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IL-33\/ST2 pathway is involved in the pathogenesis of numerous diseases including autoimmune disorders. IL-33 fulfils cardioprotective function, while soluble ST2 (sST2) is a decoy receptor that reduces protective impact of IL-33. The aim of the study was to evaluate the concentrations of sST2 and IL-33 in sera of patients with IIM and evaluate its associations with the clinical course of the disease. Patients with IIM as well as age- and sex-matched healthy controls were recruited. Concentrations of sST2 and IL-33 were assessed with ELISA in sera of both patients and controls. Patients were asked to fill in the questionnaires concerning clinical symptoms and physical functioning. Concentrations of sST2 and IL-33 were correlated with the results of laboratory tests and clinical symptoms. Concentrations of sST2 were significantly higher in IIM group than in healthy subjects (median sST2 in IIM 26.51 vs in healthy controls 21.39; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). In the majority of patients, IL-33 concentrations did not exceed the detection limit. Anti-SRP-positive patients presented significantly higher concentrations of sST2 as compared to anti-SRP-negative patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). In patients with anti-Ro52 antibodies, sST2 concentrations were significantly lower than in anti-Ro52-negative patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Concentrations of sST2 correlated with the degree of disability evaluated with Health Assessment Questionnaire. sST2 is increased in patients with IIM and its concentration correlates with the degree of disability. In patients with anti-SRP antibodies, levels of sST2 are exceptionally high.<\/jats:p>","DOI":"10.1007\/s00296-020-04554-z","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T12:02:39Z","timestamp":1585396959000},"page":"1133-1141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interleukin-33\/suppression of tumorigenicity 2 (IL-33\/ST2) axis in idiopathic inflammatory myopathies and its association with laboratory and clinical parameters: a pilot study"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-5731","authenticated-orcid":false,"given":"Aleksandra","family":"Opinc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-8551","authenticated-orcid":false,"given":"Joanna","family":"Sarnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-8497","authenticated-orcid":false,"given":"Olga","family":"Brzezi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-5282","authenticated-orcid":false,"given":"Marcin","family":"Makowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8389-7399","authenticated-orcid":false,"given":"Anna","family":"Lewandowska-Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-375X","authenticated-orcid":false,"given":"Joanna","family":"Makowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"4554_CR1","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3390\/ijms18051084","volume":"18","author":"DE Mandel","year":"2017","unstructured":"Mandel DE, Malemud CJ, Askari AD (2017) Idiopathic inflammatory myopathies: a review of the classification and impact of pathogenesis. 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Author Joanna Sarnik declares that she has no conflict of interest. Author Olga Brzezi\u0144ska declares that she has no conflict of interest. Author Marcin Makowski declares that he has no conflict of interest. Author Anna Lewandowska-Polak declares that she has no conflict of interest. Author Joanna Makowska declares that she has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (Bioethical Committee of the Medical University of Lodz, Poland. Reference number: RNN\/173\/18\/KE) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}