{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:50:23Z","timestamp":1790419823231,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T-cell large granular lymphocytic leukemia (T-LGLL) is a lymphoproliferative disorder characterized by a persistent increase in the number of large granular lymphocytes (LGLs), neutropenia, and splenomegaly. Clinical manifestations of T-LGLL in the setting of rheumatoid arthritis (RA) are often identical to those in which one would suspect Felty's syndrome (FS). These disorders are distinguished by the presence of T-cell clonality, which is present in T-LGLL but not in FS. Mutations in the signal transducer and activator of transcription 3 (<jats:italic>STAT3<\/jats:italic>) and 5b (<jats:italic>STAT5b<\/jats:italic>) genes can be used as molecular markers of T-LGLL, but their prevalence in FS is unknown.<\/jats:p><jats:p>Eighty-one patients with RA and unexplained neutropenia or\/and an increase in the number of LGLs above 2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L were stratified into RA-associated T-LGLL (<jats:italic>N<\/jats:italic>\u2009=\u200956) or FS (<jats:italic>N<\/jats:italic>\u2009=\u200925) groups based on the presence or absence of T-cell clonality. <jats:italic>STAT3<\/jats:italic> and <jats:italic>STAT5b<\/jats:italic> gene mutations were assessed in each group by means of allele-specific polymerase chain reaction assays. Clinical, immunological, laboratory data and the results of immunophenotyping of blood and bone marrow lymphocytes were also evaluated.<\/jats:p><jats:p>Mutations of the <jats:italic>STAT3<\/jats:italic> gene and an increase in the number of LGLs above 2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L were detected in RA-associated T-LGLL, but not in FS (39% vs 0% and 21% vs 0%, respectively). Mutations in the <jats:italic>STAT5b<\/jats:italic> gene were not observed in either group. Expression of CD57, CD16, and CD5<jats:sup>\u2212\/dim<\/jats:sup> on CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T-lymphocytes was observed in both RA-associated T-LGLL and FS.<\/jats:p><jats:p><jats:italic>STAT3<\/jats:italic> gene mutations or LGL counts over 2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L in RA patients are indicative of T-LGLL.<\/jats:p>","DOI":"10.1007\/s00296-020-04757-4","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T20:07:31Z","timestamp":1607198851000},"page":"147-156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-1281","authenticated-orcid":false,"given":"Vadim Romanovich","family":"Gorodetskiy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-0084","authenticated-orcid":false,"given":"Yulia Vladimirovna","family":"Sidorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-0954","authenticated-orcid":false,"given":"Natalia Alexandrovna","family":"Kupryshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-8622","authenticated-orcid":false,"given":"Vladimir Ivanovich","family":"Vasilyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-7062","authenticated-orcid":false,"given":"Natalya Alexandrovna","family":"Probatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2424-9524","authenticated-orcid":false,"given":"Natalya Valerievna","family":"Ryzhikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-9187","authenticated-orcid":false,"given":"Andrey Borisovich","family":"Sudarikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"4757_CR1","first-page":"156","volume":"141","author":"JL Spivak","year":"1977","unstructured":"Spivak JL (1977) Felty\u2019s syndrome: an analytical review. Johns Hopkins Med J 141:156\u2013162","journal-title":"Johns Hopkins Med J"},{"key":"4757_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/00005792-199069020-00001","volume":"69","author":"G Campion","year":"1990","unstructured":"Campion G, Maddison PJ, Goulding N, James I, Ahern MJ, Watt I, Sansom D (1990) The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore) 69:69\u201380","journal-title":"Medicine (Baltimore)"},{"key":"4757_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0049-0172(80)90014-1","volume":"10","author":"J Goldberg","year":"1980","unstructured":"Goldberg J, Pinals RS (1980) Felty syndrome. Semin Arthritis Rheum 10:52\u201365. https:\/\/doi.org\/10.1016\/0049-0172(80)90014-1","journal-title":"Semin Arthritis Rheum"},{"key":"4757_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1136\/ard.2006.054445","volume":"66","author":"C Turesson","year":"2007","unstructured":"Turesson C, Jacobsson LT, Sturfelt G, Matteson EL, Mathsson L, R\u00f6nnelid J (2007) Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis. Ann Rheum Dis 66:59\u201364. https:\/\/doi.org\/10.1136\/ard.2006.054445","journal-title":"Ann Rheum Dis"},{"key":"4757_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.blre.2006.01.003","volume":"20","author":"EJ Burks","year":"2006","unstructured":"Burks EJ, Loughran TP Jr (2006) Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. Blood Rev 20:245\u2013266. https:\/\/doi.org\/10.1016\/j.blre.2006.01.003","journal-title":"Blood Rev"},{"key":"4757_CR6","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1046\/j.1365-2141.2003.04201.x","volume":"120","author":"WG Morice","year":"2003","unstructured":"Morice WG, Kurtin PJ, Leibson PJ, Tefferi A, Hanson CA (2003) Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. Br J Haematol 120:1026\u20131036. https:\/\/doi.org\/10.1046\/j.1365-2141.2003.04201.x","journal-title":"Br J Haematol"},{"key":"4757_CR7","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1309\/PH7X78HF4FW4PRKW","volume":"124","author":"R Lundell","year":"2005","unstructured":"Lundell R, Hartung L, Hill S, Perkins SL, Bahler DW (2005) T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. Am J Clin Pathol 124:937\u2013946","journal-title":"Am J Clin Pathol"},{"key":"4757_CR8","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.3324\/haematol.2009.018481","volume":"95","author":"B Bareau","year":"2010","unstructured":"Bareau B, Rey J, Hamidou M, Donadieu J, Morcet J, Reman O, Schleinitz N, Tournilhac O, Roussel M, Fest T, Lamy T (2010) Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 95:1534\u20131541. https:\/\/doi.org\/10.3324\/haematol.2009.018481","journal-title":"Haematologica"},{"key":"4757_CR9","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1080\/10428194.2017.1339880","volume":"59","author":"SR Sanikommu","year":"2018","unstructured":"Sanikommu SR, Clemente MJ, Chomczynski P, Afable MG 2nd, Jerez A, Thota S, Patel B, Hirsch C, Nazha A, Desamito J, Lichtin A, Pohlman B, Sekeres MA, Radivoyevitch T, Maciejewski JP (2018) Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL). Leuk Lymphoma 59:416\u2013422. https:\/\/doi.org\/10.1080\/10428194.2017.1339880","journal-title":"Leuk Lymphoma"},{"key":"4757_CR10","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1002\/art.40654","volume":"70","author":"EC Schwaneck","year":"2018","unstructured":"Schwaneck EC, Renner R, Junker L, Einsele H, Gadeholt O, Geissinger E, Kleinert S, Gernert M, Tony HP, Schmalzing M (2018) Prevalence and characteristics of persistent clonal T cell large granular lymphocyte expansions in rheumatoid arthritis: a comprehensive analysis of 529 patients. Arthritis Rheumatol 70:1914\u20131922. https:\/\/doi.org\/10.1002\/art.40654","journal-title":"Arthritis Rheumatol"},{"key":"4757_CR11","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/art.1780400406","volume":"40","author":"G Starkebaum","year":"1997","unstructured":"Starkebaum G, Loughran TP Jr, Gaur LK, Davis P, Nepom BS (1997) Immunogenetic similarities between patients with Felty\u2019s syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum 40:624\u2013626. https:\/\/doi.org\/10.1002\/art.1780400406","journal-title":"Arthritis Rheum"},{"key":"4757_CR12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/s0037-1963(03)00133-1","volume":"40","author":"T Lamy","year":"2003","unstructured":"Lamy T, Loughran TP Jr (2003) Clinical features of large granular lymphocyte leukemia. Semin Hematol 40:185\u2013195. https:\/\/doi.org\/10.1016\/s0037-1963(03)00133-1","journal-title":"Semin Hematol"},{"key":"4757_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.clim.2009.03.515","volume":"132","author":"A Shah","year":"2009","unstructured":"Shah A, Diehl LF, St Clair EW (2009) T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. Clin Immunol 132:145\u2013152. https:\/\/doi.org\/10.1016\/j.clim.2009.03.515","journal-title":"Clin Immunol"},{"key":"4757_CR14","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00277-012-1649-1","volume":"92","author":"KG Schrenk","year":"2013","unstructured":"Schrenk KG, Krokowski M, Feller AC, Bernhard V, M\u00fcgge LO, Oelzner P, Wolf G, Hochhaus A, Neumann T (2013) Clonal T-LGL population mimicking leukemia in Felty\u2019s syndrome\u2212part of a continuous spectrum of T-LGL proliferations? Ann Hematol 92:985\u2013987. https:\/\/doi.org\/10.1007\/s00277-012-1649-1","journal-title":"Ann Hematol"},{"key":"4757_CR15","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S0140-6736(18)32208-6","volume":"392","author":"E Hasanov","year":"2018","unstructured":"Hasanov E, Fard EV, Puravath A, Johnston JS, Peerbhai S, Rojas-Hernandez CM (2018) T-cell large granular lymphocytic leukaemia in the context of rheumatoid arthritis. Lancet 392:1071. https:\/\/doi.org\/10.1016\/S0140-6736(18)32208-6","journal-title":"Lancet"},{"key":"4757_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211","volume":"82","author":"TP Loughran Jr","year":"1993","unstructured":"Loughran TP Jr (1993) Clonal diseases of large granular lymphocytes. Blood 82:1\u201314","journal-title":"Blood"},{"key":"4757_CR17","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1002\/1097-0142(19871215)60:12<2971::aid-cncr2820601220>3.0.co;2-o","volume":"60","author":"G Semenzato","year":"1987","unstructured":"Semenzato G, Pandolfi F, Chisesi T, De Rossi G, Pizzolo G, Zambello R, Trentin L, Agostini C, Dini E, Vespignani M, Cafaro A, Pasqualetti D, Giubellino MC, Migone N, Foa R (1987) The lymphoproliferative disease of granular lymphocytes. A heterogeneous disorder ranging from indolent to aggressive conditions. Cancer 60:2971\u20132978. https:\/\/doi.org\/10.1002\/1097-0142(19871215)60:12%3c2971::aid-cncr2820601220%3e3.0.co;2-o","journal-title":"Cancer"},{"key":"4757_CR18","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1182\/blood.V89.1.256","volume":"89","author":"G Semenzato","year":"1997","unstructured":"Semenzato G, Zambello R, Starkebaum G, Oshimi K, Loughran TP Jr (1997) The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis. Blood 89:256\u2013260","journal-title":"Blood"},{"key":"4757_CR19","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1200\/EDBK_200689","volume":"38","author":"A Moignet","year":"2018","unstructured":"Moignet A, Lamy T (2018) Latest advances in the diagnosis and treatment of large granular lymphocytic leukemia. Am Soc Clin Oncol Educ Book 38:616\u2013625. https:\/\/doi.org\/10.1200\/EDBK_200689","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"4757_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11899-020-00565-6","volume":"15","author":"H Cheon","year":"2020","unstructured":"Cheon H, Dziewulska KH, Moosic KB, Olson KC, Gru AA, Feith DJ, Loughran TP Jr (2020) Advances in the diagnosis and treatment of large granular lymphocytic leukemia. Curr Hematol Malig Rep 15:103\u2013112. https:\/\/doi.org\/10.1007\/s11899-020-00565-6","journal-title":"Curr Hematol Malig Rep"},{"key":"4757_CR21","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1182\/blood.v99.1.268","volume":"99","author":"WG Morice","year":"2002","unstructured":"Morice WG, Kurtin PJ, Tefferi A, Hanson CA (2002) Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B. Blood 99:268\u2013274. https:\/\/doi.org\/10.1182\/blood.v99.1.268","journal-title":"Blood"},{"key":"4757_CR22","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.berh.2004.05.002","volume":"18","author":"GP Balint","year":"2004","unstructured":"Balint GP, Balint PV (2004) Felty\u2019s syndrome. Best Pract Res Clin Rheumatol 18:631\u2013645. https:\/\/doi.org\/10.1016\/j.berh.2004.05.002","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"4757_CR23","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","volume":"366","author":"HL Koskela","year":"2012","unstructured":"Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanm\u00e4ki H, Andersson EI, Lagstr\u00f6m S, Clemente MJ, Olson T, Jalkanen SE, Majumder MM, Almusa H, Edgren H, Lepist\u00f6 M, Mattila P, Guinta K, Koistinen P, Kuittinen T, Penttinen K, Parsons A, Knowles J, Saarela J, Wennerberg K, Kallioniemi O, Porkka K, Loughran TP Jr, Heckman CA, Maciejewski JP, Mustjoki S (2012) Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 366:1905\u20131913. https:\/\/doi.org\/10.1056\/NEJMoa1114885","journal-title":"N Engl J Med"},{"key":"4757_CR24","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1182\/blood-2012-06-435297","volume":"120","author":"A Jerez","year":"2012","unstructured":"Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, Guinta K, Durkin L, Hsi ED, McGraw K, Zhang D, Wlodarski MW, Porkka K, Sekeres MA, List A, Mustjoki S, Loughran TP, Maciejewski JP (2012) STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 120:3048\u20133057. https:\/\/doi.org\/10.1182\/blood-2012-06-435297","journal-title":"Blood"},{"key":"4757_CR25","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1038\/leu.2012.350","volume":"27","author":"A Fasan","year":"2013","unstructured":"Fasan A, Kern W, Grossmann V, Haferlach C, Haferlach T, Schnittger S (2013) STAT3 mutations are highly specific for large granular lymphocytic leukemia. Leukemia 27:1598\u20131600. https:\/\/doi.org\/10.1038\/leu.2012.350","journal-title":"Leukemia"},{"key":"4757_CR26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.humpath.2017.12.014","volume":"73","author":"M Shi","year":"2018","unstructured":"Shi M, He R, Feldman AL, Viswanatha DS, Jevremovic D, Chen D, Morice WG (2018) STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia. Hum Pathol 73:74\u201381. https:\/\/doi.org\/10.1016\/j.humpath.2017.12.014","journal-title":"Hum Pathol"},{"key":"4757_CR27","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1182\/blood-2012-12-474577","volume":"121","author":"HL Rajala","year":"2013","unstructured":"Rajala HL, Eldfors S, Kuusanm\u00e4ki H, van Adrichem AJ, Olson T, Lagstr\u00f6m S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S (2013) Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood 121:4541\u20134550. https:\/\/doi.org\/10.1182\/blood-2012-12-474577","journal-title":"Blood"},{"key":"4757_CR28","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, M\u00e9nard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588. https:\/\/doi.org\/10.1136\/ard.2010.138461","journal-title":"Ann Rheum Dis"},{"key":"4757_CR29","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJ van Dongen","year":"2003","unstructured":"van Dongen JJ, Langerak AW, Br\u00fcggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, Garc\u00eda-Sanz R, van Krieken JH, Droese J, Gonz\u00e1lez D, Bastard C, White HE, Spaargaren M, Gonz\u00e1lez M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257\u20132317. https:\/\/doi.org\/10.1038\/sj.leu.2403202","journal-title":"Leukemia"},{"key":"4757_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12308-011-0131-7","volume":"5","author":"PJTA Groenen","year":"2012","unstructured":"Groenen PJTA, van Raaij A, van Altena MC, Rombout PM, Han van Krieken JM (2012) A practical approach to diagnostic Ig\/TCR clonality evaluation in clinical pathology. J Hematopathol 5:17\u201325. https:\/\/doi.org\/10.1007\/s12308-011-0131-7","journal-title":"J Hematopathol"},{"key":"4757_CR31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1084\/jem.179.2.609","volume":"179","author":"DN Posnett","year":"1994","unstructured":"Posnett DN, Sinha R, Kabak S, Russo C (1994) Clonal populations of T cells in normal elderly humans: the T cell equivalent to \u201cbenign monoclonal gammopathy.\u201d J Exp Med 179:609\u2013618. https:\/\/doi.org\/10.1084\/jem.179.2.609","journal-title":"J Exp Med"},{"key":"4757_CR32","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1182\/blood.V96.9.2987","volume":"96","author":"MH Delfau-Larue","year":"2000","unstructured":"Delfau-Larue MH, Laroche L, Wechsler J, Lepage E, Lahet C, Asso-Bonnet M, Bagot M, Farcet JP (2000) Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma. Blood 96:2987\u20132992","journal-title":"Blood"},{"key":"4757_CR33","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1182\/blood.v98.1.247","volume":"98","author":"E Dippel","year":"2001","unstructured":"Dippel E, Klemke D, Hummel M, Stein H, Goerdt S (2001) T-cell clonality of undetermined significance. Blood 98:247\u2013248. https:\/\/doi.org\/10.1182\/blood.v98.1.247","journal-title":"Blood"},{"key":"4757_CR34","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1182\/blood-2002-08-2408","volume":"101","author":"V Bigouret","year":"2003","unstructured":"Bigouret V, Hoffmann T, Arlettaz L, Villard J, Colonna M, Ticheli A, Gratwohl A, Samii K, Chapuis B, Rufer N, Roosnek E (2003) Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C\/E and NKD2D killer cell receptors. Blood 101:3198\u20133204. https:\/\/doi.org\/10.1182\/blood-2002-08-2408","journal-title":"Blood"},{"key":"4757_CR35","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.clml.2019.12.021","volume":"20","author":"YV Sidorova","year":"2020","unstructured":"Sidorova YV, Sychevskaya KA, Chernova NG, Julhakyan HL, Smirnova SJ, Ryzhikova NV, Gorodetskiy VR, Naumova EV, Sudarikov AB (2020) High incidence of clonal CD8+ T-cell proliferation in non-malignant conditions may reduce the significance of T-cell clonality assay for differential diagnosis in oncohematology. Clin Lymphoma Myeloma Leuk 20:203\u2013208. https:\/\/doi.org\/10.1016\/j.clml.2019.12.021","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"4757_CR36","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3109\/07853890.2014.882105","volume":"46","author":"HL Rajala","year":"2014","unstructured":"Rajala HL, Porkka K, Maciejewski JP, Loughran TP Jr, Mustjoki S (2014) Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. Ann Med 46:114\u2013122. https:\/\/doi.org\/10.3109\/07853890.2014.882105","journal-title":"Ann Med"},{"key":"4757_CR37","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3324\/haematol.2017.175729","volume":"103","author":"P Savola","year":"2018","unstructured":"Savola P, Br\u00fcck O, Olson T, Kelkka T, Kauppi MJ, Kovanen PE, Kyt\u00f6l\u00e4 S, Sokka-Isler T, Loughran TP, Leirisalo-Repo M, Mustjoki S (2018) Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Haematologica 103:304\u2013312. https:\/\/doi.org\/10.3324\/haematol.2017.175729","journal-title":"Haematologica"},{"key":"4757_CR38","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1080\/10428190801895337","volume":"49","author":"M Prochorec-Sobieszek","year":"2008","unstructured":"Prochorec-Sobieszek M, Che\u0142stowska M, Rymkiewicz G, Majewski M, Warzocha K, Maryniak R (2008) Biclonal T-cell receptor gammadelta+ large granular lymphocyte leukemia associated with rheumatoid arthritis. Leuk Lymphoma 49:828\u2013831. https:\/\/doi.org\/10.1080\/10428190801895337","journal-title":"Leuk Lymphoma"},{"key":"4757_CR39","doi-asserted-by":"publisher","first-page":"106299","DOI":"10.1016\/j.leukres.2020.106299","volume":"90","author":"Y Zhu","year":"2020","unstructured":"Zhu Y, Gao Q, Hu J, Liu X, Guan D, Zhang F (2020) Clinical features and treatment outcomes in patients with T-cell large granular lymphocytic leukemia: a single-institution experience. Leuk Res 90:106299. https:\/\/doi.org\/10.1016\/j.leukres.2020.106299","journal-title":"Leuk Res"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-020-04757-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00296-020-04757-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-020-04757-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T04:18:26Z","timestamp":1610597906000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00296-020-04757-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,5]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["4757"],"URL":"https:\/\/doi.org\/10.1007\/s00296-020-04757-4","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,5]]},"assertion":[{"value":"28 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest regarding the publication of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the V.A. Nasonova Research Institute of Rheumatology Ethics Committee (protocol #17 on the 20-02-2020) and was conducted in accordance with the Declaration of Helsinki of 1975, as revised in 2008.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was given by all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}