{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:09:33Z","timestamp":1771297773045,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T00:00:00Z","timestamp":1518825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005062","name":"Fujirebio Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00296-018-3987-3","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T00:28:33Z","timestamp":1518827313000},"page":"813-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Elevated serum Krebs von den Lungen-6 in systemic sclerosis: a marker of lung fibrosis and severity of the disease"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4187-3425","authenticated-orcid":false,"given":"Audrey","family":"Benyamine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0816-4053","authenticated-orcid":false,"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-1864","authenticated-orcid":false,"given":"Carine","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika\u00ebl","family":"Ebbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Robert","family":"Harl\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Kaplanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-2238","authenticated-orcid":false,"given":"Pascal","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-082X","authenticated-orcid":false,"given":"Nathalie","family":"Bardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Granel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,17]]},"reference":[{"key":"3987_CR1","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T (2009) Scleroderma. N Engl J Med 360:1989\u20132003. \n                    https:\/\/doi.org\/10.1056\/NEJMra0806188","journal-title":"N Engl J Med"},{"key":"3987_CR2","first-page":"104","volume":"34","author":"OC Meyer","year":"2007","unstructured":"Meyer OC, Fertig N, Lucas M et al (2007) Disease subsets, antinuclear antibody profile, and clinical features in 127 French and 247 US adult patients with systemic sclerosis. J Rheumatol 34:104\u2013109","journal-title":"J Rheumatol"},{"key":"3987_CR3","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/ard.2006.066068","volume":"66","author":"VD Steen","year":"2007","unstructured":"Steen VD, Medsger TA (2007) Changes in causes of death in systemic sclerosis, 1972\u20132002. Ann Rheum Dis 66:940\u2013944. \n                    https:\/\/doi.org\/10.1136\/ard.2006.066068","journal-title":"Ann Rheum Dis"},{"key":"3987_CR4","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1136\/annrheumdis-2016-209909","volume":"76","author":"O Kowal-Bielecka","year":"2017","unstructured":"Kowal-Bielecka O, Fransen J, Avouac J et al (2017) Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis 76:1327\u20131339. \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2016-209909","journal-title":"Ann Rheum Dis"},{"key":"3987_CR5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1164\/ajrccm\/148.3.637","volume":"148","author":"N Kohno","year":"1993","unstructured":"Kohno N, Awaya Y, Oyama T et al (1993) KL-6, a Mucin-like Glycoprotein, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung Disease. Am Rev Respir Dis 148:637\u2013642. \n                    https:\/\/doi.org\/10.1164\/ajrccm\/148.3.637","journal-title":"Am Rev Respir Dis"},{"key":"3987_CR6","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1159\/000018382","volume":"200","author":"S Sato","year":"2000","unstructured":"Sato S, Nagaoka T, Hasegawa M et al (2000) Elevated serum KL-6 levels in patients with systemic sclerosis: association with the severity of pulmonary fibrosis. Dermatol Basel Switz 200:196\u2013201. \n                    https:\/\/doi.org\/10.1159\/000018382","journal-title":"Dermatol Basel Switz"},{"key":"3987_CR7","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1440-1843.2006.00834.x","volume":"11","author":"A Yokoyama","year":"2006","unstructured":"Yokoyama A, Kondo K, Nakajima M et al (2006) Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. Respirology 11:164\u2013168. \n                    https:\/\/doi.org\/10.1111\/j.1440-1843.2006.00834.x","journal-title":"Respirology"},{"key":"3987_CR8","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s40291-014-0109-0","volume":"18","author":"A Lauretis De","year":"2014","unstructured":"De Lauretis A, Renzoni EA (2014) Molecular biomarkers in interstitial lung diseases. Mol Diagn Ther 18:505\u2013522. \n                    https:\/\/doi.org\/10.1007\/s40291-014-0109-0","journal-title":"Mol Diagn Ther"},{"key":"3987_CR9","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10067-015-3167-8","volume":"35","author":"EO Oguz","year":"2016","unstructured":"Oguz EO, Kucuksahin O, Turgay M et al (2016) Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. Clin Rheumatol 35:663\u2013666. \n                    https:\/\/doi.org\/10.1007\/s10067-015-3167-8","journal-title":"Clin Rheumatol"},{"key":"3987_CR10","first-page":"27","volume":"28","author":"F Bonella","year":"2011","unstructured":"Bonella F, Volpe A, Caramaschi P et al (2011) Surfactant protein D and KL-6 serum levels in systemic sclerosis: correlation with lung and systemic involvement. Sarcoidosis Vasc Diffuse Lung Dis Off J WASOG 28:27\u201333","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis Off J WASOG"},{"key":"3987_CR11","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3899\/jrheum.080633","volume":"36","author":"FN Hant","year":"2009","unstructured":"Hant FN, Ludwicka-Bradley A, Wang H-J et al (2009) Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. J Rheumatol 36:773\u2013780. \n                    https:\/\/doi.org\/10.3899\/jrheum.080633","journal-title":"J Rheumatol"},{"key":"3987_CR12","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.3899\/jrheum.160339","volume":"43","author":"M Kuwana","year":"2016","unstructured":"Kuwana M, Shirai Y, Takeuchi T (2016) Elevated serum krebs von den lungen-6 in early disease predicts subsequent deterioration of pulmonary function in patients with systemic sclerosis and interstitial lung disease. J Rheumatol 43:1825\u20131831. \n                    https:\/\/doi.org\/10.3899\/jrheum.160339","journal-title":"J Rheumatol"},{"key":"3987_CR13","first-page":"930","volume":"27","author":"K Yamane","year":"2000","unstructured":"Yamane K, Ihn H, Kubo M et al (2000) Serum levels of KL-6 as a useful marker for evaluating pulmonary fibrosis in patients with systemic sclerosis. J Rheumatol 27:930\u2013934","journal-title":"J Rheumatol"},{"key":"3987_CR14","first-page":"429","volume":"21","author":"K Yanaba","year":"2003","unstructured":"Yanaba K, Hasegawa M, Hamaguchi Y et al (2003) Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis. Clin Exp Rheumatol 21:429\u2013436","journal-title":"Clin Exp Rheumatol"},{"key":"3987_CR15","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.rmed.2012.09.001","volume":"106","author":"Y Horimasu","year":"2012","unstructured":"Horimasu Y, Hattori N, Ishikawa N et al (2012) Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels. Respir Med 106:1756\u20131764. \n                    https:\/\/doi.org\/10.1016\/j.rmed.2012.09.001","journal-title":"Respir Med"},{"key":"3987_CR16","first-page":"S-138-144","volume":"32","author":"G Kum\u00e1novics","year":"2014","unstructured":"Kum\u00e1novics G, G\u00f6rbe E, Minier T et al (2014) Follow-up of serum KL-6 lung fibrosis biomarker levels in 173 patients with systemic sclerosis. Clin Exp Rheumatol 32:S-138-144","journal-title":"Clin Exp Rheumatol"},{"key":"3987_CR17","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1148\/radiol.2322031223","volume":"232","author":"SR Desai","year":"2004","unstructured":"Desai SR, Veeraraghavan S, Hansell DM et al (2004) CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. Radiology 232:560\u2013567. \n                    https:\/\/doi.org\/10.1148\/radiol.2322031223","journal-title":"Radiology"},{"key":"3987_CR18","first-page":"S42-46","volume":"21","author":"TA Medsger","year":"2003","unstructured":"Medsger TA, Bombardieri S, Czirjak L et al (2003) Assessment of disease severity and prognosis. Clin Exp Rheumatol 21:S42-46","journal-title":"Clin Exp Rheumatol"},{"key":"3987_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","author":"WJ Youden","year":"1950","unstructured":"Youden WJ (1950) Index for rating diagnostic tests. Cancer 3:32\u201335","journal-title":"Cancer"},{"key":"3987_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/096228029900800203","volume":"8","author":"DE Shapiro","year":"1999","unstructured":"Shapiro DE (1999) The interpretation of diagnostic tests. Stat Methods Med Res 8:113\u2013134. \n                    https:\/\/doi.org\/10.1177\/096228029900800203","journal-title":"Stat Methods Med Res"},{"key":"3987_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","volume":"80","author":"D Firth","year":"1993","unstructured":"Firth D (1993) Bias reduction of maximum likelihood estimates. Biometrika 80:27\u201338","journal-title":"Biometrika"},{"key":"3987_CR22","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/sim.1047","volume":"21","author":"G Heinze","year":"2002","unstructured":"Heinze G, Schemper M (2002) A solution to the problem of separation in logistic regression. Stat Med 21:2409\u20132419. \n                    https:\/\/doi.org\/10.1002\/sim.1047","journal-title":"Stat Med"},{"key":"3987_CR23","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/ard.2006.062901","volume":"66","author":"UA Walker","year":"2007","unstructured":"Walker UA, Tyndall A, Czirjak L et al (2007) Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann Rheum Dis 66:754\u2013763. \n                    https:\/\/doi.org\/10.1136\/ard.2006.062901","journal-title":"Ann Rheum Dis"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-3987-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-3987-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-3987-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T22:33:54Z","timestamp":1550356434000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-3987-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,17]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["3987"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-3987-3","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,17]]},"assertion":[{"value":"17 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All samples came from a declared Biobank (DC 2012\u2009\u2212\u20091704) in compliance with French ethical directives. The Biobank was approved by the institutional review board of universitary Public Hospitals of Marseilles (APHM).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}