{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:54:44Z","timestamp":1774360484039,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T00:00:00Z","timestamp":1268092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s00296-010-1383-8","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T11:55:12Z","timestamp":1268049312000},"page":"779-784","source":"Crossref","is-referenced-by-count":18,"title":["Familial Mediterranean fever gene mutation frequencies and genotype\u2013phenotype correlations in the Aegean region of Turkey"],"prefix":"10.1007","volume":"31","author":[{"given":"Elif","family":"Ozalkaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Mir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Sozeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afig","family":"Berdeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Mutlubas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alphan","family":"Cura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,3,9]]},"reference":[{"key":"1383_CR1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.rdc.2007.07.009","volume":"33","author":"S Padeh","year":"2007","unstructured":"Padeh S, Berkun Y (2007) Autoinflammatory fever syndromes. Rheum Dis Clin N Am 33:585\u2013623","journal-title":"Rheum Dis Clin N Am"},{"key":"1383_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0002-9343(67)90167-2","volume":"43","author":"E Sohar","year":"1967","unstructured":"Sohar E, Gafhi J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 43:227\u2013253","journal-title":"Am J Med"},{"key":"1383_CR3","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/art.1780371215","volume":"37","author":"A Livneh","year":"1994","unstructured":"Livneh A, Zemer D, Langevitz P, Laor A, Sohar E, Pras M (1994) Colchicine treatment of AA amyloidosis of familial Mediterranean fever: an analysis of factors affecting outcome. Arthritis Rheum 37:1804\u20131811","journal-title":"Arthritis Rheum"},{"key":"1383_CR4","first-page":"100","volume":"314","author":"D Zemer","year":"1896","unstructured":"Zemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J (1896) Colchicine in the prevention and treatment of amyloidosis of familial Mediterranean fever. N Engl J Med 314:100\u20131005","journal-title":"N Engl J Med"},{"key":"1383_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.1780090102","volume":"9","author":"H Heller","year":"1966","unstructured":"Heller H, Gafni J, Michaeli D, Shahin N, Sohar E, Erlich G, Karten I, Sokoloff L (1966) The arthritis of familial Mediterranean fever (FMF). Arthritis Rheum 9:1\u201317","journal-title":"Arthritis Rheum"},{"key":"1383_CR6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","volume":"90","author":"Consortium TIF","year":"1997","unstructured":"Consortium TIF (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797\u2013807","journal-title":"Cell"},{"key":"1383_CR7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0997-25","volume":"17","author":"Consortium TFF","year":"1997","unstructured":"Consortium TFF (1997) A candidate gene for familial Mediterranean fever. Nat Genet 17:25\u201331","journal-title":"Nat Genet"},{"key":"1383_CR8","first-page":"185","volume":"30","author":"S Padeh","year":"2003","unstructured":"Padeh S, Shiner Y, Pras E, Zemer D, Langevitz P, Pras M, Livneh A (2003) Clinical and diagnostic value of genetic testing in 216 Israeli children with familial Mediterranean fever. J Rheumatol 30:185\u2013190","journal-title":"J Rheumatol"},{"key":"1383_CR9","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1542\/peds.103.5.e70","volume":"103","author":"R Brik","year":"1999","unstructured":"Brik R, Shinaw M, Kepten I, Berant M, Gershoni-Baruch R (1999) Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients. Pediatrics 103:e70","journal-title":"Pediatrics"},{"key":"1383_CR10","first-page":"1703","volume":"27","author":"Y Shinar","year":"2000","unstructured":"Shinar Y, Livneh A, Langevitz P, Zaks N, Aksentijevich I, Koziol DE, Kastner DL, Pras M, Pras E (2000) Genotype-phenotype assessment of common genotypes among patients with familial Mediterranean fever. J Rheumatol 27:1703\u20131707","journal-title":"J Rheumatol"},{"key":"1383_CR11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/rheumatology\/39.11.1275","volume":"39","author":"PI Kone","year":"2000","unstructured":"Kone PI, Dubuc M, Sportouch J, Minodier P, Garnier JM, Touitou I (2000) Phenotype-genotype correlation in 91 patients with familial Mediterranean fever reveals a high frequency of mucocutaneous features. Rheumatology 39:1275\u20131279","journal-title":"Rheumatology"},{"key":"1383_CR12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.ejhg.5200170","volume":"6","author":"M Dewalle","year":"1998","unstructured":"Dewalle M, Domingo C, Rozenbaum M et al (1998) Phenotype-genotype correlation in Jewish patients suffering from familial Mediterranean fever. Eur J Hum Genet 6:95\u201397","journal-title":"Eur J Hum Genet"},{"key":"1383_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.md.0000152370.84628.0c","volume":"84","author":"M Tunca","year":"2005","unstructured":"Tunca M, Akar S, Onen F et al (2005) Turkish FMF Study Group. Familial Mediterranean fever in Turkey: results of a nationwide multicenter study. Medicine 84:1\u201311","journal-title":"Medicine"},{"key":"1383_CR14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/qjmed\/92.6.309","volume":"92","author":"HA Majeed","year":"1999","unstructured":"Majeed HA, Rawashded M, el-Shanti H, Qubain H, Khuri-Bulos N, Shahin HM (1999) Familial Mediterranean fever in children: the expanded clinical profile. Q J M 92:309\u2013318","journal-title":"Q J M"},{"key":"1383_CR15","first-page":"1","volume":"35","author":"A Gedalia","year":"1992","unstructured":"Gedalia A, Adar A, Gorodischer R (1992) Familial Mediterranean fever in children. JRheum suppl 35:1\u20139","journal-title":"JRheum suppl"},{"key":"1383_CR16","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/1529-0131(200106)44:6<1416::AID-ART236>3.0.CO;2-6","volume":"44","author":"R Brik","year":"2001","unstructured":"Brik R, Shinawi M, Kasinetz L, Gershoni-Baruch R (2001) The musculoskeletal manifestations of familial Mediterranean fever in children genetically diagnosed with the disease. Arthritis Rheum 44:1416\u20131419","journal-title":"Arthritis Rheum"},{"key":"1383_CR17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ejmg.2006.03.002","volume":"49","author":"H Mattit","year":"2006","unstructured":"Mattit H, Joma M, Al-Cheikh S et al (2006) Familial Mediterranean fever in the Syrian population: gene mutation frequencies, carrier rates and phenotype-genotype correlation. Eur J Med Genet 49:481\u2013486","journal-title":"Eur J Med Genet"},{"key":"1383_CR18","first-page":"916","volume":"25","author":"I Touitou","year":"1998","unstructured":"Touitou I, Ben-Chetrit E, Notarnicola C et al (1998) Familial Mediterranean fever clinical and genetic features in Druzes and in Iraqi Jews: a preliminary study. J Rheumatol 25:916\u2013919","journal-title":"J Rheumatol"},{"key":"1383_CR19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.ejhg.5200674","volume":"9","author":"E Yilmaz","year":"2001","unstructured":"Yilmaz E, Ozen S, Balci B et al (2001) Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 9:553\u2013555","journal-title":"Eur J Hum Genet"},{"key":"1383_CR20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/rheumatology\/39.1.67","volume":"39","author":"F Yalcinkaya","year":"2000","unstructured":"Yalcinkaya F, Cakar N, Misiroglu M et al (2000) Genotype-phenotype correlation in a large group of Turkish patients with familial Mediterranean fever and evidence for mutation independent amyloidosis. Rheumatology 39:67","journal-title":"Rheumatology"},{"key":"1383_CR21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/302459","volume":"65","author":"C Cazeneuve","year":"1999","unstructured":"Cazeneuve C, Sarkisian T, Pecheux C et al (1999) MEFV-gene analysis in Armenian patients with familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. Am J Hum Genet 65:88\u201397","journal-title":"Am J Hum Genet"},{"key":"1383_CR22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.ejhg.5200303","volume":"7","author":"M Shohat","year":"1999","unstructured":"Shohat M, Magal N, Shohat T et al (1999) Phenotype-genotype correlation in familial Mediterranean fever: evidence for an association between Met 694Val and amyloidosis. Eur J Hum Genet 7:287\u2013292","journal-title":"Eur J Hum Genet"},{"key":"1383_CR23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/(SICI)1098-1004(200004)15:4<384::AID-HUMU19>3.0.CO;2-U","volume":"15","author":"M Medlej-Hashim","year":"2000","unstructured":"Medlej-Hashim M, Rawashdeh M, Chouery E et al (2000) Genetic screening of fourteen mutations in Jourdanian familial Mediterranean fever patients. Hum Mutat 15:384","journal-title":"Hum Mutat"},{"key":"1383_CR24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.semarthrit.2006.12.004","volume":"36","author":"HB Chaabouni","year":"2007","unstructured":"Chaabouni HB, Mohamed K, M\u2019rad R et al (2007) MEFV mutations in Tunisian patients suffering from familial Mediterranean fever. Semin Arthritis Rheum 36:397\u2013401","journal-title":"Semin Arthritis Rheum"},{"key":"1383_CR25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/qjmed\/93.4.223","volume":"93","author":"G Grateau","year":"2000","unstructured":"Grateau G, Pecheux C, Cazeneuve C et al (2000) Clinical versus genetic diagnosis of familial Mediterranean fever. Q J M 93:223\u2013229","journal-title":"Q J M"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-010-1383-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-010-1383-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-010-1383-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T11:18:40Z","timestamp":1559042320000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-010-1383-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,9]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["1383"],"URL":"https:\/\/doi.org\/10.1007\/s00296-010-1383-8","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,9]]}}}