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Dickkopf-related protein 1 (DKK1) which inhibits the Wingless protein (Wnt) signalling pathway has been shown to be a master regulator of bone remodeling in inflammatory rheumatic diseases. However, the exact relationship between DKK1 serum level and bone remodelling is not clear. The goal of this study is to review state-of-the-art knowledge on the association of serum DKK1 with a bone remodelling in PsA. The MEDLINE-PubMed, EMBASE, Scopus, Web of Science and DOAJ databases were searched for appropriate papers. The English terms: \u2018DKK1\u2019, \u2018Dickkopf-1\u2019 \u2018Dickkopf related protein 1\u2019, \u2018psoriatic arthritis\u2019 and \u2018PsA\u2019 were used for search purposes. Eight original articles and two reviews were identified up to August 2023. In four out of 8 discussed studies DKK1 serum level was higher in PsA patients than in healthy controls [Dalbeth, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; Diani, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; Chung, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; Abd el Hamid, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)], it was comparable in another (Daousiss, <jats:italic>p\u2009=\u2009<\/jats:italic>0.430) and was lower in two (Fassio2017, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; Fassio2019, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In one study, the comparative groups included patients with axial spondyloarthritis, where DKK1 serum levels were lower in PsA groups [Jadon, peripheral PsA, <jats:italic>p\u2009=\u2009<\/jats:italic>0.01]. The true relative serum concentration of DKK1 in PsA, as well as its influence on osteogenesis and osteoresorption, is still equivocal. Further studies on this matter with consistent and stringent methodology are warranted.<\/jats:p>","DOI":"10.1007\/s00296-023-05452-w","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:02:37Z","timestamp":1695722557000},"page":"2175-2183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum concentration of dickkopf-related protein 1 (DKK1) in psoriatic arthritis in the context of bone remodelling"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-9818","authenticated-orcid":false,"given":"Grzegorz","family":"Biedro\u0144","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-1738","authenticated-orcid":false,"given":"Marcin","family":"Czepiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-5412","authenticated-orcid":false,"given":"Maciej","family":"Siedlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-9739","authenticated-orcid":false,"given":"Mariusz","family":"Korkosz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"issue":"11","key":"5452_CR1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41584-020-00507-9","volume":"16","author":"DR Jadon","year":"2020","unstructured":"Jadon DR, Stober C, Pennington SR, FitzGerald O (2020) Applying precision medicine to unmet clinical needs in psoriatic disease. 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