{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:24:07Z","timestamp":1780104247266,"version":"3.54.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T00:00:00Z","timestamp":1417219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s00296-014-3178-9","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T13:20:23Z","timestamp":1417440023000},"page":"973-979","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Predicting the potential ankylosing spondylitis-related genes utilizing bioinformatics approaches"],"prefix":"10.1007","volume":"35","author":[{"given":"Hao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,29]]},"reference":[{"issue":"9570","key":"3178_CR1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369(9570):1379\u20131390","journal-title":"Lancet"},{"issue":"2","key":"3178_CR2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng.513","volume":"42","author":"JD Reveille","year":"2010","unstructured":"Reveille JD, Sims A-M, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Appleton LH (2010) Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 42(2):123","journal-title":"Nat Genet"},{"issue":"1","key":"3178_CR3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/ard.2010.138594","volume":"70","author":"P Machado","year":"2011","unstructured":"Machado P, Landew\u00e9 R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D (2011) Ankylosing spondylitis disease activity score (ASDAS): defining cut-off values for disease activity states and improvement scores. Ann Rheum Dis 70(1):47\u201353","journal-title":"Ann Rheum Dis"},{"issue":"5670","key":"3178_CR4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.1097434","volume":"304","author":"S Yekta","year":"2004","unstructured":"Yekta S, I-h Shih, Bartel DP (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304(5670):594\u2013596","journal-title":"Science"},{"issue":"5","key":"3178_CR5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-3083.2010.02381.x","volume":"71","author":"A Chatzikyriakidou","year":"2010","unstructured":"Chatzikyriakidou A, Voulgari P, Georgiou I, Drosos A (2010) The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. Scand J Immunol 71(5):382\u2013385","journal-title":"Scand J Immunol"},{"issue":"1","key":"3178_CR6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.0105-2896.2009.00852.x","volume":"233","author":"GP Thomas","year":"2010","unstructured":"Thomas GP, Brown MA (2010) Genetics and genomics of ankylosing spondylitis. Immunol Rev 233(1):162\u2013180","journal-title":"Immunol Rev"},{"key":"3178_CR7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4419-0298-6_18","volume-title":"Molecular mechanisms of spondyloarthropathies","author":"JD Taurog","year":"2009","unstructured":"Taurog JD (2009) Animal models of spondyloarthritis. Molecular mechanisms of spondyloarthropathies. Springer, Heidelberg, pp 245\u2013254"},{"issue":"11","key":"3178_CR8","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1002\/art.30555","volume":"63","author":"R D\u00edaz-Pe\u00f1a","year":"2011","unstructured":"D\u00edaz-Pe\u00f1a R, Aransay AM, Bruges-Armas J, L\u00f3pez-V\u00e1zquez A, Rodr\u00edguez-Ezpeleta N, Mendibil I, S\u00e1nchez A, Torre-Alonso JC, Bettencourt BF, Mulero J (2011) Fine mapping of a major histocompatibility complex in ankylosing spondylitis: association of the HLA-DPA1 and HLA-DPB1 regions. Arthritis Rheum 63(11):3305\u20133312","journal-title":"Arthritis Rheum"},{"issue":"4","key":"3178_CR9","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/annrheumdis-2011-200347","volume":"71","author":"N Haroon","year":"2012","unstructured":"Haroon N, Tsui FW, Uchanska-Ziegler B, Ziegler A, Inman RD (2012) Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis. Ann Rheum Dis 71(4):589\u2013595","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"3178_CR10","doi-asserted-by":"crossref","first-page":"D760","DOI":"10.1093\/nar\/gkl887","volume":"35","author":"T Barrett","year":"2007","unstructured":"Barrett T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C, Kim IF, Soboleva A, Tomashevsky M, Edgar R (2007) NCBI GEO: mining tens of millions of expression profiles\u2014database and tools update. Nucleic Acids Res 35(Suppl 1):D760\u2013D765","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"3178_CR11","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/ar3309","volume":"13","author":"FM Pimentel-Santos","year":"2011","unstructured":"Pimentel-Santos FM, Ligeiro D, Matos M, Mour\u00e3o AF, Costa J, Santos H, Barcelos A, Godinho F, Pinto P, Cruz M (2011) Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects. Arthritis Res Ther 13(2):R57","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"3178_CR12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1471-2164-7-252","volume":"7","author":"I Diboun","year":"2006","unstructured":"Diboun I, Wernisch L, Orengo C, Koltzenburg M (2006) Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genom 7(1):252","journal-title":"BMC Genom"},{"issue":"1","key":"3178_CR13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/gepi.1124","volume":"23","author":"B Efron","year":"2002","unstructured":"Efron B, Tibshirani R (2002) Empirical Bayes methods and false discovery rates for microarrays. Genet Epidemiol 23(1):70\u201386","journal-title":"Genet Epidemiol"},{"key":"3178_CR14","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","volume":"8","author":"G Alvord","year":"2007","unstructured":"Alvord G, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007) The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol 8:R183","journal-title":"Genome Biol"},{"issue":"1","key":"3178_CR15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT (2000) Gene ontology: tool for the unification of biology. Nat Genet 25(1):25\u201329","journal-title":"Nat Genet"},{"issue":"11","key":"3178_CR16","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","volume":"2","author":"B John","year":"2004","unstructured":"John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS (2004) Human microRNA targets. PLoS Biol 2(11):e363","journal-title":"PLoS Biol"},{"issue":"6","key":"3178_CR17","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1261\/rna.965408","volume":"14","author":"X Wang","year":"2008","unstructured":"Wang X (2008) miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA 14(6):1012\u20131017","journal-title":"RNA"},{"issue":"5","key":"3178_CR18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","volume":"44","author":"H Dweep","year":"2011","unstructured":"Dweep H, Sticht C, Pandey P, Gretz N (2011) miRWalk\u2013database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes. J Biomed Inform 44(5):839\u2013847","journal-title":"J Biomed Inform"},{"issue":"24","key":"3178_CR19","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/bioinformatics\/bts615","volume":"28","author":"P Loher","year":"2012","unstructured":"Loher P, Rigoutsos I (2012) Interactive exploration of RNA22 microRNA target predictions. Bioinformatics 28(24):3322\u20133323","journal-title":"Bioinformatics"},{"issue":"1","key":"3178_CR20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(1):15\u201320","journal-title":"Cell"},{"issue":"1","key":"3178_CR21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/nar\/gkg034","volume":"31","author":"C Mering Von","year":"2003","unstructured":"Von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B (2003) STRING: a database of predicted functional associations between proteins. Nucleic Acids Res 31(1):258\u2013261","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"3178_CR22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot ME, Ono K, Ruscheinski J, Wang P-L, Ideker T (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27(3):431\u2013432","journal-title":"Bioinformatics"},{"issue":"5","key":"3178_CR23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nmeth.1938","volume":"9","author":"T Nepusz","year":"2012","unstructured":"Nepusz T, Yu H, Paccanaro A (2012) Detecting overlapping protein complexes in protein\u2013protein interaction networks. Nat Methods 9(5):471\u2013472","journal-title":"Nat Methods"},{"issue":"1","key":"3178_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/nar\/29.1.37","volume":"29","author":"R Apweiler","year":"2001","unstructured":"Apweiler R, Attwood TK, Bairoch A, Bateman A, Birney E, Biswas M, Bucher P, Cerutti L, Corpet F, Croning MDR (2001) The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res 29(1):37\u201340","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"3178_CR25","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1002\/1529-0131(200108)44:8<1876::AID-ART326>3.0.CO;2-F","volume":"44","author":"JJ Anderson","year":"2001","unstructured":"Anderson JJ, Baron G, Van Der Heijde D, Felson DT, Dougados M (2001) Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum 44(8):1876\u20131886","journal-title":"Arthritis Rheum"},{"issue":"2","key":"3178_CR26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jcla.20231","volume":"22","author":"Y Zai-Xing","year":"2008","unstructured":"Zai-Xing Y, Yan L, Hao W, Ye Z, Chang L, Ren-Qian Z (2008) Preliminary clinical measurement of the expression of TNF-related apoptosis inducing ligand in patients with ankylosing spondylitis. J Clin Lab Anal 22(2):138\u2013145","journal-title":"J Clin Lab Anal"},{"issue":"12","key":"3178_CR27","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1002\/art.27699","volume":"62","author":"F Ciccia","year":"2010","unstructured":"Ciccia F, Accardo-Palumbo A, Giardina A, Di Maggio P, Principato A, Bombardieri M, Rizzo A, Alessandro R, Ferrante A, Principe S (2010) Expansion of intestinal CD4+ CD25 high Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response. Arthritis Rheum 62(12):3625\u20133634","journal-title":"Arthritis Rheum"},{"key":"3178_CR28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fimmu.2012.00339","volume":"3","author":"J Shaw","year":"2012","unstructured":"Shaw J, Kollnberger S (2012) New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease. Front Immunol 3:339","journal-title":"Front Immunol"},{"key":"3178_CR29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.neuro.30.051606.094302","volume":"31","author":"S DiMauro","year":"2008","unstructured":"DiMauro S, Schon EA (2008) Mitochondrial disorders in the nervous system. Annu Rev Neurosci 31:91\u2013123","journal-title":"Annu Rev Neurosci"},{"issue":"4\u20135","key":"3178_CR30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00332560","volume":"11","author":"D Wendling","year":"1991","unstructured":"Wendling D, Didier J, Vuitton D (1991) The phagocyte oxidative metabolism function in ankylosing spondylitis. Rheumatol Int 11(4\u20135):187\u2013189","journal-title":"Rheumatol Int"},{"issue":"20","key":"3178_CR31","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.112.125971","volume":"126","author":"EM Smolock","year":"2012","unstructured":"Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC (2012) Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Circulation 126(20):2418\u20132427","journal-title":"Circulation"},{"issue":"12","key":"3178_CR32","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/humu.20608","volume":"28","author":"R Cmejla","year":"2007","unstructured":"Cmejla R, Cmejlova J, Handrkova H, Petrak J, Pospisilova D (2007) Ribosomal protein S17 gene (RPS17) is mutated in Diamond\u2013Blackfan anemia. Hum Mutat 28(12):1178\u20131182","journal-title":"Hum Mutat"},{"issue":"1","key":"3178_CR33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ijc.24695","volume":"126","author":"ST Mees","year":"2010","unstructured":"Mees ST, Mardin WA, Wendel C, Baeumer N, Willscher E, Senninger N, Schleicher C, Colombo-Benkmann M, Haier J (2010) EP300\u2014A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. Int J Cancer 126(1):114\u2013124","journal-title":"Int J Cancer"},{"issue":"2","key":"3178_CR34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5582\/bst.2011.v5.2.46","volume":"5","author":"F Yu","year":"2011","unstructured":"Yu F, Cui Y, Zhou X, Zhang X, Han J (2011) Osteogenic differentiation of human ligament fibroblasts induced by conditioned medium of osteoclast-like cells. Biosci Trends 5(2):46","journal-title":"Biosci Trends"},{"issue":"31","key":"3178_CR35","doi-asserted-by":"crossref","first-page":"25964","DOI":"10.1074\/jbc.M112.384164","volume":"287","author":"LM Graham","year":"2012","unstructured":"Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS (2012) The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. J Biol Chem 287(31):25964\u201325974","journal-title":"J Biol Chem"},{"issue":"8","key":"3178_CR36","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1182\/blood-2006-05-021790","volume":"108","author":"VB Cismasiu","year":"2006","unstructured":"Cismasiu VB, Ghanta S, Duque J, Albu DI, Chen H-M, Kasturi R, Avram D (2006) BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood 108(8):2695\u20132702","journal-title":"Blood"},{"issue":"10","key":"3178_CR37","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1136\/ard.2008.097204","volume":"68","author":"C Wright","year":"2009","unstructured":"Wright C, Edelmann M, Kollnberger S, Kramer H, McGowan S, McHugh K, Taylor S, Kessler B, Bowness P (2009) Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway. Ann Rheum Dis 68(10):1626\u20131632","journal-title":"Ann Rheum Dis"},{"key":"3178_CR38","first-page":"523","volume-title":"Macromolecular symposia","author":"G Aldea","year":"2004","unstructured":"Aldea G, V\u00fdprachtick\u00fd D, Cimrov\u00e1 V (2004) Modification of poly (styrene-alt-maleic anhydride) with 1,3,4-oxadiazole units for electroluminescent devices. Macromolecular symposia. Wiley, Hoboken, pp 523\u2013528"},{"issue":"4","key":"3178_CR39","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/art.33430","volume":"64","author":"N Haroon","year":"2012","unstructured":"Haroon N, Maksymowych WP, Rahman P, Tsui FW, O\u2019Shea FD, Inman RD (2012) Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the spondyloarthritis research consortium of Canada cohort. Arthritis Rheum 64(4):1119\u20131126","journal-title":"Arthritis Rheum"},{"issue":"9","key":"3178_CR40","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00018-011-0662-1","volume":"68","author":"P Endert van","year":"2011","unstructured":"van Endert P (2011) Post-proteasomal and proteasome-independent generation of MHC class I ligands. Cell Mol Life Sci 68(9):1553\u20131567","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"3178_CR41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrg3502","volume":"14","author":"M Parkes","year":"2013","unstructured":"Parkes M, Cortes A, van Heel DA, Brown MA (2013) Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 14(9):661\u2013673","journal-title":"Nat Rev Genet"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-014-3178-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-014-3178-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-014-3178-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T07:28:28Z","timestamp":1559028508000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-014-3178-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,29]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["3178"],"URL":"https:\/\/doi.org\/10.1007\/s00296-014-3178-9","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,29]]}}}