{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:48:51Z","timestamp":1783648131440,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00296-018-4124-z","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T09:17:50Z","timestamp":1533806270000},"page":"2121-2131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Ankylosing spondylitis causes high burden to patients and the healthcare system: results from a German claims database analysis"],"prefix":"10.1007","volume":"38","author":[{"given":"Klaus","family":"Kr\u00fcger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"von Hin\u00fcber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen M.","family":"Jugl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-0075","authenticated-orcid":false,"given":"Kathrin","family":"Borchert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Meise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"4124_CR1","first-page":"4","volume":"78","author":"A Boonen","year":"2006","unstructured":"Boonen A, van der Linden SM (2006) The burden of ankylosing spondylitis. J Rheumatol Suppl 78:4\u201311","journal-title":"J Rheumatol Suppl"},{"issue":"6; SUPP\/28","key":"4124_CR2","first-page":"S","volume":"20","author":"J Braun","year":"2002","unstructured":"Braun J, Pincus T (2002) Mortality, course of disease and prognosis of patients with ankylosing spondylitis. Clin Exp Rheumatol 20(6; SUPP\/28):S\u2013S16","journal-title":"Clin Exp Rheumatol"},{"key":"4124_CR3","first-page":"613","volume":"27","author":"A Zink","year":"2000","unstructured":"Zink A, Braun J, Listing J, Wollenhaupt J (2000) Disability and handicap in rheumatoid arthritis and ankylosing spondylitis-results from the German rheumatological database. German Collaborative Arthritis Centers. J Rheumatol 27:613\u2013622","journal-title":"J Rheumatol"},{"issue":"10089","key":"4124_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0140-6736(16)31591-4","volume":"390","author":"J Sieper","year":"2017","unstructured":"Sieper J, Poddubnyy D (2017) Axial spondyloarthritis. Lancet 390(10089):73\u201384. https:\/\/doi.org\/10.1016\/s0140-6736(16)31591-4","journal-title":"Lancet"},{"key":"4124_CR5","unstructured":"Kiltz U, Braun J (2013) Evidenzbasierte Leitlinie der Deutschen Gesellschaft f\u00fcr Rheumatologie (DGRh) und der beteiligten medizinisch-wissenschaftlichen Fachgesellschaften und weiterer Organisationen"},{"key":"4124_CR6","first-page":"249","volume":"51","author":"SA Shaikh","year":"2007","unstructured":"Shaikh SA (2007) Ankylosing spondylitis: recent breakthroughs in diagnosis and treatment. J Can Chiropr Assoc 51:249\u2013260","journal-title":"J Can Chiropr Assoc"},{"key":"4124_CR7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G","volume":"41","author":"J Braun","year":"1998","unstructured":"Braun J, Bollow M, Remlinger G, Eggens U, Rudwaleit M, Distler A, Sieper J (1998) Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41:58\u201367","journal-title":"Arthritis Rheum"},{"issue":"1","key":"4124_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-015-0627-0","volume":"17","author":"S Exarchou","year":"2015","unstructured":"Exarchou S, Lindstr\u00f6m U, Askling J, Eriksson JK, Forsblad-d\u2019Elia H, Neovius M, Turesson C, Kristensen LE, Jacobsson LT (2015) The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study. Arthritis Res Ther 17(1):1\u20139","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"4124_CR9","doi-asserted-by":"publisher","first-page":"e006634","DOI":"10.1136\/bmjopen-2014-006634","volume":"4","author":"NN Haroon","year":"2014","unstructured":"Haroon NN, Paterson JM, Li P, Haroon N (2014) Increasing proportion of female patients with ankylosing spondylitis: a population-based study of trends in the incidence and prevalence of AS. BMJ Open 4(12):e006634","journal-title":"BMJ Open"},{"issue":"4","key":"4124_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1136\/ard.60.4.353","volume":"60","author":"A Boonen","year":"2001","unstructured":"Boonen A, Chorus A, Miedema H, van Der Heijde D, van Der Tempel H, Van der Linden S (2001) Employment, work disability, and work days lost in patients with ankylosing spondylitis: a cross sectional study of Dutch patients. Ann Rheum Dis 60(4):353\u2013358","journal-title":"Ann Rheum Dis"},{"key":"4124_CR11","doi-asserted-by":"publisher","first-page":"iii8iii18","DOI":"10.1136\/ard.61.9.818","volume":"61","author":"J Sieper","year":"2002","unstructured":"Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (2002) Ankylosing spondylitis: an overview. Ann Rheum Dis 61:iii8\u2013iii18","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"4124_CR12","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1053\/berh.2002.0244","volume":"16","author":"A Boonen","year":"2002","unstructured":"Boonen A (2002) Ankylosing spondylitis: what is the cost to society, and can it be reduced? Best Pract Res Clin Rheumatol 16(4):691\u2013705","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"4124_CR13","doi-asserted-by":"publisher","first-page":"iii40iii50","DOI":"10.1136\/ard.61.suppl_3.iii40","volume":"61","author":"M Dougados","year":"2002","unstructured":"Dougados M, Dijkmans B, Khan M, Maksymowych W, van der Linden SJ, Brandt J (2002) Conventional treatments for ankylosing spondylitis. Ann Rheum Dis 61:iii40\u2013iii50","journal-title":"Ann Rheum Dis"},{"key":"4124_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770","author":"D Heijde van der","year":"2017","unstructured":"van der Heijde D, Ramiro S, Landew\u00e9 R, Baraliakos X, Van den Bosch F, Sepriano A, Regel A, Ciurea A, Dagfinrud H, Dougados M, van Gaalen F, G\u00e9her P, van der Horst-Bruinsma I, Inman RD, Jongkees M, Kiltz U, Kvien TK, Machado PM, Marzo-Ortega H, Molto A, Navarro-Comp\u00e0n V, Ozgocmen S, Pimentel-Santos FM, Reveille J, Rudwaleit M, Sieper J, Sampaio-Barros P, Wiek D, Braun J (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210770","journal-title":"Ann Rheum Dis"},{"issue":"26","key":"4124_CR15","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","volume":"373","author":"D Baeten","year":"2015","unstructured":"Baeten D, Sieper J, Braun J, Baraliakos X, Dougados M, Emery P, Deodhar A, Porter B, Martin R, Andersson M, Mpofu S, Richards HB, Group MS, Group MS (2015) Secukinumab, an Interleukin-17A Inhibitor, in ankylosing spondylitis. N Engl J Med 373(26):2534\u20132548. https:\/\/doi.org\/10.1056\/NEJMoa1505066","journal-title":"N Engl J Med"},{"key":"4124_CR16","volume-title":"TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis (TA383). Technology appraisal guidance","author":"National Institute for Health and Care Excellence","year":"2016","unstructured":"National Institute for Health and Care Excellence (2016) TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis (TA383). Technology appraisal guidance. National Institute for Health and Care Excellence, London"},{"issue":"4, Suppl. 55","key":"4124_CR17","first-page":"118","volume":"27","author":"L Franke","year":"2009","unstructured":"Franke L, Ament A, Laar M, Boonen A, Severens J (2009) Cost-of-illness of rheumatoid arthritis and ankylosing spondylitis. Clin Exp Rheumatol 27(4, Suppl. 55):118\u2013123","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"4124_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/MAJ.0b013e3182514093","volume":"343","author":"JD Reveille","year":"2012","unstructured":"Reveille JD, Ximenes A, Ward MM (2012) Economic considerations of the treatment of ankylosing spondylitis. Am J Med Sci 343(5):371\u2013374. https:\/\/doi.org\/10.1097\/MAJ.0b013e3182514093","journal-title":"Am J Med Sci"},{"issue":"4 Suppl 73","key":"4124_CR19","first-page":"S136","volume":"30","author":"I Palla","year":"2012","unstructured":"Palla I, Trieste L, Tani C, Talarico R, Cortesi PA, Mosca M, Turchetti G (2012) A systematic literature review of the economic impact of ankylosing spondylitis. Clin Exp Rheumatol 30(4 Suppl 73):S136\u2013S141","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"4124_CR20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/pds.3895","volume":"25","author":"F Andersohn","year":"2016","unstructured":"Andersohn F, Walker J (2016) Characteristics and external validity of the German Health Risk Institute (HRI) database. Pharmacoepidemiol Drug Saf 25(1):106\u2013109. https:\/\/doi.org\/10.1002\/pds.3895","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"5","key":"4124_CR21","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"key":"4124_CR22","unstructured":"Statistisches Bundesamt (2017) DESTATIS Bev\u00f6lkerung und Erwerbst\u00e4tigkeit, Bev\u00f6lkerung mit Migrationshindergrund, Ergebnisse des Mikrozensus 2013"},{"issue":"1","key":"4124_CR23","doi-asserted-by":"publisher","first-page":"e000033","DOI":"10.1136\/rmdopen-2014-000033","volume":"1","author":"D Huscher","year":"2015","unstructured":"Huscher D, Thiele K, Rudwaleit M, Albrecht KC, Bischoff S, Krause A, Karberg K, Wassenberg S, Zink A (2015) Trends in treatment and outcomes of ankylosing spondylitis in outpatient rheumatological care in Germany between 2000 and 2012. RMD Open 1(1):e000033","journal-title":"RMD Open"},{"key":"4124_CR24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/ard.44.6.359","volume":"44","author":"J Gran","year":"1985","unstructured":"Gran J, Husby G, Hordvik M (1985) Prevalence of ankylosing spondylitis in males and females in a young middle-aged population of Tromso, northern Norway. Ann Rheum Dis 44:359\u2013367","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"4124_CR25","first-page":"241249","volume":"27","author":"SM Linden van der","year":"1984","unstructured":"van der Linden SM, Valkenburg HA, de Jongh BM, Cats A (1984) The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 27(3):241\u2013249","journal-title":"Arthritis Rheum"},{"issue":"1","key":"4124_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s003930050149","volume":"58","author":"E Feldtkeller","year":"1999","unstructured":"Feldtkeller E (1999) Age at disease onset and delayed diagnosis of spondyloarthropathies. Z Rheumatol 58(1):21\u201330","journal-title":"Z Rheumatol"},{"issue":"4","key":"4124_CR27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s10067-007-0727-6","volume":"27","author":"U Dincer","year":"2008","unstructured":"Dincer U, Cakar E, Kiralp MZ, Dursun H (2008) Diagnosis delay in patients with ankylosing spondylitis: possible reasons and proposals for new diagnostic criteria. Clin Rheumatol 27(4):457\u2013462","journal-title":"Clin Rheumatol"},{"key":"4124_CR28","doi-asserted-by":"publisher","first-page":"139608","DOI":"10.1155\/2013\/139608","volume":"2013","author":"O Baser","year":"2013","unstructured":"Baser O, Burkan A, Baser E, Koselerli R, Ertugay E, Altinbas A (2013) Health care costs associated with ankylosing spondylitis in Turkey: an analysis from nationwide real-world data. Int J Rheumatol 2013:139608","journal-title":"Int J Rheumatol"},{"issue":"4","key":"4124_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/rheumatology\/ken010","volume":"47","author":"AC Keat","year":"2008","unstructured":"Keat AC, Gaffney K, Gilbert AK, Harris C, Leeder J (2008) Influence of biologic therapy on return to work in people with work disability due to ankylosing spondylitis. Rheumatology 47(4):481\u2013483. https:\/\/doi.org\/10.1093\/rheumatology\/ken010","journal-title":"Rheumatology"},{"issue":"Suppl 1","key":"4124_CR30","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1478-6354-13-S1-S4","volume":"13","author":"G Schett","year":"2011","unstructured":"Schett G, Coates LC, Ash ZR, Finzel S, Conaghan PG (2011) Structural damage in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: traditional views, novel insights gained from TNF blockade, and concepts for the future. Arthritis Res Ther 13(Suppl 1):S4","journal-title":"Arthritis Res Ther"},{"key":"4124_CR31","unstructured":"Deutschen Gesellschaft f\u00fcr Rheumatologie (2013) Axiale Spondyloarthritis inklusive Morbus Bechterew und Fr\u00fchformen\u2014Langfassung zur S3\u2014Leitlinie. AWMF-Leitlinien Register Nummer: 060\/003, Entwicklungsstufe: S3 Version: November 2013"},{"issue":"9","key":"4124_CR32","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1136\/ard.2005.046367","volume":"65","author":"D Huscher","year":"2006","unstructured":"Huscher D, Merkesdal S, Thiele K, Zeidler H, Schneider M, Zink A (2006) Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann Rheum Dis 65(9):1175\u20131183","journal-title":"Ann Rheum Dis"},{"issue":"512","key":"4124_CR33","first-page":"FRI0242","volume":"74","author":"BC Wang","year":"2015","unstructured":"Wang BC, Tan CH, Furnback W, Ney JP, Yang YW, Fang CH, Chen WS (2015) Disease burden of ankylosing spondylitis in Taiwan: a population-based analysis. Ann Rheum Dis 74(512):FRI0242","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"4124_CR34","first-page":"29","volume":"3","author":"S Gre\u00df","year":"2007","unstructured":"Gre\u00df S (2007) Private health insurance in Germany: consequences of a dual system. Healthc Policy 3(2):29\u201337","journal-title":"Healthc Policy"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-4124-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4124-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4124-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T13:41:14Z","timestamp":1604756474000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-4124-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["4124"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-4124-z","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"3 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}