{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:37:19Z","timestamp":1770291439866,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:00:00Z","timestamp":1554508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Doctoral research grant from Anhui Medical University","award":["XJ201712"],"award-info":[{"award-number":["XJ201712"]}]},{"name":"the scientific research grant from Anhui Medical University","award":["2017xkj010"],"award-info":[{"award-number":["2017xkj010"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872687"],"award-info":[{"award-number":["81872687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00296-019-04297-6","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T02:41:56Z","timestamp":1554604916000},"page":"1439-1444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Leveraging Google Trends to investigate the global public interest in rheumatoid arthritis"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-0612","authenticated-orcid":false,"given":"Guo-Cui","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-4370","authenticated-orcid":false,"given":"Sha-Sha","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-0861","authenticated-orcid":false,"given":"Chan-Na","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4088-6446","authenticated-orcid":false,"given":"Yan-Mei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-9060","authenticated-orcid":false,"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-5134","authenticated-orcid":false,"given":"Yi-Lin","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-5747","authenticated-orcid":false,"given":"Hai-Feng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,6]]},"reference":[{"issue":"2","key":"4297_CR1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2174\/1871530317666171114122417","volume":"18","author":"SA Fazal","year":"2018","unstructured":"Fazal SA, Khan M, Nishi SE, Alam F, Zarin N, Bari MT, Ashraf GM (2018) A clinical update and global economic burden of rheumatoid arthritis. Endocr Metab Immune Disord Drug Targets 18(2):98\u2013109. \n                    https:\/\/doi.org\/10.2174\/1871530317666171114122417","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"4297_CR2","doi-asserted-by":"publisher","first-page":"545493","DOI":"10.1155\/2014\/545493","volume":"2014","author":"A Burska","year":"2014","unstructured":"Burska A, Boissinot M, Ponchel F (2014) Cytokines as biomarkers in rheumatoid arthritis. Mediators Inflamm 2014:545493. \n                    https:\/\/doi.org\/10.1155\/2014\/545493","journal-title":"Mediators Inflamm"},{"issue":"7","key":"4297_CR3","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","volume":"73","author":"M Cross","year":"2014","unstructured":"Cross M, Smith E, Hoy D, Carmona L, Wolfe F, Vos T, Williams B, Gabriel S, Lassere M, Johns N, Buchbinder R, Woolf A, March L (2014) The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 73(7):1316\u20131322. \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2013-204627","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"4297_CR4","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1093\/rheumatology\/ker161","volume":"50","author":"R Vaart van der","year":"2011","unstructured":"van der Vaart R, Drossaert CH, Taal E, van de Laar MA (2011) Patient preferences for a hospital-based rheumatology Interactive Health Communication Application and factors associated with these preferences. Rheumatology (Oxford) 50(9):1618\u20131626. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/ker161","journal-title":"Rheumatology (Oxford)"},{"issue":"3 Pt 1","key":"4297_CR5","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/j.1475-6773.2006.00510.x","volume":"41","author":"MK Bundorf","year":"2006","unstructured":"Bundorf MK, Wagner TH, Singer SJ, Baker LC (2006) Who searches the Internet for health information? Health Serv Res 41(3 Pt 1):819\u2013836. \n                    https:\/\/doi.org\/10.1111\/j.1475-6773.2006.00510.x","journal-title":"Health Serv Res"},{"issue":"18","key":"4297_CR6","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1001\/jama.289.18.2400","volume":"289","author":"L Baker","year":"2003","unstructured":"Baker L, Wagner TH, Singer S, Bundorf MK (2003) Use of the Internet and e-mail for health care information: results from a national survey. JAMA 289(18):2400\u20132406. \n                    https:\/\/doi.org\/10.1001\/jama.289.18.2400","journal-title":"JAMA"},{"key":"4297_CR7","unstructured":"NetMarketShare (2018) Search engine market share. \n                    https:\/\/www.netmarketshare.com\/search-engine-market-share\n                    \n                  . Accessed 21 June 2018"},{"issue":"3","key":"4297_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jegh.2017.06.001","volume":"7","author":"G Cervellin","year":"2017","unstructured":"Cervellin G, Comelli I, Lippi G (2017) Is Google Trends a reliable tool for digital epidemiology? Insights from different clinical settings. J Epidemiol Glob Health 7(3):185\u2013189. \n                    https:\/\/doi.org\/10.1016\/j.jegh.2017.06.001","journal-title":"J Epidemiol Glob Health"},{"key":"4297_CR9","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yebeh.2015.02.029","volume":"49","author":"F Brigo","year":"2015","unstructured":"Brigo F, Trinka E (2015) Google search behavior for status epilepticus. Epilepsy Behav 49:146\u2013149. \n                    https:\/\/doi.org\/10.1016\/j.yebeh.2015.02.029","journal-title":"Epilepsy Behav"},{"issue":"6","key":"4297_CR10","doi-asserted-by":"publisher","first-page":"e006678","DOI":"10.1136\/bmjopen-2014-006678","volume":"5","author":"M Schootman","year":"2015","unstructured":"Schootman M, Toor A, Cavazos-Rehg P, Jeffe DB, McQueen A, Eberth J, Davidson NO (2015) The utility of Google Trends data to examine interest in cancer screening. BMJ Open 5(6):e006678. \n                    https:\/\/doi.org\/10.1136\/bmjopen-2014-006678","journal-title":"BMJ Open"},{"key":"4297_CR11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.psychres.2016.10.030","volume":"246","author":"P Solano","year":"2016","unstructured":"Solano P, Ustulin M, Pizzorno E, Vichi M, Pompili M, Serafini G, Amore M (2016) A Google-based approach for monitoring suicide risk. Psychiatry Res 246:581\u2013586. \n                    https:\/\/doi.org\/10.1016\/j.psychres.2016.10.030","journal-title":"Psychiatry Res"},{"issue":"10","key":"4297_CR12","doi-asserted-by":"publisher","first-page":"e76020","DOI":"10.1371\/journal.pone.0076020","volume":"8","author":"L Rossignol","year":"2013","unstructured":"Rossignol L, Pelat C, Lambert B, Flahault A, Chartier-Kastler E, Hanslik T (2013) A method to assess seasonality of urinary tract infections based on medication sales and google trends. PLoS One 8(10):e76020. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0076020","journal-title":"PLoS One"},{"issue":"11","key":"4297_CR13","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s00296-018-4158-2","volume":"38","author":"SS Jellison","year":"2018","unstructured":"Jellison SS, Bibens M, Checketts J, Vassar M (2018) Using Google Trends to assess global public interest in osteoarthritis. Rheumatol Int 38(11):2133\u20132136. \n                    https:\/\/doi.org\/10.1007\/s00296-018-4158-2","journal-title":"Rheumatol Int"},{"issue":"1","key":"4297_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.32614\/RJ-2012-001","volume":"4","author":"AG Barnett","year":"2012","unstructured":"Barnett AG, Baker P, Dobson AJ (2012) Analysing seasonal data. R J 4(1):5\u201310. \n                    https:\/\/doi.org\/10.32614\/RJ-2012-001","journal-title":"R J"},{"key":"4297_CR15","unstructured":"Barnett AG, Baker P (2018) Seasonal analysis of health data. R package version 0:3-5. \n                    https:\/\/cran.r-project.org\/package=season\/\n                    \n                  . Accessed 06 Dec 2018"},{"issue":"5","key":"4297_CR16","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/rheumatology\/kew468","volume":"56","author":"A Abhishek","year":"2017","unstructured":"Abhishek A, Doherty M, Kuo CF, Mallen CD, Zhang W, Grainge MJ (2017) Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study. Rheumatology (Oxford) 56(5):736\u2013744. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/kew468","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"4297_CR17","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/art.1780370808","volume":"37","author":"LT Jacobsson","year":"1994","unstructured":"Jacobsson LT, Hanson RL, Knowler WC, Pillemer S, Pettitt DJ, McCance DR, Bennett PH (1994) Decreasing incidence and prevalence of rheumatoid arthritis in Pima Indians over a 25-year period. Arthritis Rheum 37(8):1158\u20131165. \n                    https:\/\/doi.org\/10.1002\/art.1780370808","journal-title":"Arthritis Rheum"},{"issue":"3","key":"4297_CR18","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/art.509","volume":"46","author":"MF Doran","year":"2002","unstructured":"Doran MF, Pond GR, Crowson CS, O\u2019Fallon WM, Gabriel SE (2002) Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a 40-year period. Arthritis Rheum 46(3):625\u2013631. \n                    https:\/\/doi.org\/10.1002\/art.509","journal-title":"Arthritis Rheum"},{"issue":"10","key":"4297_CR19","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00296-015-3270-9","volume":"35","author":"R Azevedo","year":"2015","unstructured":"Azevedo R, Bernardes M, Fonseca J, Lima A (2015) Smartphone application for rheumatoid arthritis self-management: cross-sectional study revealed the usefulness, willingness to use and patients\u2019 needs. Rheumatol Int 35(10):1675\u20131685. \n                    https:\/\/doi.org\/10.1007\/s00296-015-3270-9","journal-title":"Rheumatol Int"},{"issue":"9","key":"4297_CR20","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00296-016-3507-2","volume":"36","author":"JD Castillo-Ortiz","year":"2016","unstructured":"Castillo-Ortiz JD, de Jesus Valdivia-Nuno J, Ramirez-Gomez A, Garagarza-Mariscal H, Gallegos-Rios C, Flores-Hernandez G, Hernandez-Sanchez L, Brambila-Barba V, Castaneda-Sanchez JJ, Barajas-Ochoa Z, Suarez-Rico A, Sanchez-Gonzalez JM, Ramos-Remus C (2016) Fifteen-year trend in information on the World Wide Web for patients with rheumatoid arthritis: evolving, but opportunities for improvement remain. Rheumatol Int 36(9):1281\u20131289. \n                    https:\/\/doi.org\/10.1007\/s00296-016-3507-2","journal-title":"Rheumatol Int"},{"issue":"5","key":"4297_CR21","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/rheumatology\/kel414","volume":"46","author":"N Iikuni","year":"2007","unstructured":"Iikuni N, Nakajima A, Inoue E, Tanaka E, Okamoto H, Hara M, Tomatsu T, Kamatani N, Yamanaka H (2007) What\u2019s in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity. Rheumatology (Oxford) 46(5):846\u2013848. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/kel414","journal-title":"Rheumatology (Oxford)"},{"key":"4297_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12891-016-0911-4","volume":"17","author":"C Feldthusen","year":"2016","unstructured":"Feldthusen C, Grimby-Ekman A, Forsblad-d\u2019Elia H, Jacobsson L, Mannerkorpi K (2016) Seasonal variations in fatigue in persons with rheumatoid arthritis: a longitudinal study. BMC Musculoskelet Disord 17:59. \n                    https:\/\/doi.org\/10.1186\/s12891-016-0911-4","journal-title":"BMC Musculoskelet Disord"},{"issue":"6","key":"4297_CR23","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/rheumatology\/kem021","volume":"46","author":"G Szucs","year":"2007","unstructured":"Szucs G, Szekanecz Z, Zilahi E, Kapitany A, Barath S, Szamosi S, Vegvari A, Szabo Z, Szanto S, Czirjak L, Gyorgy Kiss C (2007) Systemic sclerosis-rheumatoid arthritis overlap syndrome: a unique combination of features suggests a distinct genetic, serological and clinical entity. Rheumatology (Oxford) 46(6):989\u2013993. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/kem021","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"4297_CR24","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1097\/00002281-200211000-00013","volume":"14","author":"JE Pope","year":"2002","unstructured":"Pope JE (2002) Scleroderma overlap syndromes. Curr Opin Rheumatol 14(6):704\u2013710. \n                    https:\/\/doi.org\/10.1097\/00002281-200211000-00013","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"4297_CR25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.semarthrit.2011.10.003","volume":"41","author":"PJ Clements","year":"2012","unstructured":"Clements PJ, Allanore Y, Khanna D, Singh M, Furst DE (2012) Arthritis in systemic sclerosis: systematic review of the literature and suggestions for the performance of future clinical trials in systemic sclerosis arthritis. Semin Arthritis Rheum 41(6):801\u2013814. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2011.10.003","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"4297_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.rbr.2014.12.011","volume":"56","author":"AM Horimoto","year":"2016","unstructured":"Horimoto AM, da Costa IP (2016) Overlap between systemic sclerosis and rheumatoid arthritis: a distinct clinical entity? Rev Bras Reumatol Engl Ed 56(4):287\u2013298. \n                    https:\/\/doi.org\/10.1016\/j.rbre.2014.12.011","journal-title":"Rev Bras Reumatol Engl Ed"},{"issue":"4","key":"4297_CR27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/RHU.0000000000000692","volume":"24","author":"N Mahroum","year":"2018","unstructured":"Mahroum N, Bragazzi NL, Sharif K, Gianfredi V, Nucci D, Rosselli R, Brigo F, Adawi M, Amital H, Watad A (2018) Leveraging Google Trends, Twitter, and Wikipedia to investigate the impact of a celebrity\u2019s death from rheumatoid arthritis. J Clin Rheumatol 24(4):188\u2013192. \n                    https:\/\/doi.org\/10.1097\/RHU.0000000000000692","journal-title":"J Clin Rheumatol"},{"issue":"4","key":"4297_CR28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/08916930701358925","volume":"40","author":"B Vogt","year":"2007","unstructured":"Vogt B, Fuhrnrohr B, Muller R, Sheriff A (2007) CRP and the disposal of dying cells: consequences for systemic lupus erythematosus and rheumatoid arthritis. Autoimmunity 40(4):295\u2013298. \n                    https:\/\/doi.org\/10.1080\/08916930701358925","journal-title":"Autoimmunity"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04297-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-019-04297-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04297-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T23:14:54Z","timestamp":1586042094000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-019-04297-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,6]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["4297"],"URL":"https:\/\/doi.org\/10.1007\/s00296-019-04297-6","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,6]]},"assertion":[{"value":"10 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}