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Multicentre, retrospective analysis of demographic, clinical and genetic data of patients with autoinflammatory diseases (AID) who received anti-IL-1 targeted therapy. The cohort comprised 152 patients with familial Mediterranean fever (FMF; n\u2009=\u200971), cryopyrin-associated periodic syndromes (CAPS; n\u2009=\u200943), TNF-receptor associated periodic syndrome (TRAPS; n\u2009=\u200919), mevalonate kinase deficiency (MKD; n\u2009=\u20093) and unclassified AID (uAID; n\u2009=\u200916). Inflammatory attacks started in 61.2% of the patients before the age of 18\u00a0years. The delay between the first AID attack and anti-IL-1 therapy was 17.8\u00a0years. Monogenetic AIDs were diagnosed by clinical symptoms. Genetic analyses confirmed the diagnosis in 87.3% of patients with FMF, 65.2% with CAPS and 94.8% with TRAPS. Among this group, heterozygous <jats:italic>MEFV<\/jats:italic> variants and variants of unknown significance (VUS) were detected in 22.5% of patients with FMF, 51.2% with CAPS and 47.4% with TRAPS. Patients with VUS were older at disease onset which is consistent with a milder phenotype. Twenty-four patients had secondary AA amyloidosis (AA) at initiation of anti-IL-1 therapy. The mean age of these patients was 16.4\u00a0years at their first attack and 44.9\u00a0years at the time of AA diagnosis. Turkish-Armenian ancestry correlated with <jats:italic>MEFV<\/jats:italic> variants and higher FMF disease activity compared to German ancestry. Molecular genetic analyses should substantiate the clinical diagnosis of a monogenetic AID. Our data support the concept of variable penetrance of VUS which can be associated with late-onset AID.<\/jats:p>","DOI":"10.1007\/s00296-023-05443-x","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:02:05Z","timestamp":1695625325000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical presentation and genetic variants in patients with autoinflammatory diseases: results from the German GARROD registry"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-1690","authenticated-orcid":false,"given":"Norbert","family":"Blank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-005X","authenticated-orcid":false,"given":"Ina","family":"K\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-2299","authenticated-orcid":false,"given":"Marc","family":"Schmalzing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-2029","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Rech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-9654","authenticated-orcid":false,"given":"Karoline","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-7071","authenticated-orcid":false,"given":"Birgit","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2805-2643","authenticated-orcid":false,"given":"Dorothee","family":"Kaudewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-7527","authenticated-orcid":false,"given":"Martin","family":"Nitschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-777X","authenticated-orcid":false,"given":"Christian S.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-0946","authenticated-orcid":false,"given":"Hanns-Martin","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-7790","authenticated-orcid":false,"given":"Martin","family":"Krusche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"5443_CR1","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D et al (1997) Criteria for the diagnosis of familial Mediterranean fever. 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JR received research grants from SOBI and Novartis and speaking and consulting honoraria from Abbvie, Biogen, BMS, Chugai, GSK, Janssen, Lilly, MSD; Mylan, Novartis, Roche, Sanofi, Sobi, UCB. MK received lecture honoraria from SOBI, Novartis, Roche, Sanofi and Medac. IK, MS, KK, BK, DK, MN, CH declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No previous preprint archiving was performed. No congress abstracts with content from this manuscript were published. No part of this manuscript was copied or published elsewhere in whole or in part in any language.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This study reports on human data. Ethics approval was stated by the local ethics committee of the University of Heidelberg (reference S-103\/2013). Each individual provided written informed consent as approved by the ethics committee (reference S-103\/2013).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}