{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:57:12Z","timestamp":1777532232390,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00296-016-3536-x","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T04:49:12Z","timestamp":1469076552000},"page":"1609-1616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum prolidase level in ankylosing spondylitis: low serum levels as a new potential gold standard biomarker for disease activity"],"prefix":"10.1007","volume":"36","author":[{"given":"Sevgi","family":"Baspinar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"K\u0131rnap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Basp\u0131nar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguzhan S\u0131tk\u0131","family":"Dizdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Kocer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"3536_CR1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/978-1-4419-0298-6_8","volume":"649","author":"G Schett","year":"2009","unstructured":"Schett G (2009) Bone formation versus bone resorption in ankylosing spondylitis. Adv Exp Med Biol 649:114\u2013121","journal-title":"Adv Exp Med Biol"},{"key":"3536_CR2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s00198-010-1338-7","volume":"22","author":"S Arends","year":"2011","unstructured":"Arends S, Spoorenberg A, Bruyn GA, Houtman PM, Leijsma MK, Kallenberg CG, Brouwer E, van de Veer E (2011) The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients with active disease: a cross-sectional analysis. Osteoporos Int 22:1431\u20131439","journal-title":"Osteoporos Int"},{"key":"3536_CR3","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the bath ankylosing spondylitis disease activity index. J Rheumatol 21:2286\u20132291","journal-title":"J Rheumatol"},{"key":"3536_CR4","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1136\/ard.2008.100826","volume":"68","author":"D Heijde Van der","year":"2009","unstructured":"Van der Heijde D, Lie E, Kvien TK, Sieper J, Van den Bosch F, Listing J, Braun J, Landew\u00e9 R (2009) ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. Ann Rheum Dis 68:1811\u20131818","journal-title":"Ann Rheum Dis"},{"key":"3536_CR5","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1136\/annrheumdis-2014-205506","volume":"73","author":"MC Turina","year":"2014","unstructured":"Turina MC, Sieper J, Yeremenko N, Conrad K, Haibel H, Rudwaleit M, Baeten D, Poddubnyy D (2014) Calprotectin serum level is an independent marker for radiographic spinal progression in axial spondyloarthritis. Ann Rheum Dis 73:1746\u20131748","journal-title":"Ann Rheum Dis"},{"key":"3536_CR6","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1093\/rheumatology\/ket269","volume":"52","author":"BF Bettencourt","year":"2013","unstructured":"Bettencourt BF, Rocha FL, Alves H, Amorim R, Caetano-Lopes J, Vieira-Sousa E, Pimentel-Santos F, Lima M, Porto G, Branco JC, Fonseca JE, Bruges-Armas J (2013) Protective effect of an ERAP1 haplotype in ankylosing spondylitis: in-vestigating non-MHC genes in HLA-B27-posi-tive individuals. Rheumatology (Oxford) 52:2168\u20132176","journal-title":"Rheumatology (Oxford)"},{"key":"3536_CR7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2613.2006.00486.x","volume":"87","author":"M Cechowska-Pasko","year":"2006","unstructured":"Cechowska-Pasko M, Pa\u0142ka J, Wojtukiewicz MZ (2006) Enhanced prolidase activity and decreased collagen content inbreast cancer tissue. Int J Exp Pathol 87:289\u2013296","journal-title":"Int J Exp Pathol"},{"key":"3536_CR8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcla.20334","volume":"24","author":"M Horoz","year":"2010","unstructured":"Horoz M, Aslan M, Bolukbas FF, Bolukbas C, Nazligul Y, CelikH Aksoy N (2010) Serum prolidase enzyme activity and itsrelation to histopathological findings in patients with non-alcoholicsteatohepatitis. J Clin Lab Anal 24:207\u2013211","journal-title":"J Clin Lab Anal"},{"key":"3536_CR9","first-page":"121","volume":"72","author":"M Wola\u0144ska","year":"2001","unstructured":"Wola\u0144ska M, Sobolewski K, Drozdzewicz M (2001) Integrins and prolidase activity in uterine leiomyoma during tumor growth. Ginekol Pol 72:121\u2013126","journal-title":"Ginekol Pol"},{"key":"3536_CR10","first-page":"320","volume":"30","author":"KS Hui","year":"1978","unstructured":"Hui KS, Lajttia A (1978) Prolidase activity in brain: comparison with other organs. J Neurochem 30:320\u2013327","journal-title":"J Neurochem"},{"key":"3536_CR11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00296-006-0247-8","volume":"27","author":"O Altindag","year":"2007","unstructured":"Altindag O, Erel O, Aksoy N, Selek S, Celik H, Karaoglanoglu M (2007) Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis. Rheumatol Int 27:339\u2013344","journal-title":"Rheumatol Int"},{"key":"3536_CR12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jbspin.2009.07.004","volume":"77","author":"H Marotte","year":"2010","unstructured":"Marotte H, Gineyts E, Miossec P (2010) Prolidase deficiency: a rare aetiology of arthritis. Joint Bone Spine 77:88\u201389","journal-title":"Joint Bone Spine"},{"key":"3536_CR13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4137\/CMAMD.S12602","volume":"6","author":"D U\u00e7ar","year":"2013","unstructured":"U\u00e7ar D, Em S, Bozkurt M, Oktayoglu P, Y\u00fcksel HK, Caglayan M, Gezer O, Nas K (2013) Serum prolidase activity in ankylosing spondylitis and rheumatoid arthritis. Clin Med Insights Arthritis Musculoskelet Disord 6:29\u201333","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"3536_CR14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"SM Linden Van der","year":"1984","unstructured":"Van der Linden SM, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modificationof the New York criteria. Arthritis Rheum 27:361\u2013368","journal-title":"Arthritis Rheum"},{"key":"3536_CR15","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/bmj.315.7118.1273","volume":"315","author":"H Hemingway","year":"1997","unstructured":"Hemingway H, Stafford M, Stansfeld S, Shipley M, Marmot M (1997) Is the\u00a0SF-36\u00a0a valid measure of change in population health? Results from the Whitehall II Study. BMJ 315:1273\u20131279","journal-title":"BMJ"},{"key":"3536_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/ard.2010.138594","volume":"70","author":"P Machado","year":"2011","unstructured":"Machado P, Landew\u00e9 R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D (2011) Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for diseaseactivity states and improvement scores. Ann Rheum Dis 70:47\u201353","journal-title":"Ann Rheum Dis"},{"key":"3536_CR17","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/785705","author":"H Przepiera-Bwdzak","year":"2015","unstructured":"Przepiera-Bwdzak H, Fischer K, Brzosko M (2015) Serum IL-6 and IL-23 levels and their correlation withangiogenic cytokines and disease activity in ankylosing spondylitis, psoriatic arthritis, and SAPHO syndrome. Mediat Inflamm. doi: 10.1155\/2015\/785705","journal-title":"Mediat Inflamm"},{"key":"3536_CR18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/art.24483","volume":"60","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Haibel H, Baraliakos X, Listing J, Marker-Hermann E, Zeidler H, Braun J, Sieper J (2009) The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum 60:717\u2013727","journal-title":"Arthritis Rheum"},{"key":"3536_CR19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/JIM.0000000000000095","volume":"62","author":"P Oktayoglu","year":"2014","unstructured":"Oktayoglu P, Bozkurt M, Mete N, Caglayan M, Em S, Nas K (2014) Elevated serum levels of calprotectin (myeloid-related protein 8\/14) in patients with ankylosing spondylitis and its association with disease activity and quality of life. J Investig Med 62:880\u2013884","journal-title":"J Investig Med"},{"key":"3536_CR20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/03009742.2014.956142","volume":"44","author":"SH Sveaas","year":"2015","unstructured":"Sveaas SH, Berg IJ, Provan SA, Semb AG, Olsen IC, Ueland T, Aukrust P, Vollestad N, Hagen KB, Kvien TK, Dagfinrud H (2015) Circulating levels of inflammatory cytokines and cytokine receptors in patients with ankylosing spondylitis: a cross-sectional comparative study. Scand J Rheumatol 44:118\u2013124","journal-title":"Scand J Rheumatol"},{"key":"3536_CR21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00296-010-1655-3","volume":"32","author":"T Andersen","year":"2012","unstructured":"Andersen T, Rasmussen TK, Hvid M, Holm CK, Madsen KJ, Jurik AG et al (2012) Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings. Rheumatol Int 32:387\u2013393","journal-title":"Rheumatol Int"},{"key":"3536_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/ar3857","volume":"14","author":"DL Mattey","year":"2012","unstructured":"Mattey DL, Packham JC, Nixon NB, Coates L, Creamer P, Hailwood S, Taylor GJ, Bhalla AK (2012) Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Res Ther 14:127","journal-title":"Arthritis Res Ther"},{"key":"3536_CR23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2474-14-99","volume":"14","author":"M Korkosz","year":"2013","unstructured":"Korkosz M, G\u0105sowski J, Leszczy\u0144ski P, Pawlak-Bu\u015b K, Jeka S, Kucharska E, Grodzicki T (2013) High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein-3a signaling but is not linked with greater structural damage. BMC Musculoskelet Disord 14:99","journal-title":"BMC Musculoskelet Disord"},{"key":"3536_CR24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/ard.2007.084426","volume":"68","author":"S Visvanathan","year":"2009","unstructured":"Visvanathan S, van der Heijde D, Deodhar A, Wagner C, Baker DG, Han J et al (2009) Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis. Ann Rheum Dis 68:175\u2013182","journal-title":"Ann Rheum Dis"},{"key":"3536_CR25","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/S0482-50042012000400006","volume":"52","author":"J Londono","year":"2012","unstructured":"Londono J, Romero-Sanchez MC, Torres VG, Bautista WA, Fernandez DJ, Qurioga Jde A et al (2012) The association between serum levels of potential biomarkers withthe presence of factors related to the clinical activity and poorprognosis in spondyloarthritis. Revista Brasileira de Reumatologia 52:536\u2013544","journal-title":"Revista Brasileira de Reumatologia"},{"key":"3536_CR26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10067-008-1011-0","volume":"28","author":"D Wendling","year":"2009","unstructured":"Wendling D, Cedoz JP, Racadot E (2009) Serum and synovialfluid levels of p40 IL12\/23 in spondyloarthropathy patients. Clin Rheumatol 28:187\u2013190","journal-title":"Clin Rheumatol"},{"key":"3536_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2015:617282","author":"R Gao","year":"2015","unstructured":"Gao R, Sun W, Chen Y, Su Y, Wang C, Dong L (2015) Elevated serum levels of soluble CD30 in ankylosing spondylitis patients and its association with disease severity-related parameters. Biomed Res Int. doi: 10.1155\/2015:617282","journal-title":"Biomed Res Int"},{"key":"3536_CR28","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00296-015-3290-5","volume":"35","author":"MA Altay","year":"2015","unstructured":"Altay MA, Ert\u00fcrk C, Bilge A, Yapt\u0131 M, Levent A, Aksoy N (2015) Evaluation of prolidase activity and oxidative status in patients with knee osteoarthritis: relationships with radiographic severity and clinical parameters. Rheumatol Int 35:1725\u20131731","journal-title":"Rheumatol Int"},{"key":"3536_CR29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(02)08215-6","volume":"359","author":"J Braun","year":"2002","unstructured":"Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W et al (2002) Treatment of active ankylosing spondylitis with infliximab: arandomised controlled multicentre trial. Lancet 359:1187\u20131193","journal-title":"Lancet"},{"key":"3536_CR30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/art.21337","volume":"53","author":"WP Maksymowych","year":"2005","unstructured":"Maksymowych WP, Inman RD, Salonen D, Dhillon SS, KrishnananthanR Stone M et al (2005) Spondyloarthritis research consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis. Arthritis Rheum 53:502\u2013509","journal-title":"Arthritis Rheum"},{"key":"3536_CR31","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0889-857X(21)00349-5","volume":"20","author":"VL Star","year":"1994","unstructured":"Star VL, Hochberg MC (1994) Osteoporosis in patients with rheumatic diseases. Rheum Dis Clin North Am 20:561\u2013576","journal-title":"Rheum Dis Clin North Am"},{"key":"3536_CR32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10067-012-2128-8","volume":"32","author":"G Dischereit","year":"2013","unstructured":"Dischereit G, Tarner IH, M\u00fcller-Ladner U, Lange U (2013) Infliximab improves bone metabolism and bone mineral density in rheumatoid arthritis and anky-losing spondylitis: a prospective 2-year study. Clin Rheumatol 32:377\u2013381","journal-title":"Clin Rheumatol"},{"key":"3536_CR33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1179\/1351000213Y.0000000079","volume":"19","author":"M Bozkurt","year":"2014","unstructured":"Bozkurt M, Caglayan M, Oktayoglu P, Em S, Batmaz I, Sariyildiz MA, Nas K, Ucar D, Y\u00fcksel H, Sarac AJ (2014) Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia. Redox Rep 19:148\u2013153","journal-title":"Redox Rep"},{"key":"3536_CR34","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1179\/1351000213Y.0000000072","volume":"19","author":"M Bozkurt","year":"2014","unstructured":"Bozkurt M, Y\u00fcksel H, Em S, Oktayoglu P, Yildiz M, Akdeniz D, Nas K (2014) Serum prolidase enzyme activity and oxidative status in patients with Beh\u00e7et\u2019s disease. Redox Rep 19:59\u201364","journal-title":"Redox Rep"},{"key":"3536_CR35","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1546-0096-10-18","volume":"10","author":"Y Butbul Aviel","year":"2012","unstructured":"Butbul Aviel Y, Mandel H, Avitan Hersh E, Bergman R, Adiv OE, Brik R (2012) Prolidase deficiency asso-ciated with systemic lupus erythematosus (SLE): single site experience and literature review. Pediatr Rheumatol Online J 10:18. doi: 10.1186\/1546-0096-10-18","journal-title":"Pediatr Rheumatol Online J"},{"key":"3536_CR36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00508-014-0534-4","volume":"126","author":"E Savas","year":"2014","unstructured":"Savas E, Aksoy N, Pehlivan Y, Sayiner ZA, Ozt\u00fcrk ZA, Tabur S, Orkmez M, Onat AM (2014) Evaluation of oxidant and antioxidant status and relation with prolidase in systemic sclerosis. Wien Klin Wochenschr 126:341\u2013346","journal-title":"Wien Klin Wochenschr"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-016-3536-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-016-3536-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-016-3536-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T14:32:24Z","timestamp":1656858744000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-016-3536-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["3536"],"URL":"https:\/\/doi.org\/10.1007\/s00296-016-3536-x","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}