{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:07:03Z","timestamp":1768252023355,"version":"3.49.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00296-021-05008-w","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:37:34Z","timestamp":1632739054000},"page":"469-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The clinical course of SARS-CoV-2 infection among children with rheumatic disease under biologic therapy: a retrospective and multicenter study"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-5644","authenticated-orcid":false,"given":"Betul","family":"Sozeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-6077","authenticated-orcid":false,"given":"Kadir","family":"Ulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-9432","authenticated-orcid":false,"given":"Ummusen","family":"Kaya-Ak\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-9668","authenticated-orcid":false,"given":"Fatih","family":"Haslak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-9922","authenticated-orcid":false,"given":"Aysenur","family":"Pac-Kisaarslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-6309","authenticated-orcid":false,"given":"Gulcin","family":"Otar-Yener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-1550","authenticated-orcid":false,"given":"Ozge","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-3463","authenticated-orcid":false,"given":"Ozge","family":"Altug-Gucenmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-6952","authenticated-orcid":false,"given":"Nihal","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-8553","authenticated-orcid":false,"given":"Esra","family":"Ba\u011flan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-3068","authenticated-orcid":false,"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-2480","authenticated-orcid":false,"given":"Figen","family":"Cakmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-0228","authenticated-orcid":false,"given":"Kubra","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-2076","authenticated-orcid":false,"given":"Deniz","family":"Gezgin-Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-8996","authenticated-orcid":false,"given":"Seher","family":"\u015eener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-2872","authenticated-orcid":false,"given":"Kenan","family":"Barut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-2363","authenticated-orcid":false,"given":"Ezgi Deniz","family":"Batu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-4909","authenticated-orcid":false,"given":"Mehmet","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0930","authenticated-orcid":false,"given":"Ozge","family":"Basaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-6955","authenticated-orcid":false,"given":"Amra","family":"Adrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-3457","authenticated-orcid":false,"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-4595","authenticated-orcid":false,"given":"Semanur","family":"Ozdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-0072","authenticated-orcid":false,"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-4339","authenticated-orcid":false,"given":"Muammer Hakan","family":"Poyrazoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9801-925X","authenticated-orcid":false,"given":"Ferhat","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-1640","authenticated-orcid":false,"given":"Selcuk","family":"Yuksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-939X","authenticated-orcid":false,"given":"Mukaddes","family":"Kalyoncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7720","authenticated-orcid":false,"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-7282","authenticated-orcid":false,"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-7387","authenticated-orcid":false,"given":"Nuray","family":"Aktay-Ayaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"5008_CR1","unstructured":"World Health Organization. Director-General\u2019s remarks at the media briefing on 2019-nCoV on 11 February 2020. http:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on February 12, 2020)"},{"key":"5008_CR2","unstructured":"World Health Organization (WHO). WHO Director-General\u2019s opening remarks at the media briefing on COVID-19\u201411 March 2020. Available at: https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19\u201411-march-2020 (Accessed on May 01, 2020)"},{"key":"5008_CR3","unstructured":"World Health Organization https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019"},{"key":"5008_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s13075-018-1780-z","volume":"20","author":"J Swart","year":"2018","unstructured":"Swart J, Giancane G, Horneff G, Magnusson B, Hofer M, Alexeeva E et al (2018) Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from pharmachild and national registries. Arthritis Res Ther 20:285","journal-title":"Arthritis Res Ther"},{"key":"5008_CR5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1136\/annrheumdis-2020-218946","volume":"80","author":"S Akiyama","year":"2021","unstructured":"Akiyama S, Hamdeh S, Micic D, Sakuraba A (2021) Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: a systematic review and meta-analysis. Ann Rheum Dis 80:384\u2013391","journal-title":"Ann Rheum Dis"},{"key":"5008_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41584-020-00562-2","volume":"17","author":"KL Hyrich","year":"2021","unstructured":"Hyrich KL, Machado PM (2021) Rheumatic disease and COVID-19: epidemiology and outcomes. Nat Rev Rheumatol 17:71\u201372","journal-title":"Nat Rev Rheumatol"},{"key":"5008_CR7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12969-021-00568-4","volume":"19","author":"DS Villacis-Nunez","year":"2021","unstructured":"Villacis-Nunez DS, Rostad CA, Rouster-Stevens K, Khosroshahi A, Chandrakasan S, Prahalad S (2021) Outcomes of COVID-19 in a cohort of pediatric patients with rheumatic diseases. Pediatr Rheumatol Online J 19:94","journal-title":"Pediatr Rheumatol Online J"},{"key":"5008_CR8","first-page":"36","volume":"128","author":"F Demir","year":"2021","unstructured":"Demir F, Ulu K, \u00c7a\u011flayan \u00c7, Co\u015fkuner T, S\u00f6zeri S (2021) Clinical course of COVID-19 in children with rheumatic disease under biologic therapy. Clin Exp Rheumatol 128:36\u201337","journal-title":"Clin Exp Rheumatol"},{"key":"5008_CR9","first-page":"e14030","volume":"75","author":"F Ayd\u0131n","year":"2021","unstructured":"Ayd\u0131n F, Kurt T, Sezer M, Tekg\u00f6z N, Tekin ZE, Y\u00fcksek SK et al (2021) Biological therapies in children with rheumatic diseases during the COVID-19 pandemic: a single-centre experience. Int J Clin Pract 75:e14030","journal-title":"Int J Clin Pract"},{"key":"5008_CR10","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","volume":"395","author":"F Zhou","year":"2020","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054\u20131062","journal-title":"Lancet"},{"key":"5008_CR11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0140-6736(20)30558-4","volume":"395","author":"T Wang","year":"2020","unstructured":"Wang T, Du Z, Zhu F, Cao Z, An Y, Gao Y et al (2020) Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet 395:52","journal-title":"Lancet"},{"key":"5008_CR12","doi-asserted-by":"publisher","first-page":"631547","DOI":"10.3389\/fped.2021.631547","volume":"9","author":"A Karbuz","year":"2021","unstructured":"Karbuz A, Akkoc G, Bedir Demirdag T, Yilmaz Ciftdogan D, Ozer A, Cakir D et al (2021) Epidemiological, clinical, and laboratory features of children with COVID-19 in Turkey. Front Pediatr 9:631547","journal-title":"Front Pediatr"},{"key":"5008_CR13","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1136\/annrheumdis-2020-217871","volume":"79","author":"M Gianfrancesco","year":"2020","unstructured":"Gianfrancesco M, Hyrich KL, Al-Adely S, Carmona L, Danila MI, Gossec L et al (2020) Characteristics associated with hospitalization for COVID-19 in people with rheumatic disease: data from the COVID-19 global rheumatology alliance physician-reported registry. Ann Rheum Dis 79:859\u2013866","journal-title":"Ann Rheum Dis"},{"key":"5008_CR14","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/annrheumdis-2021-220418","volume":"80","author":"JA Sparks","year":"2021","unstructured":"Sparks JA, Wallace ZS, Seet AM, Gianfrancesco MA, Izadi Z, Hyrich KL et al (2021) Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: results from the COVID-19 global rheumatology alliance physician registry. Ann Rheum Dis 80:1137\u20131146","journal-title":"Ann Rheum Dis"},{"key":"5008_CR15","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1002\/art.41456","volume":"72","author":"RH Haberman","year":"2020","unstructured":"Haberman RH, Castillo R, Chen A, Yan D, Ramirez D, Sekar V et al (2020) COVID-19 in patients with inflammatory arthritis: a prospective study on the effects of comorbidities and disease-modifying antirheumatic drugs on clinical outcomes. Arthritis Rheumatol 72:1981\u20131989","journal-title":"Arthritis Rheumatol"},{"key":"5008_CR16","doi-asserted-by":"publisher","first-page":"001687","DOI":"10.1136\/rmdopen-2021-001687","volume":"7","author":"C Sengler","year":"2021","unstructured":"Sengler C, Eulert S, Minden K, Niewerth M, Horneff G, Kuemmerle-Deschner J et al (2021) Clinical manifestations and outcome of SARS-CoV-2 infections in children and adolescents with rheumatic musculoskeletal diseases: data from the national paediatric rheumatology database in Germany. RMD Open 7:001687","journal-title":"RMD Open"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-021-05008-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-021-05008-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-021-05008-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T07:05:36Z","timestamp":1645254336000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-021-05008-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["5008"],"URL":"https:\/\/doi.org\/10.1007\/s00296-021-05008-w","relation":{},"ISSN":["0172-8172","1437-160X"],"issn-type":[{"value":"0172-8172","type":"print"},{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,27]]},"assertion":[{"value":"2 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors received financial support and there are no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study was approved by the Institutional Review Board (IRB) at Umraniye Training and Research Hospital via waiver of informed consent (IRB number STUDY00000771).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}