{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:28:12Z","timestamp":1765888092807},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00296-018-04237-w","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T09:29:40Z","timestamp":1546421380000},"page":"517-523","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of long-term treatment with intravenous colchicine for familial Mediterranean fever (FMF) refractory to oral colchicine"],"prefix":"10.1007","volume":"39","author":[{"given":"Chagai","family":"Grossman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Farberov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Feld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Livneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Ben-Zvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"4237_CR1","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s10067-017-3715-5","volume":"36","author":"M Alghamadi","year":"2017","unstructured":"Alghamadi M (2017) Familial Mediterranean fever, review of the literature. Clin Rheumatol 36:1707\u20131713","journal-title":"Clin Rheumatol"},{"key":"4237_CR2","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/art.24458","volume":"61","author":"E Ben-Chetrit","year":"2009","unstructured":"Ben-Chetrit E, Touitou I (2009) Familial Mediterranean fever in the world. Arthritis Rheum 61:1447\u20131453","journal-title":"Arthritis Rheum"},{"key":"4237_CR3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/00005792-199807000-00005","volume":"77","author":"J Samuels","year":"1998","unstructured":"Samuels J, Aksentijevich I, Torosyan Y, Centola M, Deng Z, Sood R, Kastner DL (1998) Familial Mediterranean fever at the millennium. Clinical spectrum, ancient mutations, and a survey of 100 American referrals to the National Institutes of Health. Medicine 77:268\u2013297","journal-title":"Medicine"},{"key":"4237_CR4","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/j.1468-3083.2011.04442.x","volume":"27","author":"M Lidar","year":"2013","unstructured":"Lidar M, Doron A, Barzilai A, Feld O, Zaks N, Livneh A, Langevitz P (2013) Erysipelas-like erythema as the presenting feature of familial Mediterranean fever. J Eur Acad Dermatol Venrereol 27:912\u2013915","journal-title":"J Eur Acad Dermatol Venrereol"},{"key":"4237_CR5","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1136\/annrheumdis-2015-208690","volume":"75","author":"S Ozen","year":"2016","unstructured":"Ozen S, Demirkaya E, Erer B, Livneh A, Ben-Chetrit E, Giancane G, Ozdogan H, Abu I, Gattorno M, Hawkins PN, Yuce S, Kallinich T, Bilginer Y, Kastner D, Carmona L (2016) EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis 75:644\u2013651","journal-title":"Ann Rheum Dis"},{"key":"4237_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13075-016-0980-7","volume":"18","author":"A Polat","year":"2016","unstructured":"Polat A, Acikel C, Sozeri B, Dursun I, Kasapcopur O, Gulez N, Simsek D, Saldir M, Dokurel I, Poyrazoglu H, Bakkaloglu S, Delibas A, Ekinci Z, Ayaz NA, Kandur Y, Peru H, Kurt YG, Polat SR, Unsal E, Makay B, Gok F, Ozen S, Demirkaya E, FMF Arthritis Vasculitis and Orphan Disease Research in Pediatric Rheumatology (FAVOR) (2016) Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever\u2014a randomized controlled noninferiority trial. Arthritis Res Ther 18:85","journal-title":"Arthritis Res Ther"},{"key":"4237_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.2174\/0929867323666151117121706","volume":"23","author":"P Portincasa","year":"2016","unstructured":"Portincasa P (2016) Colchicine, biologic agents and more for the treatment of familial mediterranean fever. The old, the new, and the rare. Curr Med Chem 23:60\u201386","journal-title":"Curr Med Chem"},{"key":"4237_CR8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0049-0172(91)90019-V","volume":"20","author":"E Ben-Chetrit","year":"1991","unstructured":"Ben-Chetrit E, Levy M (1991) Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum 20:241\u2013246","journal-title":"Semin Arthritis Rheum"},{"key":"4237_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1053\/S0049-0172(03)00137-9","volume":"33","author":"M Lidar","year":"2004","unstructured":"Lidar M, Scherrmann JM, Shinar Y, Chetrit A, Niel E, Gershoni-Baruch R, Langevitz P, Livneh A (2004) Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization. Semin Arthritis Rheum 33:273\u2013282","journal-title":"Semin Arthritis Rheum"},{"key":"4237_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.semarthrit.2013.04.011","volume":"43","author":"V Hentgen","year":"2013","unstructured":"Hentgen V, Grateau G, Kone-Paut I, Livneh A, Padeh S, Rozenbaum M, Amselem S, Gershoni-Baruch R, Touitou I, Ben-Chetrit E (2013) Evidence-based recommendations for the practical management of Familial Mediterranean Fever. Semin Arthritis Rheum 43:387\u2013391","journal-title":"Semin Arthritis Rheum"},{"key":"4237_CR11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jbspin.2006.03.006","volume":"73","author":"E Niel","year":"2006","unstructured":"Niel E, Scherrmann JM (2006) Colchicine today. Jt Bone Spine 73:672\u2013678","journal-title":"Jt Bone Spine"},{"key":"4237_CR12","first-page":"1540","volume":"34","author":"A Tufan","year":"2007","unstructured":"Tufan A, Babaoglu MO, Akdogan A, Yasar U, Calguneri M, Kalyoncu U, Karadag O, Hayran M, Ertenli AI, Bozkurt A, Kiraz S (2007) Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. J Rheumatol 34:1540\u20131544","journal-title":"J Rheumatol"},{"key":"4237_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10753-014-0004-1","volume":"38","author":"P Cetin","year":"2015","unstructured":"Cetin P, Sari I, Sozeri B, Cam O, Birlik M, Akkoc N, Onen F, Akar S (2015) Efficacy of interleukin-1 targeting treatments in patients with familial mediterranean Fever. Inflammation 38:27\u201331","journal-title":"Inflammation"},{"key":"4237_CR14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3109\/14397595.2014.987437","volume":"25","author":"O Basaran","year":"2015","unstructured":"Basaran O, Uncu N, Celikel BA, Taktak A, Gur G, Cakar N (2015) Interleukin-1 targeting treatment in familial Mediterranean fever: an experience of pediatric patients. Mod Rheumatol 25:621\u2013624","journal-title":"Mod Rheumatol"},{"key":"4237_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13075-015-0765-4","volume":"17","author":"A Gul","year":"2015","unstructured":"Gul A, Ozdogan H, Erer B, Ugurlu S, Kasapcopur O, Davis N, Sevgi S (2015) Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Res Ther 17:243","journal-title":"Arthritis Res Ther"},{"key":"4237_CR16","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00296-015-3293-2","volume":"35","author":"FK Eroglu","year":"2015","unstructured":"Eroglu FK, Besbas N, Topaloglu R, Ozen S (2015) Treatment of colchicine-resistant familial Mediterranean fever in children and adolescents. Rheumatol Int 35:1733\u20131737","journal-title":"Rheumatol Int"},{"key":"4237_CR17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/14397595.2016.1194510","volume":"27","author":"O Kucuksahin","year":"2017","unstructured":"Kucuksahin O, Yildizgoren MT, Ilgen U, Ates A, Kinikli G, Turgay M, Erten S (2017) Anti-interleukin-1 treatment in 26 patients with refractory familial mediterranean fever. Mod Rheumatol 27:350\u2013355","journal-title":"Mod Rheumatol"},{"key":"4237_CR18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.7326\/0003-4819-157-8-201210160-00003","volume":"157","author":"PJ Hashkes","year":"2012","unstructured":"Hashkes PJ, Spalding SJ, Giannini EH, Huang B, Johnson A, Park G, Barron KS, Weisman MH, Pashinian N, Reiff AO, Samuels J, Wright DA, Kastner DL, Lovell DJ (2012) Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial. Ann Intern Med 157:533\u2013541","journal-title":"Ann Intern Med"},{"key":"4237_CR19","first-page":"2620","volume":"30","author":"M Lidar","year":"2003","unstructured":"Lidar M, Kedem R, Langevitz P, Pras M, Livneh A (2003) Intravenous colchicine for treatment of patients with familial Mediterranean fever unresponsive to oral colchicine. J Rheumatol 30:2620\u20132623","journal-title":"J Rheumatol"},{"issue":"2 Suppl","key":"4237_CR20","first-page":"S105","volume":"27","author":"M Rozenbaum","year":"2009","unstructured":"Rozenbaum M, Boulman N, Feld J, Avshovich N, Petrovich S, Elias M, Slobodin G, Rosner I (2009) Intravenous colchicine treatment for six months: adjunctive therapy in familial Mediterranean fever (FMF) unresponsive to oral colchicine. Clin Exp Rheumatol 27(2 Suppl):S105","journal-title":"Clin Exp Rheumatol"},{"key":"4237_CR21","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40:1879\u20131885","journal-title":"Arthritis Rheum"},{"key":"4237_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2174\/1568010053622984","volume":"4","author":"C Cerquaglia","year":"2005","unstructured":"Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R (2005) Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy 4:117\u2013124","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"4237_CR23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature13449","volume":"513","author":"H Xu","year":"2014","unstructured":"Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S et al (2014) Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513:237\u2013241","journal-title":"Nature"},{"key":"4237_CR24","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/ni.3457","volume":"17","author":"YH Park","year":"2016","unstructured":"Park YH, Wood G, Kastner DL, Chae JJ (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17:914\u2013921","journal-title":"Nat Immunol"},{"key":"4237_CR25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0736-4679(02)00430-4","volume":"22","author":"RA Bonnel","year":"2002","unstructured":"Bonnel RA, Villalba ML, Karwoski CB, Beitz J (2002) Deaths associated with inappropriate intravenous colchicine administration. J Emerg Med 22:385\u2013387","journal-title":"J Emerg Med"},{"key":"4237_CR26","first-page":"1050","volume":"56","author":"Centers for Disease C, Prevention","year":"2007","unstructured":"Centers for Disease C, Prevention (2007) Deaths from intravenous colchicine resulting from a compounding pharmacy error--Oregon and Washington. Morb Mortal Wkly Rep 56:1050\u20131052","journal-title":"Morb Mortal Wkly Rep"},{"key":"4237_CR27","first-page":"143","volume":"23","author":"TI Evans","year":"1996","unstructured":"Evans TI, Wheeler MT, Small RE, Breitbach SA, Sanders KM, Roberts WN (1996) A comprehensive investigation of inpatient intravenous colchicine use shows more education is needed. J Rheumatol 23:143\u2013148","journal-title":"J Rheumatol"},{"key":"4237_CR28","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/rheumatology\/39.11.1275","volume":"39","author":"I Kone Paut","year":"2000","unstructured":"Kone Paut I, Dubuc M, Sportouch J, Minodier P, Garnier JM, Touitou I (2000) Phenotype-genotype correlation in 91 patients with familial Mediterranean fever reveals a high frequency of cutaneomucous features. Rheumatology 39:1275\u20131279","journal-title":"Rheumatology"},{"key":"4237_CR29","first-page":"1703","volume":"27","author":"Y Shinar","year":"2000","unstructured":"Shinar Y, Livneh A, Langevitz P, Zaks N, Aksentijevich I, Koziol DE, Kastner DL, Pras M, Pras E (2000) Genotype-phenotype assessment of common genotypes among patients with familial Mediterranean fever. J Rheumatol 27:1703\u20131707","journal-title":"J Rheumatol"},{"key":"4237_CR30","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.autrev.2012.07.025","volume":"12","author":"M Lidar","year":"2012","unstructured":"Lidar M, Yonath H, Shechter N, Sikron F, Sadetzki S, Langevitz P, Livneh A, Pras E (2012) Incomplete response to colchicine in M694V homozygote FMF patients. Autoimmun Rev 12:72\u201376","journal-title":"Autoimmun Rev"},{"key":"4237_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13023-015-0252-7","volume":"10","author":"I Ben-Zvi","year":"2015","unstructured":"Ben-Zvi I, Herskovizh C, Kukuy O, Kassel Y, Grossman C, Livneh A (2015) Familial Mediterranean fever without MEFV mutations: a case\u2013control study. Orphanet J Rare Dis 10:34","journal-title":"Orphanet J Rare Dis"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-04237-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-04237-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-04237-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:19:36Z","timestamp":1577924376000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-04237-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["4237"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-04237-w","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"6 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Chagai Grossman, Itzhak Farberov, Olga Feld, Avi Livneh and Ilan Ben-Zvi declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}