{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:50:56Z","timestamp":1783950656420,"version":"3.55.0"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["09-04-01158-\u0430"],"award-info":[{"award-number":["09-04-01158-\u0430"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00296-018-4103-4","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T08:25:39Z","timestamp":1531815939000},"page":"1963-1974","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5946-5695","authenticated-orcid":false,"given":"Elena V.","family":"Tchetina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina A.","family":"Markova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"4103_CR1","first-page":"27","volume-title":"Osteoarthritis: diagnosis and medical\/surgical management","author":"AR Poole","year":"2007","unstructured":"Poole AR, Guilak F, Abramson SB (2007) Etiopathogenesis of osteoarthritis. In: Moskowitz RW, Altman RD, Hochberg MC, Buckwalter JA, Goldberg VM (eds) Osteoarthritis: diagnosis and medical\/surgical management, 4th edn. Williams & Wilkins, Philadelphia, pp\u00a027\u201349","edition":"4"},{"key":"4103_CR2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/138945010791011956","volume":"11","author":"CB Little","year":"2010","unstructured":"Little CB, Fosang AJ (2010) Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis\u2013insights from studies of aggrecan and collagen proteolysis? Curr Drug Targets 11:561\u2013575","journal-title":"Curr Drug Targets"},{"key":"4103_CR3","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1517\/14728222.2011.636740","volume":"15","author":"J Bondeson","year":"2011","unstructured":"Bondeson J (2011) Are we moving in the right direction with osteoarthritis drug discovery? Expert Opin Ther Targets 15:1355\u20131368","journal-title":"Expert Opin Ther Targets"},{"key":"4103_CR4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F (2013) Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil 21:16\u201321","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/art.39842","volume":"69","author":"F Berenbaum","year":"2017","unstructured":"Berenbaum F, Timothy M, Griffin, Ru Liu-Bryan (2017) Metabolic regulation of inflammation in osteoarthritis. Arthritis Rheumatol 69:9\u201321","journal-title":"Arthritis Rheumatol"},{"key":"4103_CR6","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.orthres.2004.12.016","volume":"23","author":"R Yagi","year":"2005","unstructured":"Yagi R, McBurney D, Laverty D, Weiner S, Horton WEJr (2005) Intrajoint comparison of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype. J Orthop Res 23:1128\u20131138","journal-title":"J Orthop Res"},{"key":"4103_CR7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1053\/joca.1999.0304","volume":"8","author":"T Kirsch","year":"2000","unstructured":"Kirsch T, Swoboda B, Nah H (2000) Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthr Cartil 8:294\u2013302","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002230001108","volume":"67","author":"O Pullig","year":"2000","unstructured":"Pullig O, Weseloh G, Ronneberger D, K\u00e4k\u00f6nen S, Swoboda B (2000) Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Calcif Tissue Int 67:230\u2013240","journal-title":"Calcif Tissue Int"},{"key":"4103_CR9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.joca.2003.12.004","volume":"12","author":"K Johnson","year":"2004","unstructured":"Johnson K, Terkeltaub R (2004) Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess. Osteoarthr Cartil 12:321\u2013335","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.joca.2005.11.010","volume":"14","author":"CM Robertson","year":"2006","unstructured":"Robertson CM, Pennock AT, Harwood FL, Pomerleau AC, Allen RT, Amiel D (2006) Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits. Osteoarthr Cartil 14:471\u2013476","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR11","first-page":"876","volume":"32","author":"EV Tchetina","year":"2005","unstructured":"Tchetina EV, Squires G, Poole AR (2005) Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 32:876\u2013886","journal-title":"J Rheumatol"},{"key":"4103_CR12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00109-016-1425-0","volume":"94","author":"X Zhang","year":"2016","unstructured":"Zhang X, Crawford R, Xiao Y (2016) Inhibition of vascular endothelial growth factor with shRNA in chondrocytes ameliorates osteoarthritis. J Mol Med (Berl) 94:787\u2013798","journal-title":"J Mol Med (Berl)"},{"key":"4103_CR13","doi-asserted-by":"crossref","first-page":"24042","DOI":"10.1038\/srep24042","volume":"6","author":"W Xu","year":"2016","unstructured":"Xu W, Xie Y, Wang Q, Wang X, Luo F, Zhou S, Wang Z, Huang J, Tan Q, Jin M, Qi H, Tang J, Chen L, Du X, Zhao C, Liang G, Chen L (2016) A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis. Sci Rep 6:24042","journal-title":"Sci Rep"},{"key":"4103_CR14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.gendis.2014.12.003","volume":"2","author":"S Chen","year":"2015","unstructured":"Chen S, Fu P, Cong R, Wu H, Pei M (2015) Strategies to minimize hypertrophy in cartilage engineering and regeneration. Genes Dis 2:76\u201395","journal-title":"Genes Dis"},{"key":"4103_CR15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tcb.2013.05.004","volume":"23","author":"M Agathocleous","year":"2013","unstructured":"Agathocleous M, Harris WA (2013) Metabolism in physiological cell proliferation and differentiation. Trends Cell Biol 23:484\u2013492","journal-title":"Trends Cell Biol"},{"key":"4103_CR16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ncb2531","volume":"14","author":"M Agathocleous","year":"2012","unstructured":"Agathocleous M, Love NK, Randlett O, Harris JJ, Liu J, Murray AJ, Harris WA (2012) Metabolic differentiation in the embryonic retina. Nat Cell Biol 14:859\u2013864","journal-title":"Nat Cell Biol"},{"key":"4103_CR17","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Vander Heiden","year":"2009","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029\u20131033","journal-title":"Science"},{"issue":"8","key":"4103_CR18","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/bph.12413","volume":"171","author":"JC Komen","year":"2014","unstructured":"Komen JC, Thorburn DR (2014) Turn up the power\u2013pharmacological activation of mitochondrial biogenesis in mouse models. Br J Pharmacol 171(8):1818\u20131836","journal-title":"Br J Pharmacol"},{"key":"4103_CR19","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1152\/japplphysiol.00894.2013","volume":"11 5","author":"DF Wilson","year":"2013","unstructured":"Wilson DF (2013) Regulation of cellular metabolism: programming and maintaining metabolic homeostasis. J Appl Physiol (1985) 11 5:1583\u20131588","journal-title":"J Appl Physiol"},{"key":"4103_CR20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR. From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21\u201335","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4103_CR21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molcel.2013.12.004","volume":"53","author":"TD Martin","year":"2014","unstructured":"Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell 53:209\u2013220","journal-title":"Mol Cell"},{"key":"4103_CR22","doi-asserted-by":"crossref","first-page":"re7","DOI":"10.1126\/stke.3462006re7","volume":"2006","author":"S Marshall","year":"2006","unstructured":"Marshall S (2006) Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci STKE 2006:re7","journal-title":"Sci STKE"},{"key":"4103_CR23","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1172\/JCI46243","volume":"121","author":"RH Wang","year":"2011","unstructured":"Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX (2011) Hepatic Sirt1 deficiency in mice impairs mTorc2\/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Investig 121:4477\u20134490","journal-title":"J Clin Investig"},{"key":"4103_CR24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/excr.1999.4701","volume":"253","author":"B Vanhaesebroeck","year":"1999","unstructured":"Vanhaesebroeck B, Waterfield MD (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253:239\u2013254","journal-title":"Exp Cell Res"},{"key":"4103_CR25","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.4161\/15384101.2014.952973","volume":"13","author":"L Magno Di","year":"2014","unstructured":"Di Magno L, Manzi D, D\u2019Amico D, Coni S, Macone A, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Screpanti I, Agostinelli E, Gulino A, Canettieri G (2014) Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth. Cell Cycle 13:3404\u20133413","journal-title":"Cell Cycle"},{"key":"4103_CR26","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.18632\/oncotarget.4224","volume":"6","author":"A Gonnissen","year":"2015","unstructured":"Gonnissen A, Isebaert S, Haustermans K (2015) Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. Oncotarget 6:13899\u201313913","journal-title":"Oncotarget"},{"key":"4103_CR27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","volume":"148","author":"GL Semenza","year":"2012","unstructured":"Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148:399\u2013408","journal-title":"Cell"},{"key":"4103_CR28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","volume":"3","author":"JW Kim","year":"2006","unstructured":"Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177\u2013185","journal-title":"Cell Metab"},{"key":"4103_CR29","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1074\/jbc.M800102200","volume":"283","author":"H Zhang","year":"2008","unstructured":"Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283:10892\u201310903","journal-title":"J Biol Chem"},{"key":"4103_CR30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.toxlet.2014.01.033","volume":"226","author":"Y Liu","year":"2014","unstructured":"Liu Y, Ma Z, Zhao C, Wang Y, Wu G, Xiao J, McClain CJ, Li X, Feng W (2014) HIF-1\u03b1 and HIF-2\u03b1 are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1\u03b1-mediated fatty acid \u03b2-oxidation. Toxicol Lett 226:117\u2013123","journal-title":"Toxicol Lett"},{"key":"4103_CR31","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","volume":"275","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275:25130\u201325138","journal-title":"J Biol Chem"},{"key":"4103_CR32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.cmet.2011.10.008","volume":"14","author":"D Tello","year":"2011","unstructured":"Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordonez A, Corral-Escariz M, Soro I, L\u00f3pez-Bernardo E, Perales-Clemente E, Mart\u00ednez-Ruiz A, Enr\u00edquez JA, Aragon\u00e9s J, Cadenas S, Land\u00e1zuri MO (2011) Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity. Cell Metab 14:768\u2013779","journal-title":"Cell Metab"},{"key":"4103_CR33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2007.01.047","volume":"129","author":"R Fukuda","year":"2007","unstructured":"Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL (2007) HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129:111\u2013122","journal-title":"Cell"},{"key":"4103_CR34","doi-asserted-by":"crossref","first-page":"a014357.5","DOI":"10.1101\/cshperspect.a014357","volume":"4","author":"M Conacci-Sorrell","year":"2014","unstructured":"Conacci-Sorrell M, McFerrin L, Eisenman RN (2014) An overview of MYC and its interactome. Cold Spring Harb Perspect Med 4:a014357.5","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4103_CR35","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1073\/pnas.94.13.6658","volume":"94","author":"H Shim","year":"1997","unstructured":"Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R, Dang CV (1997) c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci USA 94:6658\u20136663","journal-title":"Proc Natl Acad Sci USA"},{"key":"4103_CR36","doi-asserted-by":"crossref","first-page":"e18795","DOI":"10.1371\/journal.pone.0018795","volume":"6","author":"ZQ Zhou","year":"2011","unstructured":"Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ (2011) Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One 6:e18795","journal-title":"PLoS One"},{"key":"4103_CR37","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","volume":"30","author":"DM Gwinn","year":"2008","unstructured":"Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214\u2013226","journal-title":"Mol Cell"},{"key":"4103_CR38","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/jor.23420","volume":"34","author":"RK June","year":"2016","unstructured":"June RK, Liu-Bryan R, Long F, Griffin TM (2016) Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis. J Orthop Res 34:2048\u20132058","journal-title":"J Orthop Res"},{"key":"4103_CR39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s10059-013-0130-x","volume":"35","author":"S Park","year":"2013","unstructured":"Park S, Mori R, Shimokawa I (2013) Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. Molecules Cells 35:474\u2013480","journal-title":"Molecules Cells"},{"key":"4103_CR40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","volume":"13","author":"RH Houtkooper","year":"2012","unstructured":"Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225\u2013238","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4103_CR41","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","volume":"11","author":"A Salminen","year":"2012","unstructured":"Salminen A, Kaarniranta K (2012) AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 11:230\u2013241","journal-title":"Ageing Res Rev"},{"key":"4103_CR42","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2337\/db09-0482","volume":"59","author":"JH Um","year":"2010","unstructured":"Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH (2010) AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59:554\u2013563","journal-title":"Diabetes"},{"key":"4103_CR43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.semcdb.2016.05.007","volume":"62","author":"C Maes","year":"2017","unstructured":"Maes C (2017) Signaling pathways effecting crosstalk between cartilage and adjacent tissues: seminars in cell and developmental biology: The biology and pathology of cartilage. Semin Cell Dev Biol 62:16\u201333","journal-title":"Semin Cell Dev Biol"},{"key":"4103_CR44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jor.1100020304","volume":"2","author":"JL Stambough","year":"1984","unstructured":"Stambough JL, Brighton CT, Iannotti JP, Storey BT (1984) Characterization of growth plate mitochondria. J Orthop Res 2:235\u2013246","journal-title":"J Orthop Res"},{"key":"4103_CR45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bone.2006.09.030","volume":"40","author":"IM Shapiro","year":"2007","unstructured":"Shapiro IM, Srinivas V (2007) Metabolic consideration of epiphyseal growth: survival responses in a taxing environment. Bone 40:561\u2013567","journal-title":"Bone"},{"key":"4103_CR46","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1242\/dev.108811","volume":"141","author":"J Chen","year":"2014","unstructured":"Chen J, Long F (2014) mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development 141:2848\u20132854","journal-title":"Development"},{"key":"4103_CR47","doi-asserted-by":"crossref","first-page":"11151","DOI":"10.1038\/ncomms11151","volume":"7","author":"B Yan","year":"2016","unstructured":"Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X (2016) mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun 7:11151","journal-title":"Nat Commun"},{"key":"4103_CR48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200401138","volume":"166","author":"T Fujita","year":"2004","unstructured":"Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T (2004) Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166:85\u201395","journal-title":"J Cell Biol"},{"key":"4103_CR49","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1359\/jbmr.070420","volume":"22","author":"AF Ford-Hutchinson","year":"2007","unstructured":"Ford-Hutchinson AF, Ali Z, Lines SE, Hallgr\u00edmsson B, Boyd SK, Jirik FR (2007) Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth. J Bone Miner Res 22:1245\u20131259","journal-title":"J Bone Miner Res"},{"key":"4103_CR50","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1242\/dev.028118","volume":"135","author":"G Yang","year":"2008","unstructured":"Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X (2008) PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development 135:3587\u20133597","journal-title":"Development"},{"key":"4103_CR51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bone.2010.04.606","volume":"47","author":"E Araldi","year":"2010","unstructured":"Araldi E, Schipani E (2010) Hypoxia, HIFs and bone development. Bone 47:190\u2013196","journal-title":"Bone"},{"key":"4103_CR52","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1097-4652(199608)168:2<424::AID-JCP21>3.0.CO;2-1","volume":"168","author":"R Rajpurohit","year":"1996","unstructured":"Rajpurohit R, Koch CJ, Tao Z, Teixeira CM, Shapiro IM (1996) Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol 168:424\u2013432","journal-title":"J Cell Physiol"},{"key":"4103_CR53","doi-asserted-by":"crossref","first-page":"35748","DOI":"10.1038\/srep35748","volume":"6","author":"S Cheng","year":"2016","unstructured":"Cheng S, Aghajanian P, Pourteymoor S, Alarcon C, Mohan S (2016) Prolyl hydroxylase domain-containing protein 2 (Phd2) regulates chondrocyte differentiation and secondary ossification in mice. Sci Rep 6:35748","journal-title":"Sci Rep"},{"key":"4103_CR54","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","volume":"15","author":"E Schipani","year":"2001","unstructured":"Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15:2865\u20132876","journal-title":"Genes Dev"},{"key":"4103_CR55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cellsig.2017.05.001","volume":"36","author":"S Im","year":"2017","unstructured":"Im S, Kim DW (2017) Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1\u03b1 to modulate hypoxic responses in chondrocytes. Cell Signal 36:127\u2013138","journal-title":"Cell Signal"},{"key":"4103_CR56","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1359\/jbmr.2003.18.5.844","volume":"18","author":"E Tchetina","year":"2003","unstructured":"Tchetina E, Mwale F, Poole AR (2003) Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. J Bone Miner Res 18:844\u2013851","journal-title":"J Bone Miner Res"},{"key":"4103_CR57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","volume":"273","author":"A Vortkamp","year":"1996","unstructured":"Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273:613\u2013622","journal-title":"Science"},{"key":"4103_CR58","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/dvdy.21464","volume":"237","author":"C Phornphutkul","year":"2008","unstructured":"Phornphutkul C, Wu KY, Auyeung V, Chen Q, Gruppuso PA (2008) mTOR signaling contributes to chondrocyte differentiation. Dev Dyn 237:702\u2013712","journal-title":"Dev Dyn"},{"key":"4103_CR59","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/jcs.110.21.2691","volume":"110","author":"NS Stott","year":"1997","unstructured":"Stott NS, Chuong CM (1997) Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen. J Cell Sci 110:2691\u20132701","journal-title":"J Cell Sci"},{"key":"4103_CR60","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1359\/JBMR.040706","volume":"19","author":"S Tavella","year":"2004","unstructured":"Tavella S, Biticchi R, Schito A, Minina E, Di Martino D, Pagano A, Vortkamp A, Horton WA, Cancedda R, Garofalo S (2004) Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression. J Bone Miner Res 19:1678\u20131688","journal-title":"J Bone Miner Res"},{"key":"4103_CR61","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1302\/0301-620X.81B5.9492","volume":"81","author":"T Aizawa","year":"1999","unstructured":"Aizawa T, Kokubun S, Kawamata T, Tanaka Y, Roach HI (1999) c-Myc protein in the rabbit growth plate. Changes in immunolocalisation with age and possible roles from proliferation to apoptosis. J Bone Jt Surg Br 81:921\u2013925","journal-title":"J Bone Jt Surg Br"},{"key":"4103_CR62","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S8756-3282(99)00085-X","volume":"24","author":"R Toury","year":"1999","unstructured":"Toury R, Wang Y, Hauchecorne M, Balmain N (1999) c-Myc and Mxi1 immunoreactivities in the calcifying areas of the epiphyseal-plate cartilage matrix of growing rats. Bone 24:555\u2013563","journal-title":"Bone"},{"key":"4103_CR63","first-page":"185","volume":"13","author":"ME Piedra","year":"2002","unstructured":"Piedra ME, Delgado MD, Ros MA, Leo\u00b4n J (2002) c-Myc overexpression increases cell size and impairs cartilage differentiation during chick limb development. Cell Growth Differ 13:185\u2013193","journal-title":"Cell Growth Differ"},{"key":"4103_CR64","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00467-009-1310-y","volume":"25","author":"J Bohensky","year":"1982","unstructured":"Bohensky J, Leshinsky S, Srinivas V, Shapiro IM (1982) Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression. Pediatr Nephrol 25:633\u2013642","journal-title":"Pediatr Nephrol"},{"key":"4103_CR65","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.7112108","volume":"217","author":"IM Shapiro","year":"1982","unstructured":"Shapiro IM, Golub EE, Kakuta S, Hazelgrove J, Havery J, Chance B, Frasca P (1982) Initiation of endochondral calcification is related to changes in the redox state of hypertrophic chondrocytes. Science 217:950\u2013952","journal-title":"Science"},{"key":"4103_CR66","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1038\/srep03022","volume":"3","author":"J Piao","year":"2013","unstructured":"Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y (2013) Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci Rep 3:3022","journal-title":"Sci Rep"},{"key":"4103_CR67","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature11940","volume":"495","author":"KL Cooper","year":"2013","unstructured":"Cooper KL, Oh S, Sung Y, Dasari RR, Kirschner MW, Tabin CJ (2013) Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature 495:375\u2013378","journal-title":"Nature"},{"key":"4103_CR68","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00776-011-0055-1","volume":"16","author":"F Wang","year":"2011","unstructured":"Wang F, Zhu Y (2011) Aquaporin-1: a potential membrane channel for facilitating the adaptability of rabbit nucleus pulposus cells to an extracellular matrix environment. J Orthop Sci 16:304\u2013312","journal-title":"J Orthop Sci"},{"key":"4103_CR69","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1136\/annrheumdis-2013-204599","volume":"74","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M (2015) Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann Rheum Dis 74:1432\u20131440","journal-title":"Ann Rheum Dis"},{"key":"4103_CR70","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0006-291X(05)81279-3","volume":"180","author":"P Pollesello","year":"1991","unstructured":"Pollesello P, de Bernard B, Grandolfo M, Paoletti S, Vittur F, Kvam BJ (1991) Energy state of chondrocytes assessed by 31P-NMR studies of preosseous cartilage. Biochem Biophys Res Commun 180:216\u2013222","journal-title":"Biochem Biophys Res Commun"},{"key":"4103_CR71","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1136\/ard.2009.119966","volume":"69","author":"JL Scott","year":"2010","unstructured":"Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, Boot-Handford RP, Kirkwood TB, Taylor RW, Young DA (2010) Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis 69:1502\u20131510","journal-title":"Ann Rheum Dis"},{"key":"4103_CR72","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrrheum.2010.213","volume":"7","author":"FJ Blanco","year":"2011","unstructured":"Blanco FJ, Rego I, Ruiz-Romero C (2011) The role of mitochondria in osteoarthritis. Nat Rev Rheumatol 7:161\u2013169","journal-title":"Nat Rev Rheumatol"},{"key":"4103_CR73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/dna.2017.4048","volume":"37","author":"X Yang","year":"2018","unstructured":"Yang X, Chen W, Zhao X, Chen L, Li W, Ran J, Wu L (2018) Pyruvate kinase M2 modulates the glycolysis of chondrocyte and extracellular matrix in osteoarthritis. DNA Cell Biol 37:271\u2013277","journal-title":"DNA Cell Biol"},{"key":"4103_CR74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrrheum.2014.162","volume":"11","author":"R Liu-Bryan","year":"2015","unstructured":"Liu-Bryan R, Terkeltaub R (2015) Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol 11:35\u201344","journal-title":"Nat Rev Rheumatol"},{"key":"4103_CR75","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/1440-1681.12537","volume":"43","author":"J Qu","year":"2016","unstructured":"Qu J, Lu D, Guo H, Miao W, Wu G, Zhou M (2016) PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage. Clin Exp Pharmacol Physiol 43:312\u2013318","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"4103_CR76","doi-asserted-by":"crossref","first-page":"461486","DOI":"10.1155\/2013\/461486","volume":"2013","author":"EV Tchetina","year":"2013","unstructured":"Tchetina EV, Poole AR, Zaitseva EM, Sharapova EP, Kashevarova NG, Taskina EA, Alekseeva LI, Semyonova LA, Glukhova SI, Kuzin AN, Makarov MA, Makarov SA (2013) Differences in Mammalian target of rapamycin gene expression in the peripheral blood and articular cartilages of osteoarthritic patients and disease activity. Arthritis 2013:461486","journal-title":"Arthritis"},{"key":"4103_CR77","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/art.40104","volume":"69","author":"O Alvarez-Garcia","year":"2017","unstructured":"Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK (2017) Regulated in development and DNA damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis. Arthritis Rheumatol 69:1418\u20131428","journal-title":"Arthritis Rheumatol"},{"key":"4103_CR78","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/annrheumdis-2014-205743","volume":"74","author":"F Vasheghani","year":"2015","unstructured":"Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M (2015) PPAR\u03b3 deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage. Ann Rheum Dis 74:569\u2013578","journal-title":"Ann Rheum Dis"},{"key":"4103_CR79","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biopha.2017.01.130","volume":"89","author":"JF Xue","year":"2017","unstructured":"Xue JF, Shi ZM, Zou J, Li XL (2017) Inhibition of PI3K\/AKT\/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother 89:1252\u20131261","journal-title":"Biomed Pharmacother"},{"key":"4103_CR80","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/jcp.25869","volume":"232","author":"SF Chang","year":"2017","unstructured":"Chang SF, Huang KC, Cheng CC, Su YP, Lee KC, Chen CN, Chang HI (2017) Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein-1 signaling. J Cell Physiol 232:2741\u20132749","journal-title":"J Cell Physiol"},{"key":"4103_CR81","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcb.24362","volume":"114","author":"J Chen","year":"2013","unstructured":"Chen J, Crawford R, Xiao Y (2013) Vertical inhibition of the PI3K\/Akt\/mTOR pathway for the treatment of osteoarthritis. J Cell Biochem 114:245\u2013249","journal-title":"J Cell Biochem"},{"key":"4103_CR82","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1002\/jcp.26460","volume":"233","author":"C Lin","year":"2018","unstructured":"Lin C, Shao Y, Zeng C, Zhao C, Fang H, Wang L, Pan J, Liu L, Qi W, Feng X, Qiu H, Zhang H, Chen Y, Wang H, Cai D, Xian CJ (2018) Blocking PI3K\/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis. J Cell Physiol 233:6135\u20136147","journal-title":"J Cell Physiol"},{"key":"4103_CR83","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00296-011-1929-4","volume":"32","author":"D Li","year":"2012","unstructured":"Li D, Wu Z, Duan Y, Hao D, Zhang X, Luo H, Chen B, Qiu G (2012) TNF\u03b1-mediated apoptosis in human osteoarthritic chondrocytes sensitized by PI3K-NF-\u03baB inhibitor, not mTOR inhibitor. Rheumatol Int 32:2017\u20132022","journal-title":"Rheumatol Int"},{"key":"4103_CR84","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.joca.2011.02.004","volume":"19","author":"SC Rosa","year":"2011","unstructured":"Rosa SC, Rufino AT, Judas F, Tenreiro C, Lopes MC, Mendes AF (2011) Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin. Osteoarthr Cartil 19:719\u2013727","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR85","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00264-004-0618-2","volume":"29","author":"D Pfander","year":"2005","unstructured":"Pfander D, Cramer T, Swoboda B (2005) Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop 29:6\u20139","journal-title":"Int Orthop"},{"key":"4103_CR86","first-page":"2800","volume":"21","author":"J Fern\u00e1ndez-Torres","year":"2017","unstructured":"Fern\u00e1ndez-Torres J, Zamudio-Cuevas Y, Mart\u00ednez-Nava GA, L\u00f3pez-Reyes AG (2017) Hypoxia-inducible factors (HIFs) in the articular cartilage: a systematic review. Eur Rev Med Pharmacol Sci 21:2800\u20132810","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4103_CR87","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00011-016-0926-1","volume":"65","author":"S Ishizuka","year":"2016","unstructured":"Ishizuka S, Sakai T, Hiraiwa H, Hamada T, Knudson W, Omachi T, Ono Y, Nakashima M, Matsukawa T, Oda T, Takamatsu A, Yamashita S, Ishiguro N (2016) Hypoxia-inducible factor-2\u03b1 induces expression of type X collagen and matrix metalloproteinases 13 in osteoarthritic meniscal cells. Inflamm Res 65:439\u2013448","journal-title":"Inflamm Res"},{"key":"4103_CR88","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11914-011-0047-2","volume":"9","author":"EB Rankin","year":"2011","unstructured":"Rankin EB, Giaccia AJ, Schipani E (2011) A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep 9:46\u201352","journal-title":"Curr Osteoporos Rep"},{"key":"4103_CR89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/etm.2016.3940","volume":"13","author":"L Qing","year":"2014","unstructured":"Qing L, Lei P, Liu H, Xie J, Wang L, Wen T, Hu Y (2014) Expression of hypoxia-inducible factor-1\u03b1 in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis. Exp Ther Med 13:63\u201368","journal-title":"Exp Ther Med"},{"key":"4103_CR90","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.4238\/2014.December.12.15","volume":"13","author":"H Chu","year":"2013","unstructured":"Chu H, Xu ZM, Yu H, Zhu KJ, Huang H (2013) Association between hypoxia-inducible factor-1a levels in serum and synovial fluid with the radiographic severity of knee osteoarthritis. Genet Mol Res 13:10529\u201310536","journal-title":"Genet Mol Res"},{"key":"4103_CR91","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/ar4272","volume":"15","author":"BD Markway","year":"2013","unstructured":"Markway BD, Cho H, Johnstone B (2013) Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes. Arthritis Res Ther 15:R92","journal-title":"Arthritis Res Ther"},{"key":"4103_CR92","first-page":"535","volume":"41","author":"J Gouttenoire","year":"2004","unstructured":"Gouttenoire J, Valcourt U, Ronzi\u00e8re MC, Aubert-Foucher E, Mallein-Gerin F, Herbage D (2004) Modulation of collagen synthesis in normal and osteoarthritic cartilage. Biorheology 41:535\u2013542","journal-title":"Biorheology"},{"key":"4103_CR93","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/03008207.2014.925885","volume":"55","author":"J Zhou","year":"2014","unstructured":"Zhou J, Wei X, Wei L (2014) Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease. Connect Tissue Res 55:257\u2013261","journal-title":"Connect Tissue Res"},{"key":"4103_CR94","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/jphp.12379","volume":"67","author":"R Li","year":"2015","unstructured":"Li R, Cai L, Ding J, Hu CM, Wu TN, Hu XY (2015) Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis. J Pharm Pharmacol 67:963\u2013971","journal-title":"J Pharm Pharmacol"},{"key":"4103_CR95","first-page":"95","volume":"142","author":"JP Pelletier","year":"1993","unstructured":"Pelletier JP, Faure MP, DiBattista JA, Wilhelm S, Visco D, Martel-Pelletier J (1993) Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. Am J Pathol 142:95\u2013105","journal-title":"Am J Pathol"},{"key":"4103_CR96","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s007760050142","volume":"5","author":"N Yatsugi","year":"2000","unstructured":"Yatsugi N, Tsukazaki T, Osaki M, Koji T, Yamashita S, Shindo H (2000) Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc. J Orthop Sci 5:150\u2013156","journal-title":"J Orthop Sci"},{"key":"4103_CR97","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejphar.2016.07.027","volume":"789","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Tao H, Li Y, Deng M, He B, Xia S, Zhang C, Liu S (2016) Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt\/\u03b2-catenin pathway. Eur J Pharmacol 789:109\u2013118","journal-title":"Eur J Pharmacol"},{"key":"4103_CR98","doi-asserted-by":"crossref","first-page":"343e55","DOI":"10.2741\/4105","volume":"18","author":"M Dvir-Ginzberg","year":"2013","unstructured":"Dvir-Ginzberg M, Steinmeyer J (2013) Towards elucidating the role of SirT1 in osteoarthritis. Front Biosci 18:343e55","journal-title":"Front Biosci"},{"key":"4103_CR99","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/ard.2011.200504","volume":"71","author":"O Gabay","year":"2012","unstructured":"Gabay O, Oppenhiemer H, Meir H, Zaal K, Sanchez C, Dvir-Ginzberg M (2012) Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice. Ann Rheum Dis 71:613\u2013616","journal-title":"Ann Rheum Dis"},{"key":"4103_CR100","doi-asserted-by":"crossref","first-page":"36300e10","DOI":"10.1074\/jbc.M803196200","volume":"283","author":"M Dvir-Ginzberg","year":"2008","unstructured":"Dvir-Ginzberg M, Gagarina V, Lee EJ, Hall DJ (2008) Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 283:36300e10","journal-title":"J Biol Chem"},{"key":"4103_CR101","doi-asserted-by":"crossref","first-page":"17602","DOI":"10.1038\/srep17602","volume":"5","author":"Y Wu","year":"2015","unstructured":"Wu Y, Chen L, Wang Y, Li W, Lin Y, Yu D, Zhang L, Li F, Pan Z (2015) Overexpression of Sirtuin 6 suppresses cellular senescence and NF-\u03baB mediated inflammatory responses in osteoarthritis development. Sci Rep 5:17602","journal-title":"Sci Rep"},{"key":"4103_CR102","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1136\/annrheumdis-2012-202620","volume":"73","author":"T Matsuzaki","year":"2014","unstructured":"Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M (2014) Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73:1397\u20131404","journal-title":"Ann Rheum Dis"},{"key":"4103_CR103","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/art.37750","volume":"65","author":"O Gabay","year":"2013","unstructured":"Gabay O, Sanchez C, Dvir-Ginzberg M, Gaqarina V, Zaal KJ, Song Y, He XH, McBurney MW (2013) Sirt1 enzymatic activity is required for cartilage homeostasis in vivo. Arthritis Rheum 65:159\u2013166","journal-title":"Arthritis Rheum"},{"key":"4103_CR104","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.joca.2012.11.017","volume":"21","author":"MH Moon","year":"2013","unstructured":"Moon MH, Jeong JK, Lee YJ, Seol JW, Jackson CJ, Park SY (2013) SIRT1, a class III histone deacetylase, regulates TNF\u03b1-induced inflammation in human chondrocytes. Osteoarthr Cartil 21:470\u2013480","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR105","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3892\/ijmm.2016.2842","volume":"39","author":"M Igarashi","year":"2017","unstructured":"Igarashi M, Sakamoto K, Nagaoka I (2017) Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line. Int J Mol Med 39:472\u2013478","journal-title":"Int J Mol Med"},{"key":"4103_CR106","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/annrheumdis-2013-204355","volume":"74","author":"S Yang","year":"2015","unstructured":"Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH, Kim HA, Chun CH, Chun JS (2015) NAMPT (visfatin), a direct target of hypoxia-inducible factor-2\u03b1, is an essential catabolic regulator of osteoarthritis. Ann Rheum Dis 74:595\u2013602","journal-title":"Ann Rheum Dis"},{"key":"4103_CR107","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/ijms17071019","volume":"17","author":"K Terauchi","year":"2016","unstructured":"Terauchi K, Kobayashi H, Yatabe K, Yui N, Fujiya H, Niki H, Musha H, Yudoh K (2016) The NAD-dependent deacetylase sirtuin-1 regulates the expression of osteogenic transcriptional activator runt-related transcription factor 2 (Runx2) and production of matrix metalloproteinase (MMP)-13 in chondrocytes in osteoarthritis. Int J Mol Sci 17:1019","journal-title":"Int J Mol Sci"},{"key":"4103_CR108","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/art.30333","volume":"63","author":"R Terkeltaub","year":"2011","unstructured":"Terkeltaub R, Yang B, Lotz M, Liu-Bryan R (2011) Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Arthritis Rheum 63:1928\u20131937","journal-title":"Arthritis Rheum"},{"key":"4103_CR109","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/art.39182","volume":"67","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R (2015) Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor gamma coactivator 1alpha. Arthritis Rheumatol 67:2141\u20132153","journal-title":"Arthritis Rheumatol"},{"key":"4103_CR110","doi-asserted-by":"crossref","first-page":"43245","DOI":"10.1038\/srep43245","volume":"7","author":"S Zhou","year":"2017","unstructured":"Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q (2017) AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci Rep 7:43245","journal-title":"Sci Rep"},{"key":"4103_CR111","doi-asserted-by":"crossref","first-page":"6432867","DOI":"10.1155\/2016\/6432867","volume":"2016","author":"EV Tchetina","year":"2016","unstructured":"Tchetina EV, Markova GA, Poole AR, Zukor DJ, Antoniou J, Makarov SA, Kuzin AN (2016) Deferoxamine suppresses collagen cleavage and protease, Cytokine, and COL10A1 expression and upregulates AMPK and Krebs cycle genes in human osteoarthritic cartilage. Int J Rheumatol 2016:6432867","journal-title":"Int J Rheumatol"},{"key":"4103_CR112","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.joca.2018.01.011","volume":"26","author":"BK Al-Khazraji","year":"2018","unstructured":"Al-Khazraji BK, Appleton CT, Beier F, Birmingham TB, Shoemaker JK (2018) Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review. Osteoarthr Cartil 26:462\u2013470","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR113","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/art.39279","volume":"67","author":"M Attur","year":"2015","unstructured":"Attur M, Krasnokutsky S, Statnikov A, Samuels J, Li Z, Friese O, Graverand-Gastineau HL, Rybak MP, Kraus L, Jordan VB, Aliferis JM, Abramson CF SB (2015) Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. Arthritis Rheumatol 67:2905\u20132915","journal-title":"Arthritis Rheumatol"},{"key":"4103_CR114","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.joca.2015.06.018","volume":"23","author":"F Ponchel","year":"2015","unstructured":"Ponchel F, Burska AN, Hensor EM, Raja R, Campbell M, Emery P, Conaghan PG (2015) Changes in peripheral blood immune cell composition in osteoarthritis. Osteoarthr Cartil 23:1870\u20131878","journal-title":"Osteoarthr Cartil"},{"key":"4103_CR115","first-page":"346","volume":"61","author":"S Kyostio-Moore","year":"2011","unstructured":"Kyostio-Moore S, Nambiar B, Hutto E, Ewing PJ, Piraino S, Berthelette P, Sookdeo C, Matthews G, Armentano D (2011) STR\/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers. Comp Med 61:346\u2013355","journal-title":"Comp Med"},{"key":"4103_CR116","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/art.30360","volume":"63","author":"M Attur","year":"2011","unstructured":"Attur M, Belitskaya-L\u00e9vy I, Oh C, Krasnokutsky S, Greenberg J, Samuels J, Smiles S, Lee S, Patel J, Al-Mussawir H, McDaniel G, Kraus VB, Abramson SB (2011) Increased interleukin-1\u03b2 gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum 63:1908\u20131917","journal-title":"Arthritis Rheum"},{"key":"4103_CR117","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/BOR.0b013e32833b4682","volume":"22","author":"MR Sowers","year":"2010","unstructured":"Sowers MR, Karvonen-Gutierrez CA (2010) The evolving role of obesity in knee osteoarthritis. Curr Opin Rheumatol 22:533\u2013537","journal-title":"Curr Opin Rheumatol"},{"key":"4103_CR118","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jbspin.2008.07.008","volume":"75","author":"PP Gegout","year":"2010","unstructured":"Gegout PP, Francin PJ, Mainard D, Presle N (2010) Adipokines in osteoarthritis: friends or foes of cartilage homeostasis? Jt Bone Spine 75:669\u2013671","journal-title":"Jt Bone Spine"},{"key":"4103_CR119","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jbspin.2008.07.011","volume":"75","author":"O Gabay","year":"2008","unstructured":"Gabay O, Hall DJ, Berenbaum F, Henrotin Y, Sanchez C (2008) Osteoarthritis and obesity: experimental models. Jt Bone Spine 75:675\u2013679","journal-title":"Jt Bone Spine"},{"issue":"1","key":"4103_CR120","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1186\/ar4467","volume":"16","author":"MC Laiguillon","year":"2014","unstructured":"Laiguillon MC, Houard X, Bougault C, Gosset M, Nourissat G, Sautet A, Jacques C, Berenbaum F, Sellam J (2014) Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis. Arthritis Res Ther 16(1):R38","journal-title":"Arthritis Res Ther"},{"key":"4103_CR121","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1515\/CCLM.2010.230","volume":"48","author":"WP Chen","year":"2010","unstructured":"Chen WP, Bao JP, Feng J, Hu PF, Shi ZL, Wu LD (2010) Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med 48:1141\u20131145","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"4103_CR122","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13075-016-1103-1","volume":"18","author":"J Calvet","year":"2016","unstructured":"Calvet J, Orellana C, Gratac\u00f3s J, Berenguer-Llergo A, Caix\u00e0s A, Chillar\u00f3n JJ, Pedro-Botet J, Garc\u00eda-Manrique M, Navarro N, Larrosa M (2016) Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion. Arthritis Res Ther 18(1):207","journal-title":"Arthritis Res Ther"},{"key":"4103_CR123","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00296-010-1731-8","volume":"32","author":"Y Duan","year":"2012","unstructured":"Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G (2012) Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int 32:985\u2013990","journal-title":"Rheumatol Int"},{"key":"4103_CR124","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/1354750X.2017.1401665","volume":"23","author":"A Fioravanti","year":"2018","unstructured":"Fioravanti A, Cheleschi S, De Palma A, Addimanda O, Mancarella L, Pignotti E, Pulsatelli L, Galeazzi M, Meliconi R (2018) Can adipokines serum levels be used as biomarkers of hand osteoarthritis? Biomarkers 23:265\u2013270","journal-title":"Biomarkers"},{"key":"4103_CR125","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/03008207.2011.597902","volume":"52","author":"AL McNulty","year":"2011","unstructured":"McNulty AL, Miller MR, O\u2019Connor SK, Guilak F (2011) The effects of adipokines on cartilage and meniscus catabolism. Connect Tissue Res 52:523\u2013533","journal-title":"Connect Tissue Res"},{"key":"4103_CR126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5312\/wjo.v5.i3.319","volume":"5","author":"T Poonpet","year":"2014","unstructured":"Poonpet T, Honsawek S (2014) Adipokines: Biomarkers for osteoarthritis? World J Orthop 5:319\u2013327","journal-title":"World J Orthop"},{"key":"4103_CR127","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","volume":"208","author":"LZ Shi","year":"2011","unstructured":"Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208:1367\u20131376","journal-title":"J Exp Med"},{"key":"4103_CR128","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature06878","volume":"453","author":"L Zhou","year":"2008","unstructured":"Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD, Shen Y, Du J, Rubtsov YP, Rudensky AY, Ziegler SF, Littman DR (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgamma function. Nature 453:236\u2013240","journal-title":"Nature"},{"key":"4103_CR129","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2796.2010.02218.x","volume":"267","author":"RH Straub","year":"2010","unstructured":"Straub RH, Cutolo M, Buttgereit F, Pongratz G (2010) Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med 267:543\u2013560","journal-title":"J Intern Med"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-4103-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4103-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4103-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T20:06:40Z","timestamp":1693771600000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-4103-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":129,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["4103"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-4103-4","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,17]]},"assertion":[{"value":"25 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declared that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with\u00a0animals or human subjects performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}