{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:33:03Z","timestamp":1787682783354,"version":"build-2784847793"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00296-019-04468-5","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T18:02:37Z","timestamp":1574704957000},"page":"827-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aortic involvement in relapsing polychondritis: case-based review"],"prefix":"10.1007","volume":"41","author":[{"given":"Mustafa","family":"Erdogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem Nihal","family":"Esatoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulen","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-1652","authenticated-orcid":false,"given":"Vedat","family":"Hamuryudan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"4468_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.7326\/0003-4819-104-1-74","volume":"104","author":"CJ Michet","year":"1986","unstructured":"Michet CJ, McKenna CH, Luthra HS, O\u2019Fallon WM (1986) Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med 104:74\u201378. https:\/\/doi.org\/10.7326\/0003-4819-104-1-74","journal-title":"Ann Intern Med"},{"key":"4468_CR2","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4065\/81.6.772","volume":"81","author":"C Dib","year":"2006","unstructured":"Dib C, Moustafa SE, Mookadam M, Zehr KJ, Michet CJ, Mookadam F (2006) Surgical treatment of the cardiac manifestations of relapsing polychondritis: overview of 33 patients identified through literature review and the Mayo Clinic records. Mayo Clin Proc 81:772\u2013776. https:\/\/doi.org\/10.4065\/81.6.772","journal-title":"Mayo Clin Proc"},{"key":"4468_CR3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jbspin.2017.05.009","volume":"85","author":"M Le Besnerais","year":"2018","unstructured":"Le Besnerais M, Arnaud L, Boutemy J, Bienvenu B, Levesque H, Amoura Z, Marie I (2018) Aortic involvement in relapsing polychondritis. Joint Bone Spine 85:345\u2013351. https:\/\/doi.org\/10.1016\/j.jbspin.2017.05.009","journal-title":"Joint Bone Spine"},{"key":"4468_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.semarthrit.2011.12.007","volume":"42","author":"SD Mathew","year":"2012","unstructured":"Mathew SD, Battafarano DF, Morris MJ (2012) Relapsing polychondritis in the Department of Defense population and review of the literature. Semin Arthritis Rheum 42:70\u201383. https:\/\/doi.org\/10.1016\/j.semarthrit.2011.12.007","journal-title":"Semin Arthritis Rheum"},{"key":"4468_CR5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924\u2013926","journal-title":"BMJ"},{"key":"4468_CR6","first-page":"684","volume":"109","author":"F Fern\u00e1ndez-Monr\u00e1s","year":"1997","unstructured":"Fern\u00e1ndez-Monr\u00e1s F, Forn\u00f3s C, Argim\u00f3n J, Pujadas R (1997) Aneurysmatic aortitis in the MAGIC syndrome. Medicina Cl\u00ednica 109:684\u2013685","journal-title":"Medicina Cl\u00ednica"},{"key":"4468_CR7","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/acr.23159","volume":"69","author":"S Garg","year":"2017","unstructured":"Garg S, Lipson A (2017) Not so classic: an unusual presentation of a rare disease. Arthritis Care Res 69:1066\u20131068. https:\/\/doi.org\/10.1002\/acr.23159","journal-title":"Arthritis Care Res"},{"key":"4468_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0973-3698(12)60010-7","volume":"7","author":"S Kartik","year":"2012","unstructured":"Kartik S, Bhakuni DS, Shanmuganandan K, Chauhan MS (2012) Subclinical aortitis in a case of polychondritis. Indian J Rheumatol 7:46. https:\/\/doi.org\/10.1016\/S0973-3698(12)60010-7","journal-title":"Indian J Rheumatol"},{"key":"4468_CR9","first-page":"397","volume":"20","author":"Huong D Le Thi","year":"1993","unstructured":"Le Thi Huong D, Wechsler B, Piette JC, Papo T, Jaccard A, Jault F, Gandjbakhch I, Godeau P (1993) Aortic insufficiency and recurrent valve prosthesis dehiscence in MAGIC syndrome. J Rheumatol 20:397\u2013398","journal-title":"J Rheumatol"},{"key":"4468_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5114\/reum.2019.83234","volume":"57","author":"B Maci\u0105\u017cek-Chyra","year":"2019","unstructured":"Maci\u0105\u017cek-Chyra B, Szmyrka M, Skoczy\u0144ska M, Sokolik R, Lasocka J, Wiland P (2019) Relapsing polychondritis\u2014analysis of symptoms and criteria. Reumatologia 57:8\u201318. https:\/\/doi.org\/10.5114\/reum.2019.83234","journal-title":"Reumatologia"},{"key":"4468_CR11","first-page":"15","volume":"135","author":"A Pappalardo","year":"1990","unstructured":"Pappalardo A, Sall\u00ec L, Asaro R, Scalici G (1990) Relapsing polychondritis. A case report. La Clinica terapeutica 135:15\u201322","journal-title":"La Clinica terapeutica"},{"key":"4468_CR12","first-page":"179","volume":"137","author":"M Vilien","year":"1975","unstructured":"Vilien M, Platz P, Movild B, Bendixen G (1975) Relapsing polychondritis (Danish). Ugeskr Laeger 137:179\u2013183","journal-title":"Ugeskr Laeger"},{"key":"4468_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0002-9394(67)93341-7","volume":"64","author":"B Anderson","year":"1967","unstructured":"Anderson B (1967) Ocular lesions in relapsing polychondritis and other rheumatoid syndromes. The Edward Jackson memorial lecture. Am J Ophthalmol 64:35\u201350. https:\/\/doi.org\/10.1016\/0002-9394(67)93341-7","journal-title":"Am J Ophthalmol"},{"key":"4468_CR14","first-page":"1019","volume":"116","author":"J Esdaile","year":"1977","unstructured":"Esdaile J, Hawkins D, Gold P, Freedman SO, Duguid WP (1977) Vascular involvement in relapsing polychondritis. Can Med Assoc J 116:1019\u20131022","journal-title":"Can Med Assoc J"},{"key":"4468_CR15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0002-9149(71)90124-X","volume":"28","author":"CS Alexander","year":"1971","unstructured":"Alexander CS, Derr RF, Sako Y (1971) Abnormal amino acid and lipid composition of aortic valve in relapsing polychondritis. Am J Cardiol 28:337\u2013341","journal-title":"Am J Cardiol"},{"key":"4468_CR16","first-page":"335","volume":"34","author":"J Allal","year":"1985","unstructured":"Allal J, Rossi F, Petitalot J, Vouhe P, Barraine R, Sudre Y (1985) Les manifestations cardiaques de la polychondrite chronique atrophiante. Annales de cardiologie et d\u2019ang\u00e9iologie 34:335\u2013337","journal-title":"Annales de cardiologie et d\u2019ang\u00e9iologie"},{"issue":"Suppl 1","key":"4468_CR17","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1007\/s10067-008-1016-8","volume":"28","author":"R Ananthakrishna","year":"2009","unstructured":"Ananthakrishna R, Goel R, Padhan P, Mathew J, Danda D (2009) Relapsing polychondritis\u2014case series from South India. Clin Rheumatol 28(Suppl 1):S7\u201310. https:\/\/doi.org\/10.1007\/s10067-008-1016-8","journal-title":"Clin Rheumatol"},{"key":"4468_CR18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0167-5273(87)90214-2","volume":"14","author":"A Balsa-Criado","year":"1987","unstructured":"Balsa-Criado A, Garcia-Fernandez F, Roldan I (1987) Cardiac involvement in relapsing polychondritis. Int J Cardiol 14:381\u2013383","journal-title":"Int J Cardiol"},{"key":"4468_CR19","doi-asserted-by":"publisher","first-page":"971","DOI":"10.4065\/77.9.971","volume":"77","author":"SN Barretto","year":"2002","unstructured":"Barretto SN, Oliveira GH, Michet CJ, Nyman MA, Edwards WD, Kullo IJ (2002) Multiple cardiovascular complications in a patient with relapsing polychondritis. Mayo Clin Proc 77:971\u2013974. https:\/\/doi.org\/10.4065\/77.9.971","journal-title":"Mayo Clin Proc"},{"key":"4468_CR20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jpeds.2009.09.045","volume":"156","author":"A Belot","year":"2010","unstructured":"Belot A, Duquesne A, Job-Deslandre C, Costedoat-Chalumeau N, Boudjemaa S, Wechsler B, Cochat P, Piette J-C, Cimaz R (2010) Pediatric-onset relapsing polychondritis: case series and systematic review. J Pediatr 156:484\u2013489","journal-title":"J Pediatr"},{"key":"4468_CR21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/art.1780340115","volume":"34","author":"P Bowness","year":"1991","unstructured":"Bowness P, Hawley IC, Morris T, Dearden A, Walport MJ (1991) Complete heart block and severe aortic incompetence in relapsing polychondritis: clinicopathologic findings. Arthritis Rheum 34:97\u2013100","journal-title":"Arthritis Rheum"},{"key":"4468_CR22","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/art.1780350716","volume":"35","author":"LM Buckley","year":"1992","unstructured":"Buckley LM, Ades PA (1992) Progressive aortic valve inflammation occurring despite apparent remission of relapsing polychondritis. Arthritis Rheum 35:812\u2013814","journal-title":"Arthritis Rheum"},{"key":"4468_CR23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10016-006-9046-7","volume":"20","author":"M Caceres","year":"2006","unstructured":"Caceres M, Estrera AL, Buja LM, Safi HJ (2006) Transverse aortic arch replacement associated with MAGIC syndrome: case report and literature review. Ann Vasc Surg 20:395\u2013398","journal-title":"Ann Vasc Surg"},{"key":"4468_CR24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00005792-198705000-00004","volume":"66","author":"A Chang-Miller","year":"1987","unstructured":"Chang-Miller A, Okamura M, Torres VE, Michet CJ, Wagoner RD, Donadio JV Jr, Offord KP, Holley KE (1987) Renal involvement in relapsing polychondritis. Medicine (Baltimore) 66:202\u2013217","journal-title":"Medicine (Baltimore)"},{"key":"4468_CR25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0002-9149(76)90432-X","volume":"37","author":"PR Cipriano","year":"1976","unstructured":"Cipriano PR, Alonso DR, Baltaxe HA, Gay WA Jr, Smith JP (1976) Multiple aortic aneurysms in relapsing polychondritis. Am J Cardiol 37:1097\u20131102","journal-title":"Am J Cardiol"},{"key":"4468_CR26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/ard.2006.056630","volume":"66","author":"T Daikeler","year":"2007","unstructured":"Daikeler T, K\u00f6tter I, Tyndall CB, Apperley J, Attarbaschi A, Guardiola P, Gratwohl A, Jantunen E, Marmont A (2007) Haematopoietic stem cell transplantation for vasculitis including Behcet\u2019s disease and polychondritis: a retrospective analysis of patients recorded in the European Bone Marrow Transplantation and European League Against Rheumatism databases and a review of the literature. Ann Rheumatic Dis 66:202\u2013207","journal-title":"Ann Rheumatic Dis"},{"key":"4468_CR27","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0049-0172(97)80028-5","volume":"26","author":"A Del Rosso","year":"1997","unstructured":"Del Rosso A, Petix NR, Pratesi M, Bini A (1997) Cardiovascular involvement in relapsing polychondritis. Semin Arthritis Rheum 26:840\u2013844","journal-title":"Semin Arthritis Rheum"},{"key":"4468_CR28","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/eurheartj\/ehu238","volume":"35","author":"M Gautier","year":"2014","unstructured":"Gautier M, Boutemy J, Ivascau C, Galateau-Salle F, Labombarda F (2014) Cardiac involvement in relapsing polychondritis. Eur Heart J 35:2241","journal-title":"Eur Heart J"},{"issue":"5 Suppl","key":"4468_CR29","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1016\/j.jaad.2008.05.010","volume":"59","author":"S Ghosn","year":"2008","unstructured":"Ghosn S, Malek J, Shbaklo Z, Matta M, Uthman I (2008) Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis. J Am Acad Dermatol 59(5 Suppl):S84\u2013S87. https:\/\/doi.org\/10.1016\/j.jaad.2008.05.010","journal-title":"J Am Acad Dermatol"},{"key":"4468_CR30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00541214","volume":"4","author":"M Giordano","year":"1984","unstructured":"Giordano M, Valentini G, Sodano A (1984) Relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome. Rheumatol Int 4:191\u2013193","journal-title":"Rheumatol Int"},{"key":"4468_CR31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1056\/NEJM196905222802109","volume":"280","author":"JW Hainer","year":"1969","unstructured":"Hainer JW, Hamilton GW (1969) Aortic abnormalities in relapsing polychondritis: report of a case with dissecting aortic aneurysm. N Engl J Med 280:1166\u20131168","journal-title":"N Engl J Med"},{"key":"4468_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10067-007-0688-9","volume":"27","author":"C Hidalgo-Tenorio","year":"2008","unstructured":"Hidalgo-Tenorio C, Sabio-Sanchez JM, Linares PJ, Salmeron LM, Ros-Die E, Jimenez-Alonso J (2008) Magic syndrome and true aortic aneurysm. Clin Rheumatol 27:115\u2013117. https:\/\/doi.org\/10.1007\/s10067-007-0688-9","journal-title":"Clin Rheumatol"},{"key":"4468_CR33","first-page":"363","volume":"4","author":"R Hughes","year":"1972","unstructured":"Hughes R, Berry C, Seifert M, Lessof M (1972) Relapsing polychondritis: three cases with a clinico-pathological study and literature review. Int J Med 4:363\u2013380","journal-title":"Int J Med"},{"key":"4468_CR34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/1538574413488459","volume":"47","author":"CE Jacobs","year":"2013","unstructured":"Jacobs CE, March RJ, Hunt PJ, Rivera AG, Cavanagh S, McCarthy WJ (2013) Repair of a complex thoracic aneurysm from relapsing polychondritis. Vasc Endovasc Surg 47:387\u2013389","journal-title":"Vasc Endovasc Surg"},{"key":"4468_CR35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00428-009-0865-0","volume":"456","author":"M Jansen","year":"2010","unstructured":"Jansen M, Saleh S, Bolster M, O\u2019Donnell A, Ahern T, Spence L, Sheppard MN, Burke L (2010) Thoracic vasculitis presenting as surgical problems. Virchows Arch 456:91\u201396","journal-title":"Virchows Arch"},{"key":"4468_CR36","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s10067-007-0600-7","volume":"26","author":"KT Kao","year":"2007","unstructured":"Kao KT, Potrebic S, Evans JR (2007) Relapsing polychondritis presenting as meningoencephalitis with valvular abnormality: a case report. Clin Rheumatol 26:1985\u20131988. https:\/\/doi.org\/10.1007\/s10067-007-0600-7","journal-title":"Clin Rheumatol"},{"key":"4468_CR37","first-page":"173","volume":"24","author":"R Lal","year":"1976","unstructured":"Lal R, Menon ND, Bhattacharya P, Plaha SK, Narayanan GR (1976) Relapsing polychondritis\u2013a case report with review of literature. J Assoc Physicians India 24:173\u2013177","journal-title":"J Assoc Physicians India"},{"key":"4468_CR38","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1055\/s-0028-1110387","volume":"94","author":"H Lang","year":"1946","unstructured":"Lang H, M\u00fcller D (1946) Finke J (1969) Recurrent polychondritis with aortic aneurysm. Dtsch Med Wochenschr 94:2033\u20132040","journal-title":"Dtsch Med Wochenschr"},{"key":"4468_CR39","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0022-5223(97)70127-2","volume":"114","author":"L Lang-Lazdunski","year":"1997","unstructured":"Lang-Lazdunski L, Pansard Y, Hvass U (1997) Aortic valve replacement in relapsing polychondritis. J Thorac Cardiovasc Surg 114:131\u2013132. https:\/\/doi.org\/10.1016\/S0022-5223(97)70127-2","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4468_CR40","first-page":"97","volume":"2","author":"C Mainguene","year":"1991","unstructured":"Mainguene C, Bouhour J, Dupon H (1991) Cardiovascular complications in chronic atrophic polychondritis. Apropos of an anatomo-clinical case. Review of the literature. Ann Cardiol Angeiol 2:97\u2013102","journal-title":"Ann Cardiol Angeiol"},{"key":"4468_CR41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/ard.51.3.413","volume":"51","author":"DA Marshall","year":"1992","unstructured":"Marshall DA, Jackson R, Rae AP, Capell HA (1992) Early aortic valve cusp rupture in relapsing polychondritis. Ann Rheum Dis 51:413\u2013415","journal-title":"Ann Rheum Dis"},{"key":"4468_CR42","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00296-009-1308-6","volume":"30","author":"EM McCarthy","year":"2010","unstructured":"McCarthy EM, Cunnane G (2010) Treatment of relapsing polychondritis in the era of biological agents. Rheumatol Int 30:827\u2013828. https:\/\/doi.org\/10.1007\/s00296-009-1308-6","journal-title":"Rheumatol Int"},{"key":"4468_CR43","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1093\/rheumatology\/kep172","volume":"48","author":"A Mekinian","year":"2009","unstructured":"Mekinian A, Lambert M, Beregi JP, Morell-Dubois S, Launay D, Queyrel V, Midulla M, Hachulla E, Hatron PY (2009) Aortic aneurysm in MAGIC syndrome successfully managed with combined anti-TNF-alpha and stent grafting. Rheumatology (Oxford) 48:1169\u20131170. https:\/\/doi.org\/10.1093\/rheumatology\/kep172","journal-title":"Rheumatology (Oxford)"},{"key":"4468_CR44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-2007-1022003","volume":"31","author":"C Mestres","year":"1983","unstructured":"Mestres C, Igual A, Botey A, Revert L, Murtra M (1983) Relapsing polychondritis with glomerulonephritis and severe aortic insufficiency surgically treated with success. Thorac Cardiovasc Surg 31:307\u2013309","journal-title":"Thorac Cardiovasc Surg"},{"key":"4468_CR45","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/s0151-9638(07)89267-2","volume":"134","author":"G Monsel","year":"2007","unstructured":"Monsel G, Maubec E, Picard-Dahan C, Brocheriou I, Henry Feugeas MC, Kieffer E, Franc\u00e8s C, Crickx B (2007) An\u00e9vrysmes aortiques multiples au cours d\u2019une polychondrite atrophiante. Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie 134:552\u2013554. https:\/\/doi.org\/10.1016\/s0151-9638(07)89267-2","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie"},{"key":"4468_CR46","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/RHU.0b013e3181337820","volume":"13","author":"CS Ng","year":"2007","unstructured":"Ng CS, Hogan P, McKenzie S, Gibbs H, Strutton G, Wong R (2007) Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome complicated by aneurysmal aortitis. J Clin Rheumatol 13:221\u2013223. https:\/\/doi.org\/10.1097\/RHU.0b013e3181337820","journal-title":"J Clin Rheumatol"},{"key":"4468_CR47","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/art.1780130618","volume":"13","author":"DS Owen","year":"1970","unstructured":"Owen DS, Irby R, Toone E (1970) Relapsing polychondritis with aortic involvement. Arthritis Rheum 13:877\u2013881. https:\/\/doi.org\/10.1002\/art.1780130618","journal-title":"Arthritis Rheum"},{"key":"4468_CR48","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archsurg.1972.04180050086022","volume":"104","author":"G Pappas","year":"1972","unstructured":"Pappas G, Johnson M (1972) Mitral and aortic valvular insufficiency in chronic relapsing polychondritis. Arch Surg 104:712\u2013714","journal-title":"Arch Surg"},{"issue":"1 Suppl 70","key":"4468_CR49","first-page":"S101","volume":"30","author":"MP Paroli","year":"2012","unstructured":"Paroli MP, Priori R, Spinucci G, Abicca I, Valesini G (2012) Uveitis with retinal occlusive vasculitis and sensorineural hypoacusia as first symptoms of relapsing polychondritis. Clin Exp Rheumatol 30(1 Suppl 70):S101\u2013S103","journal-title":"Clin Exp Rheumatol"},{"key":"4468_CR50","first-page":"946","volume":"23","author":"I Quere","year":"1996","unstructured":"Quere I, Biron C, Dubois A (1996) Lupus anticoagulant and thrombosis in relapsing polychondritis. J Rheumatol 23:946\u2013947","journal-title":"J Rheumatol"},{"key":"4468_CR51","first-page":"954","volume":"32","author":"YH Rho","year":"2005","unstructured":"Rho YH, Choi SJ, Choi YS, Lee YH, Ji JD, Song GG (2005) Relapsing polychondritis with aortitis without valvular involvement. J Rheumatol 32:954\u2013956","journal-title":"J Rheumatol"},{"key":"4468_CR52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/RHU.0000000000000634","volume":"24","author":"FW Rossi","year":"2018","unstructured":"Rossi FW, Mercurio V, Rivellese F, Lobasso A, Barbieri L, Tocchetti CG, de Paulis A, Marone G (2018) Severe aortic valve regurgitation in relapsing polychondritis. J Clin Rheumatol 24:109\u2013111","journal-title":"J Clin Rheumatol"},{"key":"4468_CR53","first-page":"817","volume":"54","author":"D Sasirekha","year":"2006","unstructured":"Sasirekha D, Meenakshi N, Thomas J, Jagannath B, Nayar S, Cherian K (2006) Multiple cardiovascular involvement in a case of relapsing polychondritis. J Assoc Physicians India 54:817\u2013819","journal-title":"J Assoc Physicians India"},{"key":"4468_CR54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archinte.1967.00300010111022","volume":"120","author":"J Self","year":"1967","unstructured":"Self J, Hammarsten J, Lyne B, Peterson DA (1967) Relapsing polychondritis. Arch Intern Med 120:109\u2013112","journal-title":"Arch Intern Med"},{"key":"4468_CR55","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/jcp.54.11.890","volume":"54","author":"AG Selim","year":"2001","unstructured":"Selim AG, Fulford LG, Mohiaddin RH, Sheppard MN (2001) Active aortitis in relapsing polychondritis. J Clin Pathol 54:890\u2013892","journal-title":"J Clin Pathol"},{"key":"4468_CR56","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/rheumatology\/kem229","volume":"46","author":"M Seymour","year":"2007","unstructured":"Seymour M, Home D, Williams R, Allard S (2007) Prolonged response to anti-tumour necrosis factor treatment with adalimumab (Humira) in relapsing polychondritis complicated by aortitis. Rheumatology (Oxford) 46:1738\u20131739","journal-title":"Rheumatology (Oxford)"},{"key":"4468_CR57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ccd.1810070111","volume":"7","author":"GS Sohi","year":"1981","unstructured":"Sohi GS, Desai AM, Ward WW, Flowers NC (1981) Aortic cusp involvement causing severe aortic regurgitation in a case of relapsing polychondritis. Cathet Cardiovasc Diagn 7:79\u201386","journal-title":"Cathet Cardiovasc Diagn"},{"key":"4468_CR58","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10067-014-2670-7","volume":"34","author":"R Stael","year":"2015","unstructured":"Stael R, Smith V, Wittoek R, Creytens D, Mielants H (2015) Sustained response to tocilizumab in a patient with relapsing polychondritis with aortic involvement: a case based review. Clin Rheumatol 34:189\u2013193. https:\/\/doi.org\/10.1007\/s10067-014-2670-7","journal-title":"Clin Rheumatol"},{"key":"4468_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bcr-2017-220434","volume":"2017","author":"S Subhadarshani","year":"2017","unstructured":"Subhadarshani S, Gupta V, Chahal A, Verma KK (2017) Saddle-nose and bilateral cauliflower ear deformities with pyoderma gangrenosum-like ulcers, cavitary pulmonary lesions, digital gangrene and pulselessness in a young female. BMJ Case Rep 2017:1\u20134. https:\/\/doi.org\/10.1136\/bcr-2017-220434","journal-title":"BMJ Case Rep"},{"key":"4468_CR60","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1161\/CIRCIMAGING.113.001290","volume":"7","author":"G Sugrue","year":"2014","unstructured":"Sugrue G, Durcan L, Bell L, Bolster F, Donnelly S, Kavanagh E (2014) Unsuspected cardiovascular involvement in relapsing polychondritis: a case of aortitis with critical coronary artery stenosis secondary to relapsing polychondritis. Circ Cardiovasc Imaging 7:409\u2013411. https:\/\/doi.org\/10.1161\/CIRCIMAGING.113.001290","journal-title":"Circ Cardiovasc Imaging"},{"key":"4468_CR61","first-page":"285","volume":"37","author":"S Sunder","year":"1989","unstructured":"Sunder S, Rath P, Jairaj P, Krishnaswami S (1989) Relapsing polychondritis\u2014a case report and review of literature. J Assoc Physicians India 37:285\u2013287","journal-title":"J Assoc Physicians India"},{"key":"4468_CR62","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1093\/rheumatology\/kev255","volume":"54","author":"W Terreaux","year":"2015","unstructured":"Terreaux W, Mestrallet S, Fauconier M, Pennaforte JL, Penalba C, Eschard JP, Salmon JH (2015) Failure of tocilizumab therapy in a patient with mouth and genital ulcers with inflamed cartilage syndrome complicated by aortic aneurysm. Rheumatology (Oxford) 54:2111\u20132113. https:\/\/doi.org\/10.1093\/rheumatology\/kev255","journal-title":"Rheumatology (Oxford)"},{"key":"4468_CR63","first-page":"995","volume":"90","author":"C Thuaire","year":"1997","unstructured":"Thuaire C, Benamer H, Brochet E, Aubry P, Hayem G, Vissuzaine C, Chatel D, Assayag P (1997) Anatomoclinical study of aortic insufficiency in atrophic polychondritis. Apropos of a case. Arch Mal Coeur Vaiss 90:995\u2013998","journal-title":"Arch Mal Coeur Vaiss"},{"key":"4468_CR64","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.jtcvs.2006.01.032","volume":"131","author":"RK Vaidyanathan","year":"2006","unstructured":"Vaidyanathan RK, Byalal JR, Sundaramoorthi T, Sankar NM, Thomas JM, Meenakshi NA, Cherian KM (2006) Rapidly progressive coronary ostial stenosis after aortic valve replacement in relapsing polychondritis. J Thorac Cardiovasc Surg 131:1395\u20131396. https:\/\/doi.org\/10.1016\/j.jtcvs.2006.01.032","journal-title":"J Thorac Cardiovasc Surg"},{"key":"4468_CR65","doi-asserted-by":"crossref","first-page":"340","DOI":"10.7326\/0003-4819-109-4-340","volume":"109","author":"W VanDecker","year":"1988","unstructured":"VanDecker W, Panidis IP (1988) Relapsing polychondritis and cardiac valvular involvement. Ann Intern Med 109:340\u2013341","journal-title":"Ann Intern Med"},{"key":"4468_CR66","first-page":"179","volume":"137","author":"M Vilen","year":"1975","unstructured":"Vilen M, Platz P, Movild B (1975) Relapsing polychondritis. Ugeskr Laeger 137:179\u2013183","journal-title":"Ugeskr Laeger"},{"key":"4468_CR67","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/rheumatology\/37.12.1359","volume":"37","author":"U Walker","year":"1998","unstructured":"Walker U, Weiner S, Vaith P, Uhl M, Peter H (1998) Aortitis in relapsing polychondritis. Br J Rheumatol 37:1359\u20131361","journal-title":"Br J Rheumatol"},{"key":"4468_CR68","first-page":"56","volume":"165","author":"KA Ward","year":"1984","unstructured":"Ward KA, Demos TC (1984) Viewbox: relapsing polychondritis with aortic insufficiency. IMJ Ill Med J 165:56\u201358","journal-title":"IMJ Ill Med J"},{"key":"4468_CR69","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1177\/000331970405500518","volume":"55","author":"CM Wu","year":"2004","unstructured":"Wu CM, Liu CP, Chiang HT, Lin SL (2004) Cardiac manifestations of relapsing polychondritis\u2014a case report. Angiology 55:583\u2013586. https:\/\/doi.org\/10.1177\/000331970405500518","journal-title":"Angiology"},{"key":"4468_CR70","unstructured":"Yung A, Charleson HA, Ullal R, Doube A (2000)A case of relapsing polychondritis with coronary ostial stenosis and severe aortic incompetence. Semin Arthritis Rheum 2:144-146"},{"key":"4468_CR71","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1536\/ihj.7.188","volume":"7","author":"N Yamazaki","year":"1966","unstructured":"Yamazaki N, Yawata K, Hannya H, Kimura E (1966) A case of relapsing polychondritis associated with aortic insufficiency. Jpn Heart J 7:188\u2013195. https:\/\/doi.org\/10.1536\/ihj.7.188","journal-title":"Jpn Heart J"},{"key":"4468_CR72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0002-9343(85)90547-9","volume":"79","author":"GS Firestein","year":"1985","unstructured":"Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ, Barber J, O\u2019Duffy JD (1985) Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behcet\u2019s disease. Am J Med 79:65\u201372","journal-title":"Am J Med"},{"key":"4468_CR73","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-019-01130-6","author":"E Kisamori","year":"2019","unstructured":"Kisamori E, Otani S, Yamamoto T, Nishiki M, Yamada Y, Matsumoto T (2019) Concomitant aortic valve replacement, mitral valve replacement, and coronary artery bypass grafting for aortic stenosis and mitral regurgitation in a patient with relapsing polychondritis. General Thoracic Cardiovasc Surg. https:\/\/doi.org\/10.1007\/s11748-019-01130-6","journal-title":"General Thoracic Cardiovasc Surg"},{"key":"4468_CR74","first-page":"83","volume":"82","author":"MC Mayer","year":"1991","unstructured":"Mayer MC, Visconti M, Bassano P, Galloro V (1991) Relapsing polychondritis. Recenti Prog Med 82:83\u201385","journal-title":"Recenti Prog Med"},{"key":"4468_CR75","first-page":"71","volume":"80","author":"CM Pearson","year":"1967","unstructured":"Pearson CM, Kroening R, Verity MA, Getzen JH (1967) Aortic insufficiency and aortic aneurysm in relapsing polychondritis. Trans Assoc Am Physicians 80:71\u201390","journal-title":"Trans Assoc Am Physicians"},{"key":"4468_CR76","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00393-005-0001-8","volume":"65","author":"O Schultz","year":"2006","unstructured":"Schultz O, R\u00fcckert R, Burmester G, Buttgereit F (2006) Acute mesenteric ischemia in a patient with relapsing polychondritis. Zeitschrift fur Rheumatologie 65:63\u201368. https:\/\/doi.org\/10.1007\/s00393-005-0001-8","journal-title":"Zeitschrift fur Rheumatologie"},{"key":"4468_CR77","first-page":"A3175","volume":"156","author":"EJ Ter Borg","year":"2012","unstructured":"Ter Borg EJ, van der Waal RI (2012) Een man met een rood oor. Ned Tijdschr Geneeskd 156:A3175","journal-title":"Ned Tijdschr Geneeskd"},{"key":"4468_CR78","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1007\/s00296-017-3832-0","volume":"37","author":"G Elourimi","year":"2017","unstructured":"Elourimi G, Soussan M, Warzocha U, Bugaud H, Dh\u00f4te R, Abad S (2017) Efficacy of tocilizumab highlighted by FDG-PET\/CT in a patient with relapsing polychondritis-associated aortitis. Rheumatol Int 37:1931\u20131935. https:\/\/doi.org\/10.1007\/s00296-017-3832-0","journal-title":"Rheumatol Int"},{"issue":"Suppl 82","key":"4468_CR79","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1136\/bcr.04.2011.4135","volume":"32","author":"J Loricera","year":"2014","unstructured":"Loricera J, Blanco R, Casta\u00f1eda S, Humbr\u00eda A et al (2014) Tocilizumab in refractory aortitis: a study on 16 patients and literature review. Clin Exp Rheumatol 32(Suppl 82):S79\u2013S89. https:\/\/doi.org\/10.1136\/bcr.04.2011.4135","journal-title":"Clin Exp Rheumatol"},{"key":"4468_CR80","first-page":"223","volume":"35","author":"M Sall\u00e9s","year":"2017","unstructured":"Sall\u00e9s M, M\u00ednguez S, Ros S, Tuneu R, Gelman SM (2017) Sustained response to tocilizumab in a patient with relapsing polychondritis complicated by aortitis. Clin Exp Rheumatol 35:223","journal-title":"Clin Exp Rheumatol"},{"key":"4468_CR81","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1212\/WNL.38.1.150","volume":"38","author":"SS Stewart","year":"1988","unstructured":"Stewart SS, Ashizawa T, Dudley AW Jr, Goldberg JW, Lidsky MD (1988) Cerebral vasculitis in relapsing polychondritis. Neurology 38:150\u2013152","journal-title":"Neurology"},{"key":"4468_CR82","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00005792-197605000-00001","volume":"55","author":"LP McAdam","year":"1976","unstructured":"McAdam LP, O\u2019Hanlan MA, Bluestone R, Pearson CM (1976) Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 55:193\u2013215","journal-title":"Medicine (Baltimore)"},{"key":"4468_CR83","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-197906000-00009","volume":"89","author":"JM Damiani","year":"1979","unstructured":"Damiani JM, Levine HL (1979) Relapsing polychondritis\u2014report of ten cases. Laryngoscope 89:929\u2013946","journal-title":"Laryngoscope"},{"key":"4468_CR84","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.semarthrit.2018.05.002","volume":"4","author":"TA Kermani","year":"2019","unstructured":"Kermani TA, Diab S, Sreih AG, Cuthbertson D, Borchin R, Carette S, Forbess L, Koening CL, McAlear CA, Monach PA (2019) Arterial lesions in giant cell arteritis: a longitudinal study. Semin Arthritis Rheum 4:707\u2013713","journal-title":"Semin Arthritis Rheum"},{"key":"4468_CR85","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.mayocp.2013.04.025","volume":"8","author":"J Schmidt","year":"2013","unstructured":"Schmidt J, Kermani TA, Bacani AK, Crowson CS, Cooper LT, Matteson EL, Warrington KJ (2013) Diagnostic features, treatment, and outcomes of Takayasu arteritis in a US cohort of 126 patients. Mayo Clin Proc 8:822\u2013830","journal-title":"Mayo Clin Proc"},{"key":"4468_CR86","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10067-013-2205-7","volume":"32","author":"Y Fei","year":"2013","unstructured":"Fei Y, Li X, Lin S, Song X, Wu Q, Zhu Y, Gao X, Zhang W, Zhao Y, Zeng X (2013) Major vascular involvement in Beh\u00e7et\u2019s disease: a retrospective study of 796 patients. Clin Rheumatol 32:845\u2013852","journal-title":"Clin Rheumatol"},{"key":"4468_CR87","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0039-6060(97)90284-1","volume":"121","author":"H T\u00fcz\u00fcn","year":"1997","unstructured":"T\u00fcz\u00fcn H, Be\u015firli K, Sayin A, Vural F, Hamuryudan V, Hizli N, Yurdakul S, Yazici H (1997) Management of aneurysms in Beh\u00e7et\u2019s syndrome: an analysis of 24 patients. Surgery 121:150\u2013156","journal-title":"Surgery"},{"key":"4468_CR88","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4103\/0974-2069.107235","volume":"6","author":"P Vaideeswar","year":"2013","unstructured":"Vaideeswar P, Deshpande JR (2013) Pathology of Takayasu arteritis: a brief review. Ann Pediatric Cardiol 6:52","journal-title":"Ann Pediatric Cardiol"},{"key":"4468_CR89","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nrrheum.2014.89","volume":"10","author":"GS Hoffman","year":"2014","unstructured":"Hoffman GS, Calabrese LH (2014) Vasculitis: determinants of disease patterns. Nat Rev Rheumatol 10:454","journal-title":"Nat Rev Rheumatol"},{"key":"4468_CR90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12350-018-1406-5","volume":"26","author":"S-W Lee","year":"2019","unstructured":"Lee S-W, Kim S-J, Seo Y, Jeong SY, Ahn B-C, Lee J (2019) F-18 FDG PET for assessment of disease activity of large vessel vasculitis: a systematic review and meta-analysis. J Nucl Cardiol 26:59\u201367","journal-title":"J Nucl Cardiol"},{"key":"4468_CR91","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13075-017-1316-y","volume":"19","author":"B Gudbrandsson","year":"2017","unstructured":"Gudbrandsson B, Molberg \u00d8, Palm \u00d8 (2017) TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study. Arthritis Res Ther 19:99","journal-title":"Arthritis Res Ther"},{"key":"4468_CR92","first-page":"1898","volume":"35","author":"JD Stein","year":"2008","unstructured":"Stein JD, Lee P, Kuriya B, Tenenbaum J, Daniel LB, Butany J, Provost YL, David TE (2008) Critical coronary artery stenosis and aortitis in a patient with relapsing polychondritis. J Rheumatol 35:1898\u20131900","journal-title":"J Rheumatol"},{"key":"4468_CR93","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5761\/atcs.cr.12.01885","volume":"19","author":"M Iida","year":"2013","unstructured":"Iida M, Orime Y, Umeda T, Ishii Y, Shiono M (2013) Emergency repair of acute aortic dissection in a patient with relapsing polychondritis. Ann Thorac Cardiovasc Surg 19:158\u2013161. https:\/\/doi.org\/10.5761\/atcs.cr.12.01885","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"4468_CR94","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1055\/s-0039-1687903","volume":"7","author":"R Pfister","year":"2019","unstructured":"Pfister R, Messe M, Niclauss L, Kirsch M, Haller C, Delay D (2019) 18-fluorodeoxyglucose positron emission tomography-computed tomography to guide aortic arch replacement in relapsing polychondritis. Aorta (Stamford) 7:18\u201321. https:\/\/doi.org\/10.1055\/s-0039-1687903","journal-title":"Aorta (Stamford)"},{"key":"4468_CR95","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/rheumatology\/kei245","volume":"45","author":"M Park","year":"2005","unstructured":"Park M, Lee S, Park Y, Lee S, Choi D, Shim W (2005) Post-interventional immunosuppressive treatment and vascular restenosis in Takayasu\u2019s arteritis. Rheumatology (Oxford) 45:600\u2013605. https:\/\/doi.org\/10.1093\/rheumatology\/kei245","journal-title":"Rheumatology (Oxford)"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04468-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-019-04468-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-019-04468-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T13:08:06Z","timestamp":1615468086000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-019-04468-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["4468"],"URL":"https:\/\/doi.org\/10.1007\/s00296-019-04468-5","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"4 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"G. Hatemi received research grant\/research support and\/or speaker fees from AbbVie. V. Hamuryudan received honoraria, speaker fees and research grants from Amgen, MSD, Pfize,r and Roche. The other authors (ME, SNE) have declared that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors. Written informed consent to publish was obtained from the reported patient prior to submission of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}