{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:06:19Z","timestamp":1792101979111,"version":"4.4.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00296-010-1687-8","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T11:00:02Z","timestamp":1291114802000},"page":"439-443","source":"Crossref","is-referenced-by-count":44,"title":["Possible benefits of strontium ranelate in complicated long bone fractures"],"prefix":"10.1007","volume":"32","author":[{"given":"Duarte Nuno","family":"Alegre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costa","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"1687_CR1","doi-asserted-by":"crossref","first-page":"12S","DOI":"10.1016\/S0002-9343(97)90022-X","volume":"103","author":"C Cooper","year":"1997","unstructured":"Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S\u201317S","journal-title":"Am J Med"},{"key":"1687_CR2","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","volume":"367","author":"P Sambrook","year":"2006","unstructured":"Sambrook P, Cooper C (2006) Osteoporosis. Lancet 367:2010\u20132018","journal-title":"Lancet"},{"key":"1687_CR3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.injury.2008.10.035","volume":"40","author":"VS Nikolaou","year":"2009","unstructured":"Nikolaou VS, Efstathopoulos N, Kontakis G et al (2009) The influence of osteoporosis in femoral fracture healing time. Injury 40:663\u2013668","journal-title":"Injury"},{"key":"1687_CR4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/jbmr.2000.15.4.613","volume":"15","author":"T Mashiba","year":"2000","unstructured":"Mashiba T, Hirano T, Turner CH et al (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613\u2013620","journal-title":"J Bone Miner Res"},{"key":"1687_CR5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/BRS.0b013e3181b71a96","volume":"35","author":"RA Lehman Jr","year":"2010","unstructured":"Lehman RA Jr, Dmitriev AE, Cardoso MJ et al (2010) Effect of teriparatide [rhPTH (1, 34)] and calcitonin on intertransverse process fusion in a rabbit model. Spine 35:146\u2013152","journal-title":"Spine"},{"key":"1687_CR6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s002230010055","volume":"69","author":"PJ Marie","year":"2001","unstructured":"Marie PJ, Ammann P, Boivin G et al (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121\u2013129","journal-title":"Calcif Tissue Int"},{"key":"1687_CR7","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/17453670510045318","volume":"76","author":"P Aspenberg","year":"2005","unstructured":"Aspenberg P (2005) Drugs and fracture repair. Acta Orthop 76:741\u2013748","journal-title":"Acta Orthop"},{"key":"1687_CR8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/j.1476-5381.2009.00305.x","volume":"157","author":"TC Brennan","year":"2009","unstructured":"Brennan TC, Rybchyn MS, Green W et al (2009) Osteoblasts play key roles in the mechanisms of action of strontium ranelate. Br J Pharmacol 157:1291\u20131300","journal-title":"Br J Pharmacol"},{"key":"1687_CR9","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1582-4934.2008.00673.x","volume":"13","author":"O Fromigu\u00e9","year":"2009","unstructured":"Fromigu\u00e9 O, Ha\u00ff E, Barbara A et al (2009) Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate. J Cell Mol Med 13:2189\u20132199","journal-title":"J Cell Mol Med"},{"key":"1687_CR10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(02)02040-X","volume":"450","author":"R Baron","year":"2002","unstructured":"Baron R, Tsouderos Y (2002) In vitro effects of S12911\u20132 on osteoclast function and bone marrow macrophage differenciation. Eur J Pharmacol 450:11\u201317","journal-title":"Eur J Pharmacol"},{"key":"1687_CR11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bone.2007.08.043","volume":"42","author":"E Bonnelye","year":"2008","unstructured":"Bonnelye E, Chabadel A, Saltel F et al (2008) Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 42:129\u2013138","journal-title":"Bone"},{"key":"1687_CR12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1074\/jbc.M801668200","volume":"284","author":"AS Hurtel-Lemaire","year":"2009","unstructured":"Hurtel-Lemaire AS, Mentaverri R, Caudrillier A et al (2009) The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem 284:575\u2013584","journal-title":"J Biol Chem"},{"key":"1687_CR13","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1096\/fj.06-6304fje","volume":"20","author":"R Mentaverri","year":"2006","unstructured":"Mentaverri R, Yano S, Chattopadhyay N et al (2006) The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J 20:2562\u20132564","journal-title":"FASEB J"},{"key":"1687_CR14","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1359\/jbmr.2003.18.6.1082","volume":"18","author":"N Takahashi","year":"2003","unstructured":"Takahashi N, Sasaki T, Tsouderos Y et al (2003) S12911\u20132 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18:1082\u20131087","journal-title":"J Bone Miner Res"},{"key":"1687_CR15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1359\/jbmr.070607","volume":"22","author":"P Ammann","year":"2007","unstructured":"Ammann P, Badoud I, Barraud S et al (2007) Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. J Bone Miner Res 22:1419\u20131425","journal-title":"J Bone Miner Res"},{"key":"1687_CR16","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00198-008-0815-8","volume":"20","author":"SD Bain","year":"2009","unstructured":"Bain SD, Jerome C, Shen V et al (2009) Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporos Int 20:1417\u20131428","journal-title":"Osteoporos Int"},{"key":"1687_CR17","doi-asserted-by":"crossref","unstructured":"Li YF, Luo E, Feng G et al (2010) Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporos Int In press","DOI":"10.1007\/s00198-009-1140-6"},{"key":"1687_CR18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1359\/jbmr.071012","volume":"23","author":"ME Arlot","year":"2008","unstructured":"Arlot ME, Jiang Y, Genant HK et al (2008) Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 23:215\u2013222","journal-title":"J Bone Miner Res"},{"key":"1687_CR19","doi-asserted-by":"crossref","unstructured":"Rizzoli R, Laroche M, Krieg MA et al (2010) Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Rheumatol Int In press","DOI":"10.1007\/s00296-010-1542-y"},{"key":"1687_CR20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00223-009-9317-8","volume":"86","author":"B Habermann","year":"2010","unstructured":"Habermann B, Kafchitsas K, Olender G et al (2010) Strontium ranelate enhances callus strength more than PTH 1\u201334 in an osteoporotic rat model of fracture healing. Calcif Tissue Int 86:82\u201389","journal-title":"Calcif Tissue Int"},{"key":"1687_CR21","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.bone.2010.01.379","volume":"46","author":"L Maimoun","year":"2010","unstructured":"Maimoun L, Brennan TC, Badoud I et al (2010) Strontium ranelate improves implant osseointegration. Bone 46:1436\u20131441","journal-title":"Bone"},{"key":"1687_CR22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jor.21050","volume":"28","author":"Y Li","year":"2010","unstructured":"Li Y, Feng G, Gao Y et al (2010) Strontium ranelate treatment enhances hydroxyapatite-coated titanium screws fixation in osteoporotic rats. J Orthop Res 28:578\u2013582","journal-title":"J Orthop Res"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-010-1687-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-010-1687-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-010-1687-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T05:46:48Z","timestamp":1592113608000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-010-1687-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["1687"],"URL":"https:\/\/doi.org\/10.1007\/s00296-010-1687-8","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}