":"Miettinen TP, Bj\u00f6rklund M (2016) The mevalonate pathway as a metabolic requirement for autophagy\u2014implications for growth control, proteostasis, and disease. Mol Cell Oncol 3:e1143546. https:\/\/doi.org\/10.1080\/23723556.2016.1143546","journal-title":"Mol Cell Oncol"},{"key":"803_CR39","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S1043-2760(00)00235-6","volume":"11","author":"FF Moebius","year":"2000","unstructured":"Moebius FF, Fitzky BU, Glossmann H (2000) Genetic defects in postsqualene cholesterol biosynthesis. Trends Endocrinol Metab 11:106\u2013114","journal-title":"Trends Endocrinol Metab"},{"key":"803_CR40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.28.1.205","author":"RK Nakamoto","year":"1999","unstructured":"Nakamoto RK et al (1999) Rotational coupling in the F0F1 ATP synthase. Annu Rev Biophys Biomol Struct 28:205\u2013234. https:\/\/doi.org\/10.1146\/annurev.biophys.28.1.205","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"803_CR41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00294-014-0463-9","volume":"61","author":"N Nishida Aoki","year":"2015","unstructured":"Nishida Aoki N, Mori H, Kuroda K, Ueda M (2015) Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast. Curr Genet 61:153\u2013164. https:\/\/doi.org\/10.1007\/s00294-014-0463-9","journal-title":"Curr Genet"},{"key":"803_CR42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF00324660","volume":"24","author":"P Pavlik","year":"1993","unstructured":"Pavlik P, Simon M, Schuster T, Ruis H (1993) The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization. Curr Genet 24:21\u201325","journal-title":"Curr Genet"},{"key":"803_CR43","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.bbamcr.2008.01.023","volume":"1783","author":"GG Perrone","year":"2008","unstructured":"Perrone GG, Tan SX, Dawes IW (2008) Reactive oxygen species and yeast apoptosis. Biochem Biophys Acta 1783:1354\u20131368. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.01.023","journal-title":"Biochem Biophys Acta"},{"key":"803_CR44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4161\/auto.5.1.7174","volume":"5","author":"A Rodriguez-Hernandez","year":"2009","unstructured":"Rodriguez-Hernandez A, Cordero MD, Salviati L, Artuch R, Pineda M, Briones P et al (2009) Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Autophagy 5:19\u201332","journal-title":"Autophagy"},{"issue":"1","key":"803_CR45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/BF00313188","volume":"29","author":"R Schneider","year":"1995","unstructured":"Schneider R, Massow M, Lisowsky T, Weiss H (1995) Different respiratory-defective phenotypes of Neurospora crassa and Saccharomyces cerevisiae after inactivation of the gene encoding the mitochondrial acyl carrier protein. Curr Genet 29(1):10 \u2013 7","journal-title":"Curr Genet"},{"key":"803_CR46","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal Biochem 25:192\u2013205","journal-title":"Anal Biochem"},{"key":"803_CR47","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00294-014-0472-8","volume":"61","author":"L Simonicova","year":"2015","unstructured":"Simonicova L, Dudekova H, Ferenc J, Prochazkova K, Nebohacova M, Dusinsky R, Nosek J, Tomaska L (2015) Saccharomyces cerevisiae as a model for the study of extranuclear functions of mammalian telomerase. Curr Genet 61:517\u2013527. https:\/\/doi.org\/10.1007\/s00294-014-0472-8","journal-title":"Curr Genet"},{"key":"803_CR48","doi-asserted-by":"crossref","unstructured":"Sprague GF, Cronan JE (1977) Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism. 129:1335\u20131342","DOI":"10.1128\/jb.129.3.1335-1342.1977"},{"key":"803_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00439-013-1358-4","volume":"133","author":"PD Stenson","year":"2014","unstructured":"Stenson PD, Mort M, Ball EV, Shaw K, Phillips A, Cooper DN (2014) The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine. Hum Genet 133:1\u20139. https:\/\/doi.org\/10.1007\/s00439-013-1358-4","journal-title":"Hum Genet"},{"key":"803_CR50","doi-asserted-by":"publisher","first-page":"6843","DOI":"10.3390\/ijms15046843","volume":"15","author":"PM Tricarico","year":"2014","unstructured":"Tricarico PM, Kleiner G, Valencic E, Campisciano G, Girardelli M, Crovella S, Knowles A, Marcuzzi A (2014) Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. Int J Mol Sci 15:6843\u20136856. https:\/\/doi.org\/10.3390\/ijms15046843","journal-title":"Int J Mol Sci"},{"key":"803_CR51","doi-asserted-by":"publisher","first-page":"16067","DOI":"10.3390\/ijms160716067","volume":"16","author":"PM Tricarico","year":"2015","unstructured":"Tricarico PM, Crovella S, Celsi F (2015) mevalonate pathway blockade, mitochondrial dysfunction and autophagy: a possible link. Int J Mol Sci 16:16067\u201316084. https:\/\/doi.org\/10.3390\/ijms160716067","journal-title":"Int J Mol Sci"},{"key":"803_CR52","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1159\/000471235","volume":"41","author":"PM Tricarico","year":"2017","unstructured":"Tricarico PM, Romeo A, Gratton R, Crovella S, Celsi F (2017) Lack of prenylated proteins, autophagy impairment and apoptosis in SH-SY5Y neuronal cell model of mevalonate kinase deficiency. Cell Physiol Biochem 41:1649\u20131660. https:\/\/doi.org\/10.1159\/000471235","journal-title":"Cell Physiol Biochem"},{"key":"803_CR53","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.clim.2012.09.011","volume":"147","author":"R van der Burgh","year":"2013","unstructured":"van der Burgh R, ter Haar NM, Boes ML, Frenkel J (2013) Mevalonate kinase deficiency, a metabolic autoinflammatory disease. Clin Immunol 147:197\u2013206. https:\/\/doi.org\/10.1016\/j.clim.2012.09.011","journal-title":"Clin Immunol"},{"key":"803_CR54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1439-0507.2009.01852.x","volume":"54","author":"GB Zore","year":"2011","unstructured":"Zore GB, Thakre AD, Rathod V, Karuppayil SM (2011) Evaluation of anti-Candida potential of geranium oil constituents against clinical isolates of Candida albicans differentially sensitive to fluconazole: inhibition of growth, dimorphism and sensitization. Mycoses 54:99\u2013109. https:\/\/doi.org\/10.1111\/j.1439-0507.2009.01852.x","journal-title":"Mycoses"}],"container-title":["Current Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00294-018-0803-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-018-0803-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-018-0803-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:28:10Z","timestamp":1767623290000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00294-018-0803-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,27]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["803"],"URL":"https:\/\/doi.org\/10.1007\/s00294-018-0803-2","relation":{},"ISSN":["0172-8083","1432-0983"],"issn-type":[{"value":"0172-8083","type":"print"},{"value":"1432-0983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,27]]},"assertion":[{"value":"19 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}