{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:43:37Z","timestamp":1774572217009,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00296-018-4129-7","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T03:58:48Z","timestamp":1534046328000},"page":"317-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is Henoch\u2013Sch\u00f6nlein purpura a susceptibility factor for functional gastrointestinal disorders in children?"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-822X","authenticated-orcid":false,"given":"Rabia Miray","family":"Kisla Ekinci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-313X","authenticated-orcid":false,"given":"Sibel","family":"Balc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okkes Ozgur","family":"Mart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-002X","authenticated-orcid":false,"given":"Gokhan","family":"Tumgor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-7277","authenticated-orcid":false,"given":"Dilek","family":"Dogruel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-5248","authenticated-orcid":false,"given":"Derya Ufuk","family":"Altintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-8289","authenticated-orcid":false,"given":"Mustafa","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"4129_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA (2013) 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1\u201311. \n                    https:\/\/doi.org\/10.1002\/art.37715","journal-title":"Arthritis Rheum"},{"key":"4129_CR2","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/jpc.12403","volume":"49","author":"P Trnka","year":"2013","unstructured":"Trnka P (2013) Henoch-Sch\u00f6nlein Purpura in children. J Paediatr Child Health 49:995\u20131003. \n                    https:\/\/doi.org\/10.1111\/jpc.12403","journal-title":"J Paediatr Child Health"},{"key":"4129_CR3","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.autrev.2017.10.009","volume":"16","author":"MH Heineke","year":"2017","unstructured":"Heineke MH, Ballering AV, Jamin A, Ben Mkaddem S, Monteiro RC, Van Egmond M (2017) New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Sch\u00f6nlein Purpura). Autoimmun Rev 16:1246\u20131253. \n                    https:\/\/doi.org\/10.1016\/j.autrev.2017.10.009","journal-title":"Autoimmun Rev"},{"key":"4129_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/03009742.2017.1412497","volume":"47","author":"M Mossberg","year":"2018","unstructured":"Mossberg M, Segelmark M, Kahn R, Englund M, Mohammad AJ (2018) Epidemiology of primary systemic vasculitis in children: a population-based study from southern Sweden. Scand J Rheumatol 47:295\u2013302. \n                    https:\/\/doi.org\/10.1080\/03009742.2017","journal-title":"Scand J Rheumatol"},{"key":"4129_CR5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nrgastro.2016.179","volume":"14","author":"M Soowamber","year":"2017","unstructured":"Soowamber M, Weizman AV, Pagnoux C (2017) Gastrointestinal aspects of vasculitides. Nat Rev Gastroenterol Hepatol 14:185\u2013194. \n                    https:\/\/doi.org\/10.1038\/nrgastro.2016.179","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4129_CR6","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.2340\/00015555-2733","volume":"97","author":"LE Hetland","year":"2017","unstructured":"Hetland LE, Susrud KS, Lindahl KH, Bygum A (2017) Henoch-Sch\u00f6nlein Purpura: a literature review. Acta Dermatovenereol 97:1160\u20131166. \n                    https:\/\/doi.org\/10.2340\/00015555-2733","journal-title":"Acta Dermatovenereol"},{"key":"4129_CR7","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.3748\/wjg.v23.i21.3915","volume":"23","author":"AC Boronat","year":"2017","unstructured":"Boronat AC, Ferreira-Maia AP, Matijasevich A, Wang YP (2017) Epidemiology of functional gastrointestinal disorders in children and adolescents: a systematic review. World J Gastroenterol 23:3915\u20133927. \n                    https:\/\/doi.org\/10.3748\/wjg.v23.i21.3915","journal-title":"World J Gastroenterol"},{"key":"4129_CR8","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1111\/j.1572-0241.2002.05783.x","volume":"97","author":"NA Koloski","year":"2002","unstructured":"Koloski NA, Talley NJ, Boyce PM (2002) Epidemiology and health care seeking in the functional GI disorders: a population-based study. Am J Gastroenterol 97:2290\u20132299","journal-title":"Am J Gastroenterol"},{"key":"4129_CR9","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1111\/eci.12548","volume":"45","author":"S Keely","year":"2015","unstructured":"Keely S, Walker MM, Marks E, Talley NJ (2015) Immune dysregulation in the functional gastrointestinal disorders. Eur J Clin Investig 45:1350\u20131359. \n                    https:\/\/doi.org\/10.1111\/eci.12548","journal-title":"Eur J Clin Investig"},{"key":"4129_CR10","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s10620-010-1499-4","volume":"56","author":"M Saps","year":"2011","unstructured":"Saps M, Dhroove G, Chogle A (2011) Henoch-Schonlein Purpura leads to functional gastrointestinal disorders. Dig Dis Sci 56:1789\u20131793. \n                    https:\/\/doi.org\/10.1007\/s10620-010-1499-4","journal-title":"Dig Dis Sci"},{"key":"4129_CR11","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1111\/1756-185X.12207","volume":"20","author":"E B\u00f6rekci","year":"2017","unstructured":"B\u00f6rekci E, Celikbilek M, Soyt\u00fcrk M, Akar S, B\u00f6rekci H, G\u00fcnaydin I (2017) Functional gastrointestinal disorders in patients with familial Mediterranean fever. Int J Rheum Dis 20:2101\u20132105. \n                    https:\/\/doi.org\/10.1111\/1756-185X.12207","journal-title":"Int J Rheum Dis"},{"key":"4129_CR12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1177\/0961203317747718","volume":"27","author":"M Garc\u00eda-Carrasco","year":"2018","unstructured":"Garc\u00eda-Carrasco M, Mendoza-Pinto C, Autr\u00e1n-Lim\u00f3n MA, Herrera Robles E, M\u00e9ndez Mart\u00ednez S, Etchegaray Morales I, Montiel Jarqu\u00edn \u00c1, G\u00e1lvez Romero JL, Soto-Santill\u00e1n P, Galindo-Herrera J, L\u00f3pez-Colombo A (2018) Prevalence of functional gastrointestinal disorders in adults with systemic lupus erythematosus. Lupus 27:788\u2013793. \n                    https:\/\/doi.org\/10.1177\/0961203317747718","journal-title":"Lupus"},{"key":"4129_CR13","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","volume":"69","author":"S Ozen","year":"2010","unstructured":"Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R et al (2010) EULAR\/PRINTO\/PRES criteria for Henoch-Sch\u00f6nlein Purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: final classification criteria. Ann Rheum Dis 69:798\u2013806","journal-title":"Ann Rheum Dis"},{"key":"4129_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/17474124.2018.1438188","volume":"12","author":"S Rajindrajith","year":"2018","unstructured":"Rajindrajith S, Zeevenhooven J, Devanarayana NM, Perera BJC, Benninga MA (2018) Functional abdominal pain disorders in children. Expert Rev Gastroenterol Hepatol 12:369\u2013390. \n                    https:\/\/doi.org\/10.1080\/17474124.2018.1438188","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"4129_CR15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015","author":"JS Hyams","year":"2016","unstructured":"Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, van Tilburg M (2016) Functional disorders: children and adolescents. Gastroenterology. \n                    https:\/\/doi.org\/10.1053\/j.gastro.2016.02.015","journal-title":"Gastroenterology"},{"key":"4129_CR16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/MPG.0b013e3182662401","volume":"55","author":"M Saps","year":"2012","unstructured":"Saps M, Adams P, Bonilla S, Chogle A, Nichols-Vinueza D (2012) Parental report of abdominal pain and abdominal pain-related functional gastrointestinal disorders from a community survey. J Pediatr Gastroenterol Nutr 55:707\u2013710. \n                    https:\/\/doi.org\/10.1097\/MPG.0b013e3182662401","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4129_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpeds.2016.04.008","volume":"177","author":"ML Lewis","year":"2016","unstructured":"Lewis ML, Palsson OS, Whitehead WE, van Tilburg MAL (2016) Prevalence of functional gastrointestinal disorders in children and adolescents. J Pediatr 177:39\u201343.e3. \n                    https:\/\/doi.org\/10.1016\/j.jpeds.2016.04.008","journal-title":"J Pediatr"},{"key":"4129_CR18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4291\/wjgp.v1.i3.97","volume":"1","author":"H Akiho","year":"2010","unstructured":"Akiho H, Ihara E, Nakamura K (2010) Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. World J Gastrointest Pathophysiol 1:97\u2013105","journal-title":"World J Gastrointest Pathophysiol"},{"key":"4129_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-230X-12-91","volume":"12","author":"J Chen","year":"2012","unstructured":"Chen J, Zhang Y, Deng Z (2012) Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1\/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. BMC Gastroenterol 12:91. \n                    https:\/\/doi.org\/10.1186\/1471-230X-12-91","journal-title":"BMC Gastroenterol"},{"key":"4129_CR20","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1136\/gut.2003.021154","volume":"53","author":"LH Wang","year":"2004","unstructured":"Wang LH, Fang XC, Pan GZ (2004) Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut 53:1096\u20131101. \n                    https:\/\/doi.org\/10.1136\/gut.2003.021154","journal-title":"Gut"},{"key":"4129_CR21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.gtc.2005.02.007","volume":"34","author":"P Bercik","year":"2005","unstructured":"Bercik P, Verdu EF, Collins SM (2005) Is irritable bowel syndrome a lowgrade inflammatory bowel disease? Gastroenterol Clin N Am 34:235\u2013245 vi-vii.","journal-title":"Gastroenterol Clin N Am"},{"key":"4129_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/745829","author":"E Myasoedova","year":"2011","unstructured":"Myasoedova E, Talley NJ, Manek NJ, Crowson CS (2011) Prevalence and risk factors of gastrointestinal disorders in patients with rheumatoid arthritis: results from a population-based survey in Olmsted county, Minnesota. Gastroenterol Res Pract. \n                    https:\/\/doi.org\/10.1155\/2011\/745829","journal-title":"Gastroenterol Res Pract"},{"key":"4129_CR23","first-page":"604","volume":"56","author":"G Baysoy","year":"2014","unstructured":"Baysoy G, G\u00fcler-Baysoy N, Kesicio\u011flu A, Ak\u0131n D, D\u00fcndar T, Pamuk\u00e7u-Uyan A (2014) Prevalence of irritable bowel syndrome in adolescents in Turkey: effects of gender, lifestyle and psychological factors. Turk J Pediatr 56:604\u2013611","journal-title":"Turk J Pediatr"},{"key":"4129_CR24","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/08923970801973646","volume":"30","author":"GC Vecchio Del","year":"2008","unstructured":"Del Vecchio GC, Penza R, Altomare M, Piacente L, Aceto G, Lassandro G, De Mattia D, Giordano P (2008) Cytokine pattern and endothelium damage markers in Henoch-Sch\u00f6nlein Purpura. Immunopharmacol Immunotoxicol 30:623\u2013629. \n                    https:\/\/doi.org\/10.1080\/08923970801973646","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"4129_CR25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00467-004-1726-3","volume":"20","author":"TS Ha","year":"2005","unstructured":"Ha TS (2005) The role of tumor necrosis factor-alpha in Henoch-Schonlein Purpura. Pediatr Nephrol 20:149\u2013153. \n                    https:\/\/doi.org\/10.1007\/s00467-004-1726-3","journal-title":"Pediatr Nephrol"},{"key":"4129_CR26","doi-asserted-by":"publisher","first-page":"e99006","DOI":"10.1371\/journal.pone.0099006","volume":"9","author":"M Angelis De","year":"2014","unstructured":"De Angelis M, Montemurno E, Piccolo M, Vannini L, Lauriero G, Maranzano V, Gozzi G, Serrazanetti D, Dalfino G, Gobbetti M, Gesualdo L (2014) Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN). PLoS One 9:e99006. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0099006","journal-title":"PLoS One"},{"key":"4129_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2018.03.003","volume":"58","author":"X Wang","year":"2018","unstructured":"Wang X, Zhang L, Wang Y, Liu X, Zhang H, Liu Y, Shen N, Yang J, Gai Z (2018) Gut microbiota dysbiosis is associated with Henoch-Sch\u00f6nlein Purpura in children. Int Immunopharmacol 58:1\u20138. \n                    https:\/\/doi.org\/10.1016\/j.intimp.2018.03.003","journal-title":"Int Immunopharmacol"},{"key":"4129_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11894-014-0379-z","volume":"16","author":"E Coss-Adame","year":"2014","unstructured":"Coss-Adame E, Rao SS (2014) Brain and gut interactions in irritable bowel syndrome: new paradigms and new understandings. Curr Gastroenterol Rep 16:379. \n                    https:\/\/doi.org\/10.1007\/s11894-014-0379-z","journal-title":"Curr Gastroenterol Rep"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-018-4129-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4129-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-018-4129-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:22:00Z","timestamp":1566912120000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-018-4129-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,12]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4129"],"URL":"https:\/\/doi.org\/10.1007\/s00296-018-4129-7","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,12]]},"assertion":[{"value":"26 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Authors Rabia Miray Kisla Ekinci, Sibel Balci, Okkes Ozgur Mart, Gokhan Tumgor, Sibel Yavuz, Halil Celik, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}