{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:18:19Z","timestamp":1793384299761,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Joint hypermobility affects approximately 30% of the United Kingdom (UK) population, characterised by the ability to move joints beyond the physiological limits. Associated conditions include Ehlers-Danlos syndrome and hypermobility spectrum disorders, affecting individuals across physical, psychological and social levels detrimentally impacting their health and wellbeing. The scoping review aims to describe the known biopsychosocial impact of joint hypermobility conditions in adults over the last decade. Additional objectives include to (1) identify the types of studies that address these factors, (2) to understand how the impact of the condition is measured and managed and (3) what healthcare professionals (HCPs) are involved. The scoping review was conducted using the five-stage framework by Arksey and O\u2019Malley. The search strategy related to two main keywords, \u201chypermobility\u201d and, \u201cbiopsychosocial\u201d across a number of electronic databases. A pilot search was conducted to determine the suitability of the databases and terms. Following the search, the data was extracted and charted, summarised and narratively reported. 32 studies met the inclusion criteria. The majority were conducted in either the UK or United States of America and case\u2013control in design. The biopsychosocial impact was wide-ranging including, but not limited to, musculoskeletal system and dermatology, gastroenterology, mood and anxiety disorders, education and employments. This review is the first of its kind to summarise all reported symptoms and impact of joint hypermobility conditions in adults, highlighting a clear need to promote a multidisciplinary and holistic approach in raising awareness of these conditions and improving their management.<\/jats:p>","DOI":"10.1007\/s00296-023-05298-2","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T03:02:42Z","timestamp":1678417362000},"page":"985-1014","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The biopsychosocial impact of hypermobility spectrum disorders in adults: a scoping review"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4425","authenticated-orcid":false,"given":"Natalie L.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-738X","authenticated-orcid":false,"given":"Melissa","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-8578","authenticated-orcid":false,"given":"Amar","family":"Rangan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-2416","authenticated-orcid":false,"given":"Lucksy","family":"Kottam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-7441","authenticated-orcid":false,"given":"Katherine","family":"Swainston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"5298_CR1","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s00296-021-04968-3","volume":"41","author":"B Aubry-Rozier","year":"2021","unstructured":"Aubry-Rozier B, Schwitzguebel A, Valerio F, Tanniger J, Paquier C, Berna C, Hugle T, Benaim C (2021) Are patients with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder so different? Rheumatol Int 41:1785\u20131794. https:\/\/doi.org\/10.1007\/s00296-021-04968-3","journal-title":"Rheumatol Int"},{"key":"5298_CR2","unstructured":"Hypermobility Syndromes Association (2022) Hypermobility syndromes association home. https:\/\/www.hypermobility.org. Accessed 12 March 2022"},{"key":"5298_CR3","first-page":"481","volume":"103","author":"KS Yew","year":"2021","unstructured":"Yew KS, Kamps-Schmitt KA, Borge R (2021) Hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. Am Fam Physician 103:481\u2013492","journal-title":"Am Fam Physician"},{"key":"5298_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjopen-2019-031365","volume":"9","author":"JC Demmler","year":"2019","unstructured":"Demmler JC, Atkinson MD, Reinhold EJ, Choy E, Lyons RA, Brophy ST (2019) Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case\u2013control comparison. BMJ Open 9:1\u20139. https:\/\/doi.org\/10.1136\/bmjopen-2019-031365","journal-title":"BMJ Open"},{"key":"5298_CR5","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.amjmed.2017.02.013","volume":"130","author":"B Kumar","year":"2017","unstructured":"Kumar B, Lenert P (2017) Joint hypermobility syndrome: recognizing a commonly overlooked cause of chronic pain. Am J Med 130:640\u2013647. https:\/\/doi.org\/10.1016\/j.amjmed.2017.02.013","journal-title":"Am J Med"},{"key":"5298_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph17176425","volume":"17","author":"IM Palomo-Toucedo","year":"2020","unstructured":"Palomo-Toucedo IM, Leon-Larios F, Reina-Bueno M, del Carmen V-BM, Munuera-Martinez P, Dominguez-Maldonago G (2020) Psychosocial influence of Ehlers-Danlos syndrome in daily life of patients: a qualitative study. Int J Environ Res Public Health 17:1\u201314. https:\/\/doi.org\/10.3390\/ijerph17176425","journal-title":"Int J Environ Res Public Health"},{"key":"5298_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/09638288.2017.1390695","volume":"41","author":"L Hope","year":"2019","unstructured":"Hope L, Juul-Kristensen B, Lovaas H, Lovvik C, Maeland S (2019) Subjective health complaints and illness perception amongst adults with joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome-hypermobility type\u2014a cross-sectional study. Disabil Rehabil 41:333\u2013340. https:\/\/doi.org\/10.1080\/09638288.2017.1390695","journal-title":"Disabil Rehabil"},{"key":"5298_CR8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/msc.1387","volume":"17","author":"S Palmer","year":"2019","unstructured":"Palmer S, Bridgeman K, Di Pierro I, Jones R, Phillips C, Wilson M (2019) The views of people with joint hypermobility syndrome on its impact, management and the use of patient-reported outcome measures. A thematic analysis of open-ended questionnaire responses. Musculoskelet Care 17:183\u2013193. https:\/\/doi.org\/10.1002\/msc.1387","journal-title":"Musculoskelet Care"},{"key":"5298_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00296-015-3375-1","volume":"36","author":"SA Hershenfeld","year":"2016","unstructured":"Hershenfeld SA, Wasim S, McNiven V, Parikh M, Majewski P, Faghfoury H, So J (2016) Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain. Rheumatol Int 36:341\u2013348. https:\/\/doi.org\/10.1007\/s00296-015-3375-1","journal-title":"Rheumatol Int"},{"key":"5298_CR10","first-page":"13","volume":"148","author":"M Castori","year":"2013","unstructured":"Castori M (2013) Joint hypermobility syndrome (a.k.a. Ehlers-Danlos Syndrome, hypermobility type): an updated critique. G Ital Dermatol Venereol 148:13\u201336","journal-title":"G Ital Dermatol Venereol"},{"issue":"2","key":"5298_CR11","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/jmp\/6.2.101","volume":"6","author":"GL Engel","year":"1981","unstructured":"Engel GL (1981) The clinical application of the biopsychosocial model. J Med Philos 6(2):101\u2013124","journal-title":"J Med Philos"},{"key":"5298_CR12","doi-asserted-by":"publisher","unstructured":"Clark NL, Johnson M, Rangan A, Swainston K, Kottam L (2022) Exploring the biopsychosocial impact of hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndrome (EDS) in an adult population: a protocol for a scoping review. Research Square, Preprint Version 1. 21 Dec 2022. https:\/\/doi.org\/10.21203\/rs.3.rs-2179415\/v1","DOI":"10.21203\/rs.3.rs-2179415\/v1"},{"key":"5298_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/1364557032000119616","volume":"8","author":"H Arksey","year":"2005","unstructured":"Arksey H, O\u2019Malley L (2005) Scoping studies: towards a methodological framework. Int J Soc Res Methodol 8:19\u201332. https:\/\/doi.org\/10.1080\/1364557032000119616","journal-title":"Int J Soc Res Methodol"},{"key":"5298_CR14","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s00296-011-1999-3","volume":"31","author":"AY Gasparyan","year":"2011","unstructured":"Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31:1409\u20131417. https:\/\/doi.org\/10.1007\/s00296-011-1999-3","journal-title":"Rheumatol Int"},{"key":"5298_CR15","first-page":"1","volume-title":"The Joanna Briggs Institute reviewers\u2019 manual 2015: methodology for JBI scoping reviews","author":"MDJ Peters","year":"2015","unstructured":"Peters MDJ, Godfrey CM, McInerney P, Soares CB, Khalil H, Parker D (2015) The Joanna Briggs Institute reviewers\u2019 manual 2015: methodology for JBI scoping reviews. The Joanna Briggs Institute, Adelaide, pp 1\u201325"},{"key":"5298_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.7326\/M18-0850","volume":"169","author":"AC Tricco","year":"2018","unstructured":"Tricco AC et al (2018) PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Int Med 169:467\u2013473. https:\/\/doi.org\/10.7326\/M18-0850","journal-title":"Ann Int Med"},{"key":"5298_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7759\/cureus.7881","volume":"12","author":"M Alomari","year":"2020","unstructured":"Alomari M, Hitawala A, Chadalavada P, Covut F, Al Momani L, Khazaaleh S, Gosai F, Al Ashi S, Abushahin A, Schneider A (2020) Prevalence and predictors of gastrointestinal dysmotility in patients with hypermobile Ehlers-Danlos syndrome: a tertiary care center experience. Cureus 12:1\u201312. https:\/\/doi.org\/10.7759\/cureus.7881","journal-title":"Cureus"},{"key":"5298_CR18","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s00296-018-4003-7","volume":"38","author":"C Baeza-Velasco","year":"2018","unstructured":"Baeza-Velasco C, Bourdon C, Montalescot L, de Cazotte C, Pailhez G, Bulbena A, Hamonet C (2018) Low- and high-anxious hypermobile Ehlers-Danlos syndrome patients: comparison of psychosocial and health variables. Rheumatol Int 38:871\u2013878. https:\/\/doi.org\/10.1007\/s00296-018-4003-7","journal-title":"Rheumatol Int"},{"key":"5298_CR19","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1002\/ajmg.a.36293","volume":"161A","author":"B Murray","year":"2013","unstructured":"Murray B, Yashar BM, Uhlmann WR, Clauw DJ, Petty EM (2013) Ehlers-Danlos syndrome, hypermobility type: a characterization of the patients\u2019 lived experience. Am J Med Genet A 161A:2981\u20132988. https:\/\/doi.org\/10.1002\/ajmg.a.36293","journal-title":"Am J Med Genet A"},{"key":"5298_CR20","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/ajmg.c.31935","volume":"187C","author":"CME Halverson","year":"2021","unstructured":"Halverson CME, Clayton EW, Sierra AG, Francomano C (2021) Patients with Ehlers-Danlos syndrome on the diagnostic odyssey: rethinking complexity and difficulty as a hero\u2019s journey. Am J Med Genet C 187C:416\u2013424. https:\/\/doi.org\/10.1002\/ajmg.c.31935","journal-title":"Am J Med Genet C"},{"key":"5298_CR21","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1002\/ajmg.a.62446","volume":"185","author":"TR Maya","year":"2021","unstructured":"Maya TR, Fettig V, Mehta L, Gelb BD, Kontorovich AR (2021) Dysautonomia in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders is associated with exercise intolerance and cardiac atrophy. Am J Med Genet A 185:3754\u20133761. https:\/\/doi.org\/10.1002\/ajmg.a.62446","journal-title":"Am J Med Genet A"},{"key":"5298_CR22","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s00296-019-04293-w","volume":"39","author":"S Wasim","year":"2019","unstructured":"Wasim S, Suddaby JS, Parikh M, Leylachian S, Ho B, Guerin A, So J (2019) Pain and gastrointestinal dysfunction are significant associations with psychiatric disorders in patients with Ehlers-Danlos syndrome and hypermobility spectrum disorders: a retrospective study. Rheumatol Int 39:1241\u20131248. https:\/\/doi.org\/10.1007\/s00296-019-04293-w","journal-title":"Rheumatol Int"},{"key":"5298_CR23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/msc.1407","volume":"17","author":"E Saetre","year":"2019","unstructured":"Saetre E, Eik H (2019) Flexible bodies\u2014restricted lives: a qualitative exploratory study of embodiment in living with joint hypermobility syndrome\/Ehlers-Danlos syndrome, hypermobility type. Musculoskelet Care 17:241\u2013248. https:\/\/doi.org\/10.1002\/msc.1407","journal-title":"Musculoskelet Care"},{"key":"5298_CR24","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/fampra\/cmv026","volume":"32","author":"RH Terry","year":"2015","unstructured":"Terry RH, Palmer ST, Rimes KA, Clark CJ, Simmonds JV, Horwood JP (2015) Living with joint hypermobility syndrome: patient experiences of diagnosis, referral and self-care. Fam Pract 32:354\u2013358. https:\/\/doi.org\/10.1093\/fampra\/cmv026","journal-title":"Fam Pract"},{"key":"5298_CR25","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/1756-185x.12024","volume":"16","author":"G Mullick","year":"2013","unstructured":"Mullick G, Bhakuni DS, Shanmuganandan K, Garg MK, Vasdev V, Kartik S, Jain R (2013) Clinical profile of benign joint hypermobility syndrome from a tertiary care military hospital in India. Int J Rheum Dis 16:590\u2013594. https:\/\/doi.org\/10.1111\/1756-185x.12024","journal-title":"Int J Rheum Dis"},{"key":"5298_CR26","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/ajmg.a.62197","volume":"85A","author":"KL Martinez","year":"2021","unstructured":"Martinez KL, Mauss C, Andrews J, Saboda K, Huynh JM, Sanoja AJ, Jesudas R, Byers PH, Laukaitis CM (2021) Subtle differences in autonomic symptoms in people diagnosed with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders. Am J Med Genet A 85A:2012\u20132025. https:\/\/doi.org\/10.1002\/ajmg.a.62197","journal-title":"Am J Med Genet A"},{"key":"5298_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-016-0905-2","volume":"17","author":"M Folci","year":"2016","unstructured":"Folci M, Capsoni M (2016) Arthralgias, fatigue, paresthesias and visceral pain: can joint hypermobility solve the puzzle? A case report. BMC Musculoskelet Disord 17:1\u20136. https:\/\/doi.org\/10.1186\/s12891-016-0905-2","journal-title":"BMC Musculoskelet Disord"},{"key":"5298_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s40519-015-0232-x","volume":"21","author":"C Baeza-Velasco","year":"2016","unstructured":"Baeza-Velasco C, Van den Bossche T, Grossin D, Hamonet C (2016) Difficulty eating and significant weight loss in joint hypermobility syndrome\/Ehlers\u2013Danlos syndrome, hypermobility type. Eat Weight Disord 21:175\u2013183. https:\/\/doi.org\/10.1007\/s40519-015-0232-x","journal-title":"Eat Weight Disord"},{"key":"5298_CR29","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/eat.22815","volume":"51","author":"M Lee","year":"2017","unstructured":"Lee M, Strand M (2017) Ehlers-Danlos syndrome in a young woman with anorexia nervosa and complex somatic symptoms. Int J Eat Disord 51:281\u2013284. https:\/\/doi.org\/10.1002\/eat.22815","journal-title":"Int J Eat Disord"},{"key":"5298_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-015-0549-7","volume":"16","author":"B Berglund","year":"2015","unstructured":"Berglund B, Pettersson C, Pigg M, Kristiansson P (2015) Self-reported quality of life, anxiety and depression in individuals with Ehlers-Danlos syndrome (EDS): a questionnaire study. BMC Musculoskelet Disord 16:1\u20135. https:\/\/doi.org\/10.1186\/s12891-015-0549-7","journal-title":"BMC Musculoskelet Disord"},{"key":"5298_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.12968\/ijtr.2014.21.2.60","volume":"21","author":"CJ Clark","year":"2014","unstructured":"Clark CJ, Khattab AD, Carr ECJ (2014) Chronic widespread pain and neurophysiological symptoms in joint hypermobility syndrome (JHS). Int J Ther Rehabil 21:60\u201367. https:\/\/doi.org\/10.12968\/ijtr.2014.21.2.60","journal-title":"Int J Ther Rehabil"},{"key":"5298_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4854701","volume":"2018","author":"N Inayet","year":"2018","unstructured":"Inayet N, Hayat JO, Kaul A, Tome M, Child A, Poullis A (2018) Gastrointestinal symptoms in Marfan syndrome and hypermobile Ehlers-Danlos syndrome. Gastroenterol Res Pract 2018:1\u20138. https:\/\/doi.org\/10.1155\/2018\/4854701","journal-title":"Gastroenterol Res Pract"},{"key":"5298_CR33","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s10067-014-2610-6","volume":"34","author":"I Albayrak","year":"2015","unstructured":"Albayrak I, Yilmaz H, Akkurt HE, Salli A, Karaca G (2015) Is pain the only symptom in patients with benign joint hypermobility syndrome? Clin Rheumatol 34:1613\u20131619. https:\/\/doi.org\/10.1007\/s10067-014-2610-6","journal-title":"Clin Rheumatol"},{"key":"5298_CR34","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1136\/thoraxjnl-2016-209560","volume":"72","author":"T Gaisl","year":"2017","unstructured":"Gaisl T, Giunta C, Bratton DJ, Sutherand K, Sclatzer C, Sievi N, Franzen D, Cistulli PA, Rohrbach M, Kohler M (2017) Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study. Thorax 72:729\u2013735. https:\/\/doi.org\/10.1136\/thoraxjnl-2016-209560","journal-title":"Thorax"},{"key":"5298_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0080321","volume":"8","author":"JD Zeitoun","year":"2013","unstructured":"Zeitoun JD, Lefevre JH, de Parades V, Sejourne C, Sobhani I, Coffin B, Hamonet C (2013) Functional digestive symptoms and quality of life in patients with Ehlers-Danlos syndromes: results of a national cohort study on 134 patients. PLoS ONE 8:1\u20138. https:\/\/doi.org\/10.1371\/journal.pone.0080321","journal-title":"PLoS ONE"},{"key":"5298_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nmo.13029","volume":"29","author":"A Fikree","year":"2017","unstructured":"Fikree A, Aziz Q, Sifrim D (2017) Mechanisms underlying reflux symptoms and dysphagia in patients with joint hypermobility syndrome, with and without postural tachycardia syndrome. Neurogastroenterol Motil 29:1\u20139. https:\/\/doi.org\/10.1111\/nmo.13029","journal-title":"Neurogastroenterol Motil"},{"key":"5298_CR37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/1471-0528.12082","volume":"120","author":"H Mastoroudes","year":"2012","unstructured":"Mastoroudes H, Giarenis I, Cardozo L, Srikrishna S, Vella M, Robinson D, Kazkaz H, Grahame R (2012) Prolapse and sexual function in women with benign joint hypermobility syndrome. BJOG Int J Obstet Gynaecol 120:187\u2013192. https:\/\/doi.org\/10.1111\/1471-0528.12082","journal-title":"BJOG Int J Obstet Gynaecol"},{"key":"5298_CR38","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1007\/s00192-013-2065-3","volume":"24","author":"H Mastoroudes","year":"2013","unstructured":"Mastoroudes H, Giarenis I, Cardozo L, Srikrishna S, Vella M, Robinson D, Kazkaz H, Grahame R (2013) Lower urinary tract symptoms in women with benign joint hypermobility syndrome: a case-control study. Int Urogynecol J 24:1553\u20131558. https:\/\/doi.org\/10.1007\/s00192-013-2065-3","journal-title":"Int Urogynecol J"},{"key":"5298_CR39","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1007\/s10072-015-2173-6","volume":"36","author":"F Puledda","year":"2015","unstructured":"Puledda F, Vigano A, Celletti C, Petolicchio B, Toscano M, Vicenzini E, Castori M, Laudani G, Valente D, Camerota F, Di Piero V (2015) A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. Neurol Sci 36:1417\u20131424. https:\/\/doi.org\/10.1007\/s10072-015-2173-6","journal-title":"Neurol Sci"},{"key":"5298_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/gps.4733","volume":"33","author":"A Bulbena-Cabre","year":"2018","unstructured":"Bulbena-Cabre A, Rojo C, Pailhez G, Maso EB, Martin-Lopez LM, Bulbena A (2018) Joint hypermobility is also associated with anxiety disorders in the elderly population. Int J Geriatr Psychiatry 33:113\u2013119. https:\/\/doi.org\/10.1002\/gps.4733","journal-title":"Int J Geriatr Psychiatry"},{"key":"5298_CR41","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1080\/13811118.2021.1885538","volume":"26","author":"C Baeza-Velasco","year":"2022","unstructured":"Baeza-Velasco C, Hamonet C, Montalescot L, Courtet P (2022) Suicidal behaviors in women with the hypermobile Ehlers-Danlos syndrome. Arch Suicide Res 26:1314\u20131326. https:\/\/doi.org\/10.1080\/13811118.2021.1885538","journal-title":"Arch Suicide Res"},{"key":"5298_CR42","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.apmr.2021.12.021","volume":"103","author":"B Liaghat","year":"2022","unstructured":"Liaghat B, Skou ST, Sondergaard J, Boyle E, Sograard K, Juul-Kristensesn B (2022) Clinical characteristics of 100 patients with hypermobility spectrum disorders and shoulder complaints with or without mechanical symptoms: a cross-sectional study. Archiv Phys Med Rehabil 103:1749\u20131757. https:\/\/doi.org\/10.1016\/j.apmr.2021.12.021","journal-title":"Archiv Phys Med Rehabil"},{"key":"5298_CR43","first-page":"307","volume":"26","author":"B Berglund","year":"2012","unstructured":"Berglund B, Bjorck E (2012) Women with Ehlers-Danlos syndrome experience low oral health-related quality of life. J Orofac Pain 26:307\u2013314","journal-title":"J Orofac Pain"},{"key":"5298_CR44","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1080\/09638288.2019.1636316","volume":"43","author":"S De Baets","year":"2021","unstructured":"De Baets S, Calders P, Verhoost L, Coussens M, Dewandele I, Malfait F, Vanderstraeten G, Van Hove G, Van de Velde D (2021) Patient perspectives on employment participation in the \u201chypermobile Ehlers-Danlos syndrome.\u201d Disabil Rehabil 43:668\u2013677. https:\/\/doi.org\/10.1080\/09638288.2019.1636316","journal-title":"Disabil Rehabil"},{"key":"5298_CR45","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/MCG.0000000000001173","volume":"53","author":"J Nee","year":"2019","unstructured":"Nee J, Kilaru S, Kelley J, Oza SS, Hirsch W, Ballou S, Lembo A, Wolf J (2019) Prevalence of functional GI diseases and pelvic floor symptoms in Marfan syndrome and Ehlers Danlos syndrome: a national cohort study. J Clin Gastroenterol 53:653\u2013659. https:\/\/doi.org\/10.1097\/MCG.0000000000001173","journal-title":"J Clin Gastroenterol"},{"key":"5298_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/0972-4958.198469","volume":"31","author":"R Bisaralli","year":"2017","unstructured":"Bisaralli R, Dutta PK, Marak AF, Naroem S (2017) Benign joint hypermobility syndrome: a case series. J Med Soc 31:59\u201362. https:\/\/doi.org\/10.4103\/0972-4958.198469","journal-title":"J Med Soc"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05298-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-023-05298-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05298-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T16:04:45Z","timestamp":1682352285000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-023-05298-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["5298"],"URL":"https:\/\/doi.org\/10.1007\/s00296-023-05298-2","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"assertion":[{"value":"3 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}