{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:34:45Z","timestamp":1790026485771,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s00296-013-2781-5","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T10:46:10Z","timestamp":1369997170000},"page":"2607-2616","source":"Crossref","is-referenced-by-count":60,"title":["Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients"],"prefix":"10.1007","volume":"33","author":[{"given":"Ba\u015fak","family":"B\u0131y\u0131ko\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Nalbantsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"Evrenoso\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis F.","family":"Kinane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"2781_CR1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1902\/jop.2005.76.11-S.2066","volume":"76","author":"PM Bartold","year":"2005","unstructured":"Bartold PM, Marshall RI, Haynes DR (2005) Periodontitis and rheumatoid arthritis: a review. J Periodontol 76:2066\u20132074","journal-title":"J Periodontol"},{"key":"2781_CR2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1902\/jop.2008.070616","volume":"79","author":"JO Pers","year":"2008","unstructured":"Pers JO, Saraux A, Pierre R, Youinou P (2008) Anti-TNF-\u03b1 immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol 79:1645\u20131651","journal-title":"J Periodontol"},{"key":"2781_CR3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1600-051X.2006.00961.x","volume":"33","author":"B B\u0131y\u0131ko\u011flu","year":"2006","unstructured":"B\u0131y\u0131ko\u011flu B, Buduneli N, Karde\u015fler L, Aksu K, \u00d6der G, K\u00fct\u00fck\u00e7\u00fcler N (2006) Evaluation of t-PA, PAI-2, IL-1\u03b2 and PGE2 in gingival crevicular fluid of rheumatoid arthritis patients with periodontal disease. J Clin Periodontol 33:605\u2013611","journal-title":"J Clin Periodontol"},{"key":"2781_CR4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1902\/jop.2009.090130","volume":"80","author":"B B\u0131y\u0131ko\u011flu","year":"2009","unstructured":"B\u0131y\u0131ko\u011flu B, Buduneli N, Karde\u015fler L, Aksu K, Pitkala M, Sorsa T (2009) MMP-8, MMP-13 and TIMP-1 levels in gingival crevicular fluid of rheumatoid arthritis patients with inflammatory periodontal disease. J Periodontol 80:1307\u20131314","journal-title":"J Periodontol"},{"key":"2781_CR5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1034\/j.1600-051x.2000.027004267.x","volume":"27","author":"FB Mercado","year":"2000","unstructured":"Mercado FB, Marshall RI, Klestov AC, Bartold PM (2000) Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol 27:267\u2013272","journal-title":"J Clin Periodontol"},{"key":"2781_CR6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1902\/jop.2001.72.6.779","volume":"72","author":"FB Mercado","year":"2000","unstructured":"Mercado FB, Marshall RI, Klestov AC, Bartold PM (2000) Relationship between rheumatoid arthritis and periodontitis. J Periodontol 72:779\u2013787","journal-title":"J Periodontol"},{"key":"2781_CR7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2334\/josnusd1959.34.89","volume":"34","author":"E Yavuzy\u0131lmaz","year":"1992","unstructured":"Yavuzy\u0131lmaz E, Yamal\u0131k N, \u00c7alg\u00fcner M, Ersoy F, Baykara M, Yeniay \u0130 (1992) Clinical and immunological characteristics of patients with rheumatoid arthritis and periodontal disease. J Nihon Univ Sch Dent 34:89\u201395","journal-title":"J Nihon Univ Sch Dent"},{"key":"2781_CR8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.2007.03441.x","volume":"149","author":"HE Barksby","year":"2007","unstructured":"Barksby HE, Lea S, Preshaw PM, Taylor JJ (2007) The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders. Clin Exp Immunol 149:217\u2013225","journal-title":"Clin Exp Immunol"},{"key":"2781_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00841-2","volume":"321","author":"MS Nanes","year":"2003","unstructured":"Nanes MS (2003) Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology. Gene 321:1\u201315","journal-title":"Gene"},{"key":"2781_CR10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/ard.51.2.177","volume":"51","author":"DMFM Heijde van der","year":"1992","unstructured":"van der Heijde DMFM, Van\u2019t Hof MA, Van Riel PLCM, Van Leeuwen MA, Van Rijswijk MH, van de Putte LBA (1992) Validity of single variables and composite indices for measuring disease activity in rheumatoid arthritis. Ann Rheum 51:177\u2013181","journal-title":"Ann Rheum"},{"key":"2781_CR11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0757.2004.03676.x","volume":"36","author":"PA Adriaens","year":"2004","unstructured":"Adriaens PA, Adriaens LM (2004) Effects of nonsurgical periodontal therapy on hard and soft tissues. Periodontol 2000 36:121\u2013145","journal-title":"Periodontol 2000"},{"key":"2781_CR12","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1902\/jop.2010.090732","volume":"81","author":"PM Duarte","year":"2010","unstructured":"Duarte PM, da Rocha M, Sampaio E, Mestnik MJ, Feres M, Figueiredo LC et al (2010) Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol 81:1056\u20131063","journal-title":"J Periodontol"},{"key":"2781_CR13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1902\/jop.2011.100579","volume":"82","author":"W Rosalem","year":"2011","unstructured":"Rosalem W, Rescala B, Teles RP, Fischer RG, Gustafsson A, Figueredo CM (2011) Effect of non-surgical treatment on chronic and aggressive periodontitis: clinical, immunologic and microbiologic findings. J Periodontol 82:979\u2013989","journal-title":"J Periodontol"},{"key":"2781_CR14","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/rheumatology\/keh297","volume":"43","author":"J Fransen","year":"2004","unstructured":"Fransen J, Creemers MCW, Van Riel PLC (2004) Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria. Rheumatology 43:1252\u20131255","journal-title":"Rheumatology"},{"key":"2781_CR15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.49.11.916","volume":"49","author":"DM Heijde van der","year":"1990","unstructured":"van der Heijde DM, van\u2019t Hof MA, van Riel PL, Theunisse LA, Lubberts EW, van Leewen MA, van Rijswijk MH, Van de Putte LB (1990) Judging disease activity in clinical practise in rheumatoid arthritis: first step in the development of a disease activity score. Ann Rheum Dis 49:916\u2013920","journal-title":"Ann Rheum Dis"},{"key":"2781_CR16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/RHU.0b013e3180690616","volume":"13","author":"MK Al-Katma","year":"2007","unstructured":"Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD (2007) Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 13:134\u2013137","journal-title":"J Clin Rheumatol"},{"key":"2781_CR17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1902\/jop.2009.080447","volume":"80","author":"P Ortiz","year":"2009","unstructured":"Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80:535\u2013540","journal-title":"J Periodontol"},{"key":"2781_CR18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-051X.2005.00689.x","volume":"32","author":"J Ribeiro","year":"2005","unstructured":"Ribeiro J, Leao A, Novaes AB (2005) Periodontal infection as a possible severity factor for rheumatoid arthritis. J Clin Periodontol 32:412\u2013416","journal-title":"J Clin Periodontol"},{"key":"2781_CR19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1998","unstructured":"Arnett FC, Edworthy SM, Bloch DA (1998) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315\u2013324","journal-title":"Arthritis Rheum"},{"key":"2781_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136","journal-title":"Ann Periodontol"},{"key":"2781_CR21","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1902\/jop.2000.71.11.1756","volume":"71","author":"FY Bozkurt","year":"2000","unstructured":"Bozkurt FY, Berker E, Akku\u015f S, Bulut \u015e (2000) Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis. J Periodontol 71:1756\u20131760","journal-title":"J Periodontol"},{"key":"2781_CR22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1034\/j.1600-051X.2003.00371.x","volume":"30","author":"FB Mercado","year":"2003","unstructured":"Mercado FB, Marshall RI, Bartold PM (2003) Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol 30:761\u2013772","journal-title":"J Clin Periodontol"},{"key":"2781_CR23","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/art.1780401221","volume":"40","author":"UR Kasser","year":"1997","unstructured":"Kasser UR, Gleissner C, Dehne F, Michel A, Willershausen-Z\u00f6nnchen B, Bolten WW (1997) Risk for periodontal disease in patients with longstanding rheumatoid arthritis. Arthritis Rheum 40:2248\u20132251","journal-title":"Arthritis Rheum"},{"key":"2781_CR24","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1902\/jop.2008.070501","volume":"79","author":"N Pischon","year":"2008","unstructured":"Pischon N, Pischon T, Kr\u00f6ger J, G\u00fclmez E, Kleber BM, Bernimoulin JP et al (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 79:979\u2013986","journal-title":"J Periodontol"},{"key":"2781_CR25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0528.1989.tb00623.x","volume":"17","author":"L Sj\u00f6str\u00f6m","year":"1989","unstructured":"Sj\u00f6str\u00f6m L, Laurell L, Hugoson A, Hakansson JP (1989) Periodontal conditions in adults with rheumatoid arthritis. Commun Dent Oral Epidemiol 17:234\u2013236","journal-title":"Commun Dent Oral Epidemiol"},{"key":"2781_CR26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-051X.1990.tb01091.x","volume":"17","author":"K Tolo","year":"1990","unstructured":"Tolo K, Jorkend L (1990) Serum antibodies and loss of periodontal bone in patients with rheumatoid arthritis. J Clin Periodontol 17:288\u2013291","journal-title":"J Clin Periodontol"},{"key":"2781_CR27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x","volume":"107","author":"JL Ebersole","year":"1997","unstructured":"Ebersole JL, Machen R, Steffen MJ, Willmann DE (1997) Systemic acute phase reactants, C-reactive proteins and haptoglobulin in adult periodontitis. Clin Exp Immunol 107:347\u2013352","journal-title":"Clin Exp Immunol"},{"key":"2781_CR28","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/rheumatology\/ken386","volume":"47","author":"B Galarraga","year":"2008","unstructured":"Galarraga B, Khan F, Kumar P, Pullar T, Belch JJ (2008) C-reactive protein: the underlying cause of microvascular dysfunction in rheumatoid arthritis. Rheumatology (Oxford) 47:1780\u20131784","journal-title":"Rheumatology (Oxford)"},{"key":"2781_CR29","first-page":"387","volume":"3","author":"C Gleissner","year":"1998","unstructured":"Gleissner C, Willershausen B, Kaesse U, Bolten WW (1998) The role of risk factors for periodontal disease in patients with rheumatoid arthritis. Eur J Med Res 3:387\u2013392","journal-title":"Eur J Med Res"},{"key":"2781_CR30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/154405910508400312","volume":"84","author":"F D\u2019Aiuto","year":"2005","unstructured":"D\u2019Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS (2005) Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 84:269\u2013273","journal-title":"J Dent Res"},{"key":"2781_CR31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0103-64402009000500001","volume":"20","author":"M Noronha Pinho de","year":"2009","unstructured":"de Noronha Pinho M, de Oliveira RD, Novaes AB Jr, Voltarelli JC (2009) Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J 20:355\u2013364","journal-title":"Braz Dent J"},{"key":"2781_CR32","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1902\/jop.2007.060520","volume":"78","author":"LA Miranda","year":"2007","unstructured":"Miranda LA, Islabao AG, Fischer RG, Figueredo CMS, Oppermann RV, Gustafsson A (2007) Decreased interleukin-1\u03b2 and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. J Periodontol 78:1612\u20131619","journal-title":"J Periodontol"},{"key":"2781_CR33","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1902\/jop.2009.090015","volume":"80","author":"Y Mayer","year":"2009","unstructured":"Mayer Y, Balbir-Gurman A, Machtei EE (2009) Anti-TNF-\u03b1 therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol 80:1414\u20131420","journal-title":"J Periodontol"},{"key":"2781_CR34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1902\/jop.2010.090688","volume":"81","author":"T Kobayashi","year":"2010","unstructured":"Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Ishida K, Abe A, Yamamoto Y, Yoshie H (2010) Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults. J Periodontol 81:650\u2013657","journal-title":"J Periodontol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-013-2781-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-013-2781-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-013-2781-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T11:21:47Z","timestamp":1559042507000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-013-2781-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,1]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["2781"],"URL":"https:\/\/doi.org\/10.1007\/s00296-013-2781-5","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,1]]}}}