{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:10:44Z","timestamp":1784729444075,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-022-05169-2","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T08:04:10Z","timestamp":1662365050000},"page":"523-531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of hepatitis serology and frequency of viral reactivation in patients with inflammatory arthritis receiving biologic agents: a multicenter observational study"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-5934","authenticated-orcid":false,"given":"Erhan","family":"Capkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5875-5524","authenticated-orcid":false,"given":"Ali","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-8398","authenticated-orcid":false,"given":"Murat","family":"Karkucak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-0088","authenticated-orcid":false,"given":"Yunus","family":"Durmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6490-4645","authenticated-orcid":false,"given":"Murat","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-3825","authenticated-orcid":false,"given":"\u015eebnem","family":"Ataman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-6935","authenticated-orcid":false,"given":"Nilay","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-657X","authenticated-orcid":false,"given":"Nihan","family":"C\u00fczdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4688-0464","authenticated-orcid":false,"given":"Meliha","family":"Kasapo\u011flu Aksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9349-9530","authenticated-orcid":false,"given":"Mustafa Erkut","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5903-5708","authenticated-orcid":false,"given":"M\u00fcnevver","family":"Serdaroglu Beyazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-8301","authenticated-orcid":false,"given":"Nilg\u00fcn","family":"Mesci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-396X","authenticated-orcid":false,"given":"Merve","family":"Baykul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-9470","authenticated-orcid":false,"given":"Meltem","family":"Alkan Meliko\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8461-9131","authenticated-orcid":false,"given":"Hakan","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7513-6007","authenticated-orcid":false,"given":"Deniz","family":"Dulgeroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-7169","authenticated-orcid":false,"given":"Ahmet K\u0131van\u00e7","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-0851","authenticated-orcid":false,"given":"Kemal","family":"Nas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8886-1144","authenticated-orcid":false,"given":"Elif","family":"Balevi Batur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-4852","authenticated-orcid":false,"given":"Asl\u0131","family":"\u00c7al\u0131\u015fkan U\u00e7kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-1569","authenticated-orcid":false,"given":"H\u00fclya","family":"Deveci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-3961","authenticated-orcid":false,"given":"Kemal","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-1837","authenticated-orcid":false,"given":"\u0130lknur","family":"Albayrak Gezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-6410","authenticated-orcid":false,"given":"G\u00fcrkan","family":"Akg\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-2788","authenticated-orcid":false,"given":"Mehmet Tuncay","family":"Duru\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-4229","authenticated-orcid":false,"given":"Okan","family":"K\u00fc\u00e7\u00fckakka\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-0513","authenticated-orcid":false,"given":"Selda","family":"Sar\u0131kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-3854","authenticated-orcid":false,"given":"Aylin","family":"Rezvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-8679","authenticated-orcid":false,"given":"Tu\u011fba","family":"Atan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-5991","authenticated-orcid":false,"given":"Feride","family":"G\u00f6\u011f\u00fc\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-5849","authenticated-orcid":false,"given":"G\u00f6khan","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-5917","authenticated-orcid":false,"given":"Ya\u015far","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-467X","authenticated-orcid":false,"given":"Ay\u015fe Selcen","family":"Bulut Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-962X","authenticated-orcid":false,"given":"Nuran","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-9615","authenticated-orcid":false,"given":"G\u00fcrdal","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"5169_CR1","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/hep.28025","volume":"62","author":"TJ Liang","year":"2015","unstructured":"Liang TJ, Block TM, McMahon BJ et al (2015) Present and future therapies of hepatitis B: from discovery to cure. Hepatology 62:1893\u20131908. https:\/\/doi.org\/10.1002\/hep.28025","journal-title":"Hepatology"},{"key":"5169_CR2","unstructured":"World Health Organization. Hepatitis B report (2017) Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/fs204\/en\/"},{"key":"5169_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.5005\/jp-journals-10018-1264","volume":"8","author":"H Ozkan","year":"2018","unstructured":"Ozkan H (2018) Epidemiology of chronic hepatitis B in Turkey review. Euroasian J Hepatogastroenterol Jan\u2013Jun 8:73\u201374. https:\/\/doi.org\/10.5005\/jp-journals-10018-1264","journal-title":"Euroasian J Hepatogastroenterol Jan\u2013Jun"},{"issue":"2","key":"5169_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5152\/eurjrheumatol.2014.018","volume":"1","author":"N Y\u0131lmaz","year":"2014","unstructured":"Y\u0131lmaz N, Karada\u011f \u00d6, Kimyon G, Yaz\u0131c\u0131 A, Y\u0131lmaz S, Kalyoncu U, Ka\u015fifo\u011flu T, Temiz H, Baysa B (2014) Prevalence of hepatitis B and C \u0131nfections in rheumatoid arthritis and ankylosing spondylitis: a multicenter countrywide study. Eur J Rheumatol 1(2):51\u201354. https:\/\/doi.org\/10.5152\/eurjrheumatol.2014.018","journal-title":"Eur J Rheumatol"},{"key":"5169_CR5","doi-asserted-by":"publisher","first-page":"480","DOI":"10.20524\/aog.2018.0266","volume":"31","author":"C Evangelos","year":"2018","unstructured":"Evangelos C, Anna-Bettina H, Fani A, Parthenis C, George V (2018) Hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive patients receiving immunosuppressive therapy: a systematic review. Ann Gastroenterol 31:480\u2013490. https:\/\/doi.org\/10.20524\/aog.2018.0266","journal-title":"Ann Gastroenterol"},{"key":"5169_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1055\/s-0033-1345722","volume":"33","author":"D Shouval","year":"2013","unstructured":"Shouval D, Shibolet O (2013) Immunosuppression and HBV reactivation. Semin Liver Dis 33:167\u2013177. https:\/\/doi.org\/10.1055\/s-0033-1345722","journal-title":"Semin Liver Dis"},{"key":"5169_CR7","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1097\/MEG.0000000000001130","volume":"30","author":"YC Su","year":"2018","unstructured":"Su YC, Lin PC, Yu HC, Wu CC (2018) Hepatitis B virus reactivation in patients with resolved hepatitis B virus infection receiving chemotherapy or immunosuppressive therapy. Eur J Gastroenterol Hepatol 30:925\u2013929. https:\/\/doi.org\/10.1097\/MEG.0000000000001130","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"5169_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/acr.22783","volume":"68","author":"JA Singh","year":"2016","unstructured":"Singh JA, Saag KG, Bridges SL Jr, Akl EA, Bannuru RR, Sullivan MC, Vaysbrot E et al (2016) American college of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 68:1\u201325. https:\/\/doi.org\/10.1002\/acr.22783","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"5169_CR9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/hep.20110","volume":"39","author":"ASF Lok","year":"2004","unstructured":"Lok ASF, McMahon BJ et al (2004) Practice Guidelines Committee, American Association for the Study of Liver Diseases (AASLD) Chronic hepatitis B: update of recommendations. Hepatology 39:857\u2013861. https:\/\/doi.org\/10.1002\/hep.20110","journal-title":"Hepatology"},{"key":"5169_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12072-015-9675-4","volume":"10","author":"SK Sarin","year":"2016","unstructured":"Sarin SK, Kumar M, Lau GK et al (2016) Asian-Pacific clinical practice guidelines on the management of hepatitis B. Hepatol Int 10:1\u201398. https:\/\/doi.org\/10.1007\/s12072-015-9675-4","journal-title":"Hepatol Int"},{"key":"5169_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5114\/ceh.2019.87631","volume":"3","author":"M Pawlowska","year":"2019","unstructured":"Pawlowska M, Flisiak R, Gil L, Horban A, Hus I, Jaroszewicz J, Lech-Maranda E, Styczynski J (2019) Prophylaxis of hepatitis B virus (HBV) infection reactivation\u2014recommendations of the Working Group for prevention of HBV reactivation. Clin Exp Hepatol 3:195\u2013202. https:\/\/doi.org\/10.5114\/ceh.2019.87631","journal-title":"Clin Exp Hepatol"},{"key":"5169_CR12","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1053\/j.gastro.2017.02.009","volume":"152","author":"R Loomba","year":"2017","unstructured":"Loomba R, Liang TJ (2017) Hepatitis B reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions. Gastroenterology 152:1297\u20131309. https:\/\/doi.org\/10.1053\/j.gastro.2017.02.009","journal-title":"Gastroenterology"},{"key":"5169_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11926-021-01037-3","volume":"23","author":"CD Varley","year":"2021","unstructured":"Varley CD, Winthrop KL (2021) Long-term safety of rituximab (risks of viral and opportunistic infections). Curr Rheumatol Rep 23:74\u201384. https:\/\/doi.org\/10.1007\/s11926-021-01037-3","journal-title":"Curr Rheumatol Rep"},{"key":"5169_CR14","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.3390\/jcm10215201","volume":"10","author":"L Onorato","year":"2021","unstructured":"Onorato L, Pisaturo M, Camaioni C, Grimaldi P, Codella AV, Calo F, Coppola N (2021) Risk and prevention of hepatitis B virus reactivation during immunosuppression for non-oncological diseases. J Clin Med 10:5201. https:\/\/doi.org\/10.3390\/jcm10215201","journal-title":"J Clin Med"},{"key":"5169_CR15","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/1756-185X.14034","volume":"24","author":"S Fidan","year":"2021","unstructured":"Fidan S, Capk\u0131n E, Ar\u0131ca D, Durak S, Okatan IE (2021) Risk of hepatitis B reactivation in patients receiving anti-tumor necrosis factor-\u03b1 therapy. Int J Rheum Dis 24:254\u2013259. https:\/\/doi.org\/10.1111\/1756-185X.14034","journal-title":"Int J Rheum Dis"},{"key":"5169_CR16","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s10067-012-1960-1","volume":"31","author":"HH Ryu","year":"2012","unstructured":"Ryu HH, Lee EY, Shin K, Choi IA, Lee YJ, Yoo B et al (2012) Hepatitis B virus reactivation in rheumatoid arthritis and ankylosing spondylitis patients treated with anti-TNF\u03b1 agents: a retrospective analysis of 49 cases. Clin Rheumatol 31:931\u2013936. https:\/\/doi.org\/10.1007\/s10067-012-1960-1","journal-title":"Clin Rheumatol"},{"key":"5169_CR17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1136\/ard.62.7.686","volume":"62","author":"P Ostuni","year":"2004","unstructured":"Ostuni P, Botsios C, Punzi L, Sfriso P, Todesco S (2004) Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoidarthritis treated with infliximab and low dose methotrexate. Ann Rheum Dis 62:686\u2013687. https:\/\/doi.org\/10.1136\/ard.62.7.686","journal-title":"Ann Rheum Dis"},{"key":"5169_CR18","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s12072-021-10239-x)","volume":"15","author":"G Lau","year":"2021","unstructured":"Lau G, Yu ML, Wong G, Thompson A et al (2021) APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy. Hep Intl 15:1031\u20131048. https:\/\/doi.org\/10.1007\/s12072-021-10239-x)","journal-title":"Hep Intl"},{"key":"5169_CR19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/MD.0b013e3182380a76","volume":"90","author":"R P\u00e9rez-Alvarez","year":"2011","unstructured":"P\u00e9rez-Alvarez R, D\u00edaz-Lagares C, Garc\u00eda-Hern\u00e1ndez F et al (2011) Hepatitis B virus (HBV) reactivation in patients receiving tumornecrosis factor (TNF)-targeted therapy: analysis of 257 cases. Medicine (Baltimore) 90:359\u2013371. https:\/\/doi.org\/10.1097\/MD.0b013e3182380a76","journal-title":"Medicine (Baltimore)"},{"key":"5169_CR20","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/meg.0b013e3283329d13","volume":"22","author":"X Verhelst","year":"2010","unstructured":"Verhelst X, Orlent H, Colle I, Geerts A, De Vos M, VanVlierberghe H (2010) Subfulminant hepatitis B duringtreatment with adalimumab in a patient withrheumatoid arthritis and chronic hepatitis B. Eur J Gastroenterol Hepatol 22:494\u2013499. https:\/\/doi.org\/10.1097\/meg.0b013e3283329d13","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"5169_CR21","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1126\/science.1243462","volume":"343","author":"J Lucifora","year":"2014","unstructured":"Lucifora J, Xia Y, Reisinger F et al (2014) Specific and non hepatotoxic degradation of nuclear hepatitis Bvirus cccDNA. Science 343:1221\u20131228. https:\/\/doi.org\/10.1126\/science.1243462","journal-title":"Science"},{"key":"5169_CR22","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2217\/imt-2016-0003","volume":"8","author":"YM Pers","year":"2016","unstructured":"Pers YM, Jorgensen C (2016) Perspectives of ofatumumab as CD20 targeted therapy in rheumatoid arthritis and other autoimmune diseases. Immunotherapy 8:1091\u20131096. https:\/\/doi.org\/10.2217\/imt-2016-0003","journal-title":"Immunotherapy"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-022-05169-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-022-05169-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-022-05169-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T08:05:29Z","timestamp":1677312329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-022-05169-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["5169"],"URL":"https:\/\/doi.org\/10.1007\/s00296-022-05169-2","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"1 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}