{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:16:29Z","timestamp":1778120189154,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T00:00:00Z","timestamp":1527897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00296-018-4068-3","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T05:01:38Z","timestamp":1527915698000},"page":"2217-2224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The role of mirtazapine in patients with fibromyalgia: a systematic review"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-3235","authenticated-orcid":false,"given":"Andreina A.","family":"Ottman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-3806","authenticated-orcid":false,"given":"Carly B.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-5948","authenticated-orcid":false,"given":"Jamie N.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"key":"4068_CR1","unstructured":"Mirtazapine tablets [package insert] (2016) Updated 2016. Mylan Pharmaceuticals Inc., Morgantown"},{"key":"4068_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","volume":"17","author":"LP Queiroz","year":"2013","unstructured":"Queiroz LP (2013) Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep 17:356","journal-title":"Curr Pain Headache Rep"},{"key":"4068_CR3","doi-asserted-by":"publisher","first-page":"E20","DOI":"10.3390\/biomedicines5020020","volume":"5","author":"S Kia","year":"2017","unstructured":"Kia S, Choy E (2017) Update on treatment guideline in fibromyalgia syndrome with focus on pharmacology. Biomedicines 5:E20","journal-title":"Biomedicines"},{"key":"4068_CR4","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.2014.3266","volume":"311","author":"DJ Clauw","year":"2014","unstructured":"Clauw DJ (2014) Fibromyalgia: a clinical review. JAMA 311:1547\u20131555","journal-title":"JAMA"},{"key":"4068_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/art.37739","volume":"65","author":"K Phillips","year":"2013","unstructured":"Phillips K, Clauw DJ (2013) Central pain mechanisms in the rheumatic diseases: future directions. Arthritis Rheum 65:291\u2013302","journal-title":"Arthritis Rheum"},{"key":"4068_CR6","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1017\/S0033291708003784","volume":"39","author":"K Kato","year":"2009","unstructured":"Kato K, Sullivan PF, Eveng\u00e5rd B, Pedersen NL (2009) A population-based twin study of functional somatic syndromes. Psychol Med 39:497\u2013505","journal-title":"Psychol Med"},{"key":"4068_CR7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.5001\/omj.2012.44","volume":"27","author":"F Jahan","year":"2012","unstructured":"Jahan F, Nanji K, Qidwai W, Qasim R (2012) Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management. Oman Med J 27:192\u2013195","journal-title":"Oman Med J"},{"key":"4068_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","author":"F Wolfe","year":"1990","unstructured":"Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160\u2013172","journal-title":"Arthritis Rheum"},{"key":"4068_CR9","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.3899\/jrheum.100594","volume":"38","author":"F Wolfe","year":"2011","unstructured":"Wolfe F, Clauw DJ, Fitzcharles MA et al (2011) Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol 38:1113\u20131122","journal-title":"J Rheumatol"},{"key":"4068_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","volume":"46","author":"F Wolfe","year":"2016","unstructured":"Wolfe F, Clauw DJ, Fitzcharles MA, at al (2016) Revisions to the 2010\/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 46:319\u2013329","journal-title":"Semin Arthritis Rheum"},{"key":"4068_CR11","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","volume":"76","author":"GJ Macfarlane","year":"2017","unstructured":"Macfarlane GJ, Kronisch C, Dean LE et al (2017) EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis 76:318\u2013328","journal-title":"Ann Rheum Dis"},{"key":"4068_CR12","unstructured":"Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. (updated March 2011). The Cochrane Collaboration. \n                    http:\/\/handbook.cochrane.org\n                    \n                  . Accessed 23 May 2018"},{"key":"4068_CR13","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264\u2013269","journal-title":"Ann Intern Med"},{"key":"4068_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1\u201312","journal-title":"Control Clin Trials"},{"key":"4068_CR15","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","volume":"73","author":"K Slim","year":"2003","unstructured":"Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73:712\u2013716","journal-title":"ANZ J Surg"},{"key":"4068_CR16","first-page":"265","volume":"49","author":"W Samborski","year":"2004","unstructured":"Samborski W, Leza\u0144ska-Szpera M, Rybakowski JK (2004) Effects of antidepressant mirtazapine on fibromyalgia symptoms. Rocz Akad Med Bialymst 49:265\u2013269","journal-title":"Rocz Akad Med Bialymst"},{"key":"4068_CR17","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1345\/aph.1R725","volume":"47","author":"S Yeephu","year":"2013","unstructured":"Yeephu S, Suthisisang C, Suttiruksa S, Prateepavanich P, Limampai P, Russell IJ (2013) Efficacy and safety of mirtazapine in fibromyalgia syndrome patients: a randomized placebo-controlled pilot study. Ann Pharmacother 47:921\u2013932","journal-title":"Ann Pharmacother"},{"key":"4068_CR18","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1097\/j.pain.0000000000000622","volume":"157","author":"K Miki","year":"2016","unstructured":"Miki K, Murakami M, Oka H, Onozawa K, Yoshida S, Osada K (2016) Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan. Pain 157:2089\u20132096","journal-title":"Pain"},{"key":"4068_CR19","first-page":"435","volume":"10","author":"S Suttiruksa","year":"2016","unstructured":"Suttiruksa S, Yeephu S, Prateepavanich P, Suthisisang C (2016) Effects of mirtazapine on quality of life of Thai patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled trial. Asian Biomed 10:435\u2013445","journal-title":"Asian Biomed"},{"key":"4068_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1477-7525-6-8","volume":"6","author":"JA Verbunt","year":"2008","unstructured":"Verbunt JA, Pernot DH, Smeets RJ (2008) Disability and quality of life in patients with fibromyalgia. Health Qual Life Outcomes 6:8","journal-title":"Health Qual Life Outcomes"},{"key":"4068_CR21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jpsychores.2006.09.013","volume":"62","author":"A Theadom","year":"2007","unstructured":"Theadom A, Cropley M, Humphrey KL (2007) Exploring the role of sleep and coping in quality of life in fibromyalgia. J Psychosom Res 62:145\u2013151","journal-title":"J Psychosom Res"},{"key":"4068_CR22","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/art.23828","volume":"59","author":"SM Bigatti","year":"2008","unstructured":"Bigatti SM, Hernandez AM, Cronan TA, Rand KL (2008) Sleep disturbances in fibromyalgia syndrome: relationship to pain and depression. Arthritis Rheum 59:961\u2013967","journal-title":"Arthritis Rheum"},{"key":"4068_CR23","unstructured":"Lexi-Comp Online (2018) Lexi-Comp, Inc., Hudson, Ohio. Available at: \n                    http:\/\/online.lexi.com\/\n                    \n                  . Accessed 19 Jan 2018"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-4068-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4068-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4068-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:33:00Z","timestamp":1559439180000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-4068-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,2]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4068"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-4068-3","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,2]]},"assertion":[{"value":"8 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors report no financial relationships relevant to this article to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosure"}}]}}