{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:19:33Z","timestamp":1772709573672,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00296-021-04806-6","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T06:02:34Z","timestamp":1614232954000},"page":"1281-1287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progression of gastrointestinal symptoms over time in patients with systemic sclerosis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-7088","authenticated-orcid":false,"given":"Jamie","family":"Bering","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-0716","authenticated-orcid":false,"given":"W. Leroy","family":"Griffing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-3831","authenticated-orcid":false,"given":"Michael","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1482-2262","authenticated-orcid":false,"given":"Sarah B.","family":"Umar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"issue":"2","key":"4806_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.cgh.2016.08.034","volume":"15","author":"MD Crowell","year":"2017","unstructured":"Crowell MD, Umar SB, Griffing WL, DiBaise JK, Lacy BE, Vela MF (2017) Esophageal motor abnormalities in patients with scleroderma: heterogeneity, risk factors, and effects on quality of life. ClinGastroenterolHepatol 15(2):207-213.e1. https:\/\/doi.org\/10.1016\/j.cgh.2016.08.034","journal-title":"ClinGastroenterolHepatol"},{"key":"4806_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doy136","author":"JL Horsley-Silva","year":"2019","unstructured":"Horsley-Silva JL, Umar SB, Vela MF, Griffing WL, Parish JM, DiBaise JK, Crowell MD (2019) The impact of gastroesophageal reflux disease symptoms in scleroderma: effects on sleep quality. Dis Esophagus. https:\/\/doi.org\/10.1093\/dote\/doy136","journal-title":"Dis Esophagus"},{"issue":"2","key":"4806_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/MEG.0b013e32831dac75","volume":"21","author":"K Franck-Larsson","year":"2009","unstructured":"Franck-Larsson K, Graf W, Ronnblom A (2009) Lower gastrointestinal symptoms and quality of life in patients with systemic sclerosis: a population-based study. Eur J GastroenterolHepatol 21(2):176\u2013182. https:\/\/doi.org\/10.1097\/MEG.0b013e32831dac75","journal-title":"Eur J GastroenterolHepatol"},{"issue":"1","key":"4806_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.rdc.2017.09.002","volume":"44","author":"TM Frech","year":"2018","unstructured":"Frech TM, Mar D (2018) Gastrointestinal and hepatic disease in systemic sclerosis. Rheum Dis Clin North Am 44(1):15\u201328. https:\/\/doi.org\/10.1016\/j.rdc.2017.09.002","journal-title":"Rheum Dis Clin North Am"},{"issue":"9","key":"4806_CR5","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.14309\/ajg.0000000000000260","volume":"114","author":"PT Kroner","year":"2019","unstructured":"Kroner PT, Tolaymat OA, Bowman AW, Abril A, Lacy BE (2019) Gastrointestinal manifestations of rheumatological diseases. Am J Gastroenterol 114(9):1441\u20131454. https:\/\/doi.org\/10.14309\/ajg.0000000000000260","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"4806_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s10067-016-3501-9","volume":"36","author":"B Levis","year":"2017","unstructured":"Levis B, Kwakkenbos L, Hudson M, Baron M, Thombs BD, The Canadian Scleroderma Research G (2017) The association of sociodemographic and objectively-assessed disease variables with fatigue in systemic sclerosis: an analysis of 785 canadian scleroderma research group registry patients. ClinRheumatol 36(2):373\u2013379. https:\/\/doi.org\/10.1007\/s10067-016-3501-9","journal-title":"ClinRheumatol"},{"issue":"7","key":"4806_CR7","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/apt.13963","volume":"45","author":"S Kumar","year":"2017","unstructured":"Kumar S, Singh J, Rattan S, DiMarino AJ, Cohen S, Jimenez SA (2017) Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis. Aliment PharmacolTher 45(7):883\u2013898. https:\/\/doi.org\/10.1111\/apt.13963","journal-title":"Aliment PharmacolTher"},{"issue":"41","key":"4806_CR8","doi-asserted-by":"publisher","first-page":"7062","DOI":"10.3748\/wjg.v19.i41.7062","volume":"19","author":"XP Tian","year":"2013","unstructured":"Tian XP, Zhang X (2013) Gastrointestinal complications of systemic sclerosis. World J Gastroenterol 19(41):7062\u20137068. https:\/\/doi.org\/10.3748\/wjg.v19.i41.7062","journal-title":"World J Gastroenterol"},{"issue":"1","key":"4806_CR9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/annrheumdis-2017-211480","volume":"77","author":"C Mihai","year":"2018","unstructured":"Mihai C, Antic M, Dobrota R, Bonderman D, Chadha-Boreham H, Coghlan JG, Denton CP, Doelberg M, Grunig E, Khanna D, McLaughlin VV, Muller-Ladner U, Pope JE, Rosenberg DM, Seibold JR, Vonk MC, Distler O (2018) Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort. Ann Rheum Dis 77(1):128\u2013132. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211480","journal-title":"Ann Rheum Dis"},{"key":"4806_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213455","author":"W Wu","year":"2019","unstructured":"Wu W, Jordan S, Graf N, de Oliveira PJ, Curram J, Allanore Y, Matucci-Cerinic M, Pope JE, Denton CP, Khanna D, Distler O, Collaborators E (2019) Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the european scleroderma trials and research (EUSTAR) cohort. Ann Rheum Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2018-213455","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"4806_CR11","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1159\/000489740","volume":"43","author":"E Rosato","year":"2018","unstructured":"Rosato E, Gigante A, Barbano B, Gasperini ML, Cianci R, Muscaritoli M (2018) Prognostic factors of renal involvement in systemic sclerosis. Kidney Blood Press Res 43(3):682\u2013689. https:\/\/doi.org\/10.1159\/000489740","journal-title":"Kidney Blood Press Res"},{"issue":"6","key":"4806_CR12","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/art.38390","volume":"66","author":"SI Nihtyanova","year":"2014","unstructured":"Nihtyanova SI, Schreiber BE, Ong VH, Rosenberg D, Moinzadeh P, Coghlan JG, Wells AU, Denton CP (2014) Prediction of pulmonary complications and long-term survival in systemic sclerosis. Arthritis Rheumatol 66(6):1625\u20131635. https:\/\/doi.org\/10.1002\/art.38390","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"4806_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5301\/jsrd.5000231","volume":"2","author":"D Khanna","year":"2017","unstructured":"Khanna D, Furst DE, Clements PJ, Allanore Y, Baron M, Czirjak L, Distler O, Foeldvari I, Kuwana M, Matucci-Cerinic M, Mayes M, Medsger T Jr, Merkel PA, Pope JE, Seibold JR, Steen V, Stevens W, Denton CP (2017) Standardization of the modified rodnan skin score for use in clinical trials of systemic sclerosis. J Scleroderma RelatDisord 2(1):11\u201318. https:\/\/doi.org\/10.5301\/jsrd.5000231","journal-title":"J Scleroderma RelatDisord"},{"issue":"6","key":"4806_CR14","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1136\/annrheumdis-2014-205226","volume":"74","author":"B Maurer","year":"2015","unstructured":"Maurer B, Graf N, Michel BA, Muller-Ladner U, Czirjak L, Denton CP, Tyndall A, Metzig C, Lanius V, Khanna D, Distler O, co-authors E, (2015) Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database. Ann Rheum Dis 74(6):1124\u20131131. https:\/\/doi.org\/10.1136\/annrheumdis-2014-205226","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"4806_CR15","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/annrheumdis-2017-211912","volume":"77","author":"AL Herrick","year":"2018","unstructured":"Herrick AL, Peytrignet S, Lunt M, Pan X, Hesselstrand R, Mouthon L, Silman AJ, Dinsdale G, Brown E, Czirjak L, Distler JHW, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk MC, Ancuta C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt O, Jobanputra P, Jordan AC, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov NS, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, MacGregor AJ, McHugh N, Muller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, Inanc M, McLaren JS, van Laar JM, Pathare S, Proudman SM, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Denton CP (2018) Patterns and predictors of skin score change in early diffuse systemic sclerosis from the european scleroderma observational study. Ann Rheum Dis 77(4):563\u2013570. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211912","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"4806_CR16","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1097\/BOR.0b013e3283588dcf","volume":"24","author":"VK Shanmugam","year":"2012","unstructured":"Shanmugam VK, Steen VD (2012) Renal disease in scleroderma: an update on evaluation, risk stratification, pathogenesis and management. CurrOpinRheumatol 24(6):669\u2013676. https:\/\/doi.org\/10.1097\/BOR.0b013e3283588dcf","journal-title":"CurrOpinRheumatol"},{"issue":"7","key":"4806_CR17","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1002\/art.22721","volume":"56","author":"L Shand","year":"2007","unstructured":"Shand L, Lunt M, Nihtyanova S, Hoseini M, Silman A, Black CM, Denton CP (2007) Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: application of a latent linear trajectory model. Arthritis Rheum 56(7):2422\u20132431. https:\/\/doi.org\/10.1002\/art.22721","journal-title":"Arthritis Rheum"},{"key":"4806_CR18","first-page":"3591","volume":"67","author":"TMMM Frech","year":"2015","unstructured":"Frech TMMM, Gordon JK, Domsic RT, Shah AA, Hant FN, Assassi S, Hinchcliff ME, Bernstein EJ, Steen VD, Shanmugam VK, Khanna D (2015) Longitudinal assessment of gastrointestinal symptoms in the prospective registry of early systemic sclerosis cohort: abstract number: 2978. ArthrRheumatol 67:3591\u20133592","journal-title":"ArthrRheumatol"},{"issue":"1","key":"4806_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3899\/jrheum.180004","volume":"46","author":"ZH McMahan","year":"2019","unstructured":"McMahan ZH, Frech T, Berrocal V, Lim D, Bruni C, Matucci-Cerinic M, Smith V, Melsens K, Proudman S, Zhang J, Mendoza F, Woods M, Khanna D (2019) Longitudinal assessment of patient-reported outcome measures in systemic sclerosis patients with gastroesophageal reflux disease\u2014scleroderma clinical trials consortium. J Rheumatol 46(1):78\u201384. https:\/\/doi.org\/10.3899\/jrheum.180004","journal-title":"J Rheumatol"},{"issue":"6","key":"4806_CR20","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1097\/MCG.0000000000000405","volume":"50","author":"SB Umar","year":"2016","unstructured":"Umar SB, Griffing L, Garcia H, Foxx-Orenstein AE, DiBaise JK, Crowell MD (2016) The impact of pelvic floor and lower gastrointestinal symptoms on quality of life in women with systemic sclerosis. J ClinGastroenterol 50(6):e55-59. https:\/\/doi.org\/10.1097\/MCG.0000000000000405","journal-title":"J ClinGastroenterol"},{"issue":"3","key":"4806_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5301\/jsrd.5000214","volume":"1","author":"AB Shreiner","year":"2016","unstructured":"Shreiner AB, Murray C, Denton C, Khanna D (2016) Gastrointestinal manifestations of systemic sclerosis. J Scleroderma RelatDisord 1(3):247\u2013256. https:\/\/doi.org\/10.5301\/jsrd.5000214","journal-title":"J Scleroderma RelatDisord"},{"issue":"11","key":"4806_CR22","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Muller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE (2013) 2013 classification criteria for systemic sclerosis: an american college of rheumatology\/european league against rheumatism collaborative initiative. Ann Rheum Dis 72(11):1747\u20131755. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204424","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"4806_CR23","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3899\/jrheum.110225","volume":"38","author":"D Khanna","year":"2011","unstructured":"Khanna D, Furst DE, Maranian P, Seibold JR, Impens A, Mayes MD, Clements PJ, Getzug T, Hays RD (2011) Minimally important differences of the UCLA scleroderma clinical trial consortium gastrointestinal tract instrument. J Rheumatol 38(9):1920\u20131924. https:\/\/doi.org\/10.3899\/jrheum.110225","journal-title":"J Rheumatol"},{"issue":"6","key":"4806_CR24","first-page":"1117","volume":"33","author":"SR Johnson","year":"2006","unstructured":"Johnson SR, Glaman DD, Schentag CT, Lee P (2006) Quality of life and functional status in systemic sclerosis compared to other rheumatic diseases. J Rheumatol 33(6):1117","journal-title":"J Rheumatol"},{"issue":"2","key":"4806_CR25","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/rheumatology\/keq296","volume":"50","author":"V Bodukam","year":"2011","unstructured":"Bodukam V, Hays RD, Maranian P, Furst DE, Seibold JR, Impens A, Mayes MD, Clements PJ, Khanna D (2011) Association of gastrointestinal involvement and depressive symptoms in patients with systemic sclerosis. Rheumatol (Oxford) 50(2):330\u2013334. https:\/\/doi.org\/10.1093\/rheumatology\/keq296","journal-title":"Rheumatol (Oxford)"},{"issue":"6","key":"4806_CR26","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/art.22910","volume":"57","author":"BD Thombs","year":"2007","unstructured":"Thombs BD, Taillefer SS, Hudson M, Baron M (2007) Depression in patients with systemic sclerosis: a systematic review of the evidence. Arthritis Care Res 57(6):1089\u20131097. https:\/\/doi.org\/10.1002\/art.22910","journal-title":"Arthritis Care Res"},{"issue":"12","key":"4806_CR27","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.autrev.2015.07.012","volume":"14","author":"C Almeida","year":"2015","unstructured":"Almeida C, Almeida I, Vasconcelos C (2015) Quality of life in systemic sclerosis. Autoimmun Rev 14(12):1087\u20131096. https:\/\/doi.org\/10.1016\/j.autrev.2015.07.012","journal-title":"Autoimmun Rev"},{"issue":"4","key":"4806_CR28","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/rheumatology\/kew441","volume":"56","author":"N Richard","year":"2017","unstructured":"Richard N, Hudson M, Gyger G, Baron M, Sutton E, Khalidi N, Pope JE, Carrier N, Larche M, Albert A, Fortin PR, Thorne C, Masetto A, On the behalf of Canadian Scleroderma Research G (2017) Clinical correlates of faecal incontinence in systemic sclerosis: identifying therapeutic avenues. Rheumatology (Oxford) 56(4):581\u2013588. https:\/\/doi.org\/10.1093\/rheumatology\/kew441","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"4806_CR29","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/rheumatology\/ker153","volume":"50","author":"A Forbes","year":"2011","unstructured":"Forbes A, Schizas A, Emmanuel AV, Denton CP, Thoua NM (2011) Internal anal sphincter atrophy in patients with systemic sclerosis. Rheumatology 50(9):1596\u20131602. https:\/\/doi.org\/10.1093\/rheumatology\/ker153","journal-title":"Rheumatology"},{"issue":"3","key":"4806_CR30","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.rdc.2015.04.010","volume":"41","author":"L Kwakkenbos","year":"2015","unstructured":"Kwakkenbos L, Delisle VC, Fox RS, Gholizadeh S, Jewett LR, Levis B, Milette K, Mills SD, Malcarne VL, Thombs BD (2015) Psychosocial aspects of scleroderma. Rheum Dis Clin North Am 41(3):519\u2013528. https:\/\/doi.org\/10.1016\/j.rdc.2015.04.010","journal-title":"Rheum Dis Clin North Am"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-021-04806-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-021-04806-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-021-04806-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T13:05:33Z","timestamp":1622293533000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-021-04806-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["4806"],"URL":"https:\/\/doi.org\/10.1007\/s00296-021-04806-6","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]},"assertion":[{"value":"16 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Jamie Bering MD, W. Leroy Griffing MD, Michael Crowell Ph.D, and Sarah B. Umar MD declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The questionnaire and methodology for this study was approved by the Mayo Clinic Arizona IRB (16\u2013006841).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Consent to participate in this study was implied with return of the survey by the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Consent for publication is implied with participation by return of the survey by the patient.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This data has not been deposited in a repository.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}