{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:48:29Z","timestamp":1790801309977,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00296-019-04427-0","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T07:02:42Z","timestamp":1566802962000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-5910","authenticated-orcid":false,"given":"Vera","family":"Bernardino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Panarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"issue":"6752","key":"4427_CR1","doi-asserted-by":"crossref","first-page":"590e2","DOI":"10.1136\/bmj.301.6752.590","volume":"301","author":"A Silman","year":"1990","unstructured":"Silman A, Holligan S, Brennan P et al (1990) Prevalence of symptoms of Raynaud\u2019s phenomenon in general practice. BMJ 301(6752):590e2","journal-title":"BMJ"},{"key":"4427_CR2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/micc.12281","volume":"23","author":"V Smith","year":"2016","unstructured":"Smith V, Thevissen K, Trombetta AC et al (2016) Nailfold capillaroscopy and clinical applications in systemic sclerosis. Microcirculation 23:364\u2013372","journal-title":"Microcirculation"},{"key":"4427_CR3","first-page":"155","volume":"27","author":"M Cutolo","year":"2000","unstructured":"Cutolo M, Sulli A, Pizzorni C et al (2000) Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 27:155\u2013160","journal-title":"J Rheumatol"},{"key":"4427_CR4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.berh.2013.03.001","volume":"27","author":"M Cutolo","year":"2013","unstructured":"Cutolo M, Sulli A, Smith V (2013) How to perform and interpret capillaroscopy. Best Pract Clin Rheumatol 27:237\u2013248","journal-title":"Best Pract Clin Rheumatol"},{"key":"4427_CR5","first-page":"844","volume":"17","author":"M Cutolo","year":"2018","unstructured":"Cutolo M, Melsens K, Wijnant S et al (2018) Nailfold capillaroscopy in systemic lupus erythematosus: a systematic review and critical appraisal. Autoimmun Rev 17:844\u2013852","journal-title":"Autoimmun Rev"},{"issue":"1","key":"4427_CR6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/annrheumdis-2011-200022","volume":"71","author":"M Sebastiani","year":"2012","unstructured":"Sebastiani M, Manfredi A, Vukatana G et al (2012) Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicenter validation study. Ann Rheum Dis 71(1):67\u201370","journal-title":"Ann Rheum Dis"},{"key":"4427_CR7","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J et al (2013) 2013 classification criteria for systemic sclerosis: an American college of rheumatology\/european league against rheumatism collaborative iniciative. Ann Rheum 72:1747\u20131755","journal-title":"Ann Rheum"},{"issue":"9","key":"4427_CR8","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC (1997) Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725","journal-title":"Arthritis Rheum"},{"key":"4427_CR9","first-page":"33","volume-title":"Mixed connective tissue disease and anti-nuclear antibodies","author":"D Alarcon-Segovia","year":"1987","unstructured":"Alarcon-Segovia D, Villareal M (1987) Classification and diagnostic criteria for mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed connective tissue disease and anti-nuclear antibodies. Excerpta Medica, Amsterdam, pp 33\u201340"},{"issue":"12","key":"4427_CR10","first-page":"2055","volume":"23","author":"JM Amigues","year":"1996","unstructured":"Amigues JM, Cantagrel A, Abbal M et al (1996) Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. Autoimmunity Group of the Hospitals of Toulouse. J Rheumatol 23(12):2055\u20132062","journal-title":"J Rheumatol"},{"key":"4427_CR11","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ et al (2010) Rheumatoid arthritis classification criteria: an American college of rheumatology\/european league against rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"4427_CR12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","volume":"76","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R et al (2017) 2016 American college of rheumatology\/european league against rheumatism classification criteria for primary sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis 76(1):9\u201316","journal-title":"Ann Rheum Dis"},{"key":"4427_CR13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295\u2013306","journal-title":"J Thromb Haemost"},{"key":"4427_CR14","first-page":"615","volume":"17","author":"M Mosca","year":"1999","unstructured":"Mosca M, Neri R, Bombardieri S (1999) Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria. Clin Exp Rheumatol 17:615\u2013620","journal-title":"Clin Exp Rheumatol"},{"issue":"12","key":"4427_CR15","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.40320","volume":"69","author":"I Lundberg","year":"2017","unstructured":"Lundberg I, Tj\u00e4rnlund A, Bottai M et al (2017) 2017 European league against rheumatism\/American college of rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Arthritis Rheumatol 69(12):2271\u20132282","journal-title":"Arthritis Rheumatol"},{"key":"4427_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/976427","volume-title":"Atlas of capillaroscopy in rheumatic diseases","author":"M Cutolo","year":"2010","unstructured":"Cutolo M (2010) Atlas of capillaroscopy in rheumatic diseases. Elsevier, Milano. \nhttps:\/\/doi.org\/10.1155\/2011\/976427"},{"key":"4427_CR17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/rheumatology\/keh156","volume":"43","author":"M Cutolo","year":"2004","unstructured":"Cutolo M, Pizzorni C, Tuccio M et al (2004) Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology 43:719\u2013726","journal-title":"Rheumatology"},{"key":"4427_CR18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/ard.55.8.507","volume":"55","author":"Y Kabasakal","year":"1996","unstructured":"Kabasakal Y, Elvins D, Ring E et al (1996) Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 55:507\u2013512","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"4427_CR19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1024\/0301-1526\/a000661","volume":"46","author":"J Belch","year":"2017","unstructured":"Belch J, Carlizza A, Carpentier PH et al (2017) ESVM guidelines\u2014the diagnosis and management of Raynaud\u2019s phenomenon. VASA 46(6):413\u2013423","journal-title":"VASA"},{"issue":"8","key":"4427_CR20","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/annrheumdis-2011-200742","volume":"71","author":"FM Meier","year":"2012","unstructured":"Meier FM, Frommer KW, Dinser R et al (2012) Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis 71(8):1355\u20131360","journal-title":"Ann Rheum Dis"},{"key":"4427_CR21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaut.2014.01.008","volume":"48\u201349","author":"C Tani","year":"2014","unstructured":"Tani C, Carli L, Vagnani S et al (2014) The diagnosis and classification of mixed connective tissue disease. J Autoimmun 48\u201349:46\u201349","journal-title":"J Autoimmun"},{"key":"4427_CR22","first-page":"23","volume-title":"Mixed connective tissue diseases and anti-nuclear antibodies","author":"GC Sharp","year":"1987","unstructured":"Sharp GC (1987) Diagnostic criteria for classification of MCTD. In: Kasukawa R, Sharp GC (eds) Mixed connective tissue diseases and anti-nuclear antibodies. Elsevier, Amsterdam, pp 23\u201332"},{"key":"4427_CR23","first-page":"41","volume-title":"Mixed connective tissue diseases and anti-nuclear antibodies","author":"R Kasukawa","year":"1987","unstructured":"Kasukawa R et al (1987) Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed connective tissue diseases and anti-nuclear antibodies. Elsevier, Amsterdam, pp 41\u201347"},{"key":"4427_CR24","first-page":"33","volume-title":"Mixed connective tissue diseases and anti-nuclear antibodies","author":"D Alarcon-Segovia","year":"1987","unstructured":"Alarcon-Segovia D, Cardiel MH (1987) Classification and diagnostic criteria for mixed connective tissue disease. In: Kasukawa R, Sharps GC (eds) Mixed connective tissue diseases and anti-nuclear antibodies. Elsevier, Amsterdam, pp 33\u201340"},{"issue":"4","key":"4427_CR25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/0961203307076517","volume":"16","author":"MD de Holanda","year":"2007","unstructured":"de Holanda MD, Bonf\u00e1 E, Fuller R et al (2007) Capillaroscopy is a dynamic process in mixed connective tissue disease. Lupus 16(4):254\u2013258","journal-title":"Lupus"},{"issue":"9","key":"4427_CR26","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1136\/ard.2003.013417","volume":"53","author":"IE Hoffman","year":"2004","unstructured":"Hoffman IE, Peene I, Meheus L et al (2004) Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus. Ann Rheum Dis 53(9):1155\u20131158","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"4427_CR27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00296-012-2449-6","volume":"33","author":"S Pavlov-Dolijanovic","year":"2013","unstructured":"Pavlov-Dolijanovic S, Damjanov NS, Vujasinovic SNZ et al (2013) Is there a difference in systemic lupus erythematosus with and without Raynaud\u2019s phenomenon? Rheumatol Int 33(4):859\u2013865","journal-title":"Rheumatol Int"},{"issue":"4","key":"4427_CR28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0190-9622(98)70116-1","volume":"38","author":"M Vayssairat","year":"1998","unstructured":"Vayssairat M, Abuaf N, Baudot N et al (1998) Abnormal IgG cardiolipin antibody titers in patients with Raynaud\u2019s phenomenon and\/or related disorders: prevalence and clinical significance. J Am Acad Dermatol 38(4):555\u2013558","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"4427_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/rheumatology\/29.3.205","volume":"29","author":"P Youinou","year":"1990","unstructured":"Youinou P, Pennec YL, Katsikis P et al (1990) Raynaud\u2019s phenomenon in primary Sj\u00f6gren\u2019s syndrome. Br J Rheumatol 29(3):205\u2013207","journal-title":"Br J Rheumatol"},{"issue":"10","key":"4427_CR30","first-page":"1572","volume":"19","author":"A Kraus","year":"1992","unstructured":"Kraus A, Caballero-Uribe C, Jakez J et al (1992) Raynaud\u2019s Phenomenon in primary Sj\u00f6gren\u2019s syndrome. Association with other extraglandular manifestations. J Rheumatol 19(10):1572\u20131574","journal-title":"J Rheumatol"},{"key":"4427_CR31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/rheumatology\/38.9.826","volume":"38","author":"M Tektonidou","year":"1999","unstructured":"Tektonidou M, Kaskani E, Skoupoli FN et al (1999) Microvascular abnormalities in Sj\u00f6gren\u2019s syndrome: nailfold capillaroscopy. Rheumatology 38:826\u2013830","journal-title":"Rheumatology"},{"key":"4427_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/976427","author":"C Rigamonti","year":"2011","unstructured":"Rigamonti C, Bogdanos DP, Mytilinaiou MG et al (2011) Primary biliary cirrhosis associated with systemic sclerosis: diagnostic and clinical challenges. Int J Rheumatol. \nhttps:\/\/doi.org\/10.1155\/2011\/976427","journal-title":"Int J Rheumatol"},{"issue":"8","key":"4427_CR33","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1136\/annrheumdis-2013-205127","volume":"74","author":"C Dobloug","year":"2015","unstructured":"Dobloug C, Garen T, Bitter H et al (2015) Prevalence and clinical characteristics of adult polymyositis and dermatomyositis; data from a large and unselected Norwegian cohort. Ann Rheum Dis 74(8):1551\u20131556","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"4427_CR34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11926-011-0176-8","volume":"13","author":"E Katzap","year":"2011","unstructured":"Katzap E, Barilla-LaBarca ML, Marder G (2011) Antisynthetase syndrome. Curr Rheumatol Rep 13(3):175\u2013181","journal-title":"Curr Rheumatol Rep"},{"key":"4427_CR35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10067-014-2795-8","volume":"34","author":"A Manfredi","year":"2015","unstructured":"Manfredi A, Sebastiani M, Cassone G et al (2015) Nailfold capillaroscopic changes in dermatomyositis and polymyositis. Clin Rheumatol 34:279\u2013284","journal-title":"Clin Rheumatol"},{"key":"4427_CR36","first-page":"755","volume":"77","author":"M Sebastiani","year":"2018","unstructured":"Sebastiani M, Triantafyllias K, Manfredi A et al (2018) FRI0452 Nailfold capillaroscopy in antisynthetase syndrome (NASCAR): results of a multicenter, international study of the american and european network of antisynthetase syndrome (AENEAS). Ann Rheum Dis 77:755\u2013756","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"4427_CR37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/ard.40.6.567","volume":"40","author":"GJ Carroll","year":"1981","unstructured":"Carroll GJ, Withers K, Bayliss CE (1981) The prevalence of Raynaud\u2019s syndrome in rheumatoid arthritis. Ann Rheum Dis 40(6):567\u2013570","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"4427_CR38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/rheumatology\/35.8.752","volume":"35","author":"A Saraux","year":"1996","unstructured":"Saraux A, Allain J, Guedes C et al (1996) Raynaud\u2019s phenomenon in rheumatoid arthritis. J Rheumatol 35(8):752\u2013754","journal-title":"J Rheumatol"},{"issue":"4","key":"4427_CR39","first-page":"269","volume":"8","author":"A Rajaei","year":"2017","unstructured":"Rajaei A, Dehghan P, Amiri A (2017) Nailfold capillaroscopy in 430 patients with rheumatoid arthritis. Casp J Intern Med 8(4):269\u2013274","journal-title":"Casp J Intern Med"},{"issue":"7","key":"4427_CR40","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41584-018-0022-8","volume":"14","author":"R Bordy","year":"2018","unstructured":"Bordy R, Totoson P, Prati C et al (2018) Microvascular endothelial dysfunction in rheumatoid arthritis. Nat Rev Rheumatol 14(7):404\u2013420","journal-title":"Nat Rev Rheumatol"},{"key":"4427_CR41","first-page":"89","volume":"4","author":"G Metisons","year":"2010","unstructured":"Metisons G, Stavropoulos-Kalinoglou A, Sandoo A (2010) Vascular function and inflammation in rheumatoid arthritis: the role of physical activity. Open Cardiovasc Med J 4:89\u201396","journal-title":"Open Cardiovasc Med J"},{"issue":"2","key":"4427_CR42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1191\/096120398678919787","volume":"7","author":"M Mosca","year":"1998","unstructured":"Mosca M, Tavoni A, Neri R et al (1998) Undifferentiated connective tissue disease: the clinical and serological profiles of 91 patients followed at least 1\u00a0year. Lupus 7(2):95\u2013100","journal-title":"Lupus"},{"issue":"2","key":"4427_CR43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10067-004-0988-2","volume":"24","author":"R De Angelis","year":"2005","unstructured":"De Angelis R, Cerioni A, Del Medico P et al (2005) Raynaud\u2019s phenomenon in undifferentiated connective tissue disease (UCTD). Clin Rheumatol 24(2):145\u2013151","journal-title":"Clin Rheumatol"},{"key":"4427_CR44","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1016\/j.ejim.2011.07.007","volume":"22","author":"A Pyrpasopoulou","year":"2011","unstructured":"Pyrpasopoulou A, Triantafyllou A, Anyfanti P et al (2011) Capillaroscopy as a screening test for clinical antiphospholipid syndrome. Eur J Intern Med 22:e158\u2013e159","journal-title":"Eur J Intern Med"},{"key":"4427_CR45","first-page":"1574","volume":"27","author":"A Sulli","year":"2000","unstructured":"Sulli A, Pizzorni C, Cutolo M (2000) Nailfold videocapillaroscopy abnormalities in patients with antiphospholipid antibodies. J Rheumatol 27:1574\u20131576","journal-title":"J Rheumatol"},{"issue":"6 Pt 1","key":"4427_CR46","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1549-8719.2000.tb00135.x","volume":"7","author":"H\u00c1 Lehr","year":"2000","unstructured":"Lehr H\u00c1 (2000) Microcirculatory dysfunction induced by cigarette smoking. Microcirculation 7(6 Pt 1):367\u2013384","journal-title":"Microcirculation"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04427-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-019-04427-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04427-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:38:34Z","timestamp":1598312314000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-019-04427-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,26]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["4427"],"URL":"https:\/\/doi.org\/10.1007\/s00296-019-04427-0","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,26]]},"assertion":[{"value":"23 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Vera Bernardino, Ana Rodrigues, Ana Llad\u00f3 and Ant\u00f3nio Panarra declare that they do not have any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}