{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:20:03Z","timestamp":1785162003163,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 31260252"],"award-info":[{"award-number":["No. 31260252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Xizang (Tibet) Autonomous Region","award":["2015ZR-13-11"],"award-info":[{"award-number":["2015ZR-13-11"]}]},{"name":"the Social Science Foundation of Chinese Ministry of Education","award":["No. 12YJA850011"],"award-info":[{"award-number":["No. 12YJA850011"]}]},{"name":"the NIH Data Coordination and Integration Center for LINCS-BD2K grant","award":["U54HG008230"],"award-info":[{"award-number":["U54HG008230"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00296-015-3378-y","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T04:30:17Z","timestamp":1444019417000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients"],"prefix":"10.1007","volume":"36","author":[{"given":"Bing","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutu","family":"Jiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longli","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"3378_CR1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.maturitas.2014.05.001","volume":"78","author":"PC Robinson","year":"2014","unstructured":"Robinson PC, Horsburgh S (2014) Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities. Maturitas 78:245\u2013251","journal-title":"Maturitas"},{"key":"3378_CR2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.atherosclerosis.2010.02.041","volume":"213","author":"S Otokozawa","year":"2010","unstructured":"Otokozawa S, Ai M, Asztalos BF, White CC, Demissie-Banjaw S et al (2010) Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol levels and coronary heart disease: results from the Framingham Offspring Study. Atherosclerosis 213:251\u2013255","journal-title":"Atherosclerosis"},{"key":"3378_CR3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/15257770.2013.853785","volume":"33","author":"NM Gonzalez-Senac","year":"2014","unstructured":"Gonzalez-Senac NM, Bailen R, Torres RJ, de Miguel E, Puig JG (2014) Metabolic syndrome in primary gout. Nucleosides Nucleotides Nucleic Acids 33:185\u2013191","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"3378_CR4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4330\/wjc.v2.i12.428","volume":"2","author":"G Novelli","year":"2010","unstructured":"Novelli G, Predazzi IM, Mango R, Romeo F, Mehta JL (2010) Role of genomics in cardiovascular medicine. World J Cardiol 2:428\u2013436","journal-title":"World J Cardiol"},{"key":"3378_CR5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11926-012-0309-8","volume":"15","author":"RL George","year":"2013","unstructured":"George RL, Keenan RT (2013) Genetics of hyperuricemia and gout: implications for the present and future. Curr Rheumatol Rep 15:309","journal-title":"Curr Rheumatol Rep"},{"key":"3378_CR6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","volume":"45","author":"A Koettgen","year":"2013","unstructured":"Koettgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J et al (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 45:145\u2013154","journal-title":"Nat Genet"},{"key":"3378_CR7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ejcb.2012.05.005","volume":"91","author":"P Cervero","year":"2012","unstructured":"Cervero P, Himmel M, Krueger M, Linder S (2012) Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres. Eur J Cell Biol 91:908\u2013922","journal-title":"Eur J Cell Biol"},{"key":"3378_CR8","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1182\/blood-2006-10-055087","volume":"110","author":"BT Kile","year":"2007","unstructured":"Kile BT, Panopoulos AD, Stirzaker RA, Hacking DF, Tahtamouni LH et al (2007) Mutations in the cofilin partner AIP1\/WDR1 cause autoinflammatory disease and macrothrombocytopenia. Blood 110:2371\u20132380","journal-title":"Blood"},{"key":"3378_CR9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.smim.2004.08.018","volume":"16","author":"JN Wu","year":"2004","unstructured":"Wu JN, Koretzky GA (2004) The SLP-76 family of adapter proteins. Semin Immunol 16:379\u2013393","journal-title":"Semin Immunol"},{"key":"3378_CR10","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1128\/MCB.21.18.6102-6112.2001","volume":"21","author":"J Yu","year":"2001","unstructured":"Yu J, Riou C, Davidson D, Minhas R, Robson JD et al (2001) Synergistic regulation of immunoreceptor signaling by SLP-76-related adaptor Clnk and serine\/threonine protein kinase HPK-1. Mol Cell Biol 21:6102\u20136112","journal-title":"Mol Cell Biol"},{"key":"3378_CR11","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1093\/hmg\/ddu227","volume":"23","author":"W-H Wei","year":"2014","unstructured":"Wei W-H, Guo Y, Kindt ASD, Merriman TR, Semple CA et al (2014) Abundant local interactions in the 4p16. 1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid. Hum Mol Genet 23:5061\u20135068","journal-title":"Hum Mol Genet"},{"key":"3378_CR12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00296-015-3215-3","volume":"35","author":"TB Jin","year":"2015","unstructured":"Jin TB, Ren YC, Shi XG, Jiri M, He N et al (2015) Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case\u2013control sample sets. Rheumatol Int 35:1141\u20131147","journal-title":"Rheumatol Int"},{"key":"3378_CR13","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/j.socscimed.2006.06.018","volume":"63","author":"PM Foggin","year":"2006","unstructured":"Foggin PM, Torrance ME, Dorje D, Xuri W, Marc Foggin J et al (2006) Assessment of the health status and risk factors of Kham Tibetan pastoralists in the alpine grasslands of the Tibetan plateau. Soc Sci Med (1982) 63:2512\u20132532","journal-title":"Soc Sci Med (1982)"},{"key":"3378_CR14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/RHU.0b013e3181945b79","volume":"15","author":"A Malik","year":"2009","unstructured":"Malik A, Schumacher HR, Dinnella JE, Clayburne GM (2009) Clinical diagnostic criteria for gout: comparison with the gold standard of synovial fluid crystal analysis. J Clin Rheumatol 15:22\u201324","journal-title":"J Clin Rheumatol"},{"key":"3378_CR15","doi-asserted-by":"crossref","unstructured":"Gabriel S, Ziaugra L, Tabbaa D (2009) SNP genotyping using the Sequenom MassARRAY iPLEX platform. In: Haines JL et al (eds) Current protocols in human genetics\/editorial board, Chapter 2: Unit 2.12\u2013Unit 12.12","DOI":"10.1002\/0471142905.hg0212s60"},{"key":"3378_CR16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/ng1975","volume":"39","author":"RK Thomas","year":"2007","unstructured":"Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T et al (2007) High-throughput oncogene mutation profiling in human cancer. Nat Genet 39:347\u2013351","journal-title":"Nat Genet"},{"key":"3378_CR17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/nbt1209-1135","volume":"27","author":"WS Noble","year":"2009","unstructured":"Noble WS (2009) How does multiple testing correction work? Nat Biotechnol 27:1135\u20131137","journal-title":"Nat Biotechnol"},{"key":"3378_CR18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0002-9343(72)90172-6","volume":"53","author":"E Wiedemann","year":"1972","unstructured":"Wiedemann E, Rose HG, Schwartz E (1972) Plasma lipoproteins, glucose tolerance and insulin response in primary gout. Am J Med 53:299\u2013307","journal-title":"Am J Med"},{"key":"3378_CR19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0026-0495(64)90137-4","volume":"13","author":"J Padova","year":"1964","unstructured":"Padova J, Patchefsky A, Onesti G, Faludi G, Bendersky G (1964) The effect of glucose loads on renal uric acid excretion in diabetic patients. Metabolism 13:507\u2013512","journal-title":"Metabolism"},{"key":"3378_CR20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11926-012-0240-z","volume":"14","author":"MS Lipkowitz","year":"2012","unstructured":"Lipkowitz MS (2012) Regulation of uric acid excretion by the kidney. Curr Rheumatol Rep 14:179\u2013188","journal-title":"Curr Rheumatol Rep"},{"key":"3378_CR21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1515\/cclm-2013-0525","volume":"52","author":"J Dong","year":"2014","unstructured":"Dong J, Yu S, Yang R, Li H, Guo H et al (2014) A simple and precise method for direct measurement of fractional esterification rate of high density lipoprotein cholesterol by high performance liquid chromatography. Clin Chem Lab Med 52:557\u2013564","journal-title":"Clin Chem Lab Med"},{"key":"3378_CR22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bbrc.2004.11.156","volume":"327","author":"T Fujibuchi","year":"2005","unstructured":"Fujibuchi T, Abe Y, Takeuchi T, Imai Y, Kamei Y et al (2005) AIP1\/WDR1 supports mitotic cell rounding. Biochem Biophys Res Commun 327:268\u2013275","journal-title":"Biochem Biophys Res Commun"},{"key":"3378_CR23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/art.11486","volume":"50","author":"R Liu","year":"2004","unstructured":"Liu R, Liote F, Rose DM, Merz D, Terkeltaub R (2004) Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum 50:247\u2013258","journal-title":"Arthritis Rheum"},{"key":"3378_CR24","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.2337\/diabetes.51.12.3505","volume":"51","author":"X Wang","year":"2002","unstructured":"Wang X, Shaw S, Amiri F, Eaton DC, Marrero MB (2002) Inhibition of the Jak\/STAT signaling pathway prevents the high glucose-induced increase in TGF-beta and fibronectin synthesis in mesangial cells. Diabetes 51:3505\u20133509","journal-title":"Diabetes"},{"key":"3378_CR25","doi-asserted-by":"crossref","first-page":"F762","DOI":"10.1152\/ajprenal.00181.2005","volume":"290","author":"MB Marrero","year":"2006","unstructured":"Marrero MB, Banes-Berceli AK, Stern DM, Eaton DC (2006) Role of the JAK\/STAT signaling pathway in diabetic nephropathy. Am J Physiol Renal Physiol 290:F762\u2013F768","journal-title":"Am J Physiol Renal Physiol"},{"key":"3378_CR26","unstructured":"Siniachenko OV, Diadyk AI, Nikolenko IuI, Khomenko MV (1984) Circulating immune complexes in gout. Vrach Delo (9):61\u201363"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-015-3378-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-015-3378-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-015-3378-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T07:28:33Z","timestamp":1559028513000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-015-3378-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["3378"],"URL":"https:\/\/doi.org\/10.1007\/s00296-015-3378-y","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,5]]}}}