{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:43Z","timestamp":1791412063689,"version":"4.3.3"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00296-017-3826-y","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T01:50:23Z","timestamp":1510019423000},"page":"1847-1858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Determinants of mortality in systemic sclerosis: a focused review"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-719X","authenticated-orcid":false,"given":"Dilli Ram","family":"Poudel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Danve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Tej","family":"Sehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris T.","family":"Derk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"3826_CR1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-140-1-200401060-00010","volume":"140","author":"SA Jimenez","year":"2004","unstructured":"Jimenez SA, Derk CT (2004) Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med 140:37\u201350","journal-title":"Ann Intern Med"},{"key":"3826_CR2","unstructured":"Varga J (2016) Etiology and pathogenesis of scleroderma. In: Kelley Firestein\u2019s textbook of rheumatology, vol 2, 10th edn. Elsevier\/Saunders, Philadelphia"},{"key":"3826_CR3","unstructured":"Wigley FM (2016) Clinical features & treatment of scleroderma. In: Kelley Firestein\u2019s textbook of rheumatology, vol 2, 10th edn. Elsevier\/Saunders, Philadelphia"},{"key":"3826_CR4","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1136\/ard.62.11.1088","volume":"62","author":"D Mukerjee","year":"2003","unstructured":"Mukerjee D, St G, Coleiro B, Knight C, Denton C, Davar J et al (2003) Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 62:1088\u20131093. doi:\n                        10.1136\/ard.62.11.1088","journal-title":"Ann Rheum Dis"},{"key":"3826_CR5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF00371817","volume":"283","author":"T Tamaki","year":"1991","unstructured":"Tamaki T, Mori S, Takehara K (1991) Epidemiological study of patients with systemic sclerosis in Tokyo. Arch Dermatol Res 283:366\u2013371","journal-title":"Arch Dermatol Res"},{"key":"3826_CR6","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/ard.2006.062901","volume":"66","author":"UA Walker","year":"2007","unstructured":"Walker UA, Tyndall A, Czirj\u00e1k L, Denton C, Farge-Bancel D, Kowal-Bielecka O et al (2007) Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann Rheum Dis 66:754\u2013763. doi:\n                        10.1136\/ard.2006.062901","journal-title":"Ann Rheum Dis"},{"key":"3826_CR7","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1002\/art.11073","volume":"48","author":"MD Mayes","year":"2003","unstructured":"Mayes MD, Lacey JV, Beebe-Dimmer J, Gillespie BW, Cooper B, Laing TJ et al (2003) Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum 48:2246\u20132255. doi:\n                        10.1002\/art.11073","journal-title":"Arthritis Rheum"},{"key":"3826_CR8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/art.1780340405","volume":"34","author":"RD Altman","year":"1991","unstructured":"Altman RD, Medsger TA, Bloch DA, Michel BA (1991) Predictors of survival in systemic sclerosis (scleroderma). Arthritis Rheum 34:403\u2013413. doi:\n                        10.1002\/art.1780340405","journal-title":"Arthritis Rheum"},{"key":"3826_CR9","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/ard.2006.066068","volume":"66","author":"VD Steen","year":"2007","unstructured":"Steen VD, Medsger TA (2007) Changes in causes of death in systemic sclerosis, 1972\u20132002. Ann Rheum Dis 66:940\u2013944. doi:\n                        10.1136\/ard.2006.066068","journal-title":"Ann Rheum Dis"},{"key":"3826_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.7326\/0003-4819-75-3-369","volume":"75","author":"TA Medsger","year":"1971","unstructured":"Medsger TA (1971) Survival with systemic sclerosis (scleroderma): a life-table analysis of clinical and demographic factors in 309 patients. Ann Intern Med 75:369. doi:\n                        10.7326\/0003-4819-75-3-369","journal-title":"Ann Intern Med"},{"key":"3826_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/MD.0b013e31829be125","volume":"92","author":"AC Gelber","year":"2013","unstructured":"Gelber AC, Manno RL, Shah AA, Woods A, Le EN, Boin F et al (2013) Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore) 92:191\u2013205. doi:\n                        10.1097\/MD.0b013e31829be125","journal-title":"Medicine (Baltimore)"},{"key":"3826_CR12","doi-asserted-by":"publisher","first-page":"602","DOI":"10.7326\/0003-4819-118-8-199304150-00005","volume":"118","author":"KJ Bulpitt","year":"1993","unstructured":"Bulpitt KJ, Clements PJ, Lachenbruch PA, Paulus HE, Peter JB, Agopian MS et al (1993) Early undifferentiated connective tissue disease: III. Outcome and prognostic indicators in early scleroderma (systemic sclerosis). Ann Intern Med 118:602. doi:\n                        10.7326\/0003-4819-118-8-199304150-00005","journal-title":"Ann Intern Med"},{"key":"3826_CR13","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1002\/1529-0131(199912)42:12<2660::AID-ANR23>3.0.CO;2-N","volume":"42","author":"C Bryan","year":"1999","unstructured":"Bryan C, Knight C, Black CM, Silman AJ (1999) Prediction of five-year survival following presentation with scleroderma: development of a simple model using three disease factors at first visit. Arthritis Rheum 42:2660\u20132665. doi:\n                        10.1002\/1529-0131(199912)42:12<2660:AID-ANR23>3.0.CO;2-N","journal-title":"Arthritis Rheum"},{"key":"3826_CR14","first-page":"2348","volume":"24","author":"SJ Walsh","year":"1997","unstructured":"Walsh SJ, Fenster JR (1997) Geographical clustering of mortality from systemic sclerosis in the Southeastern United States, 1981\u201390. J Rheumatol 24:2348\u20132352","journal-title":"J Rheumatol"},{"key":"3826_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.amjmed.2004.04.031","volume":"118","author":"JPA Ioannidis","year":"2005","unstructured":"Ioannidis JPA, Vlachoyiannopoulos PG, Haidich A-B, Medsger TA, Lucas M, Michet CJ et al (2005) Mortality in systemic sclerosis: an international meta-analysis of individual patient data. Am J Med 118:2\u201310. doi:\n                        10.1016\/j.amjmed.2004.04.031","journal-title":"Am J Med"},{"key":"3826_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.semarthrit.2014.05.010","volume":"44","author":"M Rubio-Rivas","year":"2014","unstructured":"Rubio-Rivas M, Royo C, Sime\u00f3n CP, Corbella X, Fonollosa V (2014) Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum 44:208\u2013219. doi:\n                        10.1016\/j.semarthrit.2014.05.010","journal-title":"Semin Arthritis Rheum"},{"key":"3826_CR17","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/rheumatology\/ker269","volume":"51","author":"M Elhai","year":"2012","unstructured":"Elhai M, Meune C, Avouac J, Kahan A, Allanore Y (2012) Trends in mortality in patients with systemic sclerosis over 40\u00a0years: a systematic review and meta-analysis of cohort studies. Rheumatology 51:1017\u20131026. doi:\n                        10.1093\/rheumatology\/ker269","journal-title":"Rheumatology"},{"key":"3826_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00296-016-3530-3","volume":"37","author":"A Psarras","year":"2017","unstructured":"Psarras A, Soulaidopoulos S, Garyfallos A, Kitas G, Dimitroulas T (2017) A critical view on cardiovascular risk in systemic sclerosis. Rheumatol Int 37:85\u201395. doi:\n                        10.1007\/s00296-016-3530-3","journal-title":"Rheumatol Int"},{"key":"3826_CR19","doi-asserted-by":"publisher","first-page":"e1728","DOI":"10.1097\/MD.0000000000001728","volume":"94","author":"CP Sime\u00f3n-Aznar","year":"2015","unstructured":"Sime\u00f3n-Aznar CP, Fonollosa-Pl\u00e1 V, Tolosa-Vilella C, Espinosa-Garriga G, Campillo-Grau M, Ramos-Casals M et al (2015) Registry of the Spanish network for systemic sclerosis: survival, prognostic factors, and causes of death. Medicine (Baltimore) 94:e1728. doi:\n                        10.1097\/MD.0000000000001728","journal-title":"Medicine (Baltimore)"},{"key":"3826_CR20","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/annrheumdis-2011-200742","volume":"71","author":"FMP Meier","year":"2012","unstructured":"Meier FMP, Frommer KW, Dinser R, Walker UA, Czirjak L, Denton CP et al (2012) Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis 71:1355\u20131360. doi:\n                        10.1136\/annrheumdis-2011-200742","journal-title":"Ann Rheum Dis"},{"key":"3826_CR21","doi-asserted-by":"crossref","first-page":"600","DOI":"10.7326\/0003-4819-133-8-200010170-00010","volume":"133","author":"VD Steen","year":"2000","unstructured":"Steen VD, Medsger TA (2000) Long-term outcomes of scleroderma renal crisis. Ann Intern Med 133:600\u2013603","journal-title":"Ann Intern Med"},{"key":"3826_CR22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/0003-4819-113-5-352","volume":"113","author":"VD Steen","year":"1990","unstructured":"Steen VD, Costantino JP, Shapiro AP, Medsger TA (1990) Outcome of renal crisis in systemic sclerosis: relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann Intern Med 113:352\u2013357","journal-title":"Ann Intern Med"},{"key":"3826_CR23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11926-007-0012-3","volume":"9","author":"F Boin","year":"2007","unstructured":"Boin F, Rosen A (2007) Autoimmunity in systemic sclerosis: current concepts. Curr Rheumatol Rep 9:165\u2013172","journal-title":"Curr Rheumatol Rep"},{"key":"3826_CR24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00005792-198311000-00001","volume":"62","author":"YM Traub","year":"1983","unstructured":"Traub YM, Shapiro AP, Rodnan GP, Medsger TA, McDonald RH, Steen VD et al (1983) Hypertension and renal failure (scleroderma renal crisis) in progressive systemic sclerosis. Review of a 25-year experience with 68 cases. Medicine (Baltimore) 62:335\u2013352","journal-title":"Medicine (Baltimore)"},{"key":"3826_CR25","first-page":"649","volume":"32","author":"VD Steen","year":"2005","unstructured":"Steen VD, Syzd A, Johnson JP, Greenberg A, Medsger TA (2005) Kidney disease other than renal crisis in patients with diffuse scleroderma. J Rheumatol 32:649\u2013655","journal-title":"J Rheumatol"},{"key":"3826_CR26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0002-9343(84)90986-0","volume":"76","author":"VD Steen","year":"1984","unstructured":"Steen VD, Medsger TA, Osial TA, Ziegler GL, Shapiro AP, Rodnan GP (1984) Factors predicting development of renal involvement in progressive systemic sclerosis. Am J Med 76:779\u2013786","journal-title":"Am J Med"},{"key":"3826_CR27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1445-5994.1981.tb03542.x","volume":"11","author":"RJ Eason","year":"1981","unstructured":"Eason RJ, Tan PL, Gow PJ (1981) Progressive systemic sclerosis in Auckland: a ten year review with emphasis on prognostic features. Aust N Z J Med 11:657\u2013662","journal-title":"Aust N Z J Med"},{"key":"3826_CR28","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/qjmed\/hcm052","volume":"100","author":"H Penn","year":"2007","unstructured":"Penn H, Howie AJ, Kingdon EJ, Bunn CC, Stratton RJ, Black CM et al (2007) Scleroderma renal crisis: patient characteristics and long-term outcomes. QJM Mon J Assoc Physicians 100:485\u2013494. doi:\n                        10.1093\/qjmed\/hcm052","journal-title":"QJM Mon J Assoc Physicians"},{"key":"3826_CR29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1136\/ard.2006.066985","volume":"67","author":"L Teixeira","year":"2008","unstructured":"Teixeira L, Mouthon L, Mahr A, Berezn\u00e9 A, Agard C, Mehrenberger M et al (2008) Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients. Ann Rheum Dis 67:110\u2013116. doi:\n                        10.1136\/ard.2006.066985","journal-title":"Ann Rheum Dis"},{"key":"3826_CR30","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/anr.1780320911","volume":"32","author":"DJ Helfrich","year":"1989","unstructured":"Helfrich DJ, Banner B, Steen VD, Medsger TA (1989) Normotensive renal failure in systemic sclerosis. Arthritis Rheum 32:1128\u20131134","journal-title":"Arthritis Rheum"},{"key":"3826_CR31","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1002\/art.10589","volume":"46","author":"PJ DeMarco","year":"2002","unstructured":"DeMarco PJ, Weisman MH, Seibold JR, Furst DE, Wong WK, Hurwitz EL et al (2002) Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose d-penicillamine in early diffuse systemic sclerosis trial. Arthritis Rheum 46:2983\u20132989. doi:\n                        10.1002\/art.10589","journal-title":"Arthritis Rheum"},{"key":"3826_CR32","first-page":"479","volume":"53","author":"K Kohno","year":"2000","unstructured":"Kohno K, Katayama T, Majima K, Fujisawa M, Iida S, Fukami K et al (2000) A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment. Clin Nephrol 53:479\u2013482","journal-title":"Clin Nephrol"},{"key":"3826_CR33","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/1529-0131(199809)41:9<1613::AID-ART11>3.0.CO;2-O","volume":"41","author":"VD Steen","year":"1998","unstructured":"Steen VD, Medsger TA (1998) Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis. Arthritis Rheum 41:1613\u20131619. doi:\n                        10.1002\/1529-0131(199809)41:9<1613:AID-ART11>3.0.CO;2-O","journal-title":"Arthritis Rheum"},{"key":"3826_CR34","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/rheumatology\/ker271","volume":"51","author":"L Guillevin","year":"2012","unstructured":"Guillevin L, B\u00e9rezn\u00e9 A, Seror R, Teixeira L, Pourrat J, Mahr A et al (2012) Scleroderma renal crisis: a retrospective multicentre study on 91 patients and 427 controls. Rheumatol Oxf Engl 51:460\u2013467. doi:\n                        10.1093\/rheumatology\/ker271","journal-title":"Rheumatol Oxf Engl"},{"key":"3826_CR35","first-page":"236","volume":"15","author":"KC Abbott","year":"2002","unstructured":"Abbott KC, Trespalacios FC, Welch PG, Agodoa LYC (2002) Scleroderma at end stage renal disease in the United States: patient characteristics and survival. J Nephrol 15:236\u2013240","journal-title":"J Nephrol"},{"key":"3826_CR36","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1111\/j.1600-6143.2004.00605.x","volume":"4","author":"EM Gibney","year":"2004","unstructured":"Gibney EM, Parikh CR, Jani A, Fischer MJ, Collier D, Wiseman AC (2004) Kidney transplantation for systemic sclerosis improves survival and may modulate disease activity. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg 4:2027\u20132031. doi:\n                        10.1111\/j.1600-6143.2004.00605.x","journal-title":"Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg"},{"key":"3826_CR37","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1002\/art.22965","volume":"56","author":"AE Gliddon","year":"2007","unstructured":"Gliddon AE, Dor\u00e9 CJ, Black CM, McHugh N, Moots R, Denton CP et al (2007) Prevention of vascular damage in scleroderma and autoimmune Raynaud\u2019s phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril. Arthritis Rheum 56:3837\u20133846. doi:\n                        10.1002\/art.22965","journal-title":"Arthritis Rheum"},{"key":"3826_CR38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1586\/1744666X.2016.1115717","volume":"12","author":"MO Becker","year":"2016","unstructured":"Becker MO, Riemekasten G (2016) Risk factors for severity and manifestations in systemic sclerosis and prediction of disease course. Expert Rev Clin Immunol 12:115\u2013135. doi:\n                        10.1586\/1744666X.2016.1115717","journal-title":"Expert Rev Clin Immunol"},{"key":"3826_CR39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00005792-200203000-00004","volume":"81","author":"C Ferri","year":"2002","unstructured":"Ferri C, Valentini G, Cozzi F, Sebastiani M, Michelassi C, La Montagna G et al (2002) Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine (Baltimore) 81:139\u2013153","journal-title":"Medicine (Baltimore)"},{"key":"3826_CR40","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1136\/ard.2009.114264","volume":"69","author":"AJ Tyndall","year":"2010","unstructured":"Tyndall AJ, Bannert B, Vonk M, Air\u00f2 P, Cozzi F, Carreira PE et al (2010) Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 69:1809\u20131815. doi:\n                        10.1136\/ard.2009.114264","journal-title":"Ann Rheum Dis"},{"key":"3826_CR41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0049-0172(89)90032-2","volume":"19","author":"DL Janosik","year":"1989","unstructured":"Janosik DL, Osborn TG, Moore TL, Shah DG, Kenney RG, Zuckner J (1989) Heart disease in systemic sclerosis. Semin Arthritis Rheum 19:191\u2013200","journal-title":"Semin Arthritis Rheum"},{"key":"3826_CR42","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/ard.2008.103382","volume":"69","author":"Y Allanore","year":"2010","unstructured":"Allanore Y, Meune C, Vonk MC, Airo P, Hachulla E, Caramaschi P et al (2010) Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis. Ann Rheum Dis 69:218\u2013221. doi:\n                        10.1136\/ard.2008.103382","journal-title":"Ann Rheum Dis"},{"key":"3826_CR43","first-page":"S48","volume":"28","author":"Y Allanore","year":"2010","unstructured":"Allanore Y, Meune C (2010) Primary myocardial involvement in systemic sclerosis: evidence for a microvascular origin. Clin Exp Rheumatol 28:S48\u2013S53","journal-title":"Clin Exp Rheumatol"},{"key":"3826_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.acvd.2009.06.009","volume":"103","author":"C Meune","year":"2010","unstructured":"Meune C, Vignaux O, Kahan A, Allanore Y (2010) Heart involvement in systemic sclerosis: evolving concept and diagnostic methodologies. Arch Cardiovasc Dis 103:46\u201352. doi:\n                        10.1016\/j.acvd.2009.06.009","journal-title":"Arch Cardiovasc Dis"},{"key":"3826_CR45","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1002\/art.22747","volume":"56","author":"A Perera","year":"2007","unstructured":"Perera A, Fertig N, Lucas M, Rodriguez-Reyna TS, Hu P, Steen VD et al (2007) Clinical subsets, skin thickness progression rate, and serum antibody levels in systemic sclerosis patients with anti-topoisomerase I antibody. Arthritis Rheum 56:2740\u20132746. doi:\n                        10.1002\/art.22747","journal-title":"Arthritis Rheum"},{"key":"3826_CR46","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/art.23463","volume":"58","author":"C Meune","year":"2008","unstructured":"Meune C, Avouac J, Wahbi K, Cabanes L, Wipff J, Mouthon L et al (2008) Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: a controlled study of 100 consecutive patients. Arthritis Rheum 58:1803\u20131809. doi:\n                        10.1002\/art.23463","journal-title":"Arthritis Rheum"},{"key":"3826_CR47","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1136\/ard.2006.057760","volume":"67","author":"P Groote de","year":"2008","unstructured":"de Groote P, Gressin V, Hachulla E, Carpentier P, Guillevin L, Kahan A et al (2008) Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis. Ann Rheum Dis 67:31\u201336. doi:\n                        10.1136\/ard.2006.057760","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 4","key":"3826_CR48","doi-asserted-by":"publisher","first-page":"iv14","DOI":"10.1093\/rheumatology\/kel312","volume":"45","author":"A Kahan","year":"2006","unstructured":"Kahan A, Allanore Y (2006) Primary myocardial involvement in systemic sclerosis. Rheumatol Oxf Engl 45(Suppl 4):iv14\u2013iv17. doi:\n                        10.1093\/rheumatology\/kel312","journal-title":"Rheumatol Oxf Engl"},{"key":"3826_CR49","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.euje.2005.01.002","volume":"6","author":"A D\u2019Andrea","year":"2005","unstructured":"D\u2019Andrea A, Stisi S, Bellissimo S, Vigorito F, Scotto di Uccio F, Tozzi N et al (2005) Early impairment of myocardial function in systemic sclerosis: non-invasive assessment by Doppler myocardial and strain rate imaging. Eur J Echocardiogr J Work Group Echocardiogr Eur Soc Cardiol 6:407\u2013418. doi:\n                        10.1016\/j.euje.2005.01.002","journal-title":"Eur J Echocardiogr J Work Group Echocardiogr Eur Soc Cardiol"},{"key":"3826_CR50","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/art.10775","volume":"48","author":"V Steen","year":"2003","unstructured":"Steen V, Medsger TA (2003) Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement. Arthritis Rheum 48:516\u2013522. doi:\n                        10.1002\/art.10775","journal-title":"Arthritis Rheum"},{"key":"3826_CR51","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.amjmed.2013.06.025","volume":"126","author":"S-Y Chu","year":"2013","unstructured":"Chu S-Y, Chen Y-J, Liu C-J, Tseng W-C, Lin M-W, Hwang C-Y et al (2013) Increased risk of acute myocardial infarction in systemic sclerosis: a nationwide population-based study. Am J Med 126:982\u2013988. doi:\n                        10.1016\/j.amjmed.2013.06.025","journal-title":"Am J Med"},{"key":"3826_CR52","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1186\/ar4267","volume":"15","author":"A Nordin","year":"2013","unstructured":"Nordin A, Jensen-Urstad K, Bj\u00f6rn\u00e5dal L, Pettersson S, Larsson A, Svenungsson E (2013) Ischemic arterial events and atherosclerosis in patients with systemic sclerosis: a population-based case\u2013control study. Arthritis Res Ther 15:R87. doi:\n                        10.1186\/ar4267","journal-title":"Arthritis Res Ther"},{"key":"3826_CR53","doi-asserted-by":"publisher","first-page":"OD16","DOI":"10.7860\/JCDR\/2016\/18781.8032","volume":"10","author":"MR Kotnur","year":"2016","unstructured":"Kotnur MR, Suresh P, Reddy VSP, Sharma T, Salim NA (2016) Systemic sclerosis with multiple pulmonary manifestations. J Clin Diagn Res JCDR 10:OD16\u2013OD17. doi:\n                        10.7860\/JCDR\/2016\/18781.8032","journal-title":"J Clin Diagn Res JCDR"},{"key":"3826_CR54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0954-6111(96)90291-7","volume":"90","author":"GC Kane","year":"1996","unstructured":"Kane GC, Varga J, Conant EF, Spirn PW, Jimenez S, Fish JE (1996) Lung involvement in systemic sclerosis (scleroderma): relation to classification based on extent of skin involvement or autoantibody status. Respir Med 90:223\u2013230","journal-title":"Respir Med"},{"key":"3826_CR55","doi-asserted-by":"publisher","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","volume":"62","author":"MM Hoeper","year":"2013","unstructured":"Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M et al (2013) Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 62:D42\u2013D50. doi:\n                        10.1016\/j.jacc.2013.10.032","journal-title":"J Am Coll Cardiol"},{"key":"3826_CR56","doi-asserted-by":"publisher","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","volume":"62","author":"G Simonneau","year":"2013","unstructured":"Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A et al (2013) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 62:D34\u2013D41. doi:\n                        10.1016\/j.jacc.2013.10.029","journal-title":"J Am Coll Cardiol"},{"key":"3826_CR57","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1007\/s10067-013-2307-2","volume":"32","author":"X Yang","year":"2013","unstructured":"Yang X, Mardekian J, Sanders KN, Mychaskiw MA, Thomas J (2013) Prevalence of pulmonary arterial hypertension in patients with connective tissue diseases: a systematic review of the literature. Clin Rheumatol 32:1519\u20131531. doi:\n                        10.1007\/s10067-013-2307-2","journal-title":"Clin Rheumatol"},{"key":"3826_CR58","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/acr.22121","volume":"66","author":"L Chung","year":"2014","unstructured":"Chung L, Domsic RT, Lingala B, Alkassab F, Bolster M, Csuka ME et al (2014) Survival and predictors of mortality in systemic sclerosis-associated pulmonary arterial hypertension: outcomes from the pulmonary hypertension assessment and recognition of outcomes in scleroderma registry. Arthritis Care Res 66:489\u2013495. doi:\n                        10.1002\/acr.22121","journal-title":"Arthritis Care Res"},{"key":"3826_CR59","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1002\/art.38029","volume":"65","author":"G Lef\u00e8vre","year":"2013","unstructured":"Lef\u00e8vre G, Dauchet L, Hachulla E, Montani D, Sobanski V, Lambert M et al (2013) Survival and prognostic factors in systemic sclerosis-associated pulmonary hypertension: a systematic review and meta-analysis. Arthritis Rheum 65:2412\u20132423. doi:\n                        10.1002\/art.38029","journal-title":"Arthritis Rheum"},{"key":"3826_CR60","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/art.24267","volume":"60","author":"SC Mathai","year":"2009","unstructured":"Mathai SC, Hummers LK, Champion HC, Wigley FM, Zaiman A, Hassoun PM et al (2009) Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis Rheum 60:569\u2013577. doi:\n                        10.1002\/art.24267","journal-title":"Arthritis Rheum"},{"key":"3826_CR61","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1378\/chest.123.2.344","volume":"123","author":"SM Kawut","year":"2003","unstructured":"Kawut SM, Taichman DB, Archer-Chicko CL, Palevsky HI, Kimmel SE (2003) Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis. Chest 123:344\u2013350","journal-title":"Chest"},{"key":"3826_CR62","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1002\/art.22069","volume":"54","author":"MR Fisher","year":"2006","unstructured":"Fisher MR, Mathai SC, Champion HC, Girgis RE, Housten-Harris T, Hummers L et al (2006) Clinical differences between idiopathic and scleroderma-related pulmonary hypertension. Arthritis Rheum 54:3043\u20133050. doi:\n                        10.1002\/art.22069","journal-title":"Arthritis Rheum"},{"key":"3826_CR63","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10067-016-3504-6","volume":"36","author":"M Michelfelder","year":"2017","unstructured":"Michelfelder M, Becker M, Riedlinger A, Siegert E, Dr\u00f6mann D, Yu X et al (2017) Interstitial lung disease increases mortality in systemic sclerosis patients with pulmonary arterial hypertension without affecting hemodynamics and exercise capacity. Clin Rheumatol 36:381\u2013390. doi:\n                        10.1007\/s10067-016-3504-6","journal-title":"Clin Rheumatol"},{"key":"3826_CR64","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1378\/chest.06-2568","volume":"132","author":"CJ Scotton","year":"2007","unstructured":"Scotton CJ, Chambers RC (2007) Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132:1311\u20131321. doi:\n                        10.1378\/chest.06-2568","journal-title":"Chest"},{"key":"3826_CR65","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1164\/ajrccm\/151.3_Pt_1.915","volume":"151","author":"GW Hunninghake","year":"1995","unstructured":"Hunninghake GW, Kalica AR (1995) Approaches to the treatment of pulmonary fibrosis. Am J Respir Crit Care Med 151:915\u2013918. doi:\n                        10.1164\/ajrccm\/151.3_Pt_1.915","journal-title":"Am J Respir Crit Care Med"},{"key":"3826_CR66","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/S2213-2600(16)30152-7","volume":"4","author":"DP Tashkin","year":"2016","unstructured":"Tashkin DP, Roth MD, Clements PJ, Furst DE, Khanna D, Kleerup EC et al (2016) Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. Lancet Respir Med 4:708\u2013719. doi:\n                        10.1016\/S2213-2600(16)30152-7","journal-title":"Lancet Respir Med"},{"key":"3826_CR67","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1056\/NEJMoa055120","volume":"354","author":"DP Tashkin","year":"2006","unstructured":"Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE et al (2006) Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 354:2655\u20132666. doi:\n                        10.1056\/NEJMoa055120","journal-title":"N Engl J Med"},{"key":"3826_CR68","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1002\/art.22580","volume":"56","author":"D Khanna","year":"2007","unstructured":"Khanna D, Yan X, Tashkin DP, Furst DE, Elashoff R, Roth MD et al (2007) Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study. Arthritis Rheum 56:1676\u20131684. doi:\n                        10.1002\/art.22580","journal-title":"Arthritis Rheum"},{"key":"3826_CR69","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1164\/rccm.200705-655OC","volume":"177","author":"C Strange","year":"2008","unstructured":"Strange C, Bolster MB, Roth MD, Silver RM, Theodore A, Goldin J et al (2008) Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease. Am J Respir Crit Care Med 177:91\u201398. doi:\n                        10.1164\/rccm.200705-655OC","journal-title":"Am J Respir Crit Care Med"},{"key":"3826_CR70","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMoa1103690","volume":"365","author":"L Richeldi","year":"2011","unstructured":"Richeldi L, Costabel U, Selman M, Kim DS, Hansell DM, Nicholson AG et al (2011) Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med 365:1079\u20131087. doi:\n                        10.1056\/NEJMoa1103690","journal-title":"N Engl J Med"},{"key":"3826_CR71","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.rdc.2015.04.007","volume":"41","author":"G Gyger","year":"2015","unstructured":"Gyger G, Baron M (2015) Systemic sclerosis: gastrointestinal disease and its management. Rheum Dis Clin N Am 41:459\u2013473. doi:\n                        10.1016\/j.rdc.2015.04.007","journal-title":"Rheum Dis Clin N Am"},{"key":"3826_CR72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00000441-197303000-00002","volume":"265","author":"R Turner","year":"1973","unstructured":"Turner R, Lipshutz W, Miller W, Rittenberg G, Schumacher HR, Cohen S (1973) Esophageal dysfunction in collagen disease. Am J Med Sci 265:191\u2013199","journal-title":"Am J Med Sci"},{"key":"3826_CR73","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/rheumatology\/28.4.281","volume":"28","author":"A Akesson","year":"1989","unstructured":"Akesson A, Wollheim FA (1989) Organ manifestations in 100 patients with progressive systemic sclerosis: a comparison between the CREST syndrome and diffuse scleroderma. Br J Rheumatol 28:281\u2013286","journal-title":"Br J Rheumatol"},{"key":"3826_CR74","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1136\/ard.2009.123273","volume":"69","author":"L Krause","year":"2010","unstructured":"Krause L, Becker MO, Brueckner CS, Bellinghausen C-J, Becker C, Schneider U et al (2010) Nutritional status as marker for disease activity and severity predicting mortality in patients with systemic sclerosis. Ann Rheum Dis 69:1951\u20131957. doi:\n                        10.1136\/ard.2009.123273","journal-title":"Ann Rheum Dis"},{"key":"3826_CR75","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3899\/jrheum.131547","volume":"41","author":"C Mecoli","year":"2014","unstructured":"Mecoli C, Purohit S, Sandorfi N, Derk CT (2014) Mortality, recurrence, and hospital course of patients with systemic sclerosis-related acute intestinal pseudo-obstruction. J Rheumatol 41:2049\u20132054. doi:\n                        10.3899\/jrheum.131547","journal-title":"J Rheumatol"},{"key":"3826_CR76","first-page":"1113","volume":"33","author":"CT Derk","year":"2006","unstructured":"Derk CT, Rasheed M, Artlett CM, Jimenez SA (2006) A cohort study of cancer incidence in systemic sclerosis. J Rheumatol 33:1113\u20131116","journal-title":"J Rheumatol"},{"key":"3826_CR77","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/ard.52.7.531","volume":"52","author":"AK Rosenthal","year":"1993","unstructured":"Rosenthal AK, McLaughlin JK, Linet MS, Persson I (1993) Scleroderma and malignancy: an epidemiological study. Ann Rheum Dis 52:531\u2013533","journal-title":"Ann Rheum Dis"},{"key":"3826_CR78","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/j.1365-2133.2010.09861.x","volume":"163","author":"AB Olesen","year":"2010","unstructured":"Olesen AB, Svaerke C, Farkas DK, S\u00f8rensen HT (2010) Systemic sclerosis and the risk of cancer: a nationwide population-based cohort study. Br J Dermatol 163:800\u2013806. doi:\n                        10.1111\/j.1365-2133.2010.09861.x","journal-title":"Br J Dermatol"},{"key":"3826_CR79","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/ard.2006.056424","volume":"66","author":"EK Pontifex","year":"2007","unstructured":"Pontifex EK, Hill CL, Roberts-Thomson P (2007) Risk factors for lung cancer in patients with scleroderma: a nested case-control study. Ann Rheum Dis 66:551\u2013553. doi:\n                        10.1136\/ard.2006.056424","journal-title":"Ann Rheum Dis"},{"key":"3826_CR80","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1136\/ard.2009.127621","volume":"70","author":"RT Domsic","year":"2011","unstructured":"Domsic RT, Rodriguez-Reyna T, Lucas M, Fertig N, Medsger TA (2011) Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma. Ann Rheum Dis 70:104\u2013109. doi:\n                        10.1136\/ard.2009.127621","journal-title":"Ann Rheum Dis"},{"key":"3826_CR81","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s10067-013-2289-0","volume":"32","author":"G Strickland","year":"2013","unstructured":"Strickland G, Pauling J, Cavill C, Shaddick G, McHugh N (2013) Mortality in systemic sclerosis-a single centre study from the UK. Clin Rheumatol 32:1533\u20131539. doi:\n                        10.1007\/s10067-013-2289-0","journal-title":"Clin Rheumatol"},{"key":"3826_CR82","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrneph.2016.124","volume":"12","author":"TG Woodworth","year":"2016","unstructured":"Woodworth TG, Suliman YA, Furst DE, Clements P (2016) Scleroderma renal crisis and renal involvement in systemic sclerosis. Nat Rev Nephrol 12:678\u2013691. doi:\n                        10.1038\/nrneph.2016.124","journal-title":"Nat Rev Nephrol"},{"key":"3826_CR83","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.semarthrit.2008.06.002","volume":"39","author":"FF Al-Dhaher","year":"2010","unstructured":"Al-Dhaher FF, Pope JE, Ouimet JM (2010) Determinants of morbidity and mortality of systemic sclerosis in Canada. Semin Arthritis Rheum 39:269\u2013277. doi:\n                        10.1016\/j.semarthrit.2008.06.002","journal-title":"Semin Arthritis Rheum"},{"key":"3826_CR84","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/MD.0000000000000018","volume":"93","author":"MA Alba","year":"2014","unstructured":"Alba MA, Velasco C, Sime\u00f3n CP, Fonollosa V, Trapiella L, Egurbide MV et al (2014) Early- versus late-onset systemic sclerosis: differences in clinical presentation and outcome in 1037 patients. Medicine (Baltimore) 93:73\u201381. doi:\n                        10.1097\/MD.0000000000000018","journal-title":"Medicine (Baltimore)"},{"key":"3826_CR85","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00296-015-3382-2","volume":"37","author":"A Fern\u00e1ndez-Codina","year":"2017","unstructured":"Fern\u00e1ndez-Codina A, Sime\u00f3n-Aznar CP, Pinal-Fernandez I, Rodr\u00edguez-Palomares J, Pizzi MN, Hidalgo CE et al (2017) Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival. Rheumatol Int 37:75\u201384. doi:\n                        10.1007\/s00296-015-3382-2","journal-title":"Rheumatol Int"},{"key":"3826_CR86","doi-asserted-by":"publisher","DOI":"10.1002\/art.40027","author":"Y Hao","year":"2016","unstructured":"Hao Y, Hudson M, Baron M, Carreira P, Stevens W, Rabusa C et al (2016) Early mortality in a multinational systemic sclerosis inception cohort. Arthritis Rheumatol Hoboken NJ. doi:\n                        10.1002\/art.40027","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"key":"3826_CR87","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/art.38390","volume":"66","author":"SI Nihtyanova","year":"2014","unstructured":"Nihtyanova SI, Schreiber BE, Ong VH, Rosenberg D, Moinzadeh P, Coghlan JG et al (2014) Prediction of pulmonary complications and long-term survival in systemic sclerosis: pulmonary complications and survival in SSc. Arthritis Rheumatol 66:1625\u20131635. doi:\n                        10.1002\/art.38390","journal-title":"Arthritis Rheumatol"},{"key":"3826_CR88","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/art.38381","volume":"66","author":"RT Domsic","year":"2014","unstructured":"Domsic RT, Nihtyanova SI, Wisniewski SR, Fine MJ, Lucas M, Kwoh CK et al (2014) Derivation and validation of a prediction rule for two year mortality in early diffuse cutaneous systemic sclerosis. Arthritis Rheumatol Hoboken NJ 66:1616\u20131624. doi:\n                        10.1002\/art.38381","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"key":"3826_CR89","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1093\/rheumatology\/ken488","volume":"48","author":"E Hachulla","year":"2009","unstructured":"Hachulla E, Carpentier P, Gressin V, Diot E, Allanore Y, Sibilia J et al (2009) Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French Itin\u00e9rAIR-Scl\u00e9rodermie study. Rheumatology 48:304\u2013308. doi:\n                        10.1093\/rheumatology\/ken488","journal-title":"Rheumatology"},{"key":"3826_CR90","first-page":"2031","volume":"28","author":"PJ Nietert","year":"2001","unstructured":"Nietert PJ, Silverstein MD, Silver RM (2001) Hospital admissions, length of stay, charges, and in-hospital death among patients with systemic sclerosis. J Rheumatol 28:2031\u20132037","journal-title":"J Rheumatol"},{"key":"3826_CR91","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/rheumatology\/ker357","volume":"51","author":"A Kom\u00f3csi","year":"2012","unstructured":"Kom\u00f3csi A, Vorobcsuk A, Faludi R, Pint\u00e9r T, Lenkey Z, K\u00f6lto G et al (2012) The impact of cardiopulmonary manifestations on the mortality of SSc: a systematic review and meta-analysis of observational studies. Rheumatol Oxf Engl 51:1027\u20131036. doi:\n                        10.1093\/rheumatology\/ker357","journal-title":"Rheumatol Oxf Engl"},{"key":"3826_CR92","first-page":"S30","volume":"30","author":"M Hinchcliff","year":"2012","unstructured":"Hinchcliff M, Desai CS, Varga J, Shah SJ (2012) Prevalence, prognosis, and factors associated with left ventricular diastolic dysfunction in systemic sclerosis. Clin Exp Rheumatol 30:S30\u2013S37","journal-title":"Clin Exp Rheumatol"},{"key":"3826_CR93","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1002\/art.24734","volume":"61","author":"S Assassi","year":"2009","unstructured":"Assassi S, del Junco D, Sutter K, McNearney TA, Reveille JD, Karnavas A et al (2009) Clinical and genetic factors predictive of mortality in early systemic sclerosis. Arthritis Care Res 61:1403\u20131411. doi:\n                        10.1002\/art.24734","journal-title":"Arthritis Care Res"},{"key":"3826_CR94","doi-asserted-by":"publisher","first-page":"e78808","DOI":"10.1371\/journal.pone.0078808","volume":"8","author":"HT Draeger","year":"2013","unstructured":"Draeger HT, Assassi S, Sharif R, Gonzalez EB, Harper BE, Arnett FC et al (2013) Right bundle branch block: a predictor of mortality in early systemic sclerosis. PLoS One 8:e78808. doi:\n                        10.1371\/journal.pone.0078808","journal-title":"PLoS One"},{"key":"3826_CR95","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1136\/ard.2006.066340","volume":"67","author":"L Czirjak","year":"2008","unstructured":"Czirjak L, Kumanovics G, Varju C, Nagy Z, Pakozdi A, Szekanecz Z et al (2008) Survival and causes of death in 366 Hungarian patients with systemic sclerosis. Ann Rheum Dis 67:59\u201363. doi:\n                        10.1136\/ard.2006.066340","journal-title":"Ann Rheum Dis"},{"key":"3826_CR96","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s10067-016-3245-6","volume":"35","author":"ST Sehra","year":"2016","unstructured":"Sehra ST, Kelly A, Baker JF, Derk CT (2016) Predictors of inpatient mortality in patients with systemic sclerosis: a case control study. Clin Rheumatol 35:1631\u20131635. doi:\n                        10.1007\/s10067-016-3245-6","journal-title":"Clin Rheumatol"},{"key":"3826_CR97","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1093\/rheumatology\/kem273","volume":"46","author":"L Chung","year":"2007","unstructured":"Chung L, Krishnan E, Chakravarty EF (2007) Hospitalizations and mortality in systemic sclerosis: results from the Nationwide Inpatient Sample. Rheumatol Oxf Engl 46:1808\u20131813. doi:\n                        10.1093\/rheumatology\/kem273","journal-title":"Rheumatol Oxf Engl"},{"key":"3826_CR98","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.semarthrit.2013.09.008","volume":"43","author":"M Hudson","year":"2014","unstructured":"Hudson M, Baron M, Tatibouet S, Furst DE, Khanna D (2014) International scleroderma renal crisis study investigators. Exposure to ACE inhibitors prior to the onset of scleroderma renal crisis-results from the international scleroderma renal crisis survey. Semin Arthritis Rheum 43:666\u2013672. doi:\n                        10.1016\/j.semarthrit.2013.09.008","journal-title":"Semin Arthritis Rheum"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-017-3826-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-017-3826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-017-3826-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T01:39:39Z","timestamp":1536629979000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-017-3826-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":98,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["3826"],"URL":"https:\/\/doi.org\/10.1007\/s00296-017-3826-y","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}