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The current study examines the correlation between serum b2MG and renal involvement, damage score, and disease activity in systemic lupus erythematosus (SLE) patients. One hundred SLE patients from Ain Shams University Hospital were enrolled and categorized into two groups. Group I had 40 patients with negative b2MG, while Group II had 60 patients with positive b2MG levels. Medical history, clinical examination, and assessing disease activity based on SLE disease activity index (SLEDAI-2\u00a0K), and damage score were recorded for all patients. Laboratory examinations, such as serum b2MG, complete blood count, blood urea nitrogen (BUN), serum creatinine, glomerular filtration rate (GFR), urine analysis, 24\u00a0h urinary protein excretion, Antinuclear antibodies (ANA), anti-dsDNA antibody, and serum complement (C3, C4). BUN, 24\u00a0h urinary protein, serum creatinine, active urinary sediment, SLEDAI score, and damage score were all elevated in group II compared to group I (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There is a positive correlation between serum b2MG and 24\u00a0h urinary protein, BUN, serum creatinine, disease activity, and damage score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while it was negatively correlated with GFR, C3, and C4 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Serum b2MG has proven to be a predictor of LN in SLE patients (Sensitivity 92.45%, Specificity 74.47%), also being a predictor of the activity of the disease as well as damage index (Sensitivity 96.67%, Specificity 85%) (Sensitivity 92.45%, Specificity 74.47%), respectively. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.<\/jats:p>","DOI":"10.1007\/s00296-022-05221-1","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T08:03:48Z","timestamp":1665129828000},"page":"323-333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum beta-2 microglobulin as a predictor of nephritis, disease activity, and damage score in systemic lupus erythematosus: a cross-sectional study"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-4837","authenticated-orcid":false,"given":"Dalia Mohamed","family":"Gamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-1466","authenticated-orcid":false,"given":"Fatma Mohammed","family":"Badr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-8701","authenticated-orcid":false,"given":"Sara Ibrahim Abd el Fattah","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-1484","authenticated-orcid":false,"given":"Nouran M.","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-198X","authenticated-orcid":false,"given":"Mohammed Abd El Monem","family":"Teama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"5221_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213819","volume":"78","author":"F Wang","year":"2019","unstructured":"Wang F, Zhang W, Wang S et al (2019) Protective effects of anti malarials in Chinese patients with systemic lupus erythematosus. 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