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Prof. Ravelli has received speaker\u2019s bureaus and consulting fees from AbbVie, BMS, Pfizer, Hoffman LaRoche, Novartis, Centocor. Prof. Martini does not have any conflict of interest to declare since 1 march 2016, when he became the Scientific Director of the G. Gaslini Hospital: this role does not allow him to render private consultancies resulting in personal income. Prof. Martini performs consultancy activities on behalf of the Gaslini Institute for Abbvie, Boehringer, Novartis, R-Pharm, but the money received for these activities were directly transferred to the Gaslini Institute\u2019s bank account. Before march 2016, when AM was the head of Pediatric Rheumatology department at the G. Gaslini Hospital, he received speaker bureaus and consultancies fees from Abbvie, Astrazeneca, Novartis, Pfizer, Roche, R-Pharm, Sanofi, UCB. Dr Consolaro, Dr Bovis, Dr Pistorio, Mr Garrone, Ms Scala, Ms Patrone, Ms Rinaldi and Mr Villa have nothing to disclose in relation to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study as per the requirement of the local ethical committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}