{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:19:24Z","timestamp":1786979964120,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00296-015-3400-4","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T04:20:03Z","timestamp":1448684403000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Investigation of the association between Rho\/Rho-kinase gene polymorphisms and systemic sclerosis"],"prefix":"10.1007","volume":"36","author":[{"given":"Yavuz","family":"Pehlivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"Yolbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde Y\u0131ld\u0131r\u0131m","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Alibaz-Oner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonca","family":"Cagatay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Oztuzcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Donmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Ozgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman Serdar","family":"Koca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Nuri","family":"Pamuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sayarl\u0131oglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunyamin","family":"Kisacik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Tuncay","family":"Demiryurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Mesut","family":"Onat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,28]]},"reference":[{"issue":"2 Suppl 65","key":"3400_CR1","first-page":"75","volume":"29","author":"E Romano","year":"2011","unstructured":"Romano E, Manetti M, Guiducci S, Ceccarelli C, Allanore Y, Matucci-Cerinic M (2011) The genetics of systemic sclerosis: an update. Clin Exp Rheumatol 29(2 Suppl 65):75\u201386","journal-title":"Clin Exp Rheumatol"},{"key":"3400_CR2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/cvr\/cvp135","volume":"83","author":"SB Haudek","year":"2009","unstructured":"Haudek SB, Gupta D, Dewald O, Schwartz RJ, Wei L, Trial J et al (2009) Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res 83:511\u2013518","journal-title":"Cardiovasc Res"},{"key":"3400_CR3","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1681\/ASN.2005121375","volume":"17","author":"GP Sun","year":"2006","unstructured":"Sun GP, Kohno M, Guo P, Nagai Y, Miyata K, Fan YY et al (2006) Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury. J Am Soc Nephrol 17:2193\u20132201","journal-title":"J Am Soc Nephrol"},{"key":"3400_CR4","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/j.1743-6109.2010.01816.x","volume":"7","author":"KJ Allahdadi","year":"2010","unstructured":"Allahdadi KJ, Hannan JL, Tostes RC, Webb RC (2010) Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ETA receptor and Rho-kinase activation. J Sex Med 7:2096\u20132103","journal-title":"J Sex Med"},{"key":"3400_CR5","doi-asserted-by":"crossref","first-page":"H608","DOI":"10.1152\/ajpheart.00942.2009","volume":"298","author":"L Tran","year":"2010","unstructured":"Tran L, Kompa AR, Kemp W, Phrommintikul A, Wang BH, Krum H (2010) Chronic urotensin-II infusion induces diastolic dysfunction and enhances collagen production in rats. Am J Physiol Heart Circ Physiol 298:H608\u2013H613","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"Suppl 3","key":"3400_CR6","first-page":"iii33-5","volume":"45","author":"C Sunderk\u00f6tter","year":"2006","unstructured":"Sunderk\u00f6tter C, Riemekasten G (2006) Pathophysiology and clinical consequences of Raynaud\u2019s phenomenon related to systemic sclerosis. Rheumatology (Oxford) 45(Suppl 3):iii33-5","journal-title":"Rheumatology (Oxford)"},{"key":"3400_CR7","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/art.23677","volume":"58","author":"A Akhmetshina","year":"2008","unstructured":"Akhmetshina A, Dees C, Pileckyte M, Szucs G, Spriewald BM, Zwerina J et al (2008) Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts. Arthritis Rheum 58:2553\u20132564","journal-title":"Arthritis Rheum"},{"key":"3400_CR8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","volume":"23","author":"Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","year":"1980","unstructured":"Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23:581\u2013590","journal-title":"Arthritis Rheum"},{"key":"3400_CR9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3899\/jrheum.110509","volume":"39","author":"Y Pehlivan","year":"2011","unstructured":"Pehlivan Y, Gogebakan B, Oztuzcu S, Ozgen M, Cetin GY, Bayraktar R et al (2011) Association between Thr21Met and Ser89Asn polymorphisms of the urotensin II gene and systemic sclerosis. J Rheuomatol 39:106\u2013111","journal-title":"J Rheuomatol"},{"key":"3400_CR10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/art.1780340220","volume":"34","author":"K Yamane","year":"1991","unstructured":"Yamane K, Kashiwagi H, Suzuki N, Miyauchi T, Yanagisawa M, Goto K et al (1991) Elevated plasma levels of endothelin-1 in systemic sclerosis. Arthritis Rheum 34:243\u2013244","journal-title":"Arthritis Rheum"},{"key":"3400_CR11","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/art.1780340807","volume":"34","author":"MB Kahaleh","year":"1991","unstructured":"Kahaleh MB (1991) Endothelin, an endothelial-dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action. Arthritis Rheum 34:978\u2013983","journal-title":"Arthritis Rheum"},{"key":"3400_CR12","doi-asserted-by":"crossref","first-page":"S447","DOI":"10.1097\/00005344-199800001-00128","volume":"31","author":"A Franco-Cereceda","year":"1998","unstructured":"Franco-Cereceda A, Holm P (1998) Selective or nonselective endothelin antagonists in porcine hypoxic pulmonary hypertension? J Cardiovasc Pharmacol 31:S447\u2013S452","journal-title":"J Cardiovasc Pharmacol"},{"key":"3400_CR13","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(01)06250-X","volume":"358","author":"RN Channick","year":"2001","unstructured":"Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF et al (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 358:1119\u20131123","journal-title":"Lancet"},{"key":"3400_CR14","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1002\/art.20676","volume":"50","author":"JH Korn","year":"2004","unstructured":"Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E et al (2004) Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 50:3985\u20133993","journal-title":"Arthritis Rheum"},{"key":"3400_CR15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1164\/ajrccm.156.2.9607123","volume":"156","author":"SH Park","year":"1997","unstructured":"Park SH, Saleh D, Giaid A, Michel RP (1997) Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am J Respir Crit Care Med 156:600\u2013608","journal-title":"Am J Respir Crit Care Med"},{"key":"3400_CR16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.bjp.0703601","volume":"131","author":"JJ Maguire","year":"2000","unstructured":"Maguire JJ, Kuc RE, Davenport AP (2000) Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. Br J Pharmacol 131:441\u2013446","journal-title":"Br J Pharmacol"},{"key":"3400_CR17","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10067-011-1688-3","volume":"30","author":"Y Pehlivan","year":"2011","unstructured":"Pehlivan Y, Onat AM, Comez G, Babacan T (2011) Urotensin-II in systemic sclerosis: a new peptide in pathogenesis. Clin Rheumatol 30:837\u2013842","journal-title":"Clin Rheumatol"},{"key":"3400_CR18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10753-012-9559-x","volume":"36","author":"AM Onat","year":"2013","unstructured":"Onat AM, Pehlivan Y, Turkbeyler IH, Demir T, Kaplan DS, Ceribasi AO et al (2013) Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension. Inflammation 36:405\u2013412","journal-title":"Inflammation"},{"key":"3400_CR19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10753-012-9521-y","volume":"36","author":"T Demir","year":"2013","unstructured":"Demir T, Turkbeyler I, Kaplan DS, Pehlivan Y, Orkmez M, Tutar E et al (2013) Effectiveness of palosuran in bleomycin-induced experimental scleroderma. Inflammation 36:75\u201379","journal-title":"Inflammation"},{"key":"3400_CR20","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s10753-011-9421-6","volume":"35","author":"AM Onat","year":"2012","unstructured":"Onat AM, Turkbeyler IH, Pehlivan Y, Demir T, Kaplan DS, Taysi S et al (2012) The efficiency of a urotensin II antagonist in an experimental lung fibrosis model. Inflammation 35:1138\u20131143","journal-title":"Inflammation"},{"key":"3400_CR21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00004872-200405000-00021","volume":"22","author":"Y Lin","year":"2004","unstructured":"Lin Y, Matsumura K, Tsuchihashi T, Fukuhara M, Fujii K, Iida M (2004) Role of ERK and Rho kinase pathways in central pressor action of urotensin II. J Hypertens 22:983\u2013988","journal-title":"J Hypertens"},{"key":"3400_CR22","first-page":"585","volume":"137","author":"AP Sappino","year":"1990","unstructured":"Sappino AP, Masouy\u00e9 I, Saurat JH, Gabbiani G (1990) Smooth muscle differentiation in scleroderma fibroblastic cells. Am J Pathol 137:585\u2013591","journal-title":"Am J Pathol"},{"key":"3400_CR23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.7705\/biomedica.v23i4.1235","volume":"23","author":"JF Restrepo","year":"2003","unstructured":"Restrepo JF, Guzm\u00e1n R, Rodr\u00edguez G, Iglesias A (2003) Expression of transforming growth factor-beta and platelet-derived growth factor in linear scleroderma. Biomedica 23:408\u2013415","journal-title":"Biomedica"},{"key":"3400_CR24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/1523-1747.ep12613617","volume":"104","author":"Y Ichiki","year":"1995","unstructured":"Ichiki Y, Smith E, LeRoy EC, Trojanowska M (1995) Different effects of basic fibroblast growth factor and transforming growth factor-beta on the two platelet-derived growth factor receptors\u2019 expression in scleroderma and healthy human dermal fibroblasts. J Investig Dermatol 104:124\u2013127","journal-title":"J Investig Dermatol"},{"key":"3400_CR25","doi-asserted-by":"crossref","first-page":"e92242","DOI":"10.1371\/journal.pone.0092242","volume":"9","author":"K Kitano","year":"2014","unstructured":"Kitano K, Usui S, Ootsuji H, Takashima S, Kobayashi D, Murai H et al (2014) Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia\/reperfusion injury. PLoS One 9:e92242","journal-title":"PLoS One"},{"key":"3400_CR26","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1161\/01.CIR.0000127939.16111.58","volume":"109","author":"T Hattori","year":"2004","unstructured":"Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H et al (2004) Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109:2234\u20132239","journal-title":"Circulation"},{"key":"3400_CR27","first-page":"959","volume":"18","author":"XZ Sun","year":"2014","unstructured":"Sun XZ, Tian XY, Wang DW, Li J (2014) Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats. Eur Rev Med Pharmacol Sci 18:959\u2013964","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3400_CR28","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/acr.21622","volume":"64","author":"A Fava","year":"2012","unstructured":"Fava A, Wung PK, Wigley FM, Hummers LK, Daya NR, Ghazarian SR et al (2012) Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud\u2019s phenomenon. Arthritis Care Res (Hoboken) 64:925\u2013929","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-015-3400-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-015-3400-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-015-3400-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T07:28:34Z","timestamp":1559028514000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-015-3400-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,28]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["3400"],"URL":"https:\/\/doi.org\/10.1007\/s00296-015-3400-4","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,28]]}}}