{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:38:43Z","timestamp":1793475523728,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-023-05416-0","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:02:22Z","timestamp":1692669742000},"page":"2089-2097","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical features of Beh\u00e7et\u2019s disease and prediction of the use of biologics in 488 cases: a single tertiary center study"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-0209","authenticated-orcid":false,"given":"Zeliha K\u00fcbra","family":"\u00c7akan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-1986","authenticated-orcid":false,"given":"Burcu","family":"Ya\u011f\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-5351","authenticated-orcid":false,"given":"Yavuz","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"issue":"7","key":"5416_CR1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.11622\/smedj.2016123","volume":"57","author":"SY Tan","year":"2016","unstructured":"Tan SY, Poole PS (2016) Hulusi beh\u00e7et (1889\u20131948): passion for dermatology. Singapore Med J. 57(7):408\u20139. https:\/\/doi.org\/10.11622\/smedj.2016123","journal-title":"Singapore Med J."},{"issue":"1","key":"5416_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41572-021-00301-1","volume":"7","author":"Y Yazici","year":"2021","unstructured":"Yazici Y, Hatemi G, Bodaghi B et al (2021) Beh\u00e7et syndrome. Nat Rev Dis Primers 7(1):67. https:\/\/doi.org\/10.1038\/s41572-021-00301-1","journal-title":"Nat Rev Dis Primers"},{"key":"5416_CR3","volume-title":"Behcet disease","author":"A Adil","year":"2023","unstructured":"Adil A, Goyal A, Quint JM (2023) Behcet disease. StatPearls Publishing, Treasure Island"},{"issue":"1","key":"5416_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/1744666X.2016.1205486","volume":"13","author":"F Davatchi","year":"2017","unstructured":"Davatchi F, Chams-Davatchi C, Shams H et al (2017) Behcet\u2019s disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol 13(1):57\u201365. https:\/\/doi.org\/10.1080\/1744666X.2016.1205486","journal-title":"Expert Rev Clin Immunol"},{"issue":"4","key":"5416_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.5152\/eurjrheum.2016.038","volume":"3","author":"D\u00dc Cansu","year":"2016","unstructured":"Cansu D\u00dc, Ka\u015fifo\u011flu T, Korkmaz C (2016) Do clinical findings of Beh\u00e7et\u2019s disease vary by gender?: A single-center experience from 329 patients. Eur J Rheumatol 3(4):157\u2013160. https:\/\/doi.org\/10.5152\/eurjrheum.2016.038","journal-title":"Eur J Rheumatol"},{"issue":"4","key":"5416_CR6","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.jaad.2007.10.452","volume":"58","author":"Y Karincaoglu","year":"2008","unstructured":"Karincaoglu Y, Borlu M, Toker SC et al (2008) Demographic and clinical properties of juvenile-onset Beh\u00e7et\u2019s disease: a controlled multicenter study. J Am Acad Dermatol 58(4):579\u2013584. https:\/\/doi.org\/10.1016\/j.jaad.2007.10.452","journal-title":"J Am Acad Dermatol"},{"key":"5416_CR7","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","volume":"10","author":"B Tong","year":"2019","unstructured":"Tong B, Liu X, Xiao J, Su G (2019) Immunopathogenesis of Behcet\u2019s disease. Front Immunol 10:665. https:\/\/doi.org\/10.3389\/fimmu.2019.00665","journal-title":"Front Immunol"},{"issue":"10","key":"5416_CR8","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1080\/14740338.2020.1817379","volume":"19","author":"G Lopalco","year":"2020","unstructured":"Lopalco G, Rigante D, Lopalco A, Emmi G, Venerito V, Vitale A, Capozio G, Denora N, Cantarini L, Iannone F (2020) Safety of systemic treatments for Beh\u00e7et\u2019s syndrome. Expert Opin Drug Saf 19(10):1269\u20131301. https:\/\/doi.org\/10.1080\/14740338.2020.1817379","journal-title":"Expert Opin Drug Saf"},{"key":"5416_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/jvc2.11","volume":"1","author":"S Vural","year":"2022","unstructured":"Vural S, Boyvat A (2022) The skin in Beh\u00e7et\u2019s disease: mucocutaneous findings and differential diagnosis. JEADV Clin Pract 1:11\u201320","journal-title":"JEADV Clin Pract"},{"issue":"2","key":"5416_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrrheum.2017.208","volume":"14","author":"H Yazici","year":"2018","unstructured":"Yazici H, Seyahi E, Hatemi G, Yazici Y (2018) Beh\u00e7et syndrome: a contemporary view. Nat Rev Rheumatol 14(2):107\u2013119. https:\/\/doi.org\/10.1038\/nrrheum.2017.208","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"5416_CR11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/diagnostics13010041","volume":"13","author":"F Alibaz-Oner","year":"2022","unstructured":"Alibaz-Oner F, Direskeneli H (2022) Update on the diagnosis of Beh\u00e7et\u2019s disease. Diagnostics (Basel) 13(1):41. https:\/\/doi.org\/10.3390\/diagnostics13010041","journal-title":"Diagnostics (Basel)"},{"key":"5416_CR12","doi-asserted-by":"publisher","first-page":"613432","DOI":"10.3389\/fmed.2020.613432","volume":"7","author":"K Nakamura","year":"2021","unstructured":"Nakamura K, Tsunemi Y, Kaneko F, Alpsoy E (2021) Mucocutaneous manifestations of Beh\u00e7et\u2019s disease. Front Med (Lausanne). 7:613432. https:\/\/doi.org\/10.3389\/fmed.2020.613432","journal-title":"Front Med (Lausanne)."},{"issue":"4","key":"5416_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5152\/eurjrheum.2020.21199","volume":"8","author":"C G\u00fcrb\u00fcz","year":"2021","unstructured":"G\u00fcrb\u00fcz C, Yal\u00e7\u0131n Kehribar D, \u00d6zgen M (2021) Clinical manifestations of Beh\u00e7et\u2019s syndrome: a single-center cohort of 777 patients. Eur J Rheumatol 8(4):211\u2013216. https:\/\/doi.org\/10.5152\/eurjrheum.2020.21199","journal-title":"Eur J Rheumatol"},{"issue":"7","key":"5416_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11910-018-0843-5","volume":"18","author":"U Uyguno\u011flu","year":"2018","unstructured":"Uyguno\u011flu U, Siva A (2018) Beh\u00e7et\u2019s syndrome and nervous system involvement. Curr Neurol Neurosci Rep 18(7):35. https:\/\/doi.org\/10.1007\/s11910-018-0843-5","journal-title":"Curr Neurol Neurosci Rep"},{"key":"5416_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/JVD.S182929","volume":"6","author":"MEA Ghembaza","year":"2018","unstructured":"Ghembaza MEA, Lounici A (2018) Superficial venous thrombosis in Beh\u00e7et\u2019s disease: a case report and a review of the literature. J Vasc Diagn Interv 6:15\u201318. https:\/\/doi.org\/10.2147\/JVD.S182929","journal-title":"J Vasc Diagn Interv"},{"issue":"11","key":"5416_CR16","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.3390\/diagnostics12112868","volume":"12","author":"C Giannessi","year":"2022","unstructured":"Giannessi C, Smorchkova O, Cozzi D et al (2022) Beh\u00e7et\u2019s disease: a radiological review of vascular and parenchymal pulmonary involvement. Diagnostics (Basel) 12(11):2868. https:\/\/doi.org\/10.3390\/diagnostics12112868","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"5416_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.rdc.2017.09.007","volume":"44","author":"I Hatemi","year":"2018","unstructured":"Hatemi I, Hatemi G, \u00c7elik AF (2018) Gastrointestinal involvement in Beh\u00e7et disease. Rheum Dis Clin North Am 44(1):45\u201364. https:\/\/doi.org\/10.1016\/j.rdc.2017.09.007","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"5416_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43166-023-00181-1","volume":"50","author":"T Erdem Sultano\u011flu","year":"2023","unstructured":"Erdem Sultano\u011flu T, Er\u00f6z R, Atao\u011flu S (2023) Evaluation of HLA-B51 frequency and its relationship with clinical findings in patients with Beh\u00e7et\u2019s disease: 4-year analysis in a single center. Egypt Rheumatol Rehabil 50(1):1\u20137. https:\/\/doi.org\/10.1186\/s43166-023-00181-1","journal-title":"Egypt Rheumatol Rehabil"},{"key":"5416_CR19","doi-asserted-by":"publisher","first-page":"624795","DOI":"10.3389\/fmed.2021.624795","volume":"8","author":"E Alpsoy","year":"2021","unstructured":"Alpsoy E, Leccese P, Emmi G, Ohno S (2021) Treatment of Beh\u00e7et\u2019s disease: an algorithmic multidisciplinary approach. Front Med 8:624795. https:\/\/doi.org\/10.3389\/fmed.2021.624795","journal-title":"Front Med"},{"key":"5416_CR20","volume-title":"Pathergy test","author":"S Rahman","year":"2022","unstructured":"Rahman S, Daveluy S (2022) Pathergy test. StatPearls Publishing, Treasure Island"},{"key":"5416_CR21","doi-asserted-by":"publisher","first-page":"1098351","DOI":"10.3389\/fmed.2022.1098351","volume":"9","author":"S Bergamo","year":"2022","unstructured":"Bergamo S (2022) The diagnosis of Adamantiades-Beh\u00e7et disease: clinical features and diagnostic\/classification criteria. Front Med (Lausanne) 9:1098351. https:\/\/doi.org\/10.3389\/fmed.2022.1098351","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"5416_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11926-021-01011-z","volume":"23","author":"F Alibaz-Oner","year":"2021","unstructured":"Alibaz-Oner F, Direskeneli H (2021) Advances in the treatment of Behcet\u2019s disease. Curr Rheumatol Rep 23(6):47. https:\/\/doi.org\/10.1007\/s11926-021-01011-z","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"5416_CR23","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s40257-021-00592-w","volume":"22","author":"DM P\u00e9rez-Garza","year":"2021","unstructured":"P\u00e9rez-Garza DM, Chavez-Alvarez S, Ocampo-Candiani J, Gomez-Flores M (2021) Erythema nodosum: a practical approach and diagnostic algorithm. Am J Clin Dermatol 22(3):367\u2013378. https:\/\/doi.org\/10.1007\/s40257-021-00592-w","journal-title":"Am J Clin Dermatol"},{"issue":"5","key":"5416_CR24","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/1756-185X.12512","volume":"21","author":"A Khabbazi","year":"2018","unstructured":"Khabbazi A, Noshad H, Shayan FK, Kavandi H, Hajialiloo M, Kolahi S (2018) Demographic and clinical features of Behcet\u2019s disease in Azerbaijan. Int J Rheum Dis 21(5):1114\u20131119. https:\/\/doi.org\/10.1111\/1756-185X.12512","journal-title":"Int J Rheum Dis"},{"issue":"1","key":"5416_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.31138\/mjr.34.1.53","volume":"34","author":"A Sadeghi","year":"2023","unstructured":"Sadeghi A, Rostami M, Amraei G, Davatchi F, Shahram F, KarimiMoghaddam A, KarimiMoghaddam Z, Zeraatchi A (2023) Clinical manifestations of Beh\u00e7et\u2019s disease: a retrospective cross-sectional study. Mediterr J Rheumatol 34(1):53\u201360. https:\/\/doi.org\/10.31138\/mjr.34.1.53","journal-title":"Mediterr J Rheumatol"},{"issue":"4","key":"5416_CR26","doi-asserted-by":"publisher","first-page":"240","DOI":"10.5152\/eurjrheum.2018.18094","volume":"5","author":"M \u0130ris","year":"2018","unstructured":"\u0130ris M, \u00d6z\u00e7\u0131kmak E, Aksoy A et al (2018) The assessment of contributing factors to oral ulcer presence in Beh\u00e7et\u2019s disease: dietary and non-dietary factors. Eur J Rheumatol 5(4):240\u2013243. https:\/\/doi.org\/10.5152\/eurjrheum.2018.18094","journal-title":"Eur J Rheumatol"},{"issue":"3","key":"5416_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/rheumatology\/kep401","volume":"49","author":"G Ciancio","year":"2010","unstructured":"Ciancio G, Colina M, La Corte R et al (2010) Nicotine-patch therapy on mucocutaneous lesions of Beh\u00e7et\u2019s disease: a case series. Rheumatology 49(3):501\u2013504. https:\/\/doi.org\/10.1093\/rheumatology\/kep401","journal-title":"Rheumatology"},{"key":"5416_CR28","doi-asserted-by":"publisher","first-page":"713052","DOI":"10.3389\/fmed.2021.713052","volume":"8","author":"I Mattioli","year":"2021","unstructured":"Mattioli I, Bettiol A, Saruhan-Direskeneli G, Direskeneli H, Emmi G (2021) Pathogenesis of Beh\u00e7et\u2019s syndrome: genetic, environmental and immunological factors. Front Med 8:713052. https:\/\/doi.org\/10.3389\/fmed.2021.713052","journal-title":"Front Med"},{"issue":"4","key":"5416_CR29","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s40257-021-00609-4","volume":"22","author":"E Alpsoy","year":"2021","unstructured":"Alpsoy E, Bozca BC, Bilgic A (2021) Beh\u00e7et disease: an update for dermatologists. Am J Clin Dermatol 22(4):477\u2013502. https:\/\/doi.org\/10.1007\/s40257-021-00609-4","journal-title":"Am J Clin Dermatol"},{"key":"5416_CR30","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.3389\/fimmu.2019.02830","volume":"10","author":"A Bettiol","year":"2019","unstructured":"Bettiol A, Hatemi G, Vannozzi L, Barilaro A, Prisco D, Emmi G (2019) Treating the different phenotypes of Beh\u00e7et\u2019s syndrome. Front Immunol 10:2830. https:\/\/doi.org\/10.3389\/fimmu.2019.02830","journal-title":"Front Immunol"},{"issue":"1","key":"5416_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13075-021-02429-7","volume":"23","author":"J Zou","year":"2021","unstructured":"Zou J, Luo JF, Shen Y et al (2021) Cluster analysis of phenotypes of patients with Beh\u00e7et\u2019s syndrome: a large cohort study from a referral center in China. Arthritis Res Ther 23(1):45. https:\/\/doi.org\/10.1186\/s13075-021-02429-7","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"5416_CR32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12016-021-08864-3","volume":"61","author":"J Chen","year":"2021","unstructured":"Chen J, Yao X (2021) A contemporary review of Behcet\u2019s syndrome. Clin Rev Allergy Immunol 61(3):363\u2013376. https:\/\/doi.org\/10.1007\/s12016-021-08864-3","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"5416_CR33","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/rheumatology\/keaa086","volume":"59","author":"O Karadag","year":"2020","unstructured":"Karadag O, Bolek EC (2020) Management of Behcet\u2019s syndrome. Rheumatology (Oxford) 59(3):108\u2013117. https:\/\/doi.org\/10.1093\/rheumatology\/keaa086","journal-title":"Rheumatology (Oxford)"},{"issue":"Suppl 127","key":"5416_CR34","first-page":"3","volume":"38","author":"G Hatemi","year":"2020","unstructured":"Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V (2020) One year in review 2020: Beh\u00e7et\u2019s syndrome. Clin Exp Rheumatol. 38(Suppl 127):3\u201310","journal-title":"Clin Exp Rheumatol."},{"issue":"1","key":"5416_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reuma.2019.03.002","volume":"17","author":"A Khabbazi","year":"2021","unstructured":"Khabbazi A, Ebrahimzadeh Attari V, Asghari Jafarabadi M, Malek Mahdavi A (2021) Quality of life in patients with Beh\u00e7et disease and its relation with clinical symptoms and disease activity. Reumatol Clin 17(1):1\u20136. https:\/\/doi.org\/10.1016\/j.reuma.2019.03.002","journal-title":"Reumatol Clin"},{"issue":"10","key":"5416_CR36","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1093\/rheumatology\/keaa010","volume":"59","author":"T Thomas","year":"2020","unstructured":"Thomas T, Chandan JS, Subramanian A et al (2020) Epidemiology, morbidity and mortality in Beh\u00e7et\u2019s disease: a cohort study using The Health Improvement Network (THIN). Rheumatology (Oxford) 59(10):2785\u20132795. https:\/\/doi.org\/10.1093\/rheumatology\/keaa010","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"5416_CR37","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.revmed.2018.02.022","volume":"39","author":"AC Desbois","year":"2018","unstructured":"Desbois AC, Terrada C, Cacoub P, Bodaghi B, Saadoun D (2018) Les manifestations oculaires de la maladie de Beh\u00e7et [ocular manifestations in Beh\u00e7et\u2019s disease]. Rev Med Interne 39(9):738\u2013745. https:\/\/doi.org\/10.1016\/j.revmed.2018.02.022","journal-title":"Rev Med Interne"},{"issue":"3","key":"5416_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4274\/tjo.galenos.2019.60308","volume":"50","author":"P \u00c7akar\u00d6zdal","year":"2020","unstructured":"\u00c7akar\u00d6zdal P (2020) Beh\u00e7et\u2019s uveitis: current diagnostic and therapeutic approach. Turk J Ophthalmol 50(3):169\u2013182. https:\/\/doi.org\/10.4274\/tjo.galenos.2019.60308","journal-title":"Turk J Ophthalmol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05416-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-023-05416-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05416-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T06:06:54Z","timestamp":1694412414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-023-05416-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["5416"],"URL":"https:\/\/doi.org\/10.1007\/s00296-023-05416-0","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]},"assertion":[{"value":"26 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest, financial or otherwise. The authors are not related to any pharma company and this study was not financially supported by any institution. The authors have no conflicts of interest to declare relevant to this article\u2019s content. This manuscript is original and it, or any part of it, has not been previously published; nor is it under consideration for publication elsewhere.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}