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The study was approved by each participants Institutional Review board (Protocol, Date): Princess Alexandria Hospital (2005\/221 March 6th 2009) Cedars Sinai Medical Center (CR00004630 October 1<sup>t<\/sup>, 2010) National Institute of Health (03-AR-0131 March 3rd 2003), University of California San Francisco (H63075-35456-01 March 12th 2010), and University of Texas Health Science Center at Houston (HSC-MS-07-0022 Feb 8th, 2007).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}