{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:53:14Z","timestamp":1771624394342,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,8,3]],"date-time":"2013-08-03T00:00:00Z","timestamp":1375488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00296-013-2835-8","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T07:36:51Z","timestamp":1375429011000},"page":"3049-3054","source":"Crossref","is-referenced-by-count":19,"title":["Regulatory T cells in Beh\u00e7et\u2019s disease: Is there a correlation with disease activity? Does regulatory T cell type matter?"],"prefix":"10.1007","volume":"33","author":[{"given":"Eren","family":"G\u00fcnd\u00fcz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hava \u00dcsk\u00fcdar","family":"Teke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazife \u015eule Ya\u015far","family":"Bilge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f6nd\u00fc \u00dcsk\u00fcdar","family":"Cansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"G\u00fclba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,3]]},"reference":[{"key":"2835_CR1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","volume":"341","author":"T Sakane","year":"1999","unstructured":"Sakane T, Takeno M, Suzuki N, Inaba G (1999) Beh\u00e7et\u2019s disease. N Engl J Med 341:1284\u20131291","journal-title":"N Engl J Med"},{"key":"2835_CR2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1371\/journal.pmed.0030297","volume":"3","author":"D McGonagle","year":"2006","unstructured":"McGonagle D, McDermott MF (2006) A proposed classification of the immunological diseases. PLos Med 3:1242\u20131248","journal-title":"PLos Med"},{"key":"2835_CR3","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1084\/jem.20080308","volume":"205","author":"J Andersson","year":"2008","unstructured":"Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O\u2019Shea JJ et al (2008) CD4+FoxP3+regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med 205:1975\u20131981","journal-title":"J Exp Med"},{"key":"2835_CR4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.smim.2011.04.001","volume":"23","author":"AN McMurchy","year":"2011","unstructured":"McMurchy AN, Bushell A, Levings MK, Wood KJ (2011) Moving to tolerance: clinical application of T regulatory cells. Sem Immunol 23:304\u2013313","journal-title":"Sem Immunol"},{"key":"2835_CR5","first-page":"1078","volume":"335","author":"International Study Group for Beh\u00e7et\u2019s Disease","year":"1990","unstructured":"International Study Group for Beh\u00e7et\u2019s Disease (1990) Criteria for diagnosis of Beh\u00e7et\u2019s disease. Lancet 335:1078\u20131080","journal-title":"Lancet"},{"key":"2835_CR6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/rheumatology\/38.8.728","volume":"38","author":"BB Bhakta","year":"1999","unstructured":"Bhakta BB, Brennan P, James TE, Chamberlain MA, Noble BA, Silman AJ (1999) Beh\u00e7et\u2019s disease: evaluation of a new instrument to measure clinical activity. Rheumatology 38:728\u2013733","journal-title":"Rheumatology"},{"key":"2835_CR7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.autrev.2011.11.026","volume":"11","author":"MP deChambrun","year":"2012","unstructured":"deChambrun MP, Wechsler B, Geri G, Cacoub P, Saadoun D (2012) New insights into the pathogenesis of Beh\u00e7et\u2019s disease. Autoimmune Rev 11:687\u2013698","journal-title":"Autoimmune Rev"},{"key":"2835_CR8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ni904","volume":"4","author":"JD Fontenot","year":"2003","unstructured":"Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+regulatory T cells. Nat Immunol 4:304\u2013306","journal-title":"Nat Immunol"},{"key":"2835_CR9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/intimm\/dxm014","volume":"19","author":"SE Allan","year":"2007","unstructured":"Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R et al (2007) Activation induced Foxp3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 19:345\u2013354","journal-title":"Int Immunol"},{"key":"2835_CR10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10165-008-0064-x","volume":"18","author":"Y Nanke","year":"2008","unstructured":"Nanke Y, Kotake S, Goto M, Ujihara H, Matsubara M, Kamatni N (2008) Decreased percentages of regulatory T cells in peripheral blood of patients with Beh\u00e7et\u2019s disease before ocular attack: a possible predictive marker of ocular attack. Mod Rheumatol 18:354\u2013358","journal-title":"Mod Rheumatol"},{"key":"2835_CR11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jneuroim.2011.01.012","volume":"50","author":"K Hamzaoui","year":"2011","unstructured":"Hamzaoui K, Borhani Haghighi A, Ghorbel IB, Houman H (2011) RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Beh\u00e7et\u2019s disease. J Neuroimmunol 50:249\u2013253","journal-title":"J Neuroimmunol"},{"key":"2835_CR12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0714.2011.01061.x","volume":"14","author":"FN Pekiner","year":"2012","unstructured":"Pekiner FN, Aytugar E, Demirel GY, Borahan MO (2012) Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Beh\u00e7et\u2019s disease and recurrent aphthous ulcerations. J Oral Pathol Med 14:73\u201379","journal-title":"J Oral Pathol Med"},{"key":"2835_CR13","first-page":"107","volume":"25","author":"K Hamzaoui","year":"2007","unstructured":"Hamzaoui K (2007) Paradoxical high regulatory T cell activity in Beh\u00e7et\u2019s disease. Clin Exp Rheumatol 25:107\u2013113","journal-title":"Clin Exp Rheumatol"},{"key":"2835_CR14","first-page":"71","volume":"24","author":"K Hamzaoui","year":"2006","unstructured":"Hamzaoui K, Hamzaoui A, Houman H (2006) CD4+CD25+regulatory T cells in patients with Beh\u00e7et\u2019s disease. Clin Exp Rheumatol 24:71\u201378","journal-title":"Clin Exp Rheumatol"},{"key":"2835_CR15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaci.2011.05.029","volume":"128","author":"G Geri","year":"2011","unstructured":"Geri G, Terrier B, Rosenzwajg M, Wechsler B, Touzot M, Seilhean D et al (2011) Critical role of IL-21 in modulating T(H)17 and regulatory T cells in Beh\u00e7et\u2019s disease. J Allergy Clin Immunol 128:655\u2013664","journal-title":"J Allergy Clin Immunol"},{"key":"2835_CR16","first-page":"393","volume":"47","author":"L Liang","year":"2011","unstructured":"Liang L, Wang H, Peng XY, Zhao M (2011) The changes of Th lymphocyte subsets in patients with Behcet disease. Zhonghua Yan Ke Za Zhi 47:393\u2013397","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"2835_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0923-1811(96)00588-9","volume":"15","author":"M Mochizuki","year":"1997","unstructured":"Mochizuki M, Morita E, Yamamoto S, Yamana S (1997) Characteristics of T cell lines established from skin lesions of Beh\u00e7et\u2019s disease. J Dermatol Sci 15:9\u201313","journal-title":"J Dermatol Sci"},{"key":"2835_CR18","first-page":"476","volume":"52","author":"S Sugita","year":"2011","unstructured":"Sugita S, Yamada Y, kaneko S, Horie S, Mochizuki M (2011) Induction of regulatory T cells by infliximab in Beh\u00e7et\u2019s disease. IOVS 52:476\u2013484","journal-title":"IOVS"},{"key":"2835_CR19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri1574","volume":"5","author":"JA Bluestone","year":"2005","unstructured":"Bluestone JA (2005) Regulatory T cell therapy: is it ready for the clinic? Nat Rev Immunol 5:343\u2013349","journal-title":"Nat Rev Immunol"},{"key":"2835_CR20","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","volume":"199","author":"Q Tang","year":"2004","unstructured":"Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J et al (2004) In vitro expanded antigen specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199:1455\u20131465","journal-title":"J Exp Med"},{"key":"2835_CR21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1600-065X.2001.1820110.x","volume":"182","author":"GC Furtado","year":"2001","unstructured":"Furtado GC, Olivares-Villagomez D, Curotto de Lafaille MA, Wensky AK, Latkowski JA, Lafaille JJ (2001) Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol Rev 182:122\u2013134","journal-title":"Immunol Rev"},{"key":"2835_CR22","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3109\/14653249.2011.571245","volume":"13","author":"J Shim","year":"2011","unstructured":"Shim J, Lee ES, Park S, Bang D, Sohn S (2011) CD4+CD25+regulatory T cells ameliorate Beh\u00e7et\u2019s disease like symptoms in a Mouse model. Cytotherapy 13:835\u2013847","journal-title":"Cytotherapy"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-013-2835-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-013-2835-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-013-2835-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T11:21:48Z","timestamp":1559042508000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-013-2835-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,3]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2835"],"URL":"https:\/\/doi.org\/10.1007\/s00296-013-2835-8","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,3]]}}}