{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:41:13Z","timestamp":1780472473314,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-023-05445-9","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T17:01:57Z","timestamp":1694451717000},"page":"2245-2250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of anti-carbamylated protein antibodies on disease activity and joint erosions in seronegative and seropositive rheumatoid arthritis"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-5732","authenticated-orcid":false,"given":"Luis M.","family":"Amezcua-Guerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Carbonell-Bobadilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-7789","authenticated-orcid":false,"given":"Carina","family":"Soto-Fajardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-3307","authenticated-orcid":false,"given":"Angelica","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6666-9127","authenticated-orcid":false,"given":"Ana B.","family":"Batres-Marroqu\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-7308","authenticated-orcid":false,"given":"Tania","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-6007","authenticated-orcid":false,"given":"Ana C.","family":"Medina-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6569-2851","authenticated-orcid":false,"given":"Adrian","family":"Hern\u00e1ndez-Diazcouder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Jim\u00e9nez-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-7461","authenticated-orcid":false,"given":"Carlos","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-9343","authenticated-orcid":false,"given":"Luis H.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"5445_CR1","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569\u20132581. https:\/\/doi.org\/10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"key":"5445_CR2","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/acr.20207","volume":"62","author":"TM Farragher","year":"2010","unstructured":"Farragher TM, Lunt M, Plant D, Bunn DK, Barton A, Symmons DP (2010) Benefit of early treatment in inflammatory polyarthritis patients with anti-cyclic citrullinated peptide antibodies versus those without antibodies. Arthritis Care Res 62:664\u2013675. https:\/\/doi.org\/10.1002\/acr.20207","journal-title":"Arthritis Care Res"},{"key":"5445_CR3","doi-asserted-by":"publisher","first-page":"978351","DOI":"10.3389\/fmed.2022.978351","volume":"9","author":"N Carbonell-Bobadilla","year":"2022","unstructured":"Carbonell-Bobadilla N, Soto-Fajardo C, Amezcua-Guerra LM, Batres-Marroqu\u00edn AB, Vargas T, Hern\u00e1ndez-Diazcouder A, Jim\u00e9nez-Rojas V, Medina-Garc\u00eda AC, Pineda C, Silveira LH (2022) Patients with seronegative rheumatoid arthritis have a different phenotype than seropositive patients: a clinical and ultrasound study. Front Med 9:978351. https:\/\/doi.org\/10.3389\/fmed.2022.978351","journal-title":"Front Med"},{"key":"5445_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/annrheumdis-2015-208873","volume":"76","author":"LB Nordberg","year":"2017","unstructured":"Nordberg LB, Lillegraven S, Lie E, Aga AB, Olsen IC, Hammer HB, Uhlig T, Jonsson MK, van der Heijde D, Kvien TK, Haavardsholm EA (2017) Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-na\u00efve patients classified according to the 2010 ACR\/EULAR criteria. Ann Rheum Dis 76:341\u2013345. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208873","journal-title":"Ann Rheum Dis"},{"key":"5445_CR5","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/acr.23497","volume":"70","author":"AC Boer","year":"2018","unstructured":"Boer AC, Boonen A, van der Helm van Mil AHM (2018) Is anti-citrullinated protein antibody-positive rheumatoid arthritis still a more severe disease than anti-citrullinated protein antibody-negative rheumatoid arthritis? A longitudinal cohort study in rheumatoid arthritis patients diagnosed from 2000 onward. Arthritis Care Res 70:987\u2013996. https:\/\/doi.org\/10.1002\/acr.23497","journal-title":"Arthritis Care Res"},{"key":"5445_CR6","doi-asserted-by":"publisher","first-page":"102392","DOI":"10.1016\/j.jaut.2019.102392","volume":"110","author":"MAM van Delft","year":"2020","unstructured":"van Delft MAM, Huizinga TWJ (2020) An overview of autoantibodies in rheumatoid arthritis. J Autoimmun 110:102392. https:\/\/doi.org\/10.1016\/j.jaut.2019.102392","journal-title":"J Autoimmun"},{"key":"5445_CR7","doi-asserted-by":"publisher","unstructured":"- Kolarz B, Ciesla M, Rosenthal AK, Dryglewska M, Majdan M (2021) The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA\/RF negative rheumatoid arthritis patients. Ther Adv Musculoskelet Dis 13:1759720X21989868. doi:https:\/\/doi.org\/10.1177\/1759720X21989868","DOI":"10.1177\/1759720X21989868"},{"key":"5445_CR8","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13075-016-1001-6","volume":"18","author":"E Reed","year":"2016","unstructured":"Reed E, Jiang X, Kharlamova N, Ytterberg AJ, Catrina AI, Israelsson L, Mathsson-Alm L, Hansson M, Alfredsson L, R\u00f6nnelid J, Lundberg K (2016) Antibodies to carbamylated \u03b1-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies. Arthritis Res Ther 18:96. https:\/\/doi.org\/10.1186\/s13075-016-1001-6","journal-title":"Arthritis Res Ther"},{"key":"5445_CR9","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s13075-015-0860-6","volume":"17","author":"J Shi","year":"2015","unstructured":"Shi J, van Steenbergen HW, van Nies JA, Levarht EW, Huizinga TW, van der Helm-van Mil AH, Toes RE, Trouw LA (2015) The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis. Arthritis Res Ther 17:339. https:\/\/doi.org\/10.1186\/s13075-015-0860-6","journal-title":"Arthritis Res Ther"},{"key":"5445_CR10","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1002\/art.40237","volume":"69","author":"ME Truchetet","year":"2017","unstructured":"Truchetet ME, Dublanc S, Barnetche T, Vittecoq O, Mariette X, Richez C, Blanco P, Mahler M, Contin-Bordes C, Schaeverbeke T (2017) Association of the presence of anti-carbamylated protein antibodies in early arthritis with a poorer clinical and radiologic outcome: data from the French ESPOIR cohort. Arthritis Rheumatol 69:2292\u20132302. https:\/\/doi.org\/10.1002\/art.40237","journal-title":"Arthritis Rheumatol"},{"key":"5445_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13075-020-02191-2","volume":"22","author":"E Reed","year":"2020","unstructured":"Reed E, Hedstr\u00f6m AK, Hansson M, Mathsson-Alm L, Brynedal B, Saevarsdottir S, Cornillet M, Jakobsson PJ, Holmdahl R, Skriner K, Serre G, Alfredsson L, R\u00f6nnelid J, Lundberg K (2020) Presence of autoantibodies in \u201cseronegative\u201d rheumatoid arthritis associates with classical risk factors and high disease activity. Arthritis Res Ther 22:170. https:\/\/doi.org\/10.1186\/s13075-020-02191-2","journal-title":"Arthritis Res Ther"},{"key":"5445_CR12","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/03009742.2020.1798500","volume":"50","author":"P Sidiras","year":"2021","unstructured":"Sidiras P, Spruyt D, Gangji V, Imbault V, Sokolova T, Durez P, Communi D, Rasschaert J, Badot V (2021) Antibodies against carbamylated proteins: prevalence and associated disease characteristics in Belgian patients with rheumatoid arthritis or other rheumatic diseases. Scand J Rheumatol 50:118\u2013123. https:\/\/doi.org\/10.1080\/03009742.2020.1798500","journal-title":"Scand J Rheumatol"},{"key":"5445_CR13","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.1093\/rheumatology\/keab050","volume":"60","author":"C Lamacchia","year":"2021","unstructured":"Lamacchia C, Courvoisier DS, Jarlborg M, Bas S, Roux-Lombard P, M\u00f6ller B, Ciurea A, Finckh A, Bentow C, Martinez-Prat L, Mahler M, Gabay C, Nissen MJ (2021) Predictive value of anti-CarP and anti-PAD3 antibodies alone or in combination with RF and ACPA for the severity of rheumatoid arthritis. Rheumatology 60:4598\u20134608. https:\/\/doi.org\/10.1093\/rheumatology\/keab050","journal-title":"Rheumatology"},{"key":"5445_CR14","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1136\/annrheumdis-2017-211585","volume":"76","author":"I M\u00f6ller","year":"2017","unstructured":"M\u00f6ller I, Janta I, Backhaus M et al (2017) The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology. Ann Rheum Dis 76:1974\u20131979. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211585","journal-title":"Ann Rheum Dis"},{"key":"5445_CR15","doi-asserted-by":"publisher","first-page":"e000752","DOI":"10.1136\/rmdopen-2018-000752","volume":"4","author":"LB Nordberg","year":"2018","unstructured":"Nordberg LB, Lillegraven S, Aga AB, Sexton J, Olsen IC, Lie E, Berner Hammer H, Uhlig T, van der Heijde D, Kvien TK, Haavardsholm EA (2018) Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR\/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial. RMD Open 4:e000752. https:\/\/doi.org\/10.1136\/rmdopen-2018-000752","journal-title":"RMD Open"},{"key":"5445_CR16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/annrheumdis-2021-220546","volume":"81","author":"F Wouters","year":"2022","unstructured":"Wouters F, Maurits MP, van Boheemen L, Verstappen M, Mankia K, Matthijssen XME, Dorj\u00e9e AL, Emery P, Knevel R, van Schaardenburg D, Toes REM, van der Helm-van Mil AHM (2022) Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis. Ann Rheum Dis 81:48\u201355. https:\/\/doi.org\/10.1136\/annrheumdis-2021-220546","journal-title":"Ann Rheum Dis"},{"key":"5445_CR17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1165\/rcmb.2010-0500OC","volume":"46","author":"O Kilsg\u00e5rd","year":"2012","unstructured":"Kilsg\u00e5rd O, Andersson P, Malmsten M, Nordin SL, Linge HM, Eliasson M, S\u00f6renson E, Erjef\u00e4lt JS, Bylund J, Olin AI, S\u00f8rensen OE, Egesten A (2012) Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities. Am J Respir Cell Mol Biol 46:240\u2013248. https:\/\/doi.org\/10.1165\/rcmb.2010-0500OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"5445_CR18","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1136\/annrheumdis-2016-210059","volume":"76","author":"C Ospelt","year":"2017","unstructured":"Ospelt C, Bang H, Feist E, Camici G, Keller S, Detert J, Kr\u00e4mer A, Gay S, Ghannam K, Burmester GR (2017) Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Ann Rheum Dis 76:1176\u20131183. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210059","journal-title":"Ann Rheum Dis"},{"key":"5445_CR19","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1136\/annrheumdis-2013-205109","volume":"73","author":"X Jiang","year":"2014","unstructured":"Jiang X, Trouw LA, van Wesemael TJ, Shi J, Bengtsson C, K\u00e4llberg H, Malmstr\u00f6m V, Israelsson L, Hreggvidsdottir H, Verduijn W, Klareskog L, Alfredsson L, Huizinga TW, Toes RE, Lundberg K, van der Woude D (2014) Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies. Ann Rheum Dis 73:1761\u20131768. https:\/\/doi.org\/10.1136\/annrheumdis-2013-205109","journal-title":"Ann Rheum Dis"},{"key":"5445_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/art.40738","volume":"71","author":"C Regueiro","year":"2019","unstructured":"Regueiro C, Rodriguez-Rodriguez L, Triguero-Martinez A et al (2019) Specific association of HLA-DRB1*03 with anti-carbamylated protein antibodies in patients with rheumatoid arthritis. Arthritis Rheumatol 71:331\u2013339. https:\/\/doi.org\/10.1002\/art.40738","journal-title":"Arthritis Rheumatol"},{"key":"5445_CR21","doi-asserted-by":"publisher","first-page":"10576","DOI":"10.3390\/ijms221910576","volume":"22","author":"EJ Kwon","year":"2021","unstructured":"Kwon EJ, Ju JH (2021) Impact of posttranslational modification in pathogenesis of rheumatoid arthritis: Focusing on citrullination, carbamylation, and acetylation. Int J Mol Sci 22:10576. https:\/\/doi.org\/10.3390\/ijms221910576","journal-title":"Int J Mol Sci"},{"key":"5445_CR22","doi-asserted-by":"publisher","first-page":"17372","DOI":"10.1073\/pnas.1114465108","volume":"108","author":"J Shi","year":"2011","unstructured":"Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, Levarht NE, van der Helm-van Mil AH, Cerami A, Huizinga TW, Toes RE, Trouw LA (2011) Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA 108:17372\u201317377. https:\/\/doi.org\/10.1073\/pnas.1114465108","journal-title":"Proc Natl Acad Sci USA"},{"key":"5445_CR23","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1002\/art.20333","volume":"50","author":"M Szkudlarek","year":"2004","unstructured":"Szkudlarek M, Narvestad E, Klarlund M, Court-Payen M, Thomsen HS, \u00d8stergaard M (2004) Ultrasonography of the metatarsophalangeal joints in rheumatoid arthritis: comparison with magnetic resonance imaging, conventional radiography, and clinical examination. Arthritis Rheum 50:2103\u20132112. https:\/\/doi.org\/10.1002\/art.20333","journal-title":"Arthritis Rheum"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05445-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-023-05445-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-023-05445-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:03:55Z","timestamp":1697699035000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-023-05445-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5445"],"URL":"https:\/\/doi.org\/10.1007\/s00296-023-05445-9","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,11]]},"assertion":[{"value":"6 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study adhered to the principles outlined in the Declaration of Helsinki and local regulations. The research protocol was approved by the local ethics committee (Comit\u00e9 de \u00c9tica del Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez; protocol #16-960). All participating patients provided informed consent, granting authorization for the utilization of their clinical and laboratory data for research purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The results of this study have not been presented at any congress or scientific meeting.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Congress abstract publication"}}]}}