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However, the evidence surrounding risk factors for IPJ osteoarthritis progression is unclear. Identifying risk factors for IPJ osteoarthritis progression may inform preventative strategies and early interventions to improve long-term outcomes for individuals at risk of IPJ osteoarthritis progression. The objectives of the study were to describe methods used to measure the progression of IPJ osteoarthritis and identify risk factors for IPJ osteoarthritis progression. MEDLINE, EMBASE, Scopus, and The Cochrane Library were searched from inception to 19th February 2020 (PROSPERO CRD42019121034). Eligible studies assessed potential risk factor\/s associated with IPJ osteoarthritis progression. Risk of bias was assessed using a modified QUIPS Tool, and a best evidence synthesis was performed. Of eight eligible studies, all measured osteoarthritis progression radiographically, and none considered symptoms. Eighteen potential risk factors were assessed. Diabetes (adjusted mean difference between 2.06 and 7.78), and larger finger epiphyseal index in males (regression coefficient <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.202) and females (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.325) were identified as risk factors (limited evidence). Older age in men and women showed mixed results; 13 variables were not risk factors (all limited evidence). Patients with diabetes and larger finger epiphyseal index might be at higher risk of radiographic IPJ osteoarthritis progression, though evidence is limited and studies are biased. Studies assessing symptomatic IPJ osteoarthritis progression are lacking.<\/jats:p>","DOI":"10.1007\/s00296-020-04687-1","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T16:02:36Z","timestamp":1598284956000},"page":"1781-1792","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors for the progression of finger interphalangeal joint osteoarthritis: a systematic review"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-1653","authenticated-orcid":false,"given":"Karishma","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-2947","authenticated-orcid":false,"given":"Xiaotian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-8654","authenticated-orcid":false,"given":"Jennifer C. 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KS, XY, JCEL, GSC, NKA, DF, and SRF certify they have no financial or commercial association that might pose a conflict of interest in connection with the submitted article. KS, XY, JCEL, GSC, NKA, DF, and SRF certify they have no non-financial association that might pose a non-financial conflict of interest in connection with the submitted article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No external editing support was provided. Information facilitation (search) support was provided by Ms Elinor Harris, Knowledge Centre Manager and Outreach Librarian and the Bodleian Health Care Libraries, University of Oxford.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"External editing and information facilitation (search) support"}}]}}