{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:51:53Z","timestamp":1761418313595},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1007\/s00296-005-0610-1","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T06:15:41Z","timestamp":1115187341000},"page":"348-353","source":"Crossref","is-referenced-by-count":22,"title":["Lack of association of tumor necrosis factor-alpha gene polymorphisms with disease susceptibility and severity in Beh\u00e7et\u2019s disease"],"prefix":"10.1007","volume":"26","author":[{"given":"A\u015fk\u0131n","family":"Ate\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclay","family":"Kinikli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur\u015fen","family":"D\u00fczg\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"610_CR1","first-page":"483","volume":"150","author":"T Lehner","year":"1999","unstructured":"Lehner T (1999) Immunopathogenesis of Beh\u00e7et\u2019s disease. Ann Med Interne (Paris) 150:483\u2013487","journal-title":"Ann Med Interne (Paris)"},{"issue":"Suppl 24","key":"610_CR2","first-page":"S6","volume":"19","author":"A G\u00fcl","year":"2001","unstructured":"G\u00fcl A (2001) Beh\u00e7et\u2019s disease: an update on the pathogenesis. Clin Exp Rheumatol 19 [Suppl\u00a024]:S6\u2013S12","journal-title":"Clin Exp Rheumatol 19"},{"key":"610_CR3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/ard.60.11.996","volume":"60","author":"H Direskeneli","year":"2001","unstructured":"Direskeneli H (2001) Beh\u00e7et\u2019s disease: infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis 60:996\u20131002","journal-title":"Ann Rheum Dis"},{"key":"610_CR4","first-page":"1544","volume":"20","author":"JL Mege","year":"1993","unstructured":"Mege JL, Dilsen N, Sanguedolce V, G\u00fcl A, Bongrand P, Roux H, Ocal L, Inanc M, Capo C (1993) Overproduction of monocyte derived tumor necrosis factor \u03b1, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Beh\u00e7et\u2019s disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 20:1544\u20131549","journal-title":"A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol"},{"key":"610_CR5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2249.1997.274-ce1159.x","volume":"107","author":"N Yamashita","year":"1997","unstructured":"Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, Kogure M, Inaba G, Sakane T (1997) Role of \u03b3\u03b4 T\u00a0lymphocytes in the development of Beh\u00e7et\u2019s disease. Clin Exp Immunol 107:241\u2013247","journal-title":"Clin Exp Immunol"},{"key":"610_CR6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1365-2249.1997.3611265.x","volume":"108","author":"S Kaneko","year":"1997","unstructured":"Kaneko S, Suzuki N, Yamashita N, Nagafuchi H, Nakajima T, Wakisaka S, Yamamoto S, Sakane T (1997) Characterization of T\u00a0cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Beh\u00e7et\u2019s disease (BD) in Japan. Clin Exp Immunol 108:204\u2013212","journal-title":"Clin Exp Immunol"},{"key":"610_CR7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.iy.07.040189.003205","volume":"7","author":"B Beutler","year":"1989","unstructured":"Beutler B, Cerami A (1989) The biology of cachectin\/TNF-\u03b1 primary mediator of the host response. Annu Rev Immunol 7:625\u2013655","journal-title":"Annu Rev Immunol"},{"key":"610_CR8","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.87.24.9769","volume":"87","author":"AE Golfeld","year":"1990","unstructured":"Golfeld AE, Doyle C, Maniatis T (1990) Human tumor necrosis factor \u03b1 gene regulation by virus and lipopolysaccharide. Proc Natl Acad Sci U\u00a0S\u00a0A 87:9769\u20139773","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"610_CR9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.171.2.465","volume":"171","author":"J Han","year":"1990","unstructured":"Han J, Brown T, Beutler B (1990) Endotoxin-responsive sequences control cachectin\/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171:465\u2013475","journal-title":"J Exp Med"},{"key":"610_CR10","first-page":"227","volume":"43","author":"B Beutler","year":"1995","unstructured":"Beutler B (1995) TNF, immunity and inflammatory disease: lessons of the past decade. J Invest Med 43:227\u2013235","journal-title":"J Invest Med"},{"key":"610_CR11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1034\/j.1399-0039.1999.540301.x","volume":"54","author":"DH Verity","year":"1999","unstructured":"Verity DH, Marr JE, Ohno S, Wallace GR, Stanford MR (1999) Beh\u00e7et\u2019s disease, the silk road and HLA-B51: historical and geographical perspectives. Tissue Antigens 54:213\u2013220","journal-title":"Tissue Antigens"},{"key":"610_CR12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0198-8859(94)00159-N","volume":"43","author":"N Mizuki","year":"1995","unstructured":"Mizuki N, Ohno S, Sato T, Ishihara M, Miyata S, Nakamura S, Naruse T, Mizuki H, Tsuji K, Inoko H (1995) Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Beh\u00e7et\u2019s disease. Hum Immunol 43:129\u2013135","journal-title":"Hum Immunol"},{"key":"610_CR13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0167-5699(93)90234-C","volume":"14","author":"RD Campbell","year":"1993","unstructured":"Campbell RD, Trowsdale J (1993) Map of the human MHC. Immunol Today 14:349\u2013352","journal-title":"Immunol Today"},{"key":"610_CR14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev.bi.57.070188.002445","volume":"57","author":"B Beutler","year":"1988","unstructured":"Beutler B, Cerami A (1988) Tumor necrosis, cachexia, shock and inflammation: a common mediator. Ann Rev Biochem 57:505\u2013518","journal-title":"Ann Rev Biochem"},{"key":"610_CR15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0889-857X(21)00716-X","volume":"18","author":"GM Verjans","year":"1992","unstructured":"Verjans GM, Messer G, Weiss EH, van der Linden SM, Kijlstra A (1992) Polymorphism of the tumor necrosis factor region in relation to disease: an overview. Rheum Dis Clin North Am 18:177\u2013185","journal-title":"Rheum Dis Clin North Am"},{"key":"610_CR16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1073\/pnas.87.3.1233","volume":"87","author":"CO Jacob","year":"1990","unstructured":"Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDewitt HO (1990) Heritable major histocompatibility complex class\u00a0II-associated differences in production of tumor necrosis factor \u03b1: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U\u00a0S\u00a0A 87:1233\u20131237","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"610_CR17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/hmg\/1.5.353","volume":"1","author":"AG Wilson","year":"1992","unstructured":"Wilson AG, di Giovine FS, Blakemore AI, Duff GW (1992) Single base polymorphism in the human tumour necrosis factor \u03b1 (TNF-\u03b1) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1:353\u2013359","journal-title":"Hum Mol Genet"},{"key":"610_CR18","first-page":"150","volume":"39","author":"S D\u2019Alfonso","year":"1994","unstructured":"D\u2019Alfonso S, Richiardi PM (1994) A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 39:150\u2013154","journal-title":"Immunogenetics"},{"key":"610_CR19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/eji.1830230135","volume":"23","author":"F Pociot","year":"1993","unstructured":"Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, Thomsen M, Nerup J, Cambon-Thomsen A (1993) Association of tumor necrosis factor (TNF) and class\u00a0II major histocompatibility complex alleles with the secretion of TNF-\u03b1 and TNF-\u03b2 by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol 23:224\u2013231","journal-title":"Eur J Immunol"},{"key":"610_CR20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1006\/bbrc.1995.1887","volume":"211","author":"A Hamann","year":"1995","unstructured":"Hamann A, Mantzoros C, Vidal-Puig A, Flier JS (1995) Genetic variability in the TNF-\u03b1 promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun 211:833\u2013839","journal-title":"Biochem Biophys Res Commun"},{"key":"610_CR21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1529-0131(200001)43:1<129::AID-ANR16>3.0.CO;2-S","volume":"43","author":"MJ Rood","year":"2000","unstructured":"Rood MJ, van Krugten MV, Zanelli E, van der Linden MW, Keijsers V, Schreuder GMT, Verduyn W, Westendorp RG, de Vries RR, Breedveld FC, Verweij CL, Huizinga TW (2000) TNF\u2212308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum 43:129\u2013134","journal-title":"Arthritis Rheum"},{"key":"610_CR22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/rheumatology\/36.5.516","volume":"36","author":"BMN Brinkman","year":"1997","unstructured":"Brinkman BMN, Huizinga TWJ, Kurban SS, van der Velde EA, Schreuder GMT, Hazes JMW, Breedveld FC, Verweij CL (1997) Tumour necrosis factor \u03b1 gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36:516\u2013521","journal-title":"Br J Rheumatol"},{"key":"610_CR23","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/1529-0131(199808)41:8<1489::AID-ART20>3.0.CO;2-5","volume":"41","author":"T H\u00f6hler","year":"1998","unstructured":"H\u00f6hler T, Schaper T, Schneider PM, Meyer zum Buschenfelde KH, Marker-Hermann E (1998) Association of different tumor necrosis factor \u03b1 promoter alleles frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 41:1489\u20131492","journal-title":"Arthritis Rheum"},{"key":"610_CR24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1034\/j.1399-0039.1999.540307.x","volume":"54","author":"DH Verity","year":"1999","unstructured":"Verity DH, Wallace GR, Vaughan RW, Kondeatis E, Madanat W, Zureikat H, Fayyad F, Marr JE, Kanawati CA, Stanford MR (1999) HLA and tumour necrosis factor (TNF) polymorphisms in ocular Beh\u00e7et\u2019s disease. Tissue Antigens 54:264\u2013272","journal-title":"Tissue Antigens"},{"key":"610_CR25","first-page":"161","volume-title":"Proceedings of the 9th international conference on Beh\u00e7et\u2019s disease 2000, May 27\u201329","author":"D \u00d6z","year":"2000","unstructured":"\u00d6z D, Karsl\u0131 F, Atalay A, \u015eahin \u015e (2000) TNF-alpha gene polymorphisms in Beh\u00e7et\u2019s disease. In: Bang D, Lee ES, Lee S (eds). Proceedings of the 9th international conference on Beh\u00e7et\u2019s disease 2000, May 27\u201329. Design Mecca Publishing, Seoul, pp161\u2013165"},{"key":"610_CR26","first-page":"15","volume":"21","author":"J Duymaz-Tozkir","year":"2003","unstructured":"Duymaz-Tozkir J, G\u00fcl A, Uyar FA, \u00d6zbek U, Saruhan-Direskeneli G (2003) Tumour necrosis factor-alpha gene promoter region \u2212308 and \u2013376\u00a0G\u2192A polymorphisms in Beh\u00e7et\u2019s disease. Clin Exp Rheumatol 21:15\u201318","journal-title":"Clin Exp Rheumatol"},{"key":"610_CR27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/art.10815","volume":"48","author":"T Ahmad","year":"2003","unstructured":"Ahmad T, Wallace GR, James T, Neville M, Bunce M, Mulcahy-Hawes K, Armuzzi A, Crawshaw J, Fortune F, Walton R, Stanford MR, Welsh KI, Marshall SE, Jewell DP (2003) Mapping the HLA association in Beh\u00e7et\u2019s disease. A role for tumor necrosis factor polymorphisms? Arthritis Rheum 48:807\u2013813","journal-title":"A role for tumor necrosis factor polymorphisms? Arthritis Rheum"},{"key":"610_CR28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0198-8859(03)00057-0","volume":"64","author":"EB Lee","year":"2003","unstructured":"Lee EB, Kim JY, Lee YJ, Park MH, Song YW (2003) TNF and TNF receptor polymorphisms in Korean Beh\u00e7et\u2019s disease patients. Hum Immunol 64:614\u2013620","journal-title":"Hum Immunol"},{"key":"610_CR29","first-page":"1078","volume":"335","author":"International","year":"1990","unstructured":"International Study Group for Beh\u00e7et\u2019s Disease (1990) Criteria for diagnosis of Beh\u00e7et\u2019s disease. Lancet 335:1078\u20131080","journal-title":"Lancet"},{"key":"610_CR30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0714.1999.tb02023.x","volume":"28","author":"I Krause","year":"1999","unstructured":"Krause I, Rosen Y, Kaplan I, Milo G, Guedj D, Molad Y, Weinberger A (1999) Recurrent aphthous stomatitis in Beh\u00e7et\u2019s disease: clinical features and correlation with systemic disease expression and severity. J Oral Pathol Med 28:193\u2013196","journal-title":"J Oral Pathol Med"},{"key":"610_CR31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HT (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 16:1215","journal-title":"Nucl Acids Res"},{"key":"610_CR32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/ard.59.8.622","volume":"59","author":"A G\u00fcl","year":"2000","unstructured":"G\u00fcl A, \u0130nan\u00e7 M, \u00d6cal L, Aral O, Koni\u00e7e M (2000) Familial aggregation of Beh\u00e7et\u2019s disease in Turkey. Ann Rheum Dis 59:622\u2013625","journal-title":"Ann Rheum Dis"},{"key":"610_CR33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1399-0039.1992.tb01953.x","volume":"40","author":"N Mizuki","year":"1992","unstructured":"Mizuki N, Ohno S, Tanaka H, Sugimura K, Seki T, Mizuki N, Kera J, Inaba G, Tsuji K, Inoko H (1992) Association of HLA-B51 and lack of association of class\u00a0II alleles with Beh\u00e7et\u2019s disease. Tissue Antigens 40:22\u201330","journal-title":"Tissue Antigens"},{"key":"610_CR34","first-page":"1428","volume":"17","author":"K Hamzaoui","year":"1990","unstructured":"Hamzaoui K, Hamza M, Ayed K (1990) Production of TNF-alpha and IL-1 in active Beh\u00e7et\u2019s disease. J Rheumatol 17:1428\u20131429","journal-title":"J Rheumatol"},{"key":"610_CR35","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF00376825","volume":"285","author":"Y Yamakawa","year":"1993","unstructured":"Yamakawa Y, Sugita Y, Takahashi Y, Yamakawa T, Tanaka S, Nakamura S, Fukushima J, Kawamoto S, Ohno S, Okuda K, et al (1993) Gene expression of tumour necrosis factor-\u03b1 (TNF-\u03b1) and heat-shock protein (HSP) 70 in patients with Beh\u00e7et\u2019s disease. Arch Dermatol Res 285:505\u2013508","journal-title":"Arch Dermatol Res"},{"key":"610_CR36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/ard.60.6.637","volume":"60","author":"PH Goossens","year":"2001","unstructured":"Goossens PH, Verburg RJ, Breedveld FC (2001) Remission of Beh\u00e7et\u2019s syndrome with tumour necrosis factor \u03b1 blocking therapy. Ann Rheum Dis 60:637","journal-title":"Ann Rheum Dis"},{"key":"610_CR37","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","volume":"94","author":"AG Wilson","year":"1997","unstructured":"Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW (1997) Effects of a polymorphism in the human tumour necrosis factor \u03b1 promoter on transcriptional activation. Proc Natl Acad Sci U\u00a0S\u00a0A 94:3195\u20133199","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"610_CR38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1365-2249.1998.00662.x","volume":"113","author":"E Louis","year":"1998","unstructured":"Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, Roland S, Mahieu P, Malaise M, De Groote D, Louis R, Belaiche J (1998) Tumour necrosis factor (TNF) gene polymorphism influences TNF-\u03b1 production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 113:401\u2013406","journal-title":"Clin Exp Immunol"},{"key":"610_CR39","first-page":"32","volume":"46","author":"BMN Brinkman","year":"1996","unstructured":"Brinkman BMN, Zuijdgeest D, Kaijzel EL, Breedveld FC, Verweij CL (1996) Relevance of the tumor necrosis factor alpha (TNF\u03b1) \u2212308 promoter polymorphism in TNF-\u03b1 gene regulation. J Inflamm 46:32\u201341","journal-title":"J Inflamm"},{"key":"610_CR40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1399-0039.1998.tb03056.x","volume":"52","author":"AM Uglialoro","year":"1998","unstructured":"Uglialoro AM, Turbay D, Pesavento PA, Delgado JC, McKenzie FE, Gribben JG, Hartl D, Yunis EJ, Goldfeld AE (1998) Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-\u03b1 gene promoter. Tissue Antigens 52:359\u2013367","journal-title":"Tissue Antigens"},{"key":"610_CR41","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/hmg\/8.8.1443","volume":"8","author":"T Skoog","year":"1999","unstructured":"Skoog T, Van\u2019t Hooft FM, Kallin B, Jovinge S, Boquist S, Nilsson J, Eriksson P, Hamsten A (1999) A common functional polymorphism (C\u2192A substitution at position -863) in the promoter region of the tumour necrosis factor-\u03b1 (TNF-\u03b1) gene associated with reduced circulating levels of TNF-\u03b1. Hum Mol Genet 8:1443\u20131449","journal-title":"Hum Mol Genet"},{"key":"610_CR42","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0161-5890(99)00127-3","volume":"36","author":"RD Allen","year":"1999","unstructured":"Allen RD (1999) Polymorphism of the human TNF-\u03b1 promoter\u2014random variation or functional diversity? Mol Immunol 36:1017\u20131027","journal-title":"Mol Immunol"},{"key":"610_CR43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-3083.1995.tb03686.x","volume":"42","author":"F Pociot","year":"1995","unstructured":"Pociot F, D\u2019Alfonso S, Compasso S, Scorza R, Richiardi PM (1995) Functional analysis of a new polymorphism in the human TNF alpha gene promoter. Scand J Immunol 42:501\u2013504","journal-title":"Scand J Immunol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-005-0610-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-005-0610-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-005-0610-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T14:40:30Z","timestamp":1625928030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-005-0610-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,5]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["610"],"URL":"https:\/\/doi.org\/10.1007\/s00296-005-0610-1","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,5]]}}}