{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:14:03Z","timestamp":1767636843963,"version":"3.48.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["R-183-000-389-112"],"award-info":[{"award-number":["R-183-000-389-112"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Genet"],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.1007\/s00294-019-00962-2","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T04:03:37Z","timestamp":1554696217000},"page":"829-836","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Regulation of centromeric heterochromatin in the cell cycle by phosphorylation of histone H3 tyrosine 41"],"prefix":"10.1007","volume":"65","author":[{"given":"Bingbing","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Sin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"962_CR1","doi-asserted-by":"publisher","first-page":"a018770","DOI":"10.1101\/cshperspect.a018770","volume":"7","author":"RC Allshire","year":"2015","unstructured":"Allshire RC, Ekwall K (2015) Epigenetic regulation of chromatin states in Schizosaccharomyces pombe. Cold Spring Harb Perspect Biol 7:a018770. https:\/\/doi.org\/10.1101\/cshperspect.a018770","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"962_CR2","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/35065138","volume":"410","author":"AJ Bannister","year":"2001","unstructured":"Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410:120\u2013124","journal-title":"Nature"},{"key":"962_CR3","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1126\/science.1164029","volume":"322","author":"EH Bayne","year":"2008","unstructured":"Bayne EH, Portoso M, Kagansky A, Kos-Braun IC, Urano T, Ekwall K, Alves F, Rappsilber J, Allshire RC (2008) Splicing factors facilitate RNAi-directed silencing in fission yeast. Science 322:602\u2013606. https:\/\/doi.org\/10.1126\/science.1164029","journal-title":"Science"},{"key":"962_CR4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1590\/S0100-879X2002000500001","volume":"35","author":"P Bjerling","year":"2002","unstructured":"Bjerling P, Ekwall K (2002) Centromere domain organization and histone modifications. Braz J Med Biol Res 35:499\u2013507","journal-title":"Braz J Med Biol Res"},{"key":"962_CR5","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/ng1602","volume":"37","author":"HP Cam","year":"2005","unstructured":"Cam HP, Sugiyama T, Chen ES, Chen X, FitzGerald PC, Grewal SI (2005) Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet 37:809\u2013819","journal-title":"Nat Genet"},{"key":"962_CR6","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cell.2009.02.004","volume":"136","author":"HP Cam","year":"2009","unstructured":"Cam HP, Chen ES, Grewal SI (2009) Transcriptional scaffolds for heterochromatin assembly. Cell 136:610\u2013614. https:\/\/doi.org\/10.1016\/j.cell.2009.02.004","journal-title":"Cell"},{"key":"962_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nature12032","volume":"496","author":"D Canzio","year":"2013","unstructured":"Canzio D et al (2013) A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature 496:377\u2013381. https:\/\/doi.org\/10.1038\/nature12032","journal-title":"Nature"},{"key":"962_CR8","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1007\/s00018-018-2866-0","volume":"75","author":"ES Chen","year":"2018","unstructured":"Chen ES (2018) Targeting epigenetics using synthetic lethality in precision medicine. Cell Mol Life Sci 75:3381\u20133392. https:\/\/doi.org\/10.1007\/s00018-018-2866-0","journal-title":"Cell Mol Life Sci"},{"key":"962_CR9","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/nature06561","volume":"451","author":"ES Chen","year":"2008","unstructured":"Chen ES, Zhang K, Nicolas E, Cam HP, Zofall M, Grewal SI (2008) Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature 451:734\u2013737. https:\/\/doi.org\/10.1038\/nature06561","journal-title":"Nature"},{"key":"962_CR10","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1158\/0008-5472.CAN-17-3677","volume":"78","author":"X Ci","year":"2018","unstructured":"Ci X et al (2018) Heterochromatin protein 1\u03b1 mediates development and aggressiveness of neuroendocrine prostate cancer. Cancer Res 78:2691\u20132704. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3677","journal-title":"Cancer Res"},{"key":"962_CR11","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00294-016-0661-8","volume":"63","author":"A D\u2019Urso","year":"2017","unstructured":"D\u2019Urso A, Brickner JH (2017) Epigenetic transcriptional memory. Curr Genet 63:435\u2013439. https:\/\/doi.org\/10.1007\/s00294-016-0661-8","journal-title":"Curr Genet"},{"key":"962_CR12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nature08448","volume":"461","author":"MA Dawson","year":"2009","unstructured":"Dawson MA, Bannister AJ, G\u00f6ttgens B, Foster SD, Bartke T, Green AR, Kouzarides T (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461:819\u2013822. https:\/\/doi.org\/10.1038\/nature08448","journal-title":"Nature"},{"key":"962_CR13","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1128\/MCB.01637-07","volume":"28","author":"JL Debeauchamp","year":"2008","unstructured":"Debeauchamp JL, Moses A, Noffsinger VJ, Ulrich DL, Job G, Kosinski AM, Partridge JF (2008) Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin. Mol Cell Biol 28:2154\u20132166. https:\/\/doi.org\/10.1128\/MCB.01637-07","journal-title":"Mol Cell Biol"},{"key":"962_CR14","doi-asserted-by":"publisher","first-page":"14707","DOI":"10.1038\/srep14707","volume":"5","author":"X Deng","year":"2015","unstructured":"Deng X, Zhou H, Zheng G, Wang W, Mao L, Zhou X, Yu Y, Lu H (2015) Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast. Sci Rep 5:14707. https:\/\/doi.org\/10.1038\/srep14707","journal-title":"Sci Rep"},{"key":"962_CR15","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1101\/gad.344205","volume":"19","author":"I Djupedal","year":"2005","unstructured":"Djupedal I, Portoso M, Sp\u00e5hr H, Bonilla C, Gustafsson CM, Allshire RC, Ekwall K (2005) RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing. Genes Dev 19:2301\u20132306","journal-title":"Genes Dev"},{"key":"962_CR16","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1242\/jcs.109.11.2637","volume":"109","author":"K Ekwall","year":"1996","unstructured":"Ekwall K, Nimmo ER, Javerzat JP, Borgstr\u00f8m B, Egel R, Cranston G, Allshire R (1996) Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J Cell Sci 109:2637\u20132648","journal-title":"J Cell Sci"},{"key":"962_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1159\/000218132","volume":"124","author":"NI Enukashvily","year":"2009","unstructured":"Enukashvily NI, Malashicheva AB, Waisertreiger IS (2009) Satellite DNA spatial localization and transcriptional activity in mouse embryonic E-14 and IOUD2 stem cells. Cytogenet Genome Res 124:277\u2013287. https:\/\/doi.org\/10.1159\/000218132","journal-title":"Cytogenet Genome Res"},{"key":"962_CR18","doi-asserted-by":"publisher","first-page":"6340","DOI":"10.1093\/nar\/gkp639","volume":"37","author":"A Eymery","year":"2009","unstructured":"Eymery A et al (2009) A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells. Nucleic Acids Res 37:6340\u20136354. https:\/\/doi.org\/10.1093\/nar\/gkp639","journal-title":"Nucleic Acids Res"},{"key":"962_CR19","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/nature04219","volume":"438","author":"W Fischle","year":"2005","unstructured":"Fischle W, Tseng BS, Dormann HL, Ueberheide BM, Garcia BA, Shabanowitz J, Hunt DF, Funabiki H, Allis CD (2005) Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature 438:1116\u20131122","journal-title":"Nature"},{"key":"962_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrg2008","volume":"8","author":"SI Grewal","year":"2007","unstructured":"Grewal SI, Jia S (2007) Heterochromatin revisited. Nat Rev Genet 8:35\u201346","journal-title":"Nat Rev Genet"},{"key":"962_CR21","doi-asserted-by":"publisher","first-page":"e1006092","DOI":"10.1371\/journal.pgen.1006092","volume":"12","author":"CJ Hale","year":"2016","unstructured":"Hale CJ, Potok ME, Lopez J, Do T, Liu A, Gallego-Bartolome J, Michaels SD, Jacobsen SE (2016) Identification of multiple proteins coupling transcriptional genes silencing to genome stability in Arabidopsis thaliana. PLoS Genet 12:e1006092. https:\/\/doi.org\/10.1371\/journal.pgen.1006092","journal-title":"PLoS Genet"},{"key":"962_CR22","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1016\/j.celrep.2017.02.072","volume":"18","author":"LL Hall","year":"2017","unstructured":"Hall LL, Byron M, Carone DM, Whitfield TW, Pouliot GP, Fischer A, Jones P, Lawrence JB (2017) Demethylated HSATII DNA and HSATII RNA foci sequester PRC1 and MeCP2 into cancer-specific nuclear bodies. Cell Rep 18:2943\u20132956. https:\/\/doi.org\/10.1016\/j.celrep.2017.02.072","journal-title":"Cell Rep"},{"key":"962_CR23","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/nature04254","volume":"438","author":"T Hirota","year":"2005","unstructured":"Hirota T, Lipp JJ, Toh BH, Peters JM (2005) Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438:1176\u20131180","journal-title":"Nature"},{"key":"962_CR24","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1016\/j.jmb.2017.09.012","volume":"429","author":"RS Issac","year":"2017","unstructured":"Issac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ (2017) Biochemical basis for distinct roles of the heterochromatin proteins Swi6 and Chp2. J Mol Biol 429:3666\u20133677. https:\/\/doi.org\/10.1016\/j.jmb.2017.09.012","journal-title":"J Mol Biol"},{"key":"962_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pharmthera.2016.01.014","volume":"162","author":"RA Jackson","year":"2016","unstructured":"Jackson RA, Chen ES (2016) Synthetic lethal approaches for assessing combinatorial efficacy of chemotherapeutic drugs. Pharmacol Ther 162:69\u201385. https:\/\/doi.org\/10.1016\/pharmthera.2016.01.014","journal-title":"Pharmacol Ther"},{"key":"962_CR27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature23267","volume":"547","author":"G Jih","year":"2017","unstructured":"Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D (2017) Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. Nature 547:463\u2013467. https:\/\/doi.org\/10.1038\/nature23267","journal-title":"Nature"},{"key":"962_CR28","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s10577-006-1063-4","volume":"14","author":"KM Johansen","year":"2006","unstructured":"Johansen KM, Johansen J (2006) Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res 14:393\u2013404. https:\/\/doi.org\/10.1007\/s10577-006-1063-4","journal-title":"Chromosome Res"},{"key":"962_CR29","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.1114955","volume":"309","author":"H Kato","year":"2005","unstructured":"Kato H, Goto DB, Martienssen RA, Urano T, Furukawa K, Murakami Y (2005) RNA polymerase II is required for RNAi-dependent heterochromatin assembly. Science 309:467\u2013469","journal-title":"Science"},{"key":"962_CR30","doi-asserted-by":"publisher","first-page":"15391","DOI":"10.1074\/jbc.M110.201343","volume":"286","author":"E Kitano","year":"2011","unstructured":"Kitano E, Hayashi A, Kanai D, Shinmyozu K, Nakayama JI (2011) Roles of fission yeast Grc3 protein in ribosomal RNA processing and heterochromatic gene silencing. J Biol Chem 286:15391\u201315402. https:\/\/doi.org\/10.1074\/jbc.M110.201343","journal-title":"J Biol Chem"},{"key":"962_CR31","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cub.2008.03.016","volume":"18","author":"A Kloc","year":"2008","unstructured":"Kloc A, Zaratiegui M, Nora E, Martienssen R (2008) RNA interference guides histone modification during the S phase of chromosomal replication. Curr Biol 18:490\u2013495. https:\/\/doi.org\/10.1016\/j.cub.2008.03.016","journal-title":"Curr Biol"},{"key":"962_CR32","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nature22822","volume":"547","author":"AG Larson","year":"2017","unstructured":"Larson AG, Elnatan D, Keenen MM, Tmka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ (2017) Liquid droplet formation by HP1\u03b1 suggests a role for phase separation in heterochromatin. Nature 547:236\u2013240. https:\/\/doi.org\/10.1038\/nature22822","journal-title":"Nature"},{"key":"962_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nature10161","volume":"475","author":"F Li","year":"2011","unstructured":"Li F, Martienssen R, Cande WZ (2011) Coordination of DNA replication and histone modification by the Rik1-Dos2 complex. Nature 475:244\u2013248. https:\/\/doi.org\/10.1038\/nature10161","journal-title":"Nature"},{"key":"962_CR34","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.celrep.2013.02.007","volume":"3","author":"PC Li","year":"2013","unstructured":"Li PC, Petreaca RC, Jensen A, Yuan JP, Green MD, Forsburg SL (2013) Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin. Cell Rep 3:638\u2013645. https:\/\/doi.org\/10.1016\/j.celrep.2013.02.007","journal-title":"Cell Rep"},{"key":"962_CR35","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/gb-2006-7-7-228","volume":"7","author":"G Lomberk","year":"2006","unstructured":"Lomberk G, Wallrath L, Urrutia R (2006) The heterochromatin protein 1 family. Genome Biol 7:228. https:\/\/doi.org\/10.1186\/gb-2006-7-7-228","journal-title":"Genome Biol"},{"key":"962_CR36","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1083\/jcb.200706176","volume":"179","author":"J Lu","year":"2007","unstructured":"Lu J, Gilbert DM (2007) Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin. J Cell Biol 179:411\u2013421","journal-title":"J Cell Biol"},{"key":"962_CR37","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/38444","volume":"389","author":"K Luger","year":"1997","unstructured":"Luger K, M\u00e4der AW, Richmond RK, Sargent DF, Richmond TJ (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:251\u2013260","journal-title":"Nature"},{"key":"962_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/ng.765","volume":"43","author":"C Maison","year":"2011","unstructured":"Maison C et al (2011) SUMOylation promotes de novo targeting of HP1\u03b1 to pericentric heterochromatin. Nat Genet 43:220\u2013227. https:\/\/doi.org\/10.1038\/ng.765","journal-title":"Nat Genet"},{"key":"962_CR39","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.celrep.2015.05.015","volume":"11","author":"JP Mallm","year":"2015","unstructured":"Mallm JP, Rippe K (2015) Aurora kinase B regulates telomerase activity via a centromeric RNA in stem cells. Cell Rep 11:1667\u20131678. https:\/\/doi.org\/10.1016\/j.celrep.2015.05.015","journal-title":"Cell Rep"},{"key":"962_CR40","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mrfmmm.2015.04.009","volume":"777","author":"R Meschini","year":"2015","unstructured":"Meschini R, Morucci E, Bemi A, Lopez-Martinez W, Palitti F (2015) Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. Mutat Res 777:52\u201359. https:\/\/doi.org\/10.1016\/j.mrfmmm.2015.04.009","journal-title":"Mutat Res"},{"key":"962_CR41","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.cell.2004.11.034","volume":"119","author":"MR Motamedi","year":"2004","unstructured":"Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D (2004) Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 119:789\u2013802. https:\/\/doi.org\/10.1016\/j.cell.2004.11.034","journal-title":"Cell"},{"key":"962_CR42","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.molcel.2008.10.026","volume":"32","author":"MR Motamedi","year":"2008","unstructured":"Motamedi MR, Hong EJ, Li X, Gerber S, Denison C, Gygi S, Moazed D (2008) HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell 32:778\u2013790. https:\/\/doi.org\/10.1016\/j.molcel.2008.10.026","journal-title":"Mol Cell"},{"key":"962_CR43","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1126\/science.1060118","volume":"292","author":"JI Nakayama","year":"2001","unstructured":"Nakayama JI, Rice JC, Strahl BD, Allis CD, Grewal SI (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292:110\u2013113","journal-title":"Science"},{"key":"962_CR44","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1534\/genetics.107.071902","volume":"176","author":"P Neumann","year":"2007","unstructured":"Neumann P, Yan H, Jiang J (2007) The centromeric retrotransposons of rice are transcribed and differentially processed by RNA interference. Genetics 176:749\u2013761. https:\/\/doi.org\/10.1534\/genetics.107.071902","journal-title":"Genetics"},{"key":"962_CR45","doi-asserted-by":"publisher","first-page":"8400","DOI":"10.1038\/srep08400","volume":"5","author":"TT Nguyen","year":"2015","unstructured":"Nguyen TT, Lim JS, Tang RM, Zhang L, Chen ES (2015) Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast. Sci Rep 5:8400. https:\/\/doi.org\/10.1038\/srep08400","journal-title":"Sci Rep"},{"key":"962_CR46","doi-asserted-by":"publisher","first-page":"18658","DOI":"10.1038\/srep18658","volume":"6","author":"TT Nguyen","year":"2016","unstructured":"Nguyen TT et al (2016) Predicting chemotherapeutic drug combinations through gene network profiling. Sci Rep 6:18658. https:\/\/doi.org\/10.1038\/srep18658","journal-title":"Sci Rep"},{"key":"962_CR47","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nsmb1239","volume":"14","author":"E Nicolas","year":"2007","unstructured":"Nicolas E, Yamada T, Cam HP, Fitzgerald PC, Kobayashi R, Grewal SI (2007) Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nat Struct Mol Biol 14:372\u2013380","journal-title":"Nat Struct Mol Biol"},{"key":"962_CR48","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/ng1452","volume":"36","author":"K Noma","year":"2004","unstructured":"Noma K, Sugiyama T, Cam H, Verdel A, Zofall M, Jia S, Moazed D, Grewal SI (2004) RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet 36:1174\u20131180","journal-title":"Nat Genet"},{"key":"962_CR49","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.devcel.2010.09.002","volume":"19","author":"AV Probst","year":"2010","unstructured":"Probst AV, Okamoto I, Casanova M, El Marjou F, Le Baccon P, Almouzni G (2010) A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation in early mouse development. Dev Cell 19:625\u2013638. https:\/\/doi.org\/10.1016\/j.devcel.2010.09.002","journal-title":"Dev Cell"},{"key":"962_CR50","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1101\/gad.1993611","volume":"25","author":"BD Reddy","year":"2011","unstructured":"Reddy BD, Wang Y, Niu L, Higuchi RC, Marguerat SB, B\u00e4hler J, Smith GR, Jia S (2011) Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions. Genes Dev 25:214\u2013219. https:\/\/doi.org\/10.1101\/gad.1993611","journal-title":"Genes Dev"},{"key":"962_CR51","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/nar\/gkx1010","volume":"46","author":"B Ren","year":"2018","unstructured":"Ren B, Tan HL, Nguyen TTT, Sayed AMM, Li Y, Mok YK, Yang H, Chen ES (2018) Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast. Nucleic Acids Res 46:189\u2013202. https:\/\/doi.org\/10.1093\/nar\/gkx1010","journal-title":"Nucleic Acids Res"},{"key":"962_CR52","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00294-016-0669-0","volume":"63","author":"X Robellet","year":"2017","unstructured":"Robellet X, Vanoosthuyse V, Bernard P (2017) The loading of condensin in the context of chromatin. Curr Genet 63:577\u2013589. https:\/\/doi.org\/10.1007\/s00294-016-0669-0","journal-title":"Curr Genet"},{"key":"962_CR53","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1038\/sj.emboj.7600401","volume":"23","author":"M Sadaie","year":"2004","unstructured":"Sadaie M, Iida T, Urano T, Nakayama J (2004) A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast. EMBO J 23:3825\u20133835. https:\/\/doi.org\/10.1038\/sj.emboj.7600401","journal-title":"EMBO J"},{"key":"962_CR54","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1128\/MCB.00791-08","volume":"28","author":"M Sadaie","year":"2008","unstructured":"Sadaie M, Kawaguchi R, Ohtani Y, Arisaka F, Tanaka K, Shirahige K, Nakayama J (2008) Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Mol Cell Biol 28:6973\u20136988","journal-title":"Mol Cell Biol"},{"key":"962_CR55","doi-asserted-by":"publisher","first-page":"e0173723","DOI":"10.1371\/journal.pone.0173723","volume":"12","author":"AC Salzberg","year":"2017","unstructured":"Salzberg AC, Harris-Becker A, Popova EY, Keasey N, Loughran TP, Claxton DF, Grigoryev SA (2017) Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability. PLoS One 12:e0173723. https:\/\/doi.org\/10.1371\/journal.pone.0173723","journal-title":"PLoS One"},{"key":"962_CR56","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00294-017-0792-6","volume":"64","author":"HD Seo","year":"2018","unstructured":"Seo HD, Kwon CS, Lee D (2018) The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Curr Genet 64:741\u2013752. https:\/\/doi.org\/10.1007\/s00294-017-0792-6","journal-title":"Curr Genet"},{"key":"962_CR57","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142422","volume":"75","author":"A Shilatifard","year":"2006","unstructured":"Shilatifard A (2006) Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem 75:243\u2013269","journal-title":"Annu Rev Biochem"},{"key":"962_CR58","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nrm2763","volume":"10","author":"JA Simon","year":"2009","unstructured":"Simon JA, Kingston RE (2009) Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 10:697\u2013708. https:\/\/doi.org\/10.1038\/nrm2763","journal-title":"Nat Rev Mol Cell Biol"},{"key":"962_CR59","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1073\/pnas.0407641102","volume":"102","author":"T Sugiyama","year":"2005","unstructured":"Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI (2005) RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci USA 102:152\u2013157","journal-title":"Proc Natl Acad Sci USA"},{"key":"962_CR60","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.cell.2006.12.035","volume":"128","author":"T Sugiyama","year":"2007","unstructured":"Sugiyama T, Cam HP, Sugiyama R, Noma K, Zofall M, Kobayashi R, Grewal SI (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128:491\u2013504. https:\/\/doi.org\/10.1016\/j.cell.2006.12.035","journal-title":"Cell"},{"key":"962_CR61","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1093\/nar\/gkw008","volume":"44","author":"S Suzuki","year":"2016","unstructured":"Suzuki S, Kato H, Suzuki Y, Chikashige Y, Hiraoka Y, Kimura H, Nagao K, Obuse C, Takahata S, Murakami Y (2016) Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast. Nucleic Acids Res 44:4147\u20134162. https:\/\/doi.org\/10.1093\/nar\/gkw008","journal-title":"Nucleic Acids Res"},{"key":"962_CR62","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/genetics\/155.2.551","volume":"155","author":"G Thon","year":"2000","unstructured":"Thon G, Verhein-Hansen J (2000) Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Genetics 155:551\u2013568","journal-title":"Genetics"},{"key":"962_CR63","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1126\/science.1200801","volume":"331","author":"DT Ting","year":"2011","unstructured":"Ting DT et al (2011) Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 331:593\u2013596. https:\/\/doi.org\/10.1126\/science.1200801","journal-title":"Science"},{"key":"962_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molcel.2007.09.011","volume":"28","author":"P Trojer","year":"2007","unstructured":"Trojer P, Reinberg D (2007) Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell 28:1\u201313","journal-title":"Mol Cell"},{"key":"962_CR70","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1126\/science.1093686","volume":"303","author":"A Verdel","year":"2004","unstructured":"Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D (2004) RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303:672\u2013676","journal-title":"Science"},{"key":"962_CR65","doi-asserted-by":"publisher","first-page":"5872","DOI":"10.1016\/j.febslet.2005.08.083","volume":"579","author":"A Verdel","year":"2005","unstructured":"Verdel A, Moazed D (2005) RNAi-directed assembly of heterochromatin in fission yeast. FEBS Lett 579:5872\u20135878. https:\/\/doi.org\/10.1016\/j.febslet.2005.08.083","journal-title":"FEBS Lett"},{"key":"962_CR66","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1101\/gad.1881710","volume":"24","author":"B Xhemalce","year":"2010","unstructured":"Xhemalce B, Kouzarides T (2010) A chromodomain switch mediated by histone H3 lys 4 acetylation regulates heterochromatin assembly. Genes Dev 24:647\u2013652. https:\/\/doi.org\/10.1101\/gad.1881710","journal-title":"Genes Dev"},{"key":"962_CR67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00294-016-0619-x","volume":"63","author":"J Yang","year":"2017","unstructured":"Yang J, Li F (2017) Are all repeats created equal? Understanding DNA repeats at an individual level. Curr Genet 63:57\u201363. https:\/\/doi.org\/10.1007\/s00294-016-0619-x","journal-title":"Curr Genet"},{"key":"962_CR68","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41586-018-0239-3","volume":"558","author":"R Yu","year":"2018","unstructured":"Yu R, Wang X, Moazed D (2018) Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation. Nature 558:615\u2013619. https:\/\/doi.org\/10.1038\/s41586-018-0239-3","journal-title":"Nature"},{"key":"962_CR69","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nsmb.1406","volume":"15","author":"K Zhang","year":"2008","unstructured":"Zhang K, Mosch K, Fischle W, Grewal SI (2008) Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat Struct Mol Biol 15:381\u2013388. https:\/\/doi.org\/10.1038\/nsmb.1406","journal-title":"Nat Struct Mol Biol"}],"container-title":["Current Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-019-00962-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00294-019-00962-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00294-019-00962-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:23:52Z","timestamp":1767623032000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00294-019-00962-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8,1]]}},"alternative-id":["962"],"URL":"https:\/\/doi.org\/10.1007\/s00294-019-00962-2","relation":{},"ISSN":["0172-8083","1432-0983"],"issn-type":[{"type":"print","value":"0172-8083"},{"type":"electronic","value":"1432-0983"}],"subject":[],"published":{"date-parts":[[2019,4,8]]},"assertion":[{"value":"6 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}