{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:48:51Z","timestamp":1784872131589,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>We aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers of endothelial dysfunction<jats:bold>.<\/jats:bold><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We studied 161 patients (123 males, 38 females) with axSpA: 153 with ankylosing spondylitis and 8 with non-radiographic axSpA, and 30 healthy controls (HC). We collected: age; sex; disease duration; extra-articular symptoms (IBD and acute anterior uveitis), comorbidities; human leukocyte antigen B27 status; and treatment. We measured serum interleukin (IL)-6, interleukin-18, IL-23, vascular endothelial growth factor (VEGF) epidermal growth factor (EGF), asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), and fetuin-A levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>IBD was diagnosed in 19 (11.8%) patients with axSpA. Compared to patients with axSpA without IBD, those with IBD had higher serum C-reactive protein (CRP) level (<jats:italic>p<\/jats:italic>\u2009=\u20090.05), erythrocyte sedimentation rate (ESR) (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), and serum ET-1 levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). In patients with axSpA and IBD, ET-1 levels correlated positively with CRP level (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and ESR (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), and ADMA levels with visual analog scale scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Patients with axSpA and IBD had higher serum levels of IL-6 (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), IL-18 (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), and ADMA (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and lower serum levels of fetuin-A (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) than did controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Patients with axSpA and IBD had higher levels of disease activity, as assessed by ESR and CRP and ET-1 levels, than did patients with axSpA without IBD. Compared to HC, patients with axSpA and IBD had increased IL-18, ADMA levels and decreased fetuin-A level.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00296-021-04940-1","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T17:02:26Z","timestamp":1625763746000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-2594","authenticated-orcid":false,"given":"Hanna","family":"Przepiera-B\u0119dzak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-2099","authenticated-orcid":false,"given":"Katarzyna","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-4367","authenticated-orcid":false,"given":"Marek","family":"Brzosko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"4940_CR1","doi-asserted-by":"publisher","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","volume":"68","author":"J Sieper","year":"2009","unstructured":"Sieper J, Rudwaleit M, Baraliakos X, Brandt J, Braun J, Burgos-Vargas R et al (2009) The assessment of spondyloarthritis international society (ASAS) handbook: a guide to assess spondyloarthritis. 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