{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:28:17Z","timestamp":1792013297341,"version":"4.4.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Czech Ministry of Health Care","award":["IGA NT 13532-4\/2012"],"award-info":[{"award-number":["IGA NT 13532-4\/2012"]}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["PRVOUK 37-08"],"award-info":[{"award-number":["PRVOUK 37-08"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A total of 143 patients (74 with RA, 69 with OA) treated with NSAIDs (&gt;1\u00a0month) and 42 healthy volunteers were included. All subjects underwent capsule endoscopy, laboratory tests and filled in questionnaires. The severity of small bowel injury was graded as: mild (red spots or sporadic erosions), moderate (10\u201320 erosions) or severe (&gt;20 erosions or ulcers). Capsule endoscopy identified small bowel lesions in 44.8\u00a0% of patients (mild 36.4\u00a0%, moderate 3.5\u00a0% and severe in 4.9\u00a0%). Mild non-specific lesions were found in 11.9\u00a0% healthy volunteers. There was a significantly higher prevalence of enteropathy in RA (56.8\u00a0%) compared to OA (31.9\u00a0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). A significant difference between NSAID users (RA and OA) with and without enteropathy was observed in erythrocytes (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), the leucocyte count (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), haemoglobin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), haematocrit (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), serum albumin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and erythrocyte sedimentation rate (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). No relationship was found between enteropathy and dyspepsia, gender or age. NSAID therapy is associated with a significant risk of small bowel injury. The risk is significantly higher in RA patients suggesting a possible influence of the underlying disease.<\/jats:p><jats:p><jats:italic>Trial registration number<\/jats:italic>: DRKS00004940.<\/jats:p>","DOI":"10.1007\/s00296-016-3552-x","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T04:56:01Z","timestamp":1471841761000},"page":"1557-1561","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis"],"prefix":"10.1007","volume":"36","clinical-trial-number":[{"clinical-trial-number":"drks00004940","registry":"10.18810\/drks"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-2651","authenticated-orcid":false,"given":"Ilja","family":"Tachec\u00ed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Bradna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Douda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drahom\u00edra","family":"Ba\u0161teck\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Kop\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Rejchrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lutonsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Soukup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bure\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"issue":"3","key":"3552_CR1","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1053\/gast.2001.21907","volume":"120","author":"L Laine","year":"2001","unstructured":"Laine L (2001) Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient. 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All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its latter amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}